13F-HR filed by Rock Springs Capital Management LP
Rock Springs Capital Management LP filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 99 holding rows worth $1,950,203,715.
- Accession
- 0001172661-26-000917
- Filer
- CIK 1595725
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 99 entries on the cover page, a total value of $1,950,203,715 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,950,203,715 with VALUE read as dollars as filed, 13F file number 028-16048. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| Eli Lilly and Company | 532457108 | COM | 105,400 | $113,271,272 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 1,335,270 | $106,354,256 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 103,250 | $86,828,088 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 2,210,322 | $84,456,404 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 139,618 | $81,305,146 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 695,010 | $74,393,870 | dollars as filed | |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 601,800 | $61,118,808 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 762,294 | $60,213,603 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 319,250 | $55,562,270 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 748,236 | $52,039,814 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 82,000 | $46,441,520 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 204,878 | $45,255,501 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 203,500 | $43,394,340 | dollars as filed | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 235,000 | $41,698,400 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 496,871 | $38,661,533 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 399,050 | $38,049,418 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 120,500 | $37,464,655 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 787,788 | $35,308,658 | dollars as filed | |
| SCHOLAR ROCK HLDG CORP | 80706P103 | COM | 733,477 | $32,309,662 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 849,030 | $30,157,546 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 1,267,241 | $29,146,543 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 568,579 | $28,792,841 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 71,250 | $28,332,563 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 1,929,931 | $27,482,217 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 222,000 | $27,068,460 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 125,000 | $24,840,000 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 347,300 | $23,050,301 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 799,163 | $21,753,217 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 260,344 | $21,316,967 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 3,927,202 | $21,089,075 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 557,194 | $19,546,366 | dollars as filed | |
| AZENTA INC | 114340102 | COM | 569,100 | $18,928,266 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 692,538 | $18,809,332 | dollars as filed | |
| CARIS LIFE SCIENCES INC | 142152107 | COMMON STOCK | 687,500 | $18,548,750 | dollars as filed | |
| ZENAS BIOPHARMA INC COM | 98937L105 | Stock | 502,077 | $18,230,416 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 912,955 | $17,857,400 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 125,500 | $17,799,665 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 623,402 | $17,299,406 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 427,596 | $15,517,459 | dollars as filed | |
| PHREESIA INC | 71944F106 | COM | 876,600 | $14,832,072 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 811,546 | $14,315,671 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 61,500 | $14,078,580 | dollars as filed | |
| UnitedHealth Group Inc | 91324P102 | COM | 40,800 | $13,468,488 | dollars as filed | |
| ARDELYX INC | 039697107 | COM | 2,299,473 | $13,405,928 | dollars as filed | |
| ACLARIS THERAPEUTICS INC COM | 00461U105 | Stock | 4,453,741 | $13,405,760 | dollars as filed | |
| SUMMIT THERAPEUTICS INC | 86627T108 | COM | 710,000 | $12,417,900 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 798,405 | $12,295,437 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 131,000 | $12,082,130 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 740,000 | $11,677,200 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 247,053 | $11,438,554 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 169,859 | $11,074,807 | dollars as filed | |
| EVOLENT HEALTH INC CL A | 30050B101 | Stock | 2,675,000 | $10,700,000 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 3,266,960 | $10,127,576 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 282,624 | $8,913,961 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 324,015 | $8,103,615 | dollars as filed | |
| HEARTFLOW INC | 42238D107 | COM | 277,700 | $8,094,955 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 103,500 | $7,916,715 | dollars as filed | |
| REGENERON PHARMACEUTICALS COM | 75886F107 | Stock | 10,100 | $7,795,887 | dollars as filed | |
| IMMUNOME INC | 45257U108 | COM | 347,666 | $7,467,866 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 213,731 | $7,239,069 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 429,095 | $7,221,669 | dollars as filed | |
| EDWARDS LIFESCIENCES CORP COM | 28176E108 | Stock | 82,500 | $7,033,125 | dollars as filed | |
| GOSSAMER BIO INC | 38341PAA0 | NOTE 5.000% 6/0 | 9,573,000 | $6,559,037 | dollars as filed | principal |
| ALPHATEC HLDGS INC | 02081G201 | COM NEW | 302,500 | $6,364,600 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 499,764 | $6,037,149 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 10,000 | $5,794,500 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 358,798 | $4,951,412 | dollars as filed | |
| SURGERY PARTNERS INC | 86881A100 | COM | 310,000 | $4,789,500 | dollars as filed | |
| EYEPOINT INC COM NEW | 30233G209 | Stock | 258,739 | $4,727,162 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 61,879 | $4,700,329 | dollars as filed | |
| AGILON HEALTH INC | 00857U107 | COM | 6,500,000 | $4,476,550 | dollars as filed | |
| MERSANA THERAPEUTICS INC | 59045L205 | COM | 152,586 | $4,414,313 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 108,481 | $4,382,632 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 180,000 | $4,289,400 | dollars as filed | |
| EDAP TMS S A | 268311107 | SPONSORED ADR | 1,286,500 | $4,232,585 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 345,820 | $4,198,255 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 257,460 | $4,119,360 | dollars as filed | |
| TALPHERA INC | 00444T209 | COM NEW | 3,589,186 | $4,091,672 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 99,429 | $4,090,509 | dollars as filed | |
| THERAVANCE BIOPHARMA INC | G8807B106 | COM | 208,771 | $3,906,105 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 139,228 | $3,895,599 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 150,500 | $3,780,560 | dollars as filed | |
| Indivior PLC | G4766E116 | Common Stock | 105,100 | $3,770,988 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 951,710 | $3,540,361 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 386,915 | $3,428,067 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 98,240 | $2,456,000 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 35,853 | $2,278,100 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 47,000 | $2,168,580 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 104,339 | $2,149,383 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 1,100,726 | $2,014,329 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 88,750 | $1,925,875 | dollars as filed | |
| CORCEPT THERAPEUTICS INC | 218352102 | COM | 50,250 | $1,748,700 | dollars as filed | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 120,000 | $1,702,800 | dollars as filed | |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 45,500 | $1,420,055 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 31,600 | $1,108,528 | dollars as filed | call |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 61,700 | $813,206 | dollars as filed | |
| LEGEND BIOTECH CORP | 52490G102 | SPONSORED ADS | 33,800 | $734,812 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 1,750 | $297,500 | dollars as filed | |
| NUVATION BIO INC | 67080N119 | WARR | 134,028 | $44,229 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-26-000917 | this filing | 2026-02-17 | acceptance time not in the bulk data set |