13F-HR filed by Siren, L.L.C.
Siren, L.L.C. filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-13, with 113 holding rows worth $3,352,424,599.
- Accession
- 0002005245-26-000003
- Filer
- CIK 2005245
- Filed
- 2026-02-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 115 entries on the cover page, a total value of $3,352,424,599 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,352,424,599 with VALUE read as dollars as filed, 13F file number 028-24464. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerInvus Financial Advisors, LLC028-19938
- included managerInvus Group, LLC028-24462
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 10,825,013 | $476,841,823 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 3,286,830 | $255,748,242 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 500,000 | $151,905,000 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 4,529,990 | $112,411,702 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 1,335,075 | $106,338,724 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 4,027,517 | $100,728,200 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 1,500,476 | $99,616,602 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 5,216,969 | $87,801,588 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 3,300,700 | $82,517,500 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 988,401 | $78,488,923 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,078,698 | $75,023,446 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 8,165,374 | $72,345,214 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 3,007,077 | $71,658,645 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 2,247,347 | $71,330,794 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,507,636 | $70,180,456 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 3,502,941 | $68,517,526 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 2,578,396 | $64,769,308 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 1,629,279 | $57,871,990 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 2,000,000 | $55,760,000 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 10,129,913 | $55,714,522 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 499,975 | $53,517,324 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 235,862 | $50,295,213 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 1,375,000 | $46,571,250 | dollars as filed | |
| TABOOLA.COM LTD | M8744T106 | ORD SHS | 9,969,495 | $45,959,372 | dollars as filed | |
| LEXICON PHARMACEUTICALS INC | 528872302 | COMMON STOCK | 38,918,903 | $44,756,738 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 1,680,121 | $44,237,586 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 7,690,405 | $43,373,884 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 2,450,000 | $41,650,000 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 812,761 | $36,427,948 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J309 | SPONSORED ADS | 1,857,362 | $35,605,630 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 8,757,249 | $32,576,966 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 3,336,264 | $30,126,464 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 2,286,867 | $28,631,575 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 818,598 | $26,817,270 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 699,999 | $25,402,964 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 1,396,513 | $23,056,430 | dollars as filed | |
| REMITLY GLOBAL INC | 75960P104 | COM | 1,618,271 | $22,332,140 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 1,950,000 | $22,054,500 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 708,469 | $21,494,949 | dollars as filed | |
| SILENCE THERAPEUTICS PLC | 82686Q101 | ADS | 2,911,438 | $17,701,543 | dollars as filed | |
| IHS HOLDING LIMITED | G4701H109 | ORD SHS | 2,357,520 | $17,587,099 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 5,208,968 | $16,147,801 | dollars as filed | |
| UPSTREAM BIO INC | 91678A107 | COMMON STOCK | 588,450 | $15,976,418 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 2,012,752 | $14,250,284 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 212,298 | $13,863,059 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,193,410 | $12,351,794 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 300,000 | $12,342,000 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,850,000 | $11,992,500 | dollars as filed | |
| NOVABRIDGE BIOSCIENCES | 44975P103 | CMN | 3,000,000 | $11,940,000 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 51,500 | $11,887,230 | dollars as filed | |
| NEUMORA THERAPEUTICS INC. | 640979100 | COM | 6,288,783 | $11,256,922 | dollars as filed | |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 800,000 | $10,712,000 | dollars as filed | |
| BENITEC BIOPHARMA INC | 08205P209 | COMMON STOCK | 775,000 | $10,439,250 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 4,000,000 | $9,880,000 | dollars as filed | |
| TAIWAN SEMICONDUCTOR MFG | 874039100 | SPONSORED ADS | 27,700 | $8,417,753 | dollars as filed | |
| ORIC PHARMACEUTICALS INC | 68622P109 | COM | 1,007,575 | $8,241,964 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 450,000 | $7,904,250 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 75,000 | $7,850,250 | dollars as filed | |
| CROWDSTRIKE HLDGS INC | 22788C105 | COM | 16,500 | $7,734,540 | dollars as filed | |
| IONQ INC COM | 46222L108 | Stock | 170,000 | $7,627,900 | dollars as filed | |
| SEER INC | 81578P106 | COM CL A | 4,000,000 | $7,320,000 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 15,000 | $7,254,300 | dollars as filed | |
| PDD HOLDINGS INC SPONSORED ADS | 722304102 | ADR | 63,401 | $7,189,039 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 720,622 | $7,155,776 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 37,485 | $6,990,953 | dollars as filed | |
| Salesforce.com, Inc | 79466L302 | COM | 26,100 | $6,914,151 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 1,000,000 | $6,900,000 | dollars as filed | |
| BILLIONTOONE INC | 090168105 | CL A | 83,833 | $6,860,893 | dollars as filed | |
| WORKIVA INC COM CL A | 98139A105 | Stock | 79,123 | $6,824,359 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 1,300,000 | $6,812,000 | dollars as filed | |
| VTV THERAPEUTICS INC | 918385204 | CL A NEW | 163,000 | $6,518,370 | dollars as filed | |
| Alphabet Inc. Reg. Shares A | 02079K305 | COM | 20,703 | $6,480,039 | dollars as filed | |
| NEBIUS GROUP N.V. | N97284108 | SHS CLASS A | 76,218 | $6,379,828 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 1,000,000 | $6,030,000 | dollars as filed | |
| X4 PHARMACEUTICALS INC | 98420X202 | COMMON STOCK | 1,500,000 | $6,000,000 | dollars as filed | |
| JFROG LTD ORD SHS | M6191J100 | Stock | 93,616 | $5,847,255 | dollars as filed | |
| ServiceNow,Inc. | 81762P102 | COM | 35,630 | $5,458,160 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 427,141 | $5,206,849 | dollars as filed | |
| WHITEHAWK THERAPEUTICS INC | 00032Q104 | CMN | 2,082,000 | $5,038,440 | dollars as filed | |
| DYNATRACE INC COM NEW | 268150109 | Stock | 115,229 | $4,994,025 | dollars as filed | |
| DATADOGINCCLASSA | 23804L103 | STOK | 36,425 | $4,953,436 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 500,000 | $4,880,000 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 7,169 | $4,732,185 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 700,000 | $4,557,000 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 724,771 | $4,290,644 | dollars as filed | |
| Adobe Inc | 00724F101 | COM | 12,051 | $4,217,729 | dollars as filed | |
| FOGHORN THERAPEUTICS INC | 344174107 | COMMON STOCK | 720,720 | $3,891,888 | dollars as filed | |
| GITLAB INC CLASS A COM | 37637K108 | Stock | 99,000 | $3,715,470 | dollars as filed | |
| KALARIS THERAPEUTICS INC | 482929106 | COM | 435,798 | $3,678,135 | dollars as filed | |
| NEW ORIENTAL ED & TECHNOLOGY SPON ADR | 647581206 | ADR | 62,000 | $3,411,860 | dollars as filed | |
| AGENUS INC | 00847G804 | COM NEW | 1,064,250 | $3,341,745 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 75,000 | $3,150,000 | dollars as filed | |
| KORRO BIO INC | 500946108 | COMMON STOCK | 347,718 | $2,785,221 | dollars as filed | |
| CELLEBRITE DI LTD ORDINARY SHARES | M2197Q107 | Stock | 150,000 | $2,705,550 | dollars as filed | |
| RANI THERAPEUTICS HLDGS INC | 753018100 | CMN | 2,000,000 | $2,700,000 | dollars as filed | |
| ZSCALERINC | 98980G102 | STOK | 12,000 | $2,699,040 | dollars as filed | |
| BLACK DIAMOND THERAPEUTICS I | 09203E105 | COM | 1,046,517 | $2,543,036 | dollars as filed | |
| MONDAY COM LTD SHS | M7S64H106 | Stock | 17,000 | $2,508,520 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 7,000 | $2,422,700 | dollars as filed | |
| Qualcomm Incorporated | 747525103 | COM | 14,000 | $2,394,700 | dollars as filed | |
| ARM HOLDINGS PLC | 042068205 | SPONSORED ADS | 21,500 | $2,350,165 | dollars as filed | |
| KE HLDGS INC SPONSORED ADS | 482497104 | ADR | 145,000 | $2,285,200 | dollars as filed | |
| Instil Bio Inc | 45783C200 | COM NEW | 203,933 | $2,243,263 | dollars as filed | |
| PALO ALTO NETWORKS INC | 697435105 | COM | 11,450 | $2,109,090 | dollars as filed | |
| COREWEAVE INC COM CL A | 21873S108 | COM | 27,500 | $1,969,275 | dollars as filed | |
| IRENLTDF | Q4982L109 | STOK | 43,100 | $1,627,887 | dollars as filed | |
| VARONIS SYS INC | 922280102 | COM | 37,500 | $1,230,000 | dollars as filed | |
| PRIMO BRANDS CORPORATION CLASS A COM SHS | 741623102 | Stock | 75,000 | $1,226,250 | dollars as filed | |
| GENERATION BIO CO | 37148K209 | COM NEW | 201,419 | $1,144,060 | dollars as filed | |
| FIGMA INC CL A | 316841105 | COM | 25,000 | $934,250 | dollars as filed | |
| Tesla Motors, Inc | 88160R101 | COM | 1,500 | $674,580 | dollars as filed | |
| CARIBOU BIOSCIENCES INC COM | 142038108 | Stock | 105,347 | $167,502 | dollars as filed | |
| Cyclerion Therapeutics Inc | 23255M204 | COM | 115,603 | $146,816 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0002005245-26-000003 | this filing | 2026-02-13 | acceptance time not in the bulk data set |