13F-HR/A filed by Opaleye Management Inc.
Opaleye Management Inc. filed this 13F-HR/A for the quarter ended 2025-12-31, filed 2026-04-13, with 54 holding rows worth $757,893,709.
- Accession
- 0001493152-26-016299
- Filer
- CIK 1595855
- Filed
- 2026-04-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, amendment of type restatement, 54 entries on the cover page, a total value of $757,893,709 stated on the cover page (in dollars after the unit check, H1), rows summing to $757,893,709 with VALUE read as dollars as filed, 13F file number 028-15896. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| HARROW INC | 415858109 | COM | 3,905,000 | $191,345,000 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 2,435,000 | $84,981,500 | dollars as filed | |
| ETON PHARMACEUTICALS INC | 29772L108 | COMMON STOCK | 2,860,000 | $48,362,600 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 330,000 | $35,323,200 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 388,257 | $29,305,638 | dollars as filed | |
| SANUWAVE HEALTH INC | 80303D305 | CMN | 981,267 | $29,281,007 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 695,000 | $22,059,300 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 1,595,000 | $19,363,300 | dollars as filed | |
| SOL-GEL TECHNOLOGIES LTD | M8694L137 | SHS NEW | 453,739 | $19,120,561 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 410,000 | $17,023,200 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 535,000 | $15,948,350 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 200,000 | $15,882,000 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 6,287,156 | $14,837,688 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 1,178,300 | $13,974,638 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 490,000 | $13,710,200 | dollars as filed | |
| ALPHA COGNITION INC | 02074J501 | COM NEW | 2,070,784 | $13,460,096 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 2,600,000 | $13,052,000 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 500,000 | $12,407,500 | dollars as filed | |
| CODEXIS INC | 192005106 | COM | 6,789,738 | $11,067,273 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 105,000 | $9,170,700 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 2,720,000 | $8,432,000 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 260,000 | $8,200,400 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 100,000 | $7,965,000 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 292,590 | $7,779,968 | dollars as filed | |
| JOURNEY MED CORP | 48115J109 | COM | 975,000 | $7,517,250 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 930,000 | $6,844,800 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 427,608 | $6,597,991 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 268,423 | $6,286,467 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 535,000 | $5,221,600 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 1,184,500 | $4,989,875 | dollars as filed | |
| VOYAGER THERAPEUTICS INC | 92915B106 | COMMON STOCK | 1,196,904 | $4,703,833 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 935,000 | $4,516,050 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 214,747 | $4,479,622 | dollars as filed | |
| PROTALIX BIOTHERAPEUTICS INC | 74365A309 | COMMON STOCK | 2,478,176 | $4,460,717 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 345,100 | $4,320,652 | dollars as filed | |
| FORTRESS BIOTECH INC | 34960Q307 | COM NEW | 1,090,000 | $3,989,400 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 955,000 | $3,352,050 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 390,844 | $3,107,210 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559702 | COMMON STOCK | 70,000 | $2,998,100 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 108,929 | $2,868,101 | dollars as filed | |
| ASSERTIO HOLDINGS INC | 04546C205 | COM NEW | 285,000 | $2,584,950 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 251,932 | $2,274,946 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 1,120,000 | $2,251,200 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367201 | COMMON STOCK | 190,671 | $2,206,063 | dollars as filed | |
| CABALETTA BIO INC | 12674W109 | COMMON STOCK | 900,000 | $1,971,000 | dollars as filed | |
| ZENTALIS PHARMACEUTICALS INC | 98943L107 | COMMON STOCK | 1,400,906 | $1,891,223 | dollars as filed | |
| GENERATION BIO CO | 37148K209 | COM NEW | 310,000 | $1,760,800 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 18,319 | $1,401,220 | dollars as filed | |
| ENANTA PHARMACEUTICALS INC | 29251M106 | COM | 75,000 | $1,182,750 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 213,363 | $708,365 | dollars as filed | |
| ATEA PHARMACEUTICALS INC | 04683R106 | COMMON STOCK | 179,815 | $641,940 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 78,926 | $479,870 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 150,000 | $213,363 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 18,444 | $19,182 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001493152-26-007085 | superseded | 2026-02-17 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001493152-26-016299 | this filing | 2026-04-13 | acceptance time not in the bulk data set |