13F-HR filed by DAFNA Capital Management LLC
DAFNA Capital Management LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 77 holding rows worth $430,518,714.
- Accession
- 0001389933-26-000002
- Filer
- CIK 1389933
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 77 entries on the cover page, a total value of $430,518,714 stated on the cover page (in dollars after the unit check, H1), rows summing to $430,518,714 with VALUE read as dollars as filed, 13F file number 028-12327. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerFischel Nathan028-12328
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 604,514 | $48,149,540 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 336,505 | $41,030,055 | dollars as filed | |
| STEREOTAXIS INC | 85916J409 | COMMON STOCK | 13,680,554 | $31,465,274 | dollars as filed | |
| ATRICURE INC | 04963C209 | COM | 597,431 | $23,634,370 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 370,997 | $23,573,149 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 506,740 | $17,518,002 | dollars as filed | |
| AXOGEN INC | 05463X106 | COM | 476,826 | $15,606,515 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 287,939 | $12,905,426 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 68,095 | $11,492,393 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 955,235 | $10,784,603 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 431,329 | $10,278,570 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 70,615 | $10,015,325 | dollars as filed | |
| Day One Biopharmaceuticals Inc | 23954D109 | Common Stock | 999,163 | $9,312,199 | dollars as filed | |
| TANDEM DIABETES CARE INC | 875372203 | COM NEW | 355,208 | $7,807,472 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 28,177 | $6,008,463 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 88,279 | $5,859,077 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 277,855 | $5,837,734 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 356,802 | $5,762,352 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 811,046 | $5,596,217 | dollars as filed | |
| INOGEN INC | 45780L104 | COM | 827,071 | $5,557,917 | dollars as filed | |
| Ascendis Pharma A/S | 04351PAD3 | Convertible bond | 4,000,000 | $5,460,000 | dollars as filed | principal |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 318,500 | $5,258,435 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 165,265 | $5,212,458 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 261,583 | $4,402,442 | dollars as filed | |
| LAKEFRONT BIOTHERAPEUTICS NV | 36315X101 | SPON ADR | 130,175 | $4,256,723 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 304,775 | $3,989,505 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 159,736 | $3,963,849 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 150,524 | $3,826,320 | dollars as filed | |
| PROCEPT BIOROBOTICS CORP COM | 74276L105 | Stock | 120,000 | $3,775,200 | dollars as filed | |
| CYBIN INC | 23256X407 | COM NEW | 455,018 | $3,722,047 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 130,248 | $3,644,339 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 939,164 | $3,578,215 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 108,875 | $3,455,693 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 340,859 | $3,384,730 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 418,255 | $3,262,389 | dollars as filed | |
| NEKTAR THERAPEUTICS | 640268306 | COMMON STOCK | 74,998 | $3,170,915 | dollars as filed | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 1,567,561 | $3,166,473 | dollars as filed | |
| CENTURY THERAPEUTICS INC | 15673T100 | COM | 2,793,586 | $2,779,059 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 261,138 | $2,741,949 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 37,000 | $2,573,350 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 143,764 | $2,525,215 | dollars as filed | |
| ALIGN TECHNOLOGY INC COM | 016255101 | Stock | 16,000 | $2,498,400 | dollars as filed | |
| KURA ONCOLOGY INC COM | 50127T109 | Stock | 235,868 | $2,450,669 | dollars as filed | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 375,915 | $2,428,411 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 75,000 | $2,275,500 | dollars as filed | |
| PROFOUND MED CORP | 74319B502 | COM NEW | 285,710 | $2,248,538 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 190,065 | $2,214,257 | dollars as filed | |
| MEDIWOUND LTD | M68830112 | COMMON STOCK | 113,612 | $2,097,278 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 59,516 | $2,093,773 | dollars as filed | |
| INSULET CORP COM | 45784P101 | Stock | 6,870 | $1,952,729 | dollars as filed | |
| ALLOGENE THERAPEUTICS INC | 019770106 | COM | 1,380,118 | $1,890,762 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 68,518 | $1,860,949 | dollars as filed | |
| TELA BIO INC | 872381108 | COM | 1,441,029 | $1,700,414 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 163,645 | $1,477,714 | dollars as filed | |
| VERRICA PHARMACEUTICALS INC | 92511W207 | COM SHS | 173,451 | $1,441,378 | dollars as filed | |
| ALECTOR INC | 014442107 | COMMON STOCK | 908,351 | $1,417,028 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 38,490 | $1,396,802 | dollars as filed | |
| ANNEXON INC | 03589W102 | COM | 272,812 | $1,369,516 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 141,045 | $1,153,748 | dollars as filed | |
| ACCURAY INC DEL | 004397105 | COM | 1,395,508 | $1,150,736 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 254,436 | $946,502 | dollars as filed | |
| POLYPID LTD | M8001Q126 | COM | 207,900 | $902,286 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 8,600 | $793,178 | dollars as filed | |
| ADICET BIO INC | 007002207 | COM NEW | 93,812 | $789,897 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 126,859 | $685,039 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 7,000 | $666,400 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 27,974 | $576,264 | dollars as filed | |
| FATE THERAPEUTICS INC | 31189P102 | COM | 550,000 | $540,430 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 126,841 | $526,390 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 64,492 | $456,603 | dollars as filed | |
| COMPUGEN LTD | M25722105 | ORD | 272,402 | $416,775 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 51,000 | $375,360 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 16,000 | $368,000 | dollars as filed | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 179,316 | $356,839 | dollars as filed | |
| ADC THERAPEUTICS SA | H0036K147 | COMMON STOCK | 77,081 | $272,096 | dollars as filed | |
| BRAINSWAY LTD | 10501L106 | CMN | 12,965 | $246,594 | dollars as filed | |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 50,000 | $137,500 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001389933-26-000002 | this filing | 2026-02-17 | acceptance time not in the bulk data set |