Skip to content
Disclosery

Opaleye Management Inc.

Follow

13F filer, CIK 1595855, BOSTON, MA

Opaleye Management Inc. reported $707,320,956 across 43 holdings for the quarter ended 2025-09-30, in a 13F-HR filed 2025-11-14. Its ten largest share positions make up 72.97% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001493152-25-023429

Period
2025-09-30
Reported value
$707M
Holdings
43
Top 10 weight
72.97%
New
11
Sold out
9

Largest buys vs the previous quarter

SecurityShares changeApprox. value
APGEnew+363,257$14.4M
ALKSnew+450,000$13.5M
ANNXnew+2,600,000$7.93M
DERMadded+876,064$6.24M
SLGLnew+204,835$5.97M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
VIGIL NEUROSCIENCE INCexited-1,000,000-$7.95M
ANIKexited-588,797-$6.23M
ARVNreduced-692,182-$5.9M
DNAexited-500,000-$5.62M
IMNMreduced-344,581-$4.04M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q3 2025

Share positions as resolved from 13F-HR 0001493152-25-023429, largest first. % of portfolio is the value over $707,320,956, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
HROWHARROW INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,990,000 shares; 2024Q4: 3,990,000 shares; 2025Q1: 3,955,000 shares; 2025Q2: 3,905,000 shares; 2025Q3: 3,905,000 shares 3,905,000$188M26.6%0Timeline
ETONETON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,780,000 shares; 2024Q4: 2,852,070 shares; 2025Q1: 2,852,070 shares; 2025Q2: 2,860,000 shares; 2025Q3: 2,860,000 shares 2,860,000$62.1M8.79%0Timeline
LQDALIQUIDIA CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,698,142 shares; 2024Q4: 1,698,142 shares; 2025Q1: 2,260,000 shares; 2025Q2: 2,475,000 shares; 2025Q3: 2,615,000 shares 2,615,000$59.5M8.41%+140,000Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 500,000 shares; 2024Q4: 500,000 shares; 2025Q1: 490,000 shares; 2025Q2: 475,000 shares; 2025Q3: 461,700 shares 461,700$46.6M6.59%-13,300Timeline
IMNMIMMUNOME INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,237,500 shares; 2024Q4: 2,040,000 shares; 2025Q1: 3,550,000 shares; 2025Q2: 3,529,581 shares; 2025Q3: 3,185,000 shares 3,185,000$37.3M5.27%-344,581Timeline
SNWVSANUWAVE HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 972,002 shares; 2025Q2: 980,000 shares; 2025Q3: 980,000 shares 980,000$36.7M5.19%0Timeline
CDXSCODEXIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 8,770,000 shares; 2024Q4: 8,840,000 shares; 2025Q1: 9,500,000 shares; 2025Q2: 12,600,000 shares; 2025Q3: 12,795,000 shares 12,795,000$31.2M4.41%+195,000Timeline
TGTXTG THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,280,000 shares; 2024Q4: 2,260,000 shares; 2025Q1: 535,000 shares; 2025Q2: 535,000 shares; 2025Q3: 535,000 shares 535,000$19.3M2.73%0Timeline
OCULOCULAR THERAPEUTIX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 5,025,000 shares; 2024Q4: 4,342,500 shares; 2025Q1: 1,595,000 shares; 2025Q2: 1,595,000 shares; 2025Q3: 1,595,000 shares 1,595,000$18.6M2.64%0Timeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 163,988 shares; 2025Q2: 266,000 shares; 2025Q3: 410,000 shares 410,000$16.5M2.33%+144,000Timeline
STOKSTOKE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: 25,000 shares; 2025Q1: 300,000 shares; 2025Q2: 562,120 shares; 2025Q3: 682,017 shares 682,017$16M2.27%+119,897Timeline
APGEAPOGEE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 363,257 shares 363,257$14.4M2.04%newTimeline
ALKSALKERMES PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 450,000 shares 450,000$13.5M1.91%newTimeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 85,000 shares; 2025Q2: 186,418 shares; 2025Q3: 193,773 shares 193,773$12.8M1.81%+7,355Timeline
SRPTSAREPTA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 500,000 shares; 2025Q3: 585,000 shares 585,000$11.3M1.59%+85,000Timeline
LRMRLARIMAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,914,077 shares; 2025Q2: 4,110,000 shares; 2025Q3: 3,720,867 shares 3,720,867$10.6M1.49%-389,133Timeline
XOMAXOMA ROYALTY CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 250,000 shares; 2024Q4: 250,000 shares; 2025Q1: 253,043 shares; 2025Q2: 255,087 shares; 2025Q3: 255,087 shares 255,087$9.83M1.39%0Timeline
RZLTREZOLUTE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 466,563 shares; 2024Q4: 465,000 shares; 2025Q1: 465,000 shares; 2025Q2: 903,442 shares; 2025Q3: 903,442 shares 903,442$8.49M1.2%0Timeline
ARVNARVINAS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 1,255,000 shares; 2024Q4: 1,625,000 shares; 2025Q1: 1,975,000 shares; 2025Q2: 1,680,000 shares; 2025Q3: 987,818 shares 987,818$8.42M1.19%-692,182Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 522,500 shares; 2024Q4: 480,000 shares; 2025Q1: 395,000 shares; 2025Q2: 490,000 shares; 2025Q3: 500,000 shares 500,000$8.11M1.15%+10,000Timeline
ANNXANNEXON INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,600,000 shares 2,600,000$7.93M1.12%newTimeline
GOSSGOSSAMER BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 3,665,010 shares; 2024Q4: 4,490,000 shares; 2025Q1: 4,287,415 shares; 2025Q2: 3,545,000 shares; 2025Q3: 2,725,000 shares 2,725,000$7.17M1.01%-820,000Timeline
PTGXPROTAGONIST THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 105,000 shares; 2024Q4: 105,000 shares; 2025Q1: 105,000 shares; 2025Q2: 105,000 shares; 2025Q3: 105,000 shares 105,000$6.98M0.99%0Timeline
DERMJOURNEY MED CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 69,323 shares; 2025Q2: 95,000 shares; 2025Q3: 971,064 shares 971,064$6.91M0.98%+876,064Timeline
SLGLSOL-GEL TECHNOLOGIES LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 204,835 shares 204,835$5.97M0.84%newTimeline
PLXPROTALIX BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 2,580,556 shares 2,580,556$5.73M0.81%newTimeline
TMCITREACE MED CONCEPTS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 702,245 shares 702,245$4.71M0.67%newTimeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 105,000 shares; 2025Q3: 100,000 shares 100,000$4.67M0.66%-5,000Timeline
MBXMBX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 250,000 shares; 2025Q2: 239,319 shares; 2025Q3: 253,000 shares 253,000$4.43M0.63%+13,681Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 2,567,990 shares; 2024Q4: 2,317,500 shares; 2025Q1: 795,000 shares; 2025Q2: 390,000 shares; 2025Q3: 390,000 shares 390,000$3.57M0.5%0Timeline
ADCTADC THERAPEUTICS SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 682,529 shares 682,529$2.73M0.39%newTimeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 775,000 shares; 2025Q3: 665,000 shares 665,000$2.65M0.38%-110,000Timeline
CABACABALETTA BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 808,882 shares 808,882$1.89M0.27%newTimeline
IRDOPUS GENETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,175,000 shares; 2025Q2: 1,220,000 shares; 2025Q3: 1,100,000 shares 1,100,000$1.81M0.26%-120,000Timeline
ZYMEZYMEWORKS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 175,000 shares; 2025Q2: 210,000 shares; 2025Q3: 100,000 shares 100,000$1.71M0.24%-110,000Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 65,000 shares 65,000$1.09M0.15%newTimeline
RIGLRIGEL PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 37,787 shares 37,787$1.07M0.15%newTimeline
ACOGALPHA COGNITION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 115,142 shares 115,142$750K0.11%newTimeline
ZNTLZENTALIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 967,000 shares; 2024Q4: 1,767,500 shares; 2025Q1: 1,985,000 shares; 2025Q2: 1,924,300 shares; 2025Q3: 316,550 shares 316,550$478K0.07%-1,607,750Timeline
PEPGPEPGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 179,200 shares; 2024Q4: 110,000 shares; 2025Q1: 420,000 shares; 2025Q2: 240,000 shares; 2025Q3: 75,000 shares 75,000$346K0.05%-165,000Timeline
IBIOIBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 375,000 shares; 2024Q4: 375,000 shares; 2025Q1: 375,000 shares; 2025Q2: 375,000 shares; 2025Q3: 375,000 shares 375,000$310K0.04%0Timeline
ADGMADAGIO MED HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2023Q4: restricted; 2024Q1: restricted; 2024Q2: restricted; 2024Q3: 110,571 shares; 2024Q4: 110,571 shares; 2025Q1: 110,571 shares; 2025Q2: 110,571 shares; 2025Q3: 110,571 shares 110,571$215K0.03%0Timeline

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
KARYOPHARM THERAPEUTICS INCKARYOPHARM THERAPEUTICS INC BONDprincipal6,000,000$4.63M0

Sold out in Q3 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
VIGIL NEUROSCIENCE INCVIGIL NEUROSCIENCE INC1,000,000$7.95Mshares
ANIKANIKA THERAPEUTICS INC588,797$6.23Mshares
GOSSAMER BIO INCGOSSAMER BIO INC11,500,000$5.95Mprincipal
DNAGINKGO BIOWORKS HOLDINGS INC500,000$5.62Mshares
ESSA PHARMA INCESSA PHARMA INC2,209,998$3.76Mshares
CARGO THERAPEUTICS INC COMCARGO THERAPEUTICS INC COM666,503$2.75Mshares
TARAPROTARA THERAPEUTICS INC855,000$2.59Mshares
RCELAVITA MEDICAL INC389,519$2.06Mshares
ELEVATION ONCOLOGY INC COMELEVATION ONCOLOGY INC COM1,442,061$529Kshares

How Q3 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001493152-25-023429 base2025-11-14acceptance time not in the bulk data set