Caligan Partners LP More: the full row for Caligan Partners LP 6,077,084 $25M 1.21% +2,056 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 6,029,775 $24.8M 0.03% 0 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 3,755,350 $15.4M +1,001,337 Timeline BIOS Capital Management, LP in group BIOS Capital Management, LP More: the full row for BIOS Capital Management, LP 3,683,429 $15.1M 36.33% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 3,116,487 $12.8M <0.01% +2,968,747 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 3,087,866 $12.7M 0.02% +369,837 13F-HR Timeline Group Nantahala Capital Management, LLC in group Nantahala Capital Management,… More: the full row for Nantahala Capital Management, LLC 3,061,359 $12.6M 0.76% +1,380,029 13F-HR/A Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 2,815,000 $11.6M 0.87% +565,000 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 2,743,658 $11.3M 1.79% +2,243,658 13F-HR Timeline MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 2,302,101 $9.46M 0.01% -328,331 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,970,187 $8.1M 1.91% +1,645,847 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 1,945,609 $8M 0.01% -367,771 13F-HR Timeline Group ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,783,781 $7.33M 0.34% -65,223 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 1,527,229 $6.28M <0.01% +1,200,420 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,434,713 $5.9M 0.02% +80,683 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,367,712 $5.62M <0.01% +829,365 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 1,189,515 $4.89M 0.09% +402 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 1,125,000 $4.62M 0.42% +5,000 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 1,007,351 $4.14M 0.11% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 790,136 $3.25M <0.01% +590,183 13F-HR/A Timeline Group Bleichroeder LP More: the full row for Bleichroeder LP 736,842 $3.03M 0.54% 0 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 683,895 $2.81M <0.01% +426,246 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 665,662 $2.74M <0.01% +544,762 13F-HR/A Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 464,900 $1.91M <0.01% +425,378 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 442,154 $1.82M <0.01% +347,739 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 330,783 $1.36M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 253,962 $1.04M <0.01% +145,321 13F-HR Timeline Group AWM Investment Company, Inc. More: the full row for AWM Investment Company, Inc. 232,590 $956K 0.08% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 196,897 $809K <0.01% -626,486 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 188,988 $777K <0.01% +30,885 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 165,053 $678K <0.01% +130,053 13F-HR Timeline Group Mink Brook Asset Management LLC in group Mink Brook Asset Management L… More: the full row for Mink Brook Asset Management LLC 161,205 $663K 0.29% -429,347 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 144,095 $592K 0.01% +127,391 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 143,137 $588K 0.1% +8,895 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 128,366 $528K <0.01% 0 13F-HR Timeline Group Texas Capital Bank Wealth Management Se… More: the full row for Texas Capital Bank Wealth Management Services Inc 122,529 $504K 0.03% +34,029 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 122,479 $503K <0.01% new 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 100,718 $414K 0.32% +32,030 13F-HR/A Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 94,820 $390K <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 71,343 $293K <0.01% new 13F-HR Timeline Group Palogic Value Management, L.P. More: the full row for Palogic Value Management, L.P. 65,088 $268K 0.09% +88 13F-HR/A Timeline Aureus Asset Management, LLC More: the full row for Aureus Asset Management, LLC 58,200 $239K 0.01% new 13F-HR Timeline Regency Capital Management Inc.\DE More: the full row for Regency Capital Management Inc.\DE 58,000 $238K 0.09% -10,000 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 55,005 $226K <0.01% -12,010 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 53,312 $219K <0.01% new 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 53,231 $219K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 52,633 $216K <0.01% +48,848 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 51,464 $212K <0.01% new 13F-HR Timeline EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 50,883 $209K 0.05% new 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 46,389 $191K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 43,937 $181K <0.01% new 13F-HR Timeline BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 42,065 $173K <0.01% 0 13F-HR Timeline Empowered Funds, LLC More: the full row for Empowered Funds, LLC 42,065 $173K <0.01% 0 13F-HR Timeline MANGROVE PARTNERS IM, LLC More: the full row for MANGROVE PARTNERS IM, LLC 41,717 $171K 0.01% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 32,208 $132K <0.01% new 13F-HR Timeline Group CAPTRUST FINANCIAL ADVISORS More: the full row for CAPTRUST FINANCIAL ADVISORS 32,000 $132K <0.01% 0 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 30,092 $124K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 25,380 $115K <0.01% new 13F-HR Timeline Miller Financial Services LLC More: the full row for Miller Financial Services LLC 27,000 $111K 0.09% +5,000 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 25,553 $105K <0.01% -56,927 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 24,657 $101K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 22,199 $90.1K <0.01% new 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 18,922 $77.8K <0.01% new 13F-HR Timeline Group JAMES INVESTMENT RESEARCH, INC. More: the full row for JAMES INVESTMENT RESEARCH, INC. 16,364 $67.3K 0.01% 0 13F-HR Timeline NewEdge Advisors, LLC More: the full row for NewEdge Advisors, LLC 16,364 $67.3K <0.01% 0 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 15,949 $65.5K <0.01% new 13F-HR/A Timeline Group State of Wyoming More: the full row for State of Wyoming 15,904 $65.4K 0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 15,793 $64.9K <0.01% new 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 15,008 $61.7K <0.01% -4,500 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 14,500 $59.6K <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 13,900 $57.1K <0.01% +11,700 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 13,357 $54.9K <0.01% +11,457 13F-HR Timeline Group KESTRA PRIVATE WEALTH SERVICES, LLC in group Kestra Advisory Services, LLC More: the full row for KESTRA PRIVATE WEALTH SERVICES, LLC 12,800 $52.6K <0.01% 0 13F-HR Timeline Group Stokes Family Office, LLC More: the full row for Stokes Family Office, LLC 12,120 $49.8K 0.01% 0 13F-HR Timeline Engineers Gate Manager LP More: the full row for Engineers Gate Manager LP 12,063 $49.6K <0.01% new 13F-HR Timeline First City Capital Management, Inc. More: the full row for First City Capital Management, Inc. 11,836 $48.6K 0.02% 0 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 11,566 $47.5K <0.01% new 13F-HR Timeline STONERIDGE INVESTMENT PARTNERS LLC More: the full row for STONERIDGE INVESTMENT PARTNERS LLC 12,695 $47K 0.03% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 11,017 $45.3K <0.01% new 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 10,500 $43.2K <0.01% new 13F-HR Timeline Carolina Wealth Management Inc More: the full row for Carolina Wealth Management Inc 10,000 $41.1K 0.02% 13F-HR Timeline Annandale Capital, LLC More: the full row for Annandale Capital, LLC 10,000 $41K 0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 8,181 $33.6K <0.01% new 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 5,203 $21.4K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 4,860 $20K <0.01% new 13F-HR Timeline Group Hilton Head Capital Partners, LLC More: the full row for Hilton Head Capital Partners, LLC 4,472 $18.4K 0.01% 0 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 4,282 $17.6K <0.01% new 13F-HR Timeline Group Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 3,490 $14.3K <0.01% +1,190 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 3,176 $13.1K <0.01% -25,565 13F-HR Timeline Group TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 3,000 $12.5K <0.01% new 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 2,014 $8.28K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 2,095 $8K <0.01% +2,090 13F-HR Timeline Group GGM Financial LLC More: the full row for GGM Financial LLC 1,005 $4.13K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 737 $3.03K <0.01% new 13F-HR/A Timeline INTERNATIONAL ASSETS INVESTMENT MANAGEM… More: the full row for INTERNATIONAL ASSETS INVESTMENT MANAGEMENT, LLC 521 $2.18K <0.01% 0 13F-HR Timeline Quarry LP More: the full row for Quarry LP 502 $2.06K <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 501 $2.06K <0.01% -29 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 188 $773 <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 142 $584 <0.01% +134 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 63 $259 <0.01% new 13F-HR Timeline