13F-HR filed by Frazier Life Sciences Management, L.P.
Frazier Life Sciences Management, L.P. filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-13, with 40 holding rows worth $3,723,154,080.
- Accession
- 0001892134-26-000001
- Filer
- CIK 1892134
- Filed
- 2026-02-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 40 entries on the cover page, a total value of $3,723,154,080 stated on the cover page (in dollars after the unit check, H1), rows summing to $3,723,154,080 with VALUE read as dollars as filed, 13F file number 028-22504. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 16,943,774 | $594,387,592 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 6,795,121 | $536,746,608 | dollars as filed | |
| ARCUTIS BIOTHERAPEUTICS INC | 03969K108 | COM | 9,874,511 | $286,755,799 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 3,545,557 | $271,199,655 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 6,652,013 | $209,804,490 | dollars as filed | |
| PHATHOM PHARMACEUTICALS INC | 71722W107 | COMMON STOCK | 12,466,489 | $206,819,053 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 4,567,274 | $189,222,162 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 10,259,409 | $128,447,801 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 488,460 | $120,424,928 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,260,000 | $100,056,600 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 22,729,436 | $84,553,502 | dollars as filed | |
| KALVISTA PHARMACEUTICALS INC | 483497103 | COM | 5,039,867 | $81,393,852 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 722,400 | $75,613,608 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 983,125 | $70,912,806 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 797,455 | $63,517,291 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 3,153,082 | $61,674,284 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 728,644 | $59,661,371 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 9,862,301 | $59,469,675 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 934,642 | $59,387,153 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 378,300 | $51,015,647 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 4,424,725 | $43,937,519 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 1,279,754 | $34,834,904 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 1,297,198 | $34,648,159 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 1,902,320 | $33,556,925 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 983,333 | $33,305,489 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 2,543,939 | $33,274,722 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 133,333 | $28,431,929 | dollars as filed | |
| AURA BIOSCIENCES INC | 05153U107 | COMMON STOCK | 5,100,000 | $27,795,000 | dollars as filed | |
| MANNKIND CORP COM NEW | 56400P706 | Stock | 4,225,000 | $23,955,750 | dollars as filed | |
| Valneva SE ADR | 92025Y103 | COM | 2,291,666 | $20,212,494 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 700,647 | $19,604,103 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 2,630,665 | $17,493,922 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 384,782 | $13,355,783 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 500,333 | $11,507,659 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 241,592 | $9,231,230 | dollars as filed | |
| AUTOLUS THERAPEUTICS PLC SPON | 05280R100 | COM | 4,623,324 | $9,200,415 | dollars as filed | |
| ALLOGENE THERAPEUTICS INC | 019770106 | COM | 3,868,750 | $5,300,188 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 521,000 | $4,886,980 | dollars as filed | |
| Xilio Therapeutics Inc. | 98422T100 | COM | 5,915,091 | $3,786,841 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 1,953,467 | $3,770,191 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001892134-26-000001 | this filing | 2026-02-13 | acceptance time not in the bulk data set |