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13F-HR filed by Opaleye Management Inc.

Opaleye Management Inc. filed this 13F-HR for the quarter ended 2015-06-30, filed 2015-08-14, with 46 holding rows worth $251,326,000.

Accession
0001546927-15-000231
Filed
2015-08-14
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q2 2015

A holdings report, 46 entries on the cover page, a total value of $251,326,000 stated on the cover page (in dollars after the unit check, H1), rows summing to $251,326,000 with VALUE read as thousands by filing date, 13F file number 028-15896. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
CHIMERIX INC COM16934W106Stock440,000$20,328,000thousands by filing date
CEMPRA INC15130J109COM490,000$16,836,000thousands by filing date
RETROPHIN INC761299106COM460,000$15,249,000thousands by filing date
AMAG PHARMACEUTICALS INC00163U106COM190,000$13,121,000thousands by filing date
ARIAD PHARMACEUTICALS INC04033A100COM1,500,000$12,405,000thousands by filing date
ULTRAGENYX PHARMACEUTICAL IN90400D108COM110,000$11,263,000thousands by filing date
IMPRIMIS PHARMA IMMY45323A201COMMON1,205,000$9,797,000thousands by filing date
SUPERNUS PHARMACEUTICALS868459108COM535,000$9,084,000thousands by filing date
AFFIMED N VN01045108COM590,300$7,951,000thousands by filing date
CLOVIS ONCOLOGY INC189464100COM90,000$7,909,000thousands by filing date
GERON CORP374163103COM1,825,000$7,811,000thousands by filing date
FIBROGEN INC31572Q808COM325,000$7,638,000thousands by filing date
MIMEDX GROUP INC602496101COM617,000$7,151,000thousands by filing date
NEUROCRINE BIOSCIENCES INC64125C109COM145,000$6,925,000thousands by filing date
CODEXIS INC192005106COM1,724,000$6,706,000thousands by filing date
AXOGEN INC05463X106COM2,120,000$6,657,000thousands by filing date
FLAMEL TECHNOLOGIES-SP ADR338488109SPON310,000$6,569,000thousands by filing date
Medgenics Inc New58436Q203COM NEW1,050,000$6,437,000thousands by filing date
OPHTHOTECH CORP683745103COM105,000$5,487,000thousands by filing date
TRILLIUM THERAPEUTICS INC COM NEW89620X506Stock250,000$5,455,000thousands by filing date
ZS PHARMA INC98979G105Common Stock95,000$4,977,000thousands by filing date
PROTALIX BIOTHERAPEUTICS INC74365AAB7NOTE 4.500% 9/12,505,000$4,885,000thousands by filing date
AMARIN CORP PLC023111206SPONS ADR NEW1,754,000$4,315,000thousands by filing date
CARA THERAPEUTICS INC140755109COM340,000$4,131,000thousands by filing date
EAGLE PHARMACEUTICALS INC269796108COM50,000$4,043,000thousands by filing date
ADAMAS PHARMACEUTICALS INC00548A106COM150,000$3,933,000thousands by filing date
MACROGENICS INC556099109COM90,000$3,417,000thousands by filing date
INSYS THERAPEUTICS INC45824V209COMMON STOCK89,000$3,197,000thousands by filing date
TETRAPHASE PHARMACEUTICALS INC88165N105COMMON STOCK65,000$3,084,000thousands by filing date
ITEK 5 02/15/2045780VAA0Bond 30/360P2 U604,700$2,963,000thousands by filing date
AVINGER INC053734109COM208,200$2,688,000thousands by filing date
Accelerate Diagnostics00430H102COM100,600$2,596,000thousands by filing date
XOMA CORP DEL98419J107COM650,000$2,522,000thousands by filing date
TENAX THERAPEUTICS INC88032L100COM635,000$2,343,000thousands by filing date
AURIS MED HLDG AGH03579101COM355,000$1,725,000thousands by filing date
TONIX PHARMACEUTICALS HOLDING890260201COM NEW190,000$1,704,000thousands by filing date
ZOGENIX INC98978L105COM912,500$1,533,000thousands by filing date
Innocoll45780Q103SPONDS ADR101,200$1,481,000thousands by filing date
EVOKE PHARMA INC30049G104COM259,100$1,355,000thousands by filing date
CELGENE CORP151020112RIGHT 12/31/2030456,492$950,000thousands by filing date
FOAMIX PHARMACEUTICALS LTDM46135105SHS85,000$871,000thousands by filing date
BIOLINERX LTD-SPONS ADR09071M106SPON250,000$495,000thousands by filing date
AGILE THERAPEUTICS INC00847L100COM55,000$472,000thousands by filing date
NEURODERM LTDM74231107ORD SHS26,000$399,000thousands by filing date
DERMIRA INC24983L104COM18,800$330,000thousands by filing date
TRACON PHARMACEUTICALS INC89237H10ACOM12,172$138,000thousands by filing date

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001546927-15-000231this filing2015-08-14acceptance time not in the bulk data set