BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 7,593,303 $323M 8.25% +5,003,000 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,697,167 $72.1M <0.01% -4,990 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 1,605,532 $68.2M <0.01% +302,558 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 1,114,363 $47.4M 0.15% +474,362 13F-HR Timeline Newtyn Management, LLC More: the full row for Newtyn Management, LLC 709,247 $30.1M 3.76% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 691,971 $29.4M <0.01% +45,057 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 669,748 $28.5M -36,555 Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 338,374 $14.4M 1.3% +38,374 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 245,321 $10.4M <0.01% +15,555 13F-HR Timeline Group WATER ISLAND CAPITAL LLC More: the full row for WATER ISLAND CAPITAL LLC 242,000 $10.3M 1.09% new 13F-HR Timeline ALPINE ASSOCIATES MANAGEMENT INC. More: the full row for ALPINE ASSOCIATES MANAGEMENT INC. 239,318 $10.2M 0.64% new 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 197,764 $8.4M <0.01% +4,616 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 196,307 $8.34M 0.01% -8,613 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 177,106 $7.53M <0.01% +43,746 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 149,523 $6.31M <0.01% new 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 96,179 $4.09M <0.01% +2,689 13F-HR Timeline Group TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 84,391 $3.59M 0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 83,623 $3.55M <0.01% +66,233 13F-HR Timeline Group TORNO CAPITAL, LLC More: the full row for TORNO CAPITAL, LLC 80,000 $3.4M 0.23% new 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 75,348 $3.2M <0.01% +364 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 70,601 $3M 0.02% new 13F-HR/A Timeline Simcoe Capital LLC More: the full row for Simcoe Capital LLC 68,053 $2.89M 1.76% 0 13F-HR Timeline TLS Advisors LLC More: the full row for TLS Advisors LLC 42,165 $1.79M 5.27% -72,702 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 36,744 $1.56M <0.01% +10,669 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 35,046 $1.49M 0.02% new 13F-HR Timeline Group CREDIT INDUSTRIEL ET COMMERCIAL More: the full row for CREDIT INDUSTRIEL ET COMMERCIAL 34,853 $1.48M 0.16% new 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 34,621 $1.47M <0.01% new 13F-HR Timeline Group RBF Capital, LLC More: the full row for RBF Capital, LLC 30,000 $1.27M 0.05% 0 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 30,018 $1.27M <0.01% +26,026 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 28,460 $1.21M <0.01% -70,178 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 28,078 $1.19M <0.01% +927 13F-HR Timeline Group SIERRA SUMMIT ADVISORS LLC More: the full row for SIERRA SUMMIT ADVISORS LLC 25,740 $1.09M 0.12% new 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 24,126 $1.03M -48,690 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 20,122 $855K <0.01% -3,876 13F-HR Timeline Group CSS LLC/IL More: the full row for CSS LLC/IL 19,561 $831K 0.04% new 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 18,388 $781K <0.01% +5,682 13F-HR Timeline Group JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 18,192 $773K <0.01% +3,673 13F-HR Timeline Group MARTINGALE ASSET MANAGEMENT L P More: the full row for MARTINGALE ASSET MANAGEMENT L P 12,200 $518K 0.01% new 13F-HR Timeline RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 11,451 $487K <0.01% -254 13F-HR Timeline Yakira Capital Management, Inc. More: the full row for Yakira Capital Management, Inc. 10,311 $438K 0.13% new 13F-HR Timeline DIVERSIFIED MANAGEMENT INC More: the full row for DIVERSIFIED MANAGEMENT INC 10,000 $425K 0.09% 0 13F-HR Timeline REGIONS FINANCIAL CORP in group REGIONS FINANCIAL CORP More: the full row for REGIONS FINANCIAL CORP 9,250 $393K <0.01% 0 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 9,139 $388K <0.01% +692 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 8,495 $361K <0.01% +4,630 13F-HR Timeline Group Kintayl Capital LP More: the full row for Kintayl Capital LP 8,476 $360K 0.17% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 7,005 $298K <0.01% +202 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 6,878 $292K <0.01% -4,140 13F-HR Timeline Group PRELUDE CAPITAL MANAGEMENT, LLC More: the full row for PRELUDE CAPITAL MANAGEMENT, LLC 6,066 $258K 0.02% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 5,682 $241K <0.01% new 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 5,677 $241K <0.01% 0 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 7,620 $239K <0.01% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 5,500 $234K <0.01% new 13F-HR Timeline PenderFund Capital Management Ltd. More: the full row for PenderFund Capital Management Ltd. 5,200 $221K 0.03% new 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 4,996 $212K <0.01% -1,786 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 4,958 $211K <0.01% new 13F-HR Timeline Group SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 4,891 $208K 0.01% new 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,762 $202K <0.01% +2,400 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 4,560 $194K <0.01% +3,807 13F-HR Timeline Group SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 4,511 $192K <0.01% new 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 4,258 $181K <0.01% -342 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,233 $137K <0.01% +2,414 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,856 $121K <0.01% 0 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 2,139 $90.9K <0.01% new 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 1,592 $67.7K <0.01% -601 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,400 $59.5K <0.01% -565 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1,217 $51.7K <0.01% -2,227 13F-HR Timeline Group State of Alaska, Department of Revenue More: the full row for State of Alaska, Department of Revenue 1,050 $44K <0.01% 0 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 959 $40.8K <0.01% 0 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 854 $36.3K <0.01% 0 13F-HR Timeline Group Costello Asset Management, INC More: the full row for Costello Asset Management, INC 600 $25.5K 0.01% 0 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 587 $25K <0.01% -415 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 470 $20K <0.01% -102 13F-HR Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 372 $15.8K <0.01% 0 13F-HR Timeline Group NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 366 $15.6K <0.01% +347 13F-HR Timeline Truvestments Capital LLC More: the full row for Truvestments Capital LLC 290 $12.3K <0.01% 0 13F-HR Timeline GAMMA Investing LLC More: the full row for GAMMA Investing LLC 152 $6.46K <0.01% 0 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 128 $5.44K <0.01% -386 13F-HR/A Timeline Quarry LP More: the full row for Quarry LP 86 $3.65K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 78 $3.31K <0.01% -67 13F-HR Timeline Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 68 $2.89K <0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 67 $2.85K <0.01% 0 13F-HR Timeline Group Optiver Holding B.V. in group Optiver Holding B.V. More: the full row for Optiver Holding B.V. 47 $2K <0.01% -43 13F-HR Timeline Group Ancora Advisors LLC in group Ancora Advisors LLC More: the full row for Ancora Advisors LLC 31 $1.32K <0.01% 0 13F-HR Timeline Group EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 25 $1.06K <0.01% -34 13F-HR Timeline Group Allworth Financial LP More: the full row for Allworth Financial LP 21 $893 <0.01% +18 13F-HR Timeline MH & ASSOCIATES SECURITIES MANAGEMENT C… More: the full row for MH & ASSOCIATES SECURITIES MANAGEMENT CORP /ADV 20 $850 <0.01% 0 13F-HR Timeline Larson Financial Group LLC More: the full row for Larson Financial Group LLC 10 $425 <0.01% 0 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 10 $425 <0.01% -4 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 8 $340 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 7 $299 <0.01% -18 13F-HR Timeline Group ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 3 $128 <0.01% 0 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 3 $128 <0.01% new 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 1 $43 <0.01% 0 13F-HR Timeline Covestor Ltd More: the full row for Covestor Ltd 8 $0 0% new 13F-HR Timeline Value filed as zero, left out of ratios.