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Disclosery

EWTX EDGEWISE THERAPEUTICS INC

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COM (common), issuer CIK 1710072

218 managers (225 13F filers) reported a position in EWTX shares at 2026-06-30, 119,185,338 shares in all. 39 filers opened a position and 26 filers sold out during the quarter.

Managers
218
13F filers
225
New
39
Added
83
Reduced
73
Sold out
26
Shares held by filers
119,185,338

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC15,518,492$631M11.94%013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …10,215,455$415M7.77%+2,850,41713F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.8,392,730$341M2.96%-2,035,70713F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,606,336$268M<0.01%+133,34513F-HRTimelineGroup
Jupiter Topco LLCin group Janus Henderson6,075,331$247M0.1%13F-HRTimelineGroup
FMR LLCin group FMR LLC5,489,135$223M0.01%+4,472,08313F-HRTimelineGroup
NOVO HOLDINGS A/S5,350,000$217M12.62%013F-HRTimeline
VANGUARD GROUP INCgroup of 6 filers holding5,280,144$215M+334,241Timeline
Driehaus Capital Management LLC4,728,623$192M1.11%+250,68113F-HRTimeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,373,974$178M2.76%-50,00013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP3,701,719$150M0.75%-2,874,22113F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.3,184,629$129M2.63%-1,245,63413F-HRTimelineGroup
Cormorant Asset Management, LP2,510,000$102M5.23%-750,00013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,174,051$88.3M<0.01%+384,23213F-HRTimelineGroup
Integral Health Asset Management, LLC2,000,000$81.3M3.33%+400,00013F-HRTimeline
BRAIDWELL LP1,996,965$81.1M3%-350,61813F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY1,948,597$79.2M<0.01%-297,43113F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,827,927$74.3M<0.01%+111,10413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.2,119,024$66.7M0.02%+396,85513F-HRTimeline
MPM BIOIMPACT LLC1,620,780$65.9M4.02%-39,91613F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,558,260$63.3M<0.01%+230,90013F-HRTimelineGroup
Qube Research & Technologies Ltd1,252,507$50.9M0.06%+426,59713F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,139,726$46.3M0.01%-79,99113F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC1,127,078$45.8M0.02%-20,09813F-HRTimelineGroup
First Light Asset Management, LLC1,095,171$44.5M2.7%+93,32513F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC902,870$36.7M0.02%+113,82713F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/816,518$33.2M<0.01%+747,09113F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP671,270$27.3M<0.01%+94,71413F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc647,926$26.3M0.04%-178,13313F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co620,532$25.2M<0.01%+24,22213F-HRTimelineGroup
Tyro Capital Management LLC612,965$24.9M5.59%new13F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC599,469$24.4M<0.01%-30,35113F-HRTimelineGroup
Parkman Healthcare Partners LLC577,036$23.4M2.41%+254,20813F-HRTimeline
Artisan Partners Limited Partnership574,925$23.4M0.04%-84,14213F-HRTimeline
NORGES BANK510,140$20.7M<0.01%new13F-HRTimeline
Opaleye Management Inc.500,000$20.3M1.84%013F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC469,707$19.1M0.01%+40,67513F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…462,000$18.8M0.03%new13F-HRTimelineGroup
Soleus Capital Management, L.P.450,889$18.3M0.63%-999,02613F-HRTimeline
Nuveen, LLCin group TIAA414,706$16.8M<0.01%+78,92313F-HRTimelineGroup
Sofinnova Investments, Inc.380,923$15.5M0.83%-5,57513F-HRTimeline
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…334,014$13.6M0.02%-70,18613F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC317,565$12.9M<0.01%+297,88713F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding293,176$11.9M-1,132,669Timeline
Squadron Capital Management LLC290,000$11.8M4.03%-60,00013F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …283,333$11.5M0.02%+2113F-HRTimelineGroup
DIADEMA PARTNERS LP272,214$11.1M3.91%new13F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC260,725$10.6M0.01%+250,12013F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC256,608$10.4M0.18%-7,59613F-HRTimeline
Schonfeld Strategic Advisors LLC255,202$10.4M0.05%+156,12713F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\244,995$9.95M<0.01%+23,12713F-HRTimelineGroup
DAFNA Capital Management LLC226,819$9.22M1.76%+114,58313F-HRTimeline
Woodline Partners LP224,290$9.11M0.03%013F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp212,347$8.63M<0.01%+19,91313F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO203,151$8.48M<0.01%+55,57813F-HRTimelineGroup
PEREGRINE CAPITAL MANAGEMENT LLC198,570$8.07M0.26%-10,10213F-HRTimeline
SEB Asset Management AB194,063$7.88M0.03%-12,44913F-HRTimeline
Granahan Investment Management, LLC193,778$7.87M0.28%-7,06513F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC191,195$7.77M0.01%+22,51713F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC190,205$7.73M<0.01%+12,96113F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.189,115$7.68M<0.01%+84,25213F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC143,199$5.82M0.27%+52,60013F-HRTimelineGroup
KVP Capital Advisors, LP133,000$5.4M3.97%013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.120,932$4.91M<0.01%-17,46713F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.117,262$4.76M0.01%new13F-HRTimelineGroup
Quantum Private Wealth, LLC113,380$4.61M1.18%-3,24413F-HRTimeline
ALPS ADVISORS INC108,795$4.42M0.02%+21,46913F-HRTimeline
Moody Aldrich Partners LLC104,952$4.26M0.77%-9,18913F-HRTimeline
Artia Global Partners LP98,800$4.01M0.76%+33,30013F-HRTimeline
Swiss National Bank96,800$3.93M<0.01%-7,10013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC94,671$3.85M<0.01%+55,51813F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC91,638$3.72M<0.01%new13F-HRTimelineGroup
HighVista Strategies LLC90,996$3.7M0.84%-93513F-HRTimeline
RHUMBLINE ADVISERS90,232$3.67M<0.01%+6,69213F-HRTimeline
Ally Bridge Group (NY) LLC83,300$3.38M4.36%-77,70013F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC82,734$3.36M0.06%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND80,197$3.26M<0.01%-8,74013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN78,898$3.21M<0.01%+53,65413F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…77,733$3.16M<0.01%+71,15913F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.71,389$2.9M0.03%new13F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…71,306$2.9M<0.01%-2,11313F-HR/ATimeline
Persistent Asset Partners Ltd69,441$2.82M0.89%+59,38813F-HRTimeline
NOMURA ASSET MANAGEMENT INTERNATIONAL I…in group NOMURA ASSET MANAGEMENT CO LTD64,918$2.64M<0.01%-2,49013F-HRTimelineGroup
DekaBank Deutsche Girozentrale80,000$2.52M<0.01%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC59,563$2.42M<0.01%+41,04613F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL56,934$2.31M0.01%+27,04513F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD56,910$2.31M<0.01%+24,01413F-HRTimeline
HighMark Wealth Management LLC53,179$2.16M0.72%013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP49,548$2.01M<0.01%-1,30013F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO47,543$1.93M<0.01%-1,53913F-HRTimelineGroup
ALGERT GLOBAL LLC47,240$1.92M0.02%+14,72013F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd45,832$1.86M0.02%+26,72413F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc44,688$1.82M<0.01%+2,15113F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP44,466$1.81M0.11%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS43,587$1.77M<0.01%+19,67613F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…41,804$1.7M0.01%+3,72013F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …40,757$1.66M<0.01%+5,30713F-HRTimelineGroup
Ensign Peak Advisors, Inc40,379$1.64M<0.01%new13F-HRTimeline
Creative Planningin group Creative Planning39,198$1.59M<0.01%+7,93013F-HRTimelineGroup
Knights of Columbus Asset Advisors LLC38,641$1.57M0.08%+22713F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding37,751$1.53M+542Timeline
FRANKLIN RESOURCES INCin group Franklin Resources37,605$1.53M<0.01%-4,12113F-HRTimelineGroup
Aquatic Capital Management LLC36,918$1.5M0.05%new13F-HRTimeline
Handelsbanken Fonder AB30,500$1.24M<0.01%-60013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC29,934$1.22M<0.01%-5,64413F-HRTimelineGroup
Verdad Advisers, LP27,234$1.11M1.06%+14,18213F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…26,566$1.08M0.02%new13F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…25,659$1.04M<0.01%-1,75013F-HRTimelineGroup
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA24,484$995K<0.01%+5,26013F-HRTimelineGroup
Campbell & CO Investment Adviser LLC23,829$968K0.05%new13F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC22,685$922K<0.01%+6,95513F-HRTimelineGroup
STRS OHIO21,100$857K<0.01%+14,20013F-HRTimeline
Police & Firemen's Retirement System of…21,096$857K0.01%+2,23113F-HRTimeline
Quantinno Capital Management LP20,299$825K<0.01%+12,84513F-HRTimeline
LMR Partners LLPin group LMR Partners LLP20,000$813K0.01%013F-HRTimelineGroup
Longaeva Partners L.P.18,790$763K0.02%-18,14113F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC18,456$750K<0.01%+9,91713F-HRTimelineGroup
China Universal Asset Management Co., L…18,373$746K0.04%-7,06313F-HRTimeline
Odyssean, LLC17,867$726K0.12%013F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…16,870$685K<0.01%013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC16,578$674K0.01%-1,90213F-HRTimeline
CAPTRUST FINANCIAL ADVISORS16,288$662K<0.01%new13F-HRTimeline
AlphaCentric Advisors LLC15,840$644K0.55%+22513F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…15,608$634K<0.01%-2,48313F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…15,288$621K<0.01%+54913F-HRTimeline
SummitTX Capital, L.P.14,738$599K0.02%new13F-HRTimeline
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC13,649$555K<0.01%+2,12513F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM13,320$541K<0.01%-1,22013F-HRTimeline
State of Wyoming12,913$525K0.05%new13F-HRTimeline
ProShare Advisors LLC12,890$524K<0.01%-1,68813F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP12,365$502K<0.01%new13F-HR/ATimelineGroup
Advisory Services Network, LLC12,209$496K0.01%+12,05813F-HRTimeline
KLP KAPITALFORVALTNING AS11,300$459K<0.01%013F-HRTimeline
J. Goldman & Co LP10,183$414K0.01%-51,23813F-HRTimeline
Verition Fund Management LLC10,000$406K<0.01%new13F-HR/ATimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP9,877$401K<0.01%+74813F-HRTimelineGroup
Connecticut Capital Management Group, L…9,824$399K0.32%-1513F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…9,395$382K0.09%-2,14913F-HRTimelineGroup
Private Advisor Group, LLC9,341$380K<0.01%new13F-HRTimeline
Bridgefront Capital, LLC9,184$373K0.1%-2,62513F-HRTimeline
PROFUND ADVISORS LLC9,164$372K0.01%+48113F-HRTimeline
Lion Point Capital, LP9,100$370K1.77%013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.8,694$353K<0.01%+21113F-HRTimelineGroup
XPONANCE LLC7,027$286K<0.01%new13F-HRTimeline
VARCOV Co.7,009$285K0.11%new13F-HRTimeline
Orion Porfolio Solutions, LLC6,930$282K<0.01%+48113F-HRTimeline
Engineers Gate Manager LP6,670$271K<0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…6,491$264K0.01%+85313F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…6,280$255K<0.01%-1,34313F-HRTimelineGroup
Marex Group Ltdin group Marex Group Ltd6,274$255K<0.01%new13F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP6,100$248K<0.01%-642,29313F-HRTimelineGroup
Rafferty Asset Management, LLC6,035$245K<0.01%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.6,014$244K0.04%-1,96213F-HRTimeline
VIRGINIA RETIREMENT SYSTEMS ET Al5,900$240K<0.01%new13F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…5,692$231K<0.01%-20,98213F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC5,655$230K<0.01%new13F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS5,569$226K<0.01%-1,15013F-HRTimeline
AXQ CAPITAL, LP5,537$225K0.02%-3,97613F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC5,470$222K<0.01%new13F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd5,466$222K<0.01%new13F-HRTimeline
PSP Research LLC5,000$203K0.11%-1,50013F-HRTimeline
GROUP ONE TRADING LLC4,477$182K0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA3,762$153K<0.01%-2,11113F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\3,386$138K<0.01%+41313F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,849$116K<0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,812$114K<0.01%-2,66113F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.2,272$92.3K<0.01%-10613F-HRTimeline
GAMMA Investing LLC2,107$85.6K<0.01%-18213F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC1,669$67K<0.01%-1,06813F-HRTimelineGroup
KBC Group NVin group KBC Group NV1,560$63K<0.01%013F-HRTimelineGroup
Parallel Advisors, LLC1,513$61.5K<0.01%+48113F-HRTimeline
BI Asset Management Fondsmaeglerselskab…in group BI Asset Management Fondsmaeg…1,439$58K<0.01%new13F-HRTimelineGroup
Eleva Capital SAS17,460$55K0.02%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,218$49.5K<0.01%-45913F-HRTimeline
Centiva Capital, LP1,217$49.4K<0.01%+67813F-HRTimeline
Steward Partners Investment Advisory, L…1,214$49.3K<0.01%-1,14013F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.1,138$46.2K<0.01%-55,64013F-HRTimelineGroup
Kemnay Advisory Services Inc.829$33.7K<0.01%+7313F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …782$31.8K<0.01%-19013F-HRTimelineGroup
Farther Finance Advisors, LLC558$22.7K<0.01%-8713F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC426$17K<0.01%-1,92413F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.369$15K<0.01%+10813F-HRTimelineGroup
SIGNATUREFD, LLC363$14.7K<0.01%013F-HRTimeline
Nykredit A/Sin group Nykredit A/S356$14.5K<0.01%13F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…324$13.2K<0.01%-40813F-HRTimelineGroup
MassMutual Private Wealth & Trust, FSB294$11.9K<0.01%013F-HRTimeline
SMA Capital LLC252$10.2K<0.01%new13F-HRTimeline
Sterling Capital Management LLC251$10.2K<0.01%-18713F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC230$9.35K<0.01%-5,37013F-HRTimeline
Aster Capital Management (DIFC) Ltd211$8.57K<0.01%-9913F-HR/ATimeline
Caitong International Asset Management …208$8.45K<0.01%-4,07013F-HRTimeline
SBI Securities Co., Ltd.206$8.37K<0.01%013F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…193$7.83K<0.01%+16013F-HRTimelineGroup
Larson Financial Group LLC180$7.31K<0.01%+413F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…176$7.15K<0.01%+413F-HRTimelineGroup
Allworth Financial LP176$7.15K<0.01%+9213F-HRTimeline
Smartleaf Asset Management LLC162$6.63K<0.01%013F-HRTimeline
Fortitude Family Office, LLC160$6.5K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC150$6.09K<0.01%+1513F-HRTimeline
Hurley Capital, LLC149$6.05K<0.01%new13F-HRTimeline