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Disclosery

13F-HR filed by SPHERA FUNDS MANAGEMENT LTD.

SPHERA FUNDS MANAGEMENT LTD. filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 99 holding rows worth $517,294,385.

Accession
0001496201-26-000002
Filer
CIK 1496201
Filed
2026-02-17
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2025

A holdings report, 100 entries on the cover page, a total value of $517,294,385 stated on the cover page (in dollars after the unit check, H1), rows summing to $517,294,385 with VALUE read as dollars as filed, 13F file number 028-15863. The quarter's positions are built on this report. The resolved quarter.

Other managers

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS881624209ADR1,123,525$35,065,215dollars as filed
BIOGEN INC COM09062X103Stock94,738$16,672,941dollars as filed
MINERALYS THERAPEUTICS INC603170101COM449,003$16,294,319dollars as filed
SYNDAX PHARMACEUTICALS INC87164F105COM762,563$16,021,449dollars as filed
NOVA LTD COMM7516K103Stock47,846$15,712,148dollars as filed
TOWER SEMICONDUCTOR LTD SHS NEWM87915274Stock122,513$14,385,476dollars as filed
COGENT BIOSCIENCES INC19240Q201COM378,500$13,444,320dollars as filed
ASTRAZENECA PLC SPONSORED ADR046353108ADR135,060$12,416,066dollars as filed
PRAXIS PRECISION MEDICINES I74006W207COM NEW40,000$11,789,600dollars as filedcall
SANOFI SA SPONSORED ADR80105N105ADR239,515$11,606,897dollars as filed
Eli Lilly and Company532457108COM9,040$9,715,107dollars as filed
AMICUS THERAPEUTICS INC03152W109COM658,377$9,375,288dollars as filed
IMMATICS N.VN44445109SHS861,105$9,041,603dollars as filed
BIOMARIN PHARMACEUTICAL INC09061G101COM147,000$8,736,210dollars as filed
SPDR SER TR78464A870S&P BIOTECH70,000$8,535,100dollars as filedput
BRIDGEBIO PHARMA INC10806X102COM107,746$8,241,492dollars as filed
ORIC PHARMACEUTICALS INC68622P109COM1,004,378$8,215,812dollars as filed
ULTRAGENYX PHARMACEUTICAL IN90400D108COM350,000$8,050,000dollars as filedcall
DYNE THERAPEUTICS INC COM26818M108Stock392,894$7,685,007dollars as filed
TREVI THERAPEUTICS INC COM89532M101Stock598,534$7,493,646dollars as filed
Johnson & Johnson478160104COM35,831$7,415,225dollars as filed
SAVARA INC805111101COM1,178,164$7,104,329dollars as filed
SCHOLAR ROCK HLDG CORP80706P103COM158,265$6,971,573dollars as filed
WAVE LIFE SCIENCES LTD SHSY95308105Stock408,166$6,938,822dollars as filed
ULTRAGENYX PHARMACEUTICAL IN90400D108COM300,623$6,914,329dollars as filed
CYBIN INC23256X407COM NEW825,576$6,753,212dollars as filed
ANNEXON INC03589W102COM1,316,212$6,607,384dollars as filed
BIOCRYST PHARMACEUTICALS INC COM09058V103Stock837,889$6,535,534dollars as filed
CELLDEX THERAPEUTICS INC NEW15117B202COM NEW239,764$6,511,990dollars as filed
SOLENO THERAPEUTICS INC834203309COM136,314$6,311,338dollars as filed
APELLIS PHARMACEUTICALS INC03753U106COM250,961$6,304,140dollars as filed
NICE LTD SPONSORED ADR653656108ADR55,700$6,296,328dollars as filedcall
GSK PLC SPONSORED ADR37733W204ADR122,000$5,982,880dollars as filed
ENPHASE ENERGY INC COM29355A107Stock186,500$5,977,325dollars as filed
NOVO-NORDISK A S ADR670100205ADR115,677$5,885,646dollars as filed
CYTOKINETICS INC23282W605COM NEW91,717$5,827,698dollars as filed
AbbVie,Inc.00287Y109COM25,256$5,770,743dollars as filed
SOLAREDGE TECHNOLOGIES INC83417M104COM196,536$5,670,064dollars as filed
ACADIA PHARMACEUTICALS INC004225108COM212,202$5,667,915dollars as filed
VOR BIOPHARMA INC929033207COMMON STOCK410,417$5,368,254dollars as filed
Merck & Co.,Inc.58933Y105COM48,600$5,115,636dollars as filed
NOVARTIS AG SPONSORED ADR66987V109ADR37,000$5,101,190dollars as filed
FORTE BIOSCIENCES INC34962G208COMMON STOCK185,869$5,068,648dollars as filed
KODIAK SCIENCES INC50015M109COM175,500$4,906,980dollars as filed
TANGO THERAPEUTICS INC87583X109COM544,563$4,824,828dollars as filed
Solaredge Technologies Inc Note 2.250 percent 7/083417MAE4Convertible4,000,000$4,699,440dollars as filed
ASTRIA THERAPEUTICS INC COM04635X102Stock355,725$4,656,440dollars as filed
MEDIWOUND LTDM68830112COMMON STOCK230,347$4,252,206dollars as filed
CAMTEK LTD ORDM20791105Stock39,498$4,200,415dollars as filed
REVOLUTION MEDICINES INC COM76155X100Stock52,500$4,181,625dollars as filed
ISHARES TR46428743220 YR TR BD ETF47,000$4,096,520dollars as filedcall
Advanced Micro Devices,Inc.007903107COM18,040$3,863,446dollars as filed
CLIMB BIO INC28658R106COMMON STOCK932,247$3,728,988dollars as filed
ALPHA COGNITION INC02074J501COM NEW567,616$3,689,504dollars as filed
ENLIVEN THERAPEUTICS INC COM29337E102Stock226,765$3,492,181dollars as filed
PROTARA THERAPEUTICS INC74365U107COM STK650,000$3,464,500dollars as filed
Broadcom Inc.11135F101COM9,755$3,376,206dollars as filed
ELEDON PHARMACEUTICALS INC28617k101COM2,132,131$3,219,518dollars as filed
BIOAGE LABS INC COM09077V100Stock243,035$3,215,353dollars as filed
CORVUS PHARMACEUTICALS INC221015100COM407,709$3,139,359dollars as filed
ELBIT SYS LTD ORDM3760D101Stock5,340$3,084,971dollars as filed
KURA ONCOLOGY INC COM50127T109Stock295,522$3,070,474dollars as filed
MAZE THERAPEUTICS INC COM578784100Stock71,843$2,976,455dollars as filed
ZIM INTEGRATED SHIPPING SERVM9T951109SHS136,005$2,887,386dollars as filed
STRUCTURE THERAPEUTICS INC COMP86366E106EQUITY41,000$2,851,550dollars as filed
EVOMMUNE INC30054Y107COMMON STOCK166,147$2,844,437dollars as filed
VERASTEM INC92337C203COMMON STOCK343,678$2,653,194dollars as filed
Amgen Inc.031162100COM7,500$2,454,825dollars as filed
NURIX THERAPEUTICS INC67080M103COMMON STOCK124,000$2,352,280dollars as filed
ASCENDIS PHARMA A/S DKK 1.0 AD04351P101SPONSORED ADR11,000$2,345,640dollars as filed
TENAX THERAPEUTICS INC88032L605COM NEW190,111$2,317,453dollars as filed
JANUX THERAPEUTICS INC47103J105COM157,840$2,178,192dollars as filed
Pfizer Inc.717081103COM86,000$2,141,400dollars as filed
TAYSHA GENE THERAPIES INC877619106COMMON STOCK368,146$2,024,803dollars as filed
CONTINEUM THERAPEUTICS INC CL A21217B100Stock173,475$1,982,819dollars as filed
MADRIGAL PHARMACEUTICALS INC COM558868105Stock3,300$1,921,722dollars as filed
PHARVARIS NVN69605108COMMON STOCK63,953$1,774,696dollars as filed
VARONIS SYS INC922280102COM52,500$1,722,000dollars as filed
PRECISION BIOSCIENCES INC74019P207COM NEW396,116$1,647,843dollars as filed
Ventyx Biosciences Inc92332V107Common Stock180,114$1,626,429dollars as filed
IShares Bitcoin Trust Registered46438F101SHS30,055$1,492,231dollars as filed
Day One Biopharmaceuticals Inc23954D109Common Stock145,371$1,354,858dollars as filed
VOYAGER THERAPEUTICS INC92915B106COMMON STOCK339,761$1,335,261dollars as filed
ENTRADA THERAPEUTICS INC COM29384C108Stock110,942$1,140,484dollars as filed
TENAYA THERAPEUTICS INC87990A106COM1,500,000$1,067,250dollars as filed
PERSPECTIVE THERAPEUTICS INC46489V302COMMON STOCK349,973$962,426dollars as filed
Bristol-Myers Squibb Company110122108COM17,500$943,950dollars as filed
JASPER THERAPEUTICS INC471871202COM NEW485,401$888,284dollars as filed
PEPGEN INC COM713317105Stock121,467$790,750dollars as filed
SHATTUCK LABS INC82024L103COMMON STOCK195,212$712,524dollars as filed
PALISADE BIO INC696389402COMMON STOCK184,100$432,635dollars as filed
WEREWOLF THERAPEUTICS INC95075A107CMN626,810$397,084dollars as filed
SKYE BIOSCIENCE INC83086J200COM NEW478,928$359,052dollars as filed
PRELUDE THERAPEUTICS INC74065P101CMN122,752$355,981dollars as filed
APREA THERAPEUTICS INC03836J201COM NEW270,000$230,310dollars as filed
ONKURE THERAPEUTICS INC68277Q105COM CL A60,454$175,317dollars as filed
MEREO BIOPHARMA GROUP PLC589492107CMN255,400$106,425dollars as filed
PROMIS NEUROSCIENCES INC74346M505COM SHS11,807$80,586dollars as filed
Applied Therapeutics Inc03828A101Common Stock50,000$5,000dollars as filed

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001496201-26-000002this filing2026-02-17acceptance time not in the bulk data set