VANGUARD GROUP INC group of 2 filers holding More: the full row for VANGUARD GROUP INC 16,733,255 $1.33B +1,057,853 Timeline FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 14,582,796 $1.16B 6.04% -42,896 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. JANUS HENDERSON GROUP PLC in group Janus Henderson More: the full row for JANUS HENDERSON GROUP PLC 12,303,502 $980M 0.44% +947,448 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 9,455,357 $753M 4.41% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 8,926,656 $711M 0.01% +598,898 13F-HR Timeline Group FMR LLC in group FMR LLC More: the full row for FMR LLC 8,587,981 $684M 0.03% -813,706 13F-HR Timeline Group Nextech Invest Ltd. More: the full row for Nextech Invest Ltd. 7,601,087 $605M 58.53% 0 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 6,987,639 $557M 0.1% -2,825,797 13F-HR Timeline Group Paradigm Biocapital Advisors LP in group Paradigm Biocapital Advisors … More: the full row for Paradigm Biocapital Advisors LP 6,644,403 $529M 14.17% +421,112 13F-HR Timeline Group Bellevue Group AG in group Bellevue Group AG More: the full row for Bellevue Group AG 5,005,719 $399M 7.56% -568,119 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 4,109,290 $327M 0.01% -1,145,349 13F-HR Timeline Group UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 3,437,349 $274M +2,007,017 Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 3,404,717 $271M 0.03% -468,989 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 3,356,782 $267M 9% -618,131 13F-HR Timeline Group Alphabet Inc. in group Alphabet Inc. More: the full row for Alphabet Inc. 3,345,102 $266M 10.33% -788,175 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 3,161,963 $252M 0.02% +16,323 13F-HR Timeline Group DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 2,894,613 $231M 2.96% -755,729 13F-HR Timeline Group WESTFIELD CAPITAL MANAGEMENT CO LP More: the full row for WESTFIELD CAPITAL MANAGEMENT CO LP 2,845,013 $227M 0.94% +331,046 13F-HR Timeline GENERAL ATLANTIC, L.P. More: the full row for GENERAL ATLANTIC, L.P. 2,812,928 $224M 7.8% +338,500 13F-HR Timeline Casdin Capital, LLC More: the full row for Casdin Capital, LLC 2,577,333 $205M 12.75% -70,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 2,500,895 $199M 0.77% -414,988 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 2,491,583 $198M 0.03% +1,753,557 13F-HR/A Timeline Group NORGES BANK More: the full row for NORGES BANK 2,455,347 $196M 0.02% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 2,205,555 $176M 0.27% +1,463,155 13F-HR Timeline Group T. Rowe Price Investment Management, In… More: the full row for T. Rowe Price Investment Management, Inc. 2,200,376 $175M 0.11% -2,581,942 13F-HR/A Timeline Lunate Capital Ltd in group Lunate Capital Ltd More: the full row for Lunate Capital Ltd 2,196,200 $175M 66.2% 0 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,170,000 $173M 1.7% new 13F-HR/A Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 2,056,857 $164M 0.04% +832,098 13F-HR Timeline Group Polar Capital Holdings Plc in group Polar Capital Holdings Plc More: the full row for Polar Capital Holdings Plc 2,013,791 $160M 0.73% +1,535,686 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 2,000,000 $159M 10.62% +250,000 13F-HR Timeline Holocene Advisors, LP More: the full row for Holocene Advisors, LP 1,907,948 $152M 0.32% -1,529,335 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 1,683,729 $134M 0.02% +48,334 13F-HR Timeline Group D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 1,613,730 $129M 0.1% +801,451 13F-HR Timeline Group Rock Springs Capital Management LP More: the full row for Rock Springs Capital Management LP 1,335,270 $106M 5.46% 0 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 1,335,075 $106M 3.17% +291,355 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,302,361 $104M 0.07% +122,276 13F-HR Timeline Group Caligan Partners LP More: the full row for Caligan Partners LP 1,283,900 $102M 9.36% +219,651 13F-HR Timeline Integral Health Asset Management, LLC More: the full row for Integral Health Asset Management, LLC 1,200,000 $95.6M 4.84% +800,000 13F-HR Timeline DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 1,161,646 $92.5M 0.02% -279,172 13F-HR Timeline Group Jefferies Financial Group Inc. in group Jefferies Financial Group Inc. More: the full row for Jefferies Financial Group Inc. 1,141,195 $90.9M 0.74% +1,128,195 13F-HR Timeline Group Pictet Asset Management Holding SA in group Pictet Asset Management Holdi… More: the full row for Pictet Asset Management Holding SA 1,137,121 $90.7M 0.09% -174,620 13F-HR Timeline Group a16z Capital Management, L.L.C. group of 2 filers holding More: the full row for a16z Capital Management, L.L.C. 1,104,017 $87.9M -1,644,506 Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 1,090,416 $86.9M 0.1% +492,961 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 1,060,171 $84.4M 0.02% +108,681 13F-HR Timeline Group Candriam S.C.A. More: the full row for Candriam S.C.A. 1,030,992 $82.1M 0.41% +162,268 13F-HR/A Timeline Hood River Capital Management LLC More: the full row for Hood River Capital Management LLC 945,585 $75.3M 0.83% +17,462 13F-HR Timeline AIHC Capital Management Ltd More: the full row for AIHC Capital Management Ltd 900,392 $71.7M 67.21% 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 879,845 $70.1M 0.01% +125,978 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 850,323 $67.7M 0.01% -9,225 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 800,118 $63.7M 0.05% +371,809 13F-HR Timeline Group Frazier Life Sciences Management, L.P. More: the full row for Frazier Life Sciences Management, L.P. 797,455 $63.5M 1.71% -200,000 13F-HR Timeline TWO SIGMA INVESTMENTS, LP group of 2 filers holding More: the full row for TWO SIGMA INVESTMENTS, LP 709,381 $56.5M +661,283 Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 651,732 $51.9M <0.01% -782,910 13F-HR/A Timeline Group First Turn Management, LLC More: the full row for First Turn Management, LLC 638,385 $50.8M 5.81% -4,665 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 619,387 $49.3M 0.03% +194,706 13F-HR Timeline Group DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 604,514 $48.1M 11.18% -52,662 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 542,069 $43.2M 0.01% +12,799 13F-HR Timeline Group MIC Capital Management UK LLP More: the full row for MIC Capital Management UK LLP 508,569 $40.5M 9.18% 0 13F-HR Timeline MPM BIOIMPACT LLC More: the full row for MPM BIOIMPACT LLC 505,672 $40.3M 4.61% +189,950 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 503,721 $40.1M 0.01% +311,392 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 467,360 $37.2M 0.02% +16,346 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 446,616 $35.6M 0.06% new 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 436,473 $34.8M 1.15% 0 13F-HR Timeline FRONTIER CAPITAL MANAGEMENT CO LLC More: the full row for FRONTIER CAPITAL MANAGEMENT CO LLC 430,768 $34.3M 0.36% +307,988 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 421,627 $33.6M <0.01% -2,076,700 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 415,207 $33.1M 0.06% +319,611 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 406,241 $32.4M 0.01% +68,767 13F-HR Timeline Group Boxer Capital Management, LLC in group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 400,000 $31.9M 6.97% 0 13F-HR Timeline Group LORD, ABBETT & CO. LLC More: the full row for LORD, ABBETT & CO. LLC 399,484 $31.8M 0.1% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 386,191 $30.8M 0.03% +225,095 13F-HR Timeline Group EVENTIDE ASSET MANAGEMENT, LLC More: the full row for EVENTIDE ASSET MANAGEMENT, LLC 378,261 $30.1M 0.47% -216,777 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 370,520 $29.5M 0.02% -165,084 13F-HR Timeline Checkpoint Capital L.P. More: the full row for Checkpoint Capital L.P. 370,000 $29.5M 9.34% -122,300 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 367,851 $29.3M <0.01% +166,909 13F-HR Timeline Group Defilade Capital Management, L.P. More: the full row for Defilade Capital Management, L.P. 363,454 $28.9M 3.92% 13F-HR Timeline Mass General Brigham, Inc More: the full row for Mass General Brigham, Inc 344,091 $27.4M 3.38% 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 327,152 $26.1M 0.67% +62,144 13F-HR Timeline VOLORIDGE INVESTMENT MANAGEMENT, LLC More: the full row for VOLORIDGE INVESTMENT MANAGEMENT, LLC 322,289 $25.7M 0.09% +173,144 13F-HR Timeline Nicholas Investment Partners, LP More: the full row for Nicholas Investment Partners, LP 317,711 $25.3M 1.84% +49,800 13F-HR Timeline JENNISON ASSOCIATES LLC More: the full row for JENNISON ASSOCIATES LLC 305,260 $24.3M 0.01% new 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 295,000 $23.5M 0.86% -335,000 13F-HR Timeline California Public Employees Retirement … More: the full row for California Public Employees Retirement System 291,006 $23.2M 0.01% +60,032 13F-HR Timeline Swiss National Bank More: the full row for Swiss National Bank 276,331 $22M 0.01% +5,500 13F-HR Timeline RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 244,174 $19.4M 0.01% -33,986 13F-HR Timeline Group Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 241,057 $19.2M 0.01% +233,752 13F-HR Timeline Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 239,097 $19M 0.05% new 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 235,808 $18.8M 0.03% -12,670 13F-HR/A Timeline Catalyst Funds Management Pty Ltd More: the full row for Catalyst Funds Management Pty Ltd 223,569 $17.8M 4.13% +13,400 13F-HR Timeline MARSICO CAPITAL MANAGEMENT LLC More: the full row for MARSICO CAPITAL MANAGEMENT LLC 219,460 $17.5M 0.49% new 13F-HR Timeline Decheng Capital LLC More: the full row for Decheng Capital LLC 200,000 $15.9M 2.14% -10,000 13F-HR Timeline BAILLIE GIFFORD & CO in group BAILLIE GIFFORD & CO More: the full row for BAILLIE GIFFORD & CO 194,959 $15.5M 0.01% new 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 189,333 $15.1M 0.08% +53,884 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 183,221 $14.6M 0.02% +65,013 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 171,543 $13.7M 0.01% +2,133 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 160,448 $12.8M 0.01% +6,634 13F-HR Timeline Mitsubishi UFJ Trust & Banking Corp group of 2 filers holding More: the full row for Mitsubishi UFJ Trust & Banking Corp 154,514 $12.3M +123,000 Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 153,380 $12.2M <0.01% -2,009 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 151,453 $12.1M 1.22% -179,616 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 145,079 $11.6M 0.86% +5,943 13F-HR/A Timeline Group VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 139,312 $11.1M 0.01% -112,498 13F-HR Timeline Ikarian Capital, LLC in group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 138,142 $11M 1.42% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 136,048 $10.8M <0.01% -154,401 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 135,390 $10.8M 0.01% -4,695 13F-HR Timeline STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 130,936 $10.4M 0.02% +45,360 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 129,407 $10.3M 0.01% +9,600 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 127,170 $10.1M 0.01% +56,881 13F-HR Timeline Group BANK OF NOVA SCOTIA in group BANK OF NOVA SCOTIA More: the full row for BANK OF NOVA SCOTIA 125,913 $10M 0.01% new 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 120,240 $9.58M 2.47% -55,208 13F-HR Timeline BESSEMER GROUP INC in group BESSEMER GROUP INC More: the full row for BESSEMER GROUP INC 117,662 $9.37M 0.01% -126,205 13F-HR Timeline Group WCM INVESTMENT MANAGEMENT, LLC More: the full row for WCM INVESTMENT MANAGEMENT, LLC 117,215 $9.34M 0.02% -136,162 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 115,900 $9.23M 2.03% new 13F-HR Timeline ALGERT GLOBAL LLC More: the full row for ALGERT GLOBAL LLC 113,930 $9.07M 0.14% -52,385 13F-HR/A Timeline Gotham Asset Management, LLC More: the full row for Gotham Asset Management, LLC 113,829 $9.07M 0.03% +14,715 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 113,268 $9.02M 0.01% new 13F-HR Timeline Group CANADA PENSION PLAN INVESTMENT BOARD More: the full row for CANADA PENSION PLAN INVESTMENT BOARD 108,675 $8.66M 0.01% new 13F-HR Timeline Zweig-DiMenna Associates LLC More: the full row for Zweig-DiMenna Associates LLC 104,600 $8.33M 0.59% new 13F-HR Timeline Artia Global Partners LP More: the full row for Artia Global Partners LP 104,190 $8.3M 1.33% 0 13F-HR Timeline BNP PARIBAS ASSET MANAGEMENT Holding S.… in group BNP PARIBAS ASSET MANAGEMENT … More: the full row for BNP PARIBAS ASSET MANAGEMENT Holding S.A. 103,552 $8.25M 0.01% +102,276 13F-HR Timeline Group NEOS Investment Management LLC More: the full row for NEOS Investment Management LLC 101,888 $8.12M 0.05% -25,033 13F-HR Timeline Tema ETFs LLC More: the full row for Tema ETFs LLC 100,603 $8.01M 0.62% -26,318 13F-HR Timeline Opaleye Management Inc. More: the full row for Opaleye Management Inc. 100,000 $7.96M 1.05% 0 13F-HR/A Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 100,000 $7.96M 0.57% 0 13F-HR Timeline Granahan Investment Management, LLC More: the full row for Granahan Investment Management, LLC 99,194 $7.9M 0.34% -19,498 13F-HR Timeline Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 98,880 $7.88M 0.01% -25,759 13F-HR Timeline Group STATE OF WISCONSIN INVESTMENT BOARD More: the full row for STATE OF WISCONSIN INVESTMENT BOARD 97,804 $7.79M 0.02% -12,793 13F-HR Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 97,505 $7.77M 0.01% +91,511 13F-HR Timeline Group WORLDQUANT MILLENNIUM ADVISORS LLC More: the full row for WORLDQUANT MILLENNIUM ADVISORS LLC 94,010 $7.49M 0.03% +84,019 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 92,391 $7.36M 0.04% new 13F-HR Timeline Atle Fund Management AB More: the full row for Atle Fund Management AB 90,184 $7.18M 2.29% +4,829 13F-HR Timeline M&G PLC in group M&G PLC More: the full row for M&G PLC 88,952 $7.12M 0.04% new 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 74,698 $5.95M 0.02% -105,135 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 73,197 $5.83M 0.05% -3,732 13F-HR Timeline Treasurer of the State of North Carolina More: the full row for Treasurer of the State of North Carolina 72,617 $5.78M 0.02% -5,301 13F-HR Timeline Allianz Asset Management GmbH in group Allianz SE More: the full row for Allianz Asset Management GmbH 71,570 $5.7M 0.01% -1,907 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 66,523 $5.3M <0.01% +4,392 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 65,800 $5.24M 3.55% 13F-HR/A Timeline Universal- Beteiligungs- und Serviceges… in group Universal- Beteiligungs- und … More: the full row for Universal- Beteiligungs- und Servicegesellschaft mbH 65,627 $5.23M 0.01% -13,105 13F-HR Timeline Group Informed Momentum Co LLC More: the full row for Informed Momentum Co LLC 64,236 $5.12M 0.57% new 13F-HR Timeline GENERAL AMERICAN INVESTORS CO INC More: the full row for GENERAL AMERICAN INVESTORS CO INC 64,045 $5.1M 0.32% new 13F-HR Timeline SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 62,489 $4.98M <0.01% +10,559 13F-HR Timeline Group STEMPOINT CAPITAL LP More: the full row for STEMPOINT CAPITAL LP 62,032 $4.94M 0.85% -123,348 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 60,237 $4.8M <0.01% +12,703 13F-HR Timeline Group MOORE CAPITAL MANAGEMENT, LP More: the full row for MOORE CAPITAL MANAGEMENT, LP 55,600 $4.43M 0.09% 0 13F-HR Timeline SUPERSTRING CAPITAL MANAGEMENT LP More: the full row for SUPERSTRING CAPITAL MANAGEMENT LP 54,879 $4.37M 2.34% new 13F-HR Timeline Handelsbanken Fonder AB More: the full row for Handelsbanken Fonder AB 54,175 $4.32M 0.01% -4,200 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 52,500 $4.18M 0.87% -7,500 13F-HR Timeline Group PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O… More: the full row for PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO 52,165 $4.15M 0.01% -1,978 13F-HR Timeline Wedmont Private Capital More: the full row for Wedmont Private Capital 40,056 $4.11M 0.14% +50 13F-HR Timeline State of New Jersey Common Pension Fund… in group State of New Jersey Common Pe… More: the full row for State of New Jersey Common Pension Fund D 50,085 $3.99M 0.01% -8,223 13F-HR Timeline Group Legato Capital Management LLC More: the full row for Legato Capital Management LLC 48,751 $3.88M 0.33% +14,097 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 47,412 $3.78M 0.01% +41,912 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 45,702 $3.64M <0.01% +28,402 13F-HR Timeline Group Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 45,517 $3.63M 0.01% +3,716 13F-HR Timeline Creative Planning in group Creative Planning More: the full row for Creative Planning 44,144 $3.52M <0.01% +5,206 13F-HR Timeline Group Cinctive Capital Management LP More: the full row for Cinctive Capital Management LP 42,635 $3.4M 0.2% new 13F-HR Timeline GROUP ONE TRADING LLC More: the full row for GROUP ONE TRADING LLC 40,145 $3.2M 0.09% +35,865 13F-HR Timeline Erste Asset Management GmbH in group Erste Asset Management GmbH More: the full row for Erste Asset Management GmbH 39,400 $3.17M 0.03% 0 13F-HR Timeline Group FIRST TRUST ADVISORS LP in group FIRST TRUST ADVISORS LP More: the full row for FIRST TRUST ADVISORS LP 39,365 $3.14M <0.01% new 13F-HR Timeline Group ARIZONA STATE RETIREMENT SYSTEM More: the full row for ARIZONA STATE RETIREMENT SYSTEM 39,161 $3.12M 0.02% -2,138 13F-HR Timeline DIADEMA PARTNERS LP More: the full row for DIADEMA PARTNERS LP 37,020 $2.95M 1.76% -22,059 13F-HR Timeline S&CO INC More: the full row for S&CO INC 34,171 $2.72M 0.17% +12,000 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 34,001 $2.71M 0.21% -8,766 13F-HR Timeline Aquatic Capital Management LLC More: the full row for Aquatic Capital Management LLC 33,537 $2.67M 0.08% -13,028 13F-HR Timeline Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 32,807 $2.61M 0.05% +1,644 13F-HR Timeline Group Trexquant Investment LP More: the full row for Trexquant Investment LP 32,463 $2.59M 0.02% -131,250 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 32,217 $2.57M <0.01% +130 13F-HR Timeline Group Quantinno Capital Management LP More: the full row for Quantinno Capital Management LP 32,063 $2.55M 0.01% +7,348 13F-HR Timeline Weiss Asset Management LP in group Weiss Asset Management LP More: the full row for Weiss Asset Management LP 30,022 $2.39M 0.03% new 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. KLP KAPITALFORVALTNING AS More: the full row for KLP KAPITALFORVALTNING AS 30,004 $2.39M 0.01% +1,100 13F-HR Timeline GUGGENHEIM CAPITAL LLC in group GUGGENHEIM CAPITAL LLC More: the full row for GUGGENHEIM CAPITAL LLC 29,982 $2.39M 0.02% -391 13F-HR Timeline Group Raiffeisen Bank International AG in group Raiffeisen Bank International… More: the full row for Raiffeisen Bank International AG 29,000 $2.31M 0.03% +9,000 13F-HR Timeline Group KVP Capital Advisors, LP More: the full row for KVP Capital Advisors, LP 27,500 $2.19M 2.26% 13F-HR Timeline Headlands Technologies LLC More: the full row for Headlands Technologies LLC 27,275 $2.17M 0.18% -9,925 13F-HR Timeline Sandy Cove Advisors, LLC More: the full row for Sandy Cove Advisors, LLC 27,008 $2.15M 0.64% 0 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 26,929 $2.14M 0.07% -10,150 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 25,900 $2.06M 0.04% new 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 25,665 $2.04M +9,242 Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 23,635 $1.88M <0.01% +13,256 13F-HR Timeline Group DARK FOREST CAPITAL MANAGEMENT LP More: the full row for DARK FOREST CAPITAL MANAGEMENT LP 23,458 $1.87M 0.09% new 13F-HR Timeline COMERICA BANK More: the full row for COMERICA BANK 23,285 $1.85M 0.01% -466,931 13F-HR Timeline Fiduciary Trust Co in group Fiduciary Trust Co More: the full row for Fiduciary Trust Co 23,098 $1.84M 0.02% +3 13F-HR Timeline Group Shay Capital LLC More: the full row for Shay Capital LLC 22,260 $1.77M 0.29% -23,740 13F-HR Timeline DekaBank Deutsche Girozentrale More: the full row for DekaBank Deutsche Girozentrale 50,000 $1.72M <0.01% 0 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 21,269 $1.69M 0.03% +10,553 13F-HR Timeline HARBOR CAPITAL ADVISORS, INC. More: the full row for HARBOR CAPITAL ADVISORS, INC. 21,076 $1.68M 0.13% -514 13F-HR Timeline TEACHER RETIREMENT SYSTEM OF TEXAS More: the full row for TEACHER RETIREMENT SYSTEM OF TEXAS 20,820 $1.66M 0.01% -13,504 13F-HR Timeline AlphaQuest LLC More: the full row for AlphaQuest LLC 20,664 $1.65M 0.09% +8,751 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 20,430 $1.63M <0.01% -1,705 13F-HR Timeline Group Amundi in group Amundi More: the full row for Amundi 20,067 $1.6M <0.01% new 13F-HR Timeline Group Nan Fung Group Holdings Ltd More: the full row for Nan Fung Group Holdings Ltd 19,253 $1.53M 1.37% 0 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 18,845 $1.5M 0.1% new 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 18,652 $1.49M 0.34% -1,924 13F-HR Timeline BIT Capital GmbH More: the full row for BIT Capital GmbH 18,400 $1.47M 0.06% +16,878 13F-HR Timeline NEUBERGER BERMAN GROUP LLC in group NEUBERGER BERMAN GROUP LLC More: the full row for NEUBERGER BERMAN GROUP LLC 18,358 $1.46M <0.01% +1,063 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 17,537 $1.4M 0.67% +3,910 13F-HR Timeline B. Metzler seel. Sohn & Co. AG in group B. Metzler seel. Sohn & Co. AG More: the full row for B. Metzler seel. Sohn & Co. AG 17,440 $1.39M 0.01% -8,381 13F-HR Timeline Group FORA Capital, LLC More: the full row for FORA Capital, LLC 17,357 $1.37M 0.17% +10,988 13F-HR Timeline SG Americas Securities, LLC More: the full row for SG Americas Securities, LLC 16,723 $1.33M <0.01% +6,009 13F-HR Timeline CANADA LIFE ASSURANCE Co in group CANADA LIFE ASSURANCE Co More: the full row for CANADA LIFE ASSURANCE Co 16,549 $1.32M <0.01% -18,334 13F-HR Timeline Group FRED ALGER MANAGEMENT, LLC in group FRED ALGER MANAGEMENT, LLC More: the full row for FRED ALGER MANAGEMENT, LLC 16,250 $1.29M 0.01% -100,530 13F-HR Timeline Group