13F-HR filed by Opaleye Management Inc.
Opaleye Management Inc. filed this 13F-HR for the quarter ended 2025-09-30, filed 2025-11-14, with 43 holding rows worth $707,320,956.
- Accession
- 0001493152-25-023429
- Filer
- CIK 1595855
- Filed
- 2025-11-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q3 2025
A holdings report, 43 entries on the cover page, a total value of $707,320,956 stated on the cover page (in dollars after the unit check, H1), rows summing to $707,320,956 with VALUE read as dollars as filed, 13F file number 028-15896. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| HARROW INC | 415858109 | COM | 3,905,000 | $188,142,900 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 2,860,000 | $62,147,800 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 2,615,000 | $59,465,100 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 461,700 | $46,627,083 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 3,185,000 | $37,296,350 | dollars as filed | |
| SANUWAVE HEALTH INC | 80303D305 | CMN | 980,000 | $36,730,400 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 12,795,000 | $31,219,800 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 535,000 | $19,326,875 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 1,595,000 | $18,645,550 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 410,000 | $16,514,800 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 682,017 | $16,027,400 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 363,257 | $14,432,201 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 450,000 | $13,500,000 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 193,773 | $12,804,520 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 585,000 | $11,272,950 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 3,720,867 | $10,564,900 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 255,087 | $9,831,053 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 903,442 | $8,492,355 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 987,818 | $8,416,209 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $8,110,000 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 2,600,000 | $7,930,000 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 2,725,000 | $7,166,750 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 105,000 | $6,975,150 | dollars as filed | |
| JOURNEY MED CORP | 48115J109 | COM | 971,064 | $6,913,976 | dollars as filed | |
| SOL-GEL TECHNOLOGIES LTD | M8694L137 | SHS NEW | 204,835 | $5,970,940 | dollars as filed | |
| PROTALIX BIOTHERAPEUTICS INC | 74365A309 | COMMON STOCK | 2,580,556 | $5,728,834 | dollars as filed | |
| TREACE MED CONCEPTS INC | 89455T109 | COM | 702,245 | $4,712,064 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 100,000 | $4,670,000 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576UAA4 | BOND | 6,000,000 | $4,630,842 | dollars as filed | principal |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 253,000 | $4,427,500 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 390,000 | $3,568,500 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 682,529 | $2,730,116 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 665,000 | $2,653,350 | dollars as filed | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 808,882 | $1,892,784 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 1,100,000 | $1,815,000 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 100,000 | $1,708,000 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 65,000 | $1,089,400 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559702 | COMMON STOCK | 37,787 | $1,070,506 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 115,142 | $749,574 | dollars as filed | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 316,550 | $477,991 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 75,000 | $346,500 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 375,000 | $310,425 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 110,571 | $214,508 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001493152-25-023429 | this filing | 2025-11-14 | acceptance time not in the bulk data set |