13F-HR/A filed by Avoro Capital Advisors LLC
Avoro Capital Advisors LLC filed this 13F-HR/A for the quarter ended 2025-12-31, filed 2026-03-16, with 34 holding rows worth $10,174,376,432.
- Accession
- 0001104659-26-027799
- Filer
- CIK 1633313
- Filed
- 2026-03-16
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, amendment of type restatement, 34 entries on the cover page, a total value of $10,174,376,432 stated on the cover page (in dollars after the unit check, H1), rows summing to $10,174,376,432 with VALUE read as dollars as filed, 13F file number 028-16573. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 2,606,060 | $1,269,802,735 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 5,111,111 | $1,089,893,310 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,807,500 | $1,052,579,550 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 990,000 | $832,540,500 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 2,888,888 | $712,226,448 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 10,625,000 | $705,393,750 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 7,474,747 | $581,610,064 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 6,555,555 | $455,938,850 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 5,455,000 | $393,469,150 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 14,555,555 | $364,034,431 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 3,111,111 | $310,302,211 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 12,222,222 | $307,022,217 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 5,888,888 | $298,213,288 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 2,100,000 | $256,053,000 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 5,424,444 | $243,123,580 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 4,350,000 | $175,740,000 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 2,170,000 | $172,840,500 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 6,150,000 | $147,169,500 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 2,900,000 | $134,270,000 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 10,777,777 | $130,842,213 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 21,700,000 | $119,350,000 | dollars as filed | |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 5,000,000 | $66,950,000 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 685,000 | $52,032,600 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 1,500,000 | $46,680,000 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,333,340 | $40,413,535 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 1,400,000 | $39,172,000 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 500,000 | $37,740,000 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 1,337,500 | $37,289,500 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 3,300,000 | $32,769,000 | dollars as filed | |
| MANNKIND CORP COM NEW | 56400P706 | Stock | 4,444,444 | $25,199,997 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 1,800,000 | $22,860,000 | dollars as filed | |
| INCYTE CORP COM | 45337C102 | Stock | 135,000 | $13,333,950 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 2,849,402 | $6,895,553 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 50,000 | $625,000 | dollars as filed | call |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-015748 | superseded | 2026-02-17 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001104659-26-027799 | this filing | 2026-03-16 | acceptance time not in the bulk data set |