Opaleye Management Inc.
Follow13F filer, CIK 1595855, BOSTON, MA
Opaleye Management Inc. reported $1,104,182,260 across 58 holdings for the quarter ended 2026-06-30, in a 13F-HR filed 2026-08-14. Its ten largest share positions make up 64.76% of the portfolio.
Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001420506-26-001803
- Period
- 2026-06-30
- Reported value
- $1.1B
- Holdings
- 58
- Top 10 weight
- 64.76%
- New
- 13
- Sold out
- 9
Largest buys vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| IRONadded | +434,000 | $31.7M |
| IMMXnew | +2,345,000 | $24.2M |
| MGTXadded | +1,426,741 | $19.3M |
| GLUEnew | +745,000 | $18M |
| REPLnew | +1,384,993 | $15.3M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Largest sells vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| CATXexited | -4,675,000 | -$19.5M |
| HROWreduced | -432,230 | -$18.4M |
| LQDAreduced | -97,500 | -$7.77M |
| SNWVreduced | -675,127 | -$6.75M |
| JBIOreduced | -282,608 | -$6.28M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Holdings, Q2 2026
Share positions as resolved from 13F-HR 0001420506-26-001803, largest first. % of portfolio is the value over $1,104,182,260, the sum of the share positions whose value is usable for ratios (method).
| Security | History | Shares | Value | % of portfolio | Change | Latest event | Timeline |
|---|---|---|---|---|---|---|---|
| LQDALIQUIDIA CORPORATION | 2,447,500 | $195M | 17.67% | -97,500 | Timeline | ||
| ETONETON PHARMACEUTICALS INC | 2,860,000 | $104M | 9.38% | 0 | Timeline | ||
| HROWHARROW INC | 2,400,000 | $102M | 9.23% | -432,230 | Timeline | ||
| IRONDISC MEDICINE INC | 855,000 | $62.5M | 5.66% | +434,000 | Timeline | ||
| URGNUROGEN PHARMA LTD | 1,439,996 | $53M | 4.8% | +9,996 | Timeline | ||
| APGEAPOGEE THERAPEUTICS INC | 390,000 | $51.8M | 4.69% | 0 | Timeline | ||
| MGTXMEIRAGTX HLDGS PLC | 3,550,000 | $48M | 4.34% | +1,426,741 | Timeline | ||
| SLGLSOL-GEL TECHNOLOGIES LTD | 500,000 | $37.1M | 3.36% | 0 | Timeline | ||
| RZLTREZOLUTE INC | 6,300,000 | $32.8M | 2.97% | 0 | Timeline | ||
| TGTXTG THERAPEUTICS INC | 535,000 | $29.4M | 2.66% | 0 | Timeline | ||
| IMMXIMMIX BIOPHARMA INC | 2,345,000 | $24.2M | 2.19% | new | Timeline | ||
| CBIOCRESCENT BIOPHARMA INC. | 1,319,351 | $23.7M | 2.15% | +6,736 | Timeline | ||
| STOKSTOKE THERAPEUTICS INC | 700,000 | $22.9M | 2.07% | 0 | Timeline | ||
| ACOGALPHA COGNITION INC | 2,895,467 | $20.9M | 1.89% | +333,517 | Timeline | ||
| EWTXEDGEWISE THERAPEUTICS INC | 500,000 | $20.3M | 1.84% | 0 | Timeline | ||
| RVMDREVOLUTION MEDICINES INC | 100,000 | $18.7M | 1.7% | 0 | Timeline | ||
| GLUEMONTE ROSA THERAPEUTICS INC | 745,000 | $18M | 1.63% | new | Timeline | ||
| ALMSALUMIS INC | 550,000 | $15.5M | 1.4% | 0 | Timeline | ||
| CDXSCODEXIS INC | 6,785,000 | $15.3M | 1.39% | 0 | Timeline | ||
| REPLREPLIMUNE GROUP INC | 1,384,993 | $15.3M | 1.39% | new | Timeline | ||
| XOMAXOMA ROYALTY CORPORATION | 338,374 | $14.4M | 1.3% | +38,374 | Timeline | ||
| MBXMBX BIOSCIENCES INC | 260,000 | $14.4M | 1.3% | 0 | Timeline | ||
| RYTMRHYTHM PHARMACEUTICALS INC | 122,500 | $13.6M | 1.23% | -500 | Timeline | ||
| EDITEDITAS MEDICINE INC | 3,861,930 | $12.5M | 1.13% | +1,934,933 | Timeline | ||
| PTGXPROTAGONIST THERAPEUTICS INC | 100,000 | $12.3M | 1.11% | 0 | Timeline | ||
| CABACABALETTA BIO INC | 3,863,800 | $12M | 1.09% | +2,483,800 | Timeline | ||
| QTTBQ32 BIO INC | 931,000 | $11.9M | 1.07% | -325,228 | Timeline | ||
| ANNXANNEXON INC | 1,714,451 | $9.79M | 0.89% | -617,310 | Timeline | ||
| VSTMVERASTEM INC | 1,800,000 | $6.88M | 0.62% | new | Timeline | ||
| ZNTLZENTALIS PHARMACEUTICALS INC | 1,412,656 | $6.85M | 0.62% | 0 | Timeline | ||
| RLMDRELMADA THERAPEUTICS INC | 935,000 | $6.47M | 0.59% | 0 | Timeline | ||
| OCULOCULAR THERAPEUTIX INC | 600,000 | $5.89M | 0.53% | 0 | Timeline | ||
| TRVITREVI THERAPEUTICS INC | 310,000 | $5.78M | 0.52% | -35,100 | Timeline | ||
| BBOTBRIDGEBIO ONCOLOGY THERAPEUT | 700,000 | $5.33M | 0.48% | +646,718 | Timeline | ||
| LYELLYELL IMMUNOPHARMA INC | 344,025 | $4.83M | 0.44% | +264,928 | Timeline | ||
| IRDOPUS GENETICS INC | 1,125,000 | $4.62M | 0.42% | +5,000 | Timeline | ||
| FDMT4D MOLECULAR THERAPEUTICS IN | 334,437 | $4.45M | 0.4% | +222,146 | Timeline | ||
| NTLAINTELLIA THERAPEUTICS INC | 250,000 | $4.23M | 0.38% | +5,000 | Timeline | ||
| VYGRVOYAGER THERAPEUTICS INC | 1,185,000 | $4.15M | 0.38% | +35,000 | Timeline | ||
| BDSXBIODESIX INC | 180,000 | $4.06M | 0.37% | -58,047 | Timeline | ||
| RCKTROCKET PHARMACEUTICALS INC | 1,000,000 | $3.42M | 0.31% | +45,000 | Timeline | ||
| JBIOJADE BIOSCIENCES INC | 145,000 | $3.22M | 0.29% | -282,608 | Timeline | ||
| SNWVSANUWAVE HEALTH INC | 306,140 | $3.06M | 0.28% | -675,127 | Timeline | ||
| FBIOFORTRESS BIOTECH INC | 890,000 | $2.72M | 0.25% | -152,000 | Timeline | ||
| DERMJOURNEY MED CORP | 350,000 | $2.48M | 0.22% | -610,000 | Timeline | ||
| PHATPHATHOM PHARMACEUTICALS INC | 185,589 | $2.01M | 0.18% | new | Timeline | ||
| INBXINHIBRX BIOSCIENCES INC | 20,291 | $1.92M | 0.17% | new | Timeline | ||
| ENTAENANTA PHARMACEUTICALS INC | 125,000 | $1.82M | 0.17% | 0 | Timeline | ||
| COAGHEMAB THERAPEUTICS HLDGS INC | 47,652 | $1.75M | 0.16% | new | Timeline | ||
| TRAXFIRST TRACKS BIOTHERAPEUTICS | 65,000 | $1.31M | 0.12% | new | Timeline | ||
| CGONCG ONCOLOGY INC | 17,789 | $1.26M | 0.11% | -77,011 | Timeline | ||
| BHVNBIOHAVEN LTD | 77,915 | $1.16M | 0.1% | new | Timeline | ||
| AVIRATEA PHARMACEUTICALS INC | 235,000 | $1.09M | 0.1% | -87,600 | Timeline | ||
| KTTAPASITHEA THERAPEUTICS CORP | 2,050,000 | $1.06M | 0.1% | new | Timeline | ||
| ADCTADC THERAPEUTICS SA | 700,000 | $749K | 0.07% | new | Timeline | ||
| OKYOOKYO PHARMA LTD | 375,204 | $563K | 0.05% | new | Timeline | ||
| PTNPALATIN TECHNOLOGIES INC | 20,500 | $221K | 0.02% | new | Timeline | ||
| ADGMADAGIO MED HLDGS INC | 18,444 | $13.4K | <0.01% | 0 | Timeline |
Sold out in Q2 2026
Positions in the previous quarter's report that this quarter's report no longer lists.
| Security | Shares before | Value before | Type |
|---|---|---|---|
| CATXPERSPECTIVE THERAPEUTICS INC | 4,675,000 | $19.5M | shares |
| ASRTASSERTIO HOLDINGS INC | 265,707 | $5.06M | shares |
| STROSUTRO BIOPHARMA INC | 190,671 | $4.75M | shares |
| TECXTECTONIC THERAPEUTIC INC | 123,000 | $3.8M | shares |
| RIGLRIGEL PHARMACEUTICALS INC | 70,000 | $1.89M | shares |
| NXTCNEXTCURE INC | 141,181 | $1.51M | shares |
| PERSPECTIVE THERAPEUTICS INCPERSPECTIVE THERAPEUTICS INC | 200,000 | $834K | shares |
| PLXPROTALIX BIOTHERAPEUTICS INC | 340,000 | $738K | shares |
| LBRXLB PHARMACEUTICALS INC | 14,506 | $358K | shares |
How Q2 2026 was built
Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).
| Filing | Role | Amendment | Filed | Accepted | Ingested |
|---|---|---|---|---|---|
| 13F-HR 0001420506-26-001803 | base | 2026-08-14 | acceptance time not in the bulk data set |
Filings
Every filing of this filer: 13F reports and notices, the 13D and 13G it filed or is a reporting person of, and Forms 3, 4 and 5 it reported as an owner.
| Filing | Subject | Filed | Accepted | Ingested |
|---|---|---|---|---|
| Form 4 0001493152-26-045809 | Grace Therapeutics, Inc. | 2026-10-05 | ||
| Form 4 0001493152-26-045511 | Alpha Cognition Inc. | 2026-10-02 | ||
| Form 4 0001493152-26-045358 | Grace Therapeutics, Inc. | 2026-10-01 | ||
| Form 4/A 0001493152-26-045347 | Grace Therapeutics, Inc. | 2026-10-01 | ||
| Form 4 0001493152-26-044690 | Alpha Cognition Inc. | 2026-09-28 | ||
| 13F-HR 0001420506-26-001803 | Quarter ended 2026-06-30 | 2026-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001420506-26-001151 | Quarter ended 2026-03-31 | 2026-05-15 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001493152-26-016299 | Quarter ended 2025-12-31 | 2026-04-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-26-007085 | Quarter ended 2025-12-31 | 2026-02-17 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-25-023429 | Quarter ended 2025-09-30 | 2025-11-14 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001641172-25-024301 | Quarter ended 2025-06-30 | 2025-08-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001641172-25-023977 | Quarter ended 2025-06-30 | 2025-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001641172-25-010914 | Quarter ended 2025-03-31 | 2025-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-25-006852 | Quarter ended 2024-12-31 | 2025-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-24-045811 | Quarter ended 2024-09-30 | 2024-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-24-032150 | Quarter ended 2024-06-30 | 2024-08-14 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001493152-24-021780 | Quarter ended 2024-03-31 | 2024-05-29 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-24-019869 | Quarter ended 2024-03-31 | 2024-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-24-006653 | Quarter ended 2023-12-31 | 2024-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-23-041364 | Quarter ended 2023-09-30 | 2023-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-23-028636 | Quarter ended 2023-06-30 | 2023-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-23-016769 | Quarter ended 2023-03-31 | 2023-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-23-004277 | Quarter ended 2022-12-31 | 2023-02-10 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-22-032068 | Quarter ended 2022-09-30 | 2022-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-22-022856 | Quarter ended 2022-06-30 | 2022-08-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-22-013764 | Quarter ended 2022-03-31 | 2022-05-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-22-004434 | Quarter ended 2021-12-31 | 2022-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-21-028799 | Quarter ended 2021-09-30 | 2021-11-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-21-020260 | Quarter ended 2021-06-30 | 2021-08-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-21-012017 | Quarter ended 2021-03-31 | 2021-05-18 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-21-003697 | Quarter ended 2020-12-31 | 2021-02-12 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-20-021694 | Quarter ended 2020-09-30 | 2020-11-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-20-015902 | Quarter ended 2020-06-30 | 2020-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-20-009140 | Quarter ended 2020-03-31 | 2020-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-20-002529 | Quarter ended 2019-12-31 | 2020-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-19-017503 | Quarter ended 2019-09-30 | 2019-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-19-012567 | Quarter ended 2019-06-30 | 2019-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-19-007425 | Quarter ended 2019-03-31 | 2019-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-19-002114 | Quarter ended 2018-12-31 | 2019-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-18-016123 | Quarter ended 2018-09-30 | 2018-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-18-011830 | Quarter ended 2018-06-30 | 2018-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-18-006822 | Quarter ended 2018-03-31 | 2018-05-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-18-001743 | Quarter ended 2017-12-31 | 2018-02-09 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-17-013210 | Quarter ended 2017-09-30 | 2017-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-17-009239 | Quarter ended 2017-06-30 | 2017-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001493152-17-005196 | Quarter ended 2017-03-31 | 2017-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-17-010166 | Quarter ended 2016-12-31 | 2017-02-21 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-16-000542 | Quarter ended 2016-09-30 | 2016-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-16-000512 | Quarter ended 2016-06-30 | 2016-08-12 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001546927-16-000514 | Quarter ended 2016-06-30 | 2016-08-12 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001546927-16-000499 | Quarter ended 2016-03-31 | 2016-05-27 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-16-000493 | Quarter ended 2016-03-31 | 2016-05-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-16-000408 | Quarter ended 2015-12-31 | 2016-02-12 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-15-000281 | Quarter ended 2015-09-30 | 2015-11-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-15-000231 | Quarter ended 2015-06-30 | 2015-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-15-000149 | Quarter ended 2015-03-31 | 2015-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-15-000070 | Quarter ended 2014-12-31 | 2015-02-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-14-000196 | Quarter ended 2014-09-30 | 2014-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-14-000159 | Quarter ended 2014-06-30 | 2014-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-14-000115 | Quarter ended 2014-03-31 | 2014-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001546927-14-000060 | Quarter ended 2013-12-31 | 2014-02-14 | acceptance time not in the bulk data set |