13F-HR/A filed by Opaleye Management Inc.
Opaleye Management Inc. filed this 13F-HR/A for the quarter ended 2025-06-30, filed 2025-08-15, with 41 holding rows worth $494,141,450.
- Accession
- 0001641172-25-024301
- Filer
- CIK 1595855
- Filed
- 2025-08-15
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2025
A holdings report, amendment of type restatement, 41 entries on the cover page, a total value of $494,141,450 stated on the cover page (in dollars after the unit check, H1), rows summing to $494,141,450 with VALUE read as dollars as filed, 13F file number 028-15896. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| HARROW INC | 415858109 | COM | 3,905,000 | $119,258,700 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 2,860,000 | $40,755,000 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 3,529,581 | $32,825,103 | dollars as filed | |
| SANUWAVE HEALTH INC | 80303D305 | CMN | 980,000 | $32,202,800 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 2,475,000 | $30,838,500 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 12,600,000 | $30,744,000 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 475,000 | $30,015,250 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 535,000 | $19,254,650 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 1,595,000 | $14,801,600 | dollars as filed | |
| ARVINAS INC | 04335A105 | COM | 1,680,000 | $12,364,800 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 4,110,000 | $11,877,900 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 186,418 | $9,872,697 | dollars as filed | |
| SAREPTA THERAPEUTICS INC | 803607100 | COM | 500,000 | $8,550,000 | dollars as filed | |
| VIGIL NEUROSCIENCE INC | 92673K108 | COM | 1,000,000 | $7,950,000 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 266,000 | $6,916,000 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 255,087 | $6,428,192 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 490,000 | $6,423,900 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 562,120 | $6,380,062 | dollars as filed | |
| ANIKA THERAPEUTICS INC | 035255108 | COM | 588,797 | $6,229,472 | dollars as filed | |
| GOSSAMER BIO INC | 38341PAA0 | NOTE 5.000% 6/0 | 11,500,000 | $5,948,973 | dollars as filed | principal |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 105,000 | $5,803,350 | dollars as filed | |
| GINKGO BIOWORKS HOLDINGS INC | 37611X209 | COMMON STOCK | 500,000 | $5,625,000 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576UAA4 | BOND | 6,000,000 | $4,556,052 | dollars as filed | principal |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 3,545,000 | $4,360,350 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 903,442 | $4,029,351 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 105,000 | $3,862,950 | dollars as filed | |
| ESSA PHARMA INC | 29668H708 | COM NEW | 2,209,998 | $3,756,997 | dollars as filed | |
| CARGO THERAPEUTICS INC COM | 14179K101 | Stock | 666,503 | $2,745,992 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 239,319 | $2,730,630 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 210,000 | $2,635,500 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 855,000 | $2,590,650 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 775,000 | $2,325,000 | dollars as filed | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 1,924,300 | $2,232,188 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 390,000 | $2,133,300 | dollars as filed | |
| AVITA THERAPEUTICS, INC. | 05380C102 | COM | 389,519 | $2,060,556 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 1,220,000 | $1,149,362 | dollars as filed | |
| JOURNEY MED CORP | 48115J109 | COM | 95,000 | $682,100 | dollars as filed | |
| ELEVATION ONCOLOGY INC COM | 28623U101 | Stock | 1,442,061 | $529,381 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 375,000 | $285,000 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 240,000 | $266,400 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 110,571 | $143,742 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001641172-25-023977 | superseded | 2025-08-14 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001641172-25-024301 | this filing | 2025-08-15 | acceptance time not in the bulk data set |