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Disclosery

RYTM RHYTHM PHARMACEUTICALS INC

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COM (common), issuer CIK 1649904

295 managers (306 13F filers) reported a position in RYTM shares at 2026-06-30, 77,229,835 shares in all. 62 filers opened a position and 41 filers sold out during the quarter.

Managers
295
13F filers
306
New
62
Added
106
Reduced
101
Sold out
41
Shares held by filers
77,229,835

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
VANGUARD GROUP INCgroup of 7 filers holding6,684,248$742M+157,376Timeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,666,837$740M6.43%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,156,902$684M0.01%-80,24913F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP5,604,483$622M3.12%013F-HRTimelineGroup
PRIMECAP MANAGEMENT CO/CA/3,168,853$352M0.21%-248,65613F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO2,652,746$292M0.02%+1,099,10213F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC2,586,295$287M4.46%+212,50013F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,573,529$286M0.01%+301,67813F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/2,566,171$285M0.03%+911,29513F-HRTimeline
WESTFIELD CAPITAL MANAGEMENT CO LP2,208,595$245M0.8%+279,47213F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,126,502$236M0.02%+161,07013F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,785,716$198M0.29%+499,41313F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc1,663,632$185M0.52%+48,04613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,533,698$170M0.01%+117,42913F-HRTimelineGroup
Capital Research Global Investorsin group Capital Research Global Inves…1,532,303$170M0.02%+416,84313F-HRTimelineGroup
Franklin Resourcesgroup of 2 filers holding1,273,506$141M+37,224Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,263,652$140M0.08%-154,96713F-HRTimelineGroup
Checkpoint Capital L.P.1,186,000$132M33.79%-41,20013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.1,136,275$126M2.56%+410,76413F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY1,112,240$123M0.01%+408,26213F-HRTimelineGroup
FMR LLCin group FMR LLC1,025,840$114M<0.01%-663,83113F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…957,785$106M0.1%+290,73913F-HRTimelineGroup
Jupiter Topco LLCin group Janus Henderson925,490$103M0.04%13F-HRTimelineGroup
Woodline Partners LP758,891$84.3M0.26%013F-HRTimeline
ALLIANCEBERNSTEIN L.P.894,723$77.8M0.03%-15,69013F-HRTimeline
Rock Springs Capital Management LP692,598$76.9M3.75%+2,85013F-HRTimeline
NORGES BANK685,844$76.1M0.01%new13F-HRTimeline
UBS Group AGgroup of 2 filers holding659,228$73.2M-113,872Timeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co552,738$61.4M0.01%+26,27913F-HRTimelineGroup
Integral Health Asset Management, LLC550,000$61.1M2.51%-50,00013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.543,271$60.3M<0.01%+178,96513F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP540,332$60M0.01%+41,81813F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…488,747$54.3M0.01%+214,99013F-HRTimelineGroup
LOOMIS SAYLES & CO L Pin group LOOMIS SAYLES & CO L P434,102$48.2M0.06%-31,00013F-HRTimelineGroup
Candriam S.C.A.433,025$48M0.22%-31,31513F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC422,921$47M0.09%+159,95313F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.414,210$46M0.07%-432,59113F-HRTimelineGroup
Sofinnova Investments, Inc.408,027$45.3M2.42%-42,06913F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC401,634$44.6M0.01%+17,67713F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…397,000$44.1M0.06%-328,74413F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp394,044$43.8M0.01%+100,74613F-HRTimelineGroup
BRAIDWELL LP381,128$42.3M1.57%+70,50013F-HRTimeline
Artisan Partners Limited Partnership354,816$39.4M0.06%-35,85313F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/325,470$36.1M<0.01%-303,19713F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC322,900$35.9M0.68%+8,80013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC316,719$35.2M0.02%-135,10613F-HRTimelineGroup
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…311,461$34.6M3.85%+5,46113F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC272,974$30.3M0.03%+39,16413F-HRTimelineGroup
Capital World Investors221,450$24.6M<0.01%+105,75713F-HRTimeline
Duquesne Family Office LLC203,618$22.6M0.52%new13F-HRTimeline
Nuveen, LLCin group TIAA203,078$22.5M0.01%+85,70213F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS197,374$21.9M0.01%-50,50213F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC193,215$21.5M0.38%+127,39713F-HRTimeline
Assenagon Asset Management S.A.186,491$20.7M0.03%new13F-HR/ATimeline
SCHRODER INVESTMENT MANAGEMENT GROUP160,518$17.7M0.01%+28,84413F-HRTimeline
First Turn Management, LLC154,018$17.1M1.83%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND148,152$16.4M0.02%+22,94513F-HRTimeline
Nicholas Investment Partners, LP139,270$15.5M0.87%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC136,158$15.1M0.71%-75,29213F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…135,867$15.1M0.03%-15,97513F-HRTimeline
Qube Research & Technologies Ltd134,410$14.9M0.02%-143,53313F-HRTimeline
NEXTBio Capital Management LP131,758$14.6M6.73%+5,68013F-HRTimeline
Driehaus Capital Management LLC129,285$14.4M0.08%-307,26113F-HRTimeline
SummitTX Capital, L.P.126,401$14M0.37%-39,19813F-HRTimeline
Logos Global Management LP125,000$13.9M0.6%-325,00013F-HRTimeline
Opaleye Management Inc.122,500$13.6M1.23%-50013F-HRTimeline
SEGALL BRYANT & HAMILL, LLC121,866$13.5M0.16%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\115,232$12.8M<0.01%-26,36913F-HRTimelineGroup
Longaeva Partners L.P.110,074$12.2M0.35%new13F-HRTimeline
Swiss National Bank109,700$12.2M0.01%-2,50013F-HRTimeline
PFM Health Sciences, LP101,550$11.3M0.98%-35,07113F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc94,946$10.5M0.01%+15,58913F-HRTimelineGroup
AXIOM INVESTORS LLC /DE86,880$9.65M0.08%-4,86913F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…86,709$9.63M0.01%-29,00313F-HRTimelineGroup
First Light Asset Management, LLC85,765$9.52M0.58%-1,41613F-HRTimeline
ALGERT GLOBAL LLC83,431$9.26M0.11%+24,91813F-HRTimeline
Granahan Investment Management, LLC83,270$9.25M0.33%+5,56113F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC83,035$9.22M0.01%+9,60113F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.80,400$8.93M1.28%new13F-HRTimelineGroup
WCM INVESTMENT MANAGEMENT, LLC80,552$8.86M0.02%-6813F-HRTimeline
Atom Investors LP73,465$8.16M0.73%+16,46513F-HRTimeline
SILVERCREST ASSET MANAGEMENT GROUP LLC73,432$8.15M0.05%+26,54513F-HRTimeline
RHUMBLINE ADVISERS73,333$8.14M0.01%+3,47513F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN72,147$8.01M<0.01%+38,03913F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC69,145$7.68M0.01%+38,95513F-HRTimelineGroup
CAPITAL FUND MANAGEMENT S.A.68,548$7.61M0.05%new13F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC68,281$7.58M0.01%-189,73013F-HRTimeline
PICTON MAHONEY ASSET MANAGEMENT65,880$7.31M0.07%+15,50813F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…64,031$7.11M0.01%-1,77513F-HR/ATimeline
Blue Owl Capital Holdings LP61,455$6.82M1.04%013F-HRTimeline
ExodusPoint Capital Management, LP61,147$6.79M0.06%+43,37213F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC59,208$6.57M<0.01%-7113F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC58,347$6.48M<0.01%+46,01113F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC58,069$6.45M<0.01%+8,14913F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …57,170$6.35M<0.01%+6,40113F-HRTimelineGroup
Trexquant Investment LP56,248$6.25M0.04%new13F-HRTimeline
Man Group plcin group Man Group plc50,788$5.64M0.01%+46,76613F-HRTimelineGroup
Nan Fung Group Holdings Ltd49,120$5.45M4.15%013F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD47,400$5.26M<0.01%new13F-HRTimeline
Hillsdale Investment Management Inc.44,000$4.89M0.11%+3,70013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc43,908$4.88M<0.01%-3,12413F-HRTimelineGroup
Cinctive Capital Management LP42,739$4.75M0.19%new13F-HRTimeline
Zweig-DiMenna Associates LLC42,100$4.67M0.42%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …41,929$4.66M<0.01%-1,94313F-HRTimelineGroup
TD Asset Management Inc38,778$4.31M<0.01%013F-HRTimeline
EFG International AGin group EFG International AG33,577$3.73M0.07%-63713F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP32,482$3.61M<0.01%-53,02413F-HRTimelineGroup
Exome Asset Management LLC32,209$3.58M2.21%-8,37213F-HRTimeline
Rafferty Asset Management, LLC32,207$3.58M0.01%-17,89813F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding32,227$3.57M-6,012Timeline
STATE OF WISCONSIN INVESTMENT BOARD32,189$3.57M0.01%-4,38213F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…32,104$3.56M0.02%+3,21513F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.30,168$3.35M<0.01%-2,48413F-HRTimelineGroup
Schonfeld Strategic Advisors LLC28,607$3.18M0.02%new13F-HRTimeline
ASPIRIANT, LLC27,960$3.1M0.08%-5,04713F-HRTimeline
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLCin group MUTUAL OF AMERICA CAPITAL MAN…27,861$3.09M0.03%+5,33213F-HRTimelineGroup
Creative Planningin group Creative Planning25,835$2.87M<0.01%+4,75013F-HRTimelineGroup
WEDGE CAPITAL MANAGEMENT L L P/NC23,422$2.6M0.04%-1,11313F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…23,109$2.57M<0.01%+7,51113F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO22,087$2.45M<0.01%-18,59813F-HRTimelineGroup
Advisors Asset Management, Inc.21,896$2.43M0.04%+3,17813F-HRTimeline
SG Americas Securities, LLC21,333$2.37M<0.01%+2,57313F-HRTimeline
CAPTRUST FINANCIAL ADVISORS19,945$2.21M<0.01%+1,79813F-HRTimeline
Aquatic Capital Management LLC19,754$2.19M0.08%-9,91713F-HRTimeline
Legato Capital Management LLC19,024$2.11M0.18%new13F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP18,973$2.11M<0.01%-17813F-HRTimelineGroup
Handelsbanken Fonder AB18,921$2.1M0.01%+1,40013F-HRTimeline
LAZARD ASSET MANAGEMENT LLCin group LAZARD ASSET MANAGEMENT LLC18,319$2.03M<0.01%-14,56913F-HRTimelineGroup
Knights of Columbus Asset Advisors LLC18,043$2M0.1%+2,45413F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…17,664$1.96M0.01%-1,72213F-HRTimelineGroup
PROFUND ADVISORS LLC16,805$1.87M0.05%-5,98213F-HRTimeline
Police & Firemen's Retirement System of…16,280$1.81M0.01%+1,68613F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC15,641$1.74M0.01%+6,42213F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding15,445$1.71M-35,339Timeline
STATE BOARD OF ADMINISTRATION OF FLORID…15,342$1.7M<0.01%+69213F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM15,073$1.67M0.01%-50813F-HRTimeline
NATIXIS ADVISORS, LLCin group Natixis Investment Managers14,483$1.61M<0.01%new13F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL13,886$1.54M0.01%-5,76013F-HRTimeline
Jasper Ridge Partners, L.P.13,845$1.54M0.03%013F-HR/ATimeline
HighVista Strategies LLC13,657$1.52M0.35%-3,13913F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC13,209$1.47M<0.01%+2,55713F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…13,158$1.46M0.34%+5,72413F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP12,689$1.41M<0.01%+35013F-HRTimelineGroup
KLP KAPITALFORVALTNING AS12,500$1.39M<0.01%013F-HRTimeline
Entropy Technologies, LP12,077$1.34M0.05%+1,75913F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP12,066$1.33M<0.01%+7,14813F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC11,664$1.3M0.01%-2,07513F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS11,465$1.27M<0.01%+27013F-HRTimelineGroup
Bridgefront Capital, LLC11,282$1.25M0.33%-1,21313F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC10,984$1.22M0.01%-5,57013F-HRTimelineGroup
MACKENZIE FINANCIAL CORP10,936$1.21M<0.01%new13F-HRTimeline
China Universal Asset Management Co., L…10,917$1.21M0.07%-1,20113F-HRTimeline
Cannon Financial Strategists, Inc.10,000$1.11M0.13%013F-HRTimeline
ProShare Advisors LLC9,476$1.05M<0.01%-1,24413F-HRTimeline
AlphaCentric Advisors LLC9,449$1.05M0.89%+15213F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …9,393$1.04M<0.01%-53,54313F-HRTimelineGroup
INCEPTIONR LLC9,353$1.04M0.25%+4,97413F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP8,174$908K<0.01%-1,45413F-HRTimelineGroup
EXCHANGE TRADED CONCEPTS, LLC7,966$884K<0.01%-49713F-HR/ATimeline
Y-Intercept (Hong Kong) Ltd7,925$880K0.02%new13F-HRTimeline
TOTH FINANCIAL ADVISORY CORP7,800$866K0.08%-2,20013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC7,679$853K<0.01%-12,82513F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…7,657$850K<0.01%+71913F-HRTimelineGroup
Pathstone Holdings, LLCin group Pathstone Holdings, LLC6,911$767K<0.01%new13F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS6,370$707K<0.01%-96013F-HRTimeline
State of Wyoming6,354$705K0.07%new13F-HRTimeline
LPL Financial LLC6,284$698K<0.01%+8613F-HRTimeline
STRS OHIO6,000$666K<0.01%-22,91413F-HRTimeline
Walleye Capital LLCin group Walleye Capital LLC5,996$666K<0.01%new13F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…5,945$660K<0.01%+1,10113F-HRTimelineGroup
CANADA LIFE ASSURANCE Coin group CANADA LIFE ASSURANCE Co5,797$642K<0.01%013F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…5,601$622K<0.01%new13F-HRTimeline
E. Ohman J:or Asset Management AB5,523$613K0.01%+1,11413F-HRTimeline
Gotham Asset Management, LLC5,516$612K<0.01%+66813F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…5,463$607K<0.01%013F-HRTimeline
XPONANCE LLC5,465$607K<0.01%+47513F-HRTimeline
Avior Wealth Management, LLC5,440$604K0.02%+79013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,010$556K0.01%+64513F-HRTimelineGroup
Fulcrum Asset Management LLP5,049$556K0.06%new13F-HRTimeline
ALLSTATE CORPin group ALLSTATE CORP4,925$547K0.01%new13F-HRTimelineGroup
Mitsubishi UFJ Trust & Banking Corpgroup of 2 filers holding4,860$540K+3,860Timeline
E Fund Management Co., Ltd.4,751$528K0.01%-1,70213F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP4,600$511K<0.01%+30013F-HRTimelineGroup
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…4,290$476K<0.01%-97013F-HRTimelineGroup
Abel Hall, LLC4,258$473K0.08%+24313F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC4,220$469K<0.01%-1,41713F-HRTimelineGroup
O'SHAUGHNESSY ASSET MANAGEMENT, LLC4,122$458K<0.01%new13F-HRTimeline
Matisse Capital4,000$444K0.18%new13F-HRTimeline
Magnetar Financial LLCin group Magnetar Financial LLC3,908$434K<0.01%new13F-HRTimelineGroup
Quantinno Capital Management LP3,838$426K<0.01%-1313F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC3,769$418K<0.01%new13F-HRTimelineGroup
Ensign Peak Advisors, Inc3,709$412K<0.01%-15013F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al3,700$411K<0.01%new13F-HRTimeline
Freestone Capital Holdings, LLCin group Freestone Capital Holdings, L…3,700$411K0.01%013F-HRTimelineGroup
Sound View Wealth Advisors Group, LLC3,682$409K0.03%new13F-HRTimeline
Swiss Life Asset Management Ltdin group Swiss Life Asset Management L…3,539$393K<0.01%+19813F-HRTimelineGroup
SIMPLEX TRADING, LLC3,435$381K0.01%new13F-HRTimeline
Amundiin group Amundi3,422$380K<0.01%-59513F-HRTimelineGroup
Inspire Investing, LLCin group Inspire Investing, LLC3,417$379K0.02%new13F-HRTimelineGroup
Yorktown Management & Research Co Inc3,300$366K0.22%new13F-HRTimeline