13F-HR filed by Opaleye Management Inc.
Opaleye Management Inc. filed this 13F-HR for the quarter ended 2026-06-30, filed 2026-08-14, with 58 holding rows worth $1,104,182,260.
- Accession
- 0001420506-26-001803
- Filer
- CIK 1595855
- Filed
- 2026-08-14
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q2 2026
A holdings report, 58 entries on the cover page, a total value of $1,104,182,260 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,104,182,260 with VALUE read as dollars as filed, 13F file number 028-15896. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 2,447,500 | $195,139,175 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 2,860,000 | $103,532,000 | dollars as filed | |
| HARROW INC | 415858109 | COM | 2,400,000 | $101,928,000 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 855,000 | $62,534,700 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 1,439,996 | $52,991,853 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 390,000 | $51,764,700 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 3,550,000 | $47,960,500 | dollars as filed | |
| SOL-GEL TECHNOLOGIES LTD | M8694L137 | SHS NEW | 500,000 | $37,070,000 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 6,300,000 | $32,760,000 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 535,000 | $29,392,900 | dollars as filed | |
| IMMIX BIOPHARMA INC | 45258H106 | COMMON STOCK | 2,345,000 | $24,176,950 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 1,319,351 | $23,748,318 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 700,000 | $22,904,000 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 2,895,467 | $20,905,272 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $20,315,000 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 100,000 | $18,728,000 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 745,000 | $18,029,000 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 550,000 | $15,477,000 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 6,785,000 | $15,334,100 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 1,384,993 | $15,331,873 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 338,374 | $14,380,895 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 260,000 | $14,352,000 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 122,500 | $13,601,175 | dollars as filed | |
| EDITAS MEDICINE INC | 28106W103 | COM | 3,861,930 | $12,512,653 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 100,000 | $12,258,000 | dollars as filed | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 3,863,800 | $12,016,418 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 931,000 | $11,860,940 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 1,714,451 | $9,789,515 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 1,800,000 | $6,876,000 | dollars as filed | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 1,412,656 | $6,851,382 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 935,000 | $6,470,200 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 600,000 | $5,892,000 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 310,000 | $5,781,500 | dollars as filed | |
| BRIDGEBIO ONCOLOGY THERAPEUT | 107924102 | COM NEW | 700,000 | $5,334,000 | dollars as filed | |
| LYELL IMMUNOPHARMA INC COM NEW | 55083R203 | Stock | 344,025 | $4,833,551 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 1,125,000 | $4,623,750 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 334,437 | $4,448,012 | dollars as filed | |
| INTELLIA THERAPEUTICS INC | 45826J105 | COM | 250,000 | $4,230,000 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 1,185,000 | $4,147,500 | dollars as filed | |
| BIODESIX INC COM | 09075X207 | Stock | 180,000 | $4,059,000 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 1,000,000 | $3,420,000 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 145,000 | $3,221,900 | dollars as filed | |
| SANUWAVE HEALTH INC | 80303D305 | CMN | 306,140 | $3,061,400 | dollars as filed | |
| FORTRESS BIOTECH INC | 34960Q307 | COM NEW | 890,000 | $2,723,400 | dollars as filed | |
| JOURNEY MED CORP | 48115J109 | COM | 350,000 | $2,478,000 | dollars as filed | |
| PHATHOM PHARMACEUTICALS INC | 71722W107 | COMMON STOCK | 185,589 | $2,013,641 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 20,291 | $1,922,572 | dollars as filed | |
| ENANTA PHARMACEUTICALS INC | 29251M106 | COM | 125,000 | $1,822,500 | dollars as filed | |
| HEMAB THERAPEUTICS HLDGS INC | 423494103 | COM SHS | 47,652 | $1,750,258 | dollars as filed | |
| FIRST TRACKS BIOTHERAPEUTICS | 337185102 | ORD SHS *A* | 65,000 | $1,307,800 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 17,789 | $1,263,908 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 77,915 | $1,159,375 | dollars as filed | |
| ATEA PHARMACEUTICALS INC | 04683R106 | COMMON STOCK | 235,000 | $1,092,750 | dollars as filed | |
| PASITHEA THERAPEUTICS CORP | 70261F202 | COM NEW | 2,050,000 | $1,056,570 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 700,000 | $749,000 | dollars as filed | |
| OKYO PHARMA LTD | G6724L116 | SHS NEW | 375,204 | $562,806 | dollars as filed | |
| PALATIN TECHNOLOGIES INC | 696077601 | COM NEW | 20,500 | $221,195 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 18,444 | $13,353 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001420506-26-001803 | this filing | 2026-08-14 | acceptance time not in the bulk data set |