13F-HR filed by BAKER BROS. ADVISORS LP
BAKER BROS. ADVISORS LP filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 86 holding rows worth $17,078,624,105.
- Accession
- 0001104659-26-016374
- Filer
- CIK 1263508
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 86 entries on the cover page, a total value of $17,078,624,105 stated on the cover page (in dollars after the unit check, H1), rows summing to $17,078,624,105 with VALUE read as dollars as filed, 13F file number 028-10519. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| INCYTE CORP COM | 45337C102 | Stock | 30,743,991 | $3,036,583,991 | dollars as filed | |
| BEONE MEDICINES LTD SPONSORED ADS | 07725L102 | ADR | 8,799,053 | $2,673,240,292 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 2,141,701 | $1,247,198,160 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 6,592,746 | $1,147,401,514 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 42,896,690 | $1,145,770,590 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 7,915,792 | $789,521,094 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 9,455,357 | $753,119,185 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 8,657,242 | $673,620,000 | dollars as filed | |
| SUMMIT THERAPEUTICS INC | 86627T108 | COM | 36,391,063 | $636,479,692 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 5,604,483 | $599,903,860 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 19,919,186 | $556,940,441 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 1,126,488 | $332,021,073 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 10,012,267 | $280,143,231 | dollars as filed | |
| GRAIL INC | 384747101 | COM | 2,085,333 | $178,483,651 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 6,575,940 | $163,181,951 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 2,175,645 | $144,441,072 | dollars as filed | |
| IONIS PHARMACEUTICALS INC COM | 462222100 | Stock | 1,791,841 | $141,752,542 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 5,457,881 | $138,739,335 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 12,094,094 | $126,987,987 | dollars as filed | |
| IDEAYA BIOSCIENCES INC COM | 45166A102 | Stock | 3,618,826 | $125,102,815 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 5,555,017 | $120,543,869 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 875,796 | $118,105,470 | dollars as filed | |
| KINIKSA PHARMACEUTICALS INTL P ORD SHS CL A | G52694109 | Stock | 2,826,246 | $116,582,648 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 11,045,336 | $107,360,666 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 3,336,697 | $105,906,763 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 1,432,529 | $99,632,392 | dollars as filed | |
| ABCELLERA BIOLOGICS INC COM | 00288U106 | Stock | 27,525,640 | $94,137,689 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 4,658,556 | $88,372,807 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 2,322,656 | $80,619,390 | dollars as filed | |
| BICYCLE THERAPEUTICS PLC-ADR | 088786108 | SPONSORED ADS | 10,885,357 | $77,068,328 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,648,869 | $76,754,852 | dollars as filed | |
| MONTE ROSA THERAPEUTICS INC | 61225M102 | COM | 4,345,736 | $68,141,140 | dollars as filed | |
| CELCUITY INC | 15102KAA8 | NOTE 2.750% 8/0 | 30,750,000 | $66,580,023 | dollars as filed | principal |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 2,772,692 | $63,771,916 | dollars as filed | |
| DENALI THERAPEUTICS INC COM | 24823R105 | Stock | 3,731,695 | $61,610,284 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 1,971,678 | $61,358,619 | dollars as filed | |
| ENTRADA THERAPEUTICS INC COM | 29384C108 | Stock | 5,072,730 | $52,147,664 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 1,547,090 | $46,938,711 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 950,000 | $38,380,000 | dollars as filed | |
| BIONTECH SE SPONSORED ADS | 09075V102 | ADR | 368,923 | $35,121,470 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,000,000 | $32,760,000 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 789,759 | $32,545,968 | dollars as filed | |
| PRELUDE THERAPEUTICS INC | 74065P101 | CMN | 10,123,824 | $29,359,090 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J309 | SPONSORED ADS | 1,461,425 | $28,015,517 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 337,050 | $26,765,141 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 1,641,137 | $25,322,744 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 4,004,756 | $22,026,158 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 2,822,727 | $22,017,271 | dollars as filed | |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 2,349,280 | $21,213,998 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 25,174 | $21,170,075 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 2,233,099 | $20,946,469 | dollars as filed | |
| CERUS CORP | 157085101 | COM | 10,008,345 | $20,617,191 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 991,691 | $20,428,835 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 903,400 | $18,844,924 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 4,250,826 | $18,108,519 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 665,370 | $18,071,449 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 1,102,106 | $16,873,243 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 670,751 | $16,775,483 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 370,208 | $16,592,723 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 400,000 | $16,456,000 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 1,420,838 | $16,240,178 | dollars as filed | |
| SERA PROGNOSTICS INC | 81749D107 | CMN | 5,498,170 | $16,219,602 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 813,449 | $15,911,062 | dollars as filed | |
| ALUMIS INC | 022307102 | COM | 1,562,500 | $15,250,000 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 143,937 | $14,478,623 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 375,000 | $10,406,250 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 1,160,117 | $9,814,590 | dollars as filed | |
| ABSCI CORPORATION | 00091E109 | COM | 2,134,803 | $7,450,462 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 270,000 | $6,434,100 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 364,705 | $6,406,043 | dollars as filed | |
| VTV THERAPEUTICS INC | 918385204 | CL A NEW | 148,314 | $5,931,077 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 344,063 | $5,849,071 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 952,996 | $5,641,736 | dollars as filed | |
| PROTARA THERAPEUTICS INC | 74365U107 | COM STK | 971,614 | $5,178,703 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 200,000 | $4,452,000 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 271,406 | $4,179,652 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 475,737 | $3,568,028 | dollars as filed | |
| VIR BIOTECHNOLOGY INC | 92764N102 | COM | 542,539 | $3,271,510 | dollars as filed | |
| Tscan Therapeutics Inc | 89854M101 | COM | 2,784,792 | $2,784,792 | dollars as filed | |
| SANA BIOTECHNOLOGY INC | 799566104 | COM | 310,483 | $1,263,666 | dollars as filed | |
| SKYE BIOSCIENCE INC | 83086J200 | COM NEW | 1,450,638 | $1,087,543 | dollars as filed | |
| KALA BIO INC | 483119202 | COM NEW | 1,804,055 | $1,002,874 | dollars as filed | |
| ALIGOS THERAPEUTICS INC | 01626L204 | COM NEW | 83,055 | $774,073 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 10,607 | $278,858 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 22,809 | $54,970 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 833,333 | $16,667 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-016374 | this filing | 2026-02-17 | acceptance time not in the bulk data set |