13F-HR filed by ORBIMED ADVISORS LLC
ORBIMED ADVISORS LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 107 holding rows worth $4,899,391,958.
- Accession
- 0001172661-26-001119
- Filer
- CIK 1055951
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 108 entries on the cover page, a total value of $4,899,391,958 stated on the cover page (in dollars after the unit check, H1), rows summing to $4,899,391,958 with VALUE read as dollars as filed, 13F file number 028-06774. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerORBIMED CAPITAL LLC028-10410
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 15,518,492 | $385,091,379 | dollars as filed | |
| Eli Lilly and Company | 532457108 | COM | 301,200 | $323,693,616 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 2,419,300 | $230,680,255 | dollars as filed | |
| SINOVAC BIOTECH LTD | P8696W104 | SHS | 2,718,735 | $184,466,170 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 1,842,900 | $157,107,225 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 5,693,589 | $154,580,941 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 263,400 | $149,179,224 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 3,561,655 | $146,526,487 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 3,935,203 | $124,116,303 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 146,000 | $122,778,700 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 7,959,538 | $122,576,885 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 288,800 | $114,841,320 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 325,000 | $114,227,750 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 8,288,510 | $96,561,142 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 2,153,300 | $86,993,320 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,067,550 | $84,774,146 | dollars as filed | |
| CARIS LIFE SCIENCES INC | 142152107 | COMMON STOCK | 3,116,011 | $84,069,977 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 365,800 | $83,801,122 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 15,219,994 | $81,731,368 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,161,803 | $80,803,399 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 299,800 | $68,630,216 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 1,516,550 | $62,967,156 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 2,429,868 | $61,038,284 | dollars as filed | |
| ARRIVENT BIOPHARMA INC | 04272N102 | COM | 3,027,328 | $60,909,839 | dollars as filed | |
| Cigna Corporation | 125523100 | COM | 205,000 | $56,422,150 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 1,642,891 | $55,644,718 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 7,165,006 | $55,170,546 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 105,200 | $51,258,700 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 367,900 | $49,613,155 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 2,190,907 | $47,542,682 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 999,000 | $46,503,450 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 253,121 | $46,230,019 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 2,468,314 | $45,096,097 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 619,530 | $44,686,699 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 314,240 | $44,568,659 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 2,202,184 | $43,074,719 | dollars as filed | |
| Bristol-Myers Squibb Company | 110122108 | COM | 775,000 | $41,803,500 | dollars as filed | |
| Pfizer Inc. | 717081103 | COM | 1,652,900 | $41,157,210 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 3,190,700 | $39,947,564 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 2,406,335 | $37,153,812 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 171,977 | $36,672,375 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 351,716 | $35,720,277 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 980,400 | $35,578,716 | dollars as filed | |
| Elevance Health, Inc. | 036752103 | COM | 99,100 | $34,739,505 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 1,196,955 | $32,640,963 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,909,256 | $31,636,842 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 3,840,500 | $31,415,290 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 3,641,756 | $29,789,564 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 119,800 | $29,535,492 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 94,500 | $27,852,930 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 1,954,426 | $26,971,079 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 46,500 | $26,944,425 | dollars as filed | |
| BRUKER CORP | 116794108 | COM | 555,789 | $26,183,220 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 239,800 | $25,668,192 | dollars as filed | |
| SHATTUCK LABS INC | 82024L103 | COMMON STOCK | 6,306,127 | $23,017,364 | dollars as filed | |
| ESPERION THERAPEUTICS INC NEW COM | 29664W105 | Stock | 5,965,498 | $22,072,343 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 1,187,300 | $21,561,368 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 2,125,000 | $21,101,250 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 5,822,854 | $20,554,675 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 875,487 | $20,503,906 | dollars as filed | |
| 0 | 000000000 | 0 | 6,210,899 | $20,134,459 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 447,200 | $20,043,504 | dollars as filed | |
| BRIGHTSPRING HEALTH SVCS | 10950A106 | COM | 488,500 | $18,294,325 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 353,500 | $17,901,240 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 737,400 | $17,645,982 | dollars as filed | |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 1,226,700 | $16,425,513 | dollars as filed | |
| KEROS THERAPEUTICS INC COM | 492327101 | Stock | 804,212 | $16,373,756 | dollars as filed | |
| CARLSMED INC | 14280C105 | COMMON STOCK | 1,252,600 | $15,469,610 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 3,525,650 | $15,019,269 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 2,380,715 | $14,355,711 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 1,741,800 | $13,586,040 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 371,000 | $13,177,920 | dollars as filed | |
| CORBUS PHARMACEUTICALS | 21833P301 | COM NEW | 1,597,287 | $13,001,916 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 150,000 | $12,787,500 | dollars as filed | call |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 154,400 | $12,642,272 | dollars as filed | |
| RELMADA THERAPEUTICS INC | 75955J402 | COMMON STOCK | 2,610,600 | $12,609,198 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 574,600 | $11,986,156 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 1,102,730 | $10,762,645 | dollars as filed | |
| BIOAGE LABS INC COM | 09077V100 | Stock | 790,901 | $10,463,620 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 729,900 | $10,393,776 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 4,166,000 | $10,081,720 | dollars as filed | |
| ADICET BIO INC | 007002207 | COM NEW | 1,027,944 | $8,655,288 | dollars as filed | |
| REPARE THERAPEUTICS INC | 760273102 | COM | 3,322,488 | $8,638,469 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 85,664 | $8,544,127 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 531,163 | $8,195,845 | dollars as filed | |
| KINIKSA PHARMACEUTICALS INTL P ORD SHS CL A | G52694109 | Stock | 187,199 | $7,721,959 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 2,252,987 | $7,479,917 | dollars as filed | |
| PMV PHARMACEUTICALS INC | 69353Y103 | COM | 4,975,291 | $6,219,114 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 382,400 | $6,175,760 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 205,400 | $5,699,850 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 3,133,405 | $5,577,461 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 25,400 | $4,420,616 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 1,871,420 | $4,397,837 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 209,100 | $3,519,153 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 270,006 | $2,794,562 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 1,404,902 | $2,683,363 | dollars as filed | |
| IMAGENEBIO INC | 45175G207 | CMN | 378,556 | $2,612,036 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 125,000 | $2,225,000 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 25,900 | $2,062,935 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 3,060,000 | $2,025,414 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 157,300 | $1,909,622 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 21,700 | $1,895,278 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 23,200 | $1,762,272 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240QAA0 | NOTE 1.625%11/1 | 1,000,000 | $1,174,100 | dollars as filed | principal |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 56,000 | $952,000 | dollars as filed | |
| TRAWS PHARMA INC | 68232V884 | COM NEW | 605,531 | $684,250 | dollars as filed | |
| VISTAGEN THERAPEUTICS INC | 92840H400 | COM | 45,200 | $29,918 | dollars as filed | call |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-26-001119 | this filing | 2026-02-17 | acceptance time not in the bulk data set |