13F-HR filed by Affinity Asset Advisors, LLC
Affinity Asset Advisors, LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-13, with 95 holding rows worth $1,755,015,212.
- Accession
- 0001315863-26-000153
- Filer
- CIK 1773195
- Filed
- 2026-02-13
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 95 entries on the cover page, a total value of $1,755,015,212 stated on the cover page (in dollars after the unit check, H1), rows summing to $1,755,015,212 with VALUE read as dollars as filed, 13F file number 028-20754. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,500,000 | $182,895,000 | dollars as filed | put |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 1,234,926 | $93,212,214 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 450,000 | $78,318,000 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 505,000 | $68,101,775 | dollars as filed | |
| ISHARES TR | 464287556 | ISHARES BIOTECH | 400,000 | $67,508,000 | dollars as filed | call |
| Ventyx Biosciences Inc | 92332V107 | Common Stock | 6,484,558 | $58,555,559 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 1,250,000 | $56,025,000 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 185,000 | $54,526,900 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 800,000 | $50,832,000 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,432,591 | $46,931,681 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 2,700,000 | $45,900,000 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 135,000 | $44,186,850 | dollars as filed | call |
| TEVA PHARMACEUTICAL INDS LTD SPONSORED ADS | 881624209 | ADR | 1,400,000 | $43,694,000 | dollars as filed | |
| Health Care Select Sector SPDR Fund | 81369Y209 | SHS | 250,000 | $38,700,000 | dollars as filed | call |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 1,700,000 | $36,890,000 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 523,725 | $34,146,870 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 322,633 | $32,453,653 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 3,200,000 | $31,776,000 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 1,000,000 | $27,980,000 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 989,490 | $26,983,392 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 2,150,172 | $26,920,153 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 730,000 | $26,491,700 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 320,000 | $24,476,800 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 802,342 | $24,318,986 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 550,000 | $22,220,000 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 444,692 | $21,558,668 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,932,106 | $19,997,297 | dollars as filed | |
| OMEROS CORP | 682143AK8 | NOTE 9.500% 6/1 | 6,525,000 | $19,383,995 | dollars as filed | principal |
| UNIQURE NV | N90064101 | SHS | 800,000 | $19,144,000 | dollars as filed | call |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 1,051,054 | $19,087,141 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 967,620 | $18,355,751 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 3,300,000 | $18,150,000 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 31,131 | $18,128,827 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 2,797,153 | $16,866,833 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 172,125 | $15,033,398 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 600,552 | $15,019,806 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 200,000 | $14,576,000 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 3,900,000 | $14,508,000 | dollars as filed | |
| VERA THERAPEUTICS INC | 92337R101 | COMMON STOCK | 250,000 | $12,660,000 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 350,000 | $12,432,000 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 7,150,000 | $11,654,500 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 300,000 | $11,463,000 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 714,956 | $11,031,771 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422GAA5 | CNV | 7,000,000 | $9,989,000 | dollars as filed | principal |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 275,000 | $9,647,000 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 350,000 | $9,506,000 | dollars as filed | |
| ZURA BIO LTD | G9TY5A101 | COMMON STOCK | 1,813,671 | $9,503,636 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 1,000,000 | $8,860,000 | dollars as filed | |
| SUTRO BIOPHARMA INC | 869367201 | COMMON STOCK | 748,382 | $8,658,780 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 100,000 | $7,965,000 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 250,000 | $7,885,000 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 250,000 | $7,780,000 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 300,000 | $7,149,000 | dollars as filed | |
| SAGIMET BIOSCIENCES INC A | 786700104 | COMMON STOCK | 1,148,245 | $6,797,610 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 889,575 | $6,547,272 | dollars as filed | |
| CELCUITY INC | 15102KAA8 | NOTE 2.750% 8/0 | 3,000,000 | $6,515,700 | dollars as filed | principal |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 30,000 | $6,397,200 | dollars as filed | |
| SUMMIT THERAPEUTICS INC | 86627T108 | COM | 350,000 | $6,121,500 | dollars as filed | put |
| VERRICA PHARMACEUTICALS INC | 92511W207 | COM SHS | 707,338 | $5,877,979 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 643,370 | $5,809,631 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 245,000 | $5,635,000 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 2,351,144 | $5,548,700 | dollars as filed | |
| AVADEL PHARMACEUTICALS PLC | G29687103 | COM SHS | 250,000 | $5,387,500 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 1,300,000 | $5,200,000 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 200,000 | $5,084,000 | dollars as filed | |
| PROQR THERAPEUTICS NV | N71542109 | SHS EURO | 2,454,278 | $4,957,642 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 115,000 | $4,739,150 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 70,000 | $4,647,300 | dollars as filed | |
| IBIO INC | 451033708 | CMN | 2,057,200 | $3,970,396 | dollars as filed | |
| NEXTCURE INC | 65343E207 | COM NEW | 247,294 | $3,509,102 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 75,000 | $3,491,250 | dollars as filed | |
| Amgen Inc. | 031162100 | COM | 10,000 | $3,273,100 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 20,000 | $3,199,200 | dollars as filed | |
| ARRIVENT BIOPHARMA INC | 04272N102 | COM | 150,000 | $3,018,000 | dollars as filed | |
| MERSANA THERAPEUTICS INC | 59045L205 | COM | 100,000 | $2,893,000 | dollars as filed | |
| OAKTREE ACQUISITION CORP III | G6717R120 | UNIT 10/04/2029 | 250,000 | $2,652,500 | dollars as filed | |
| Arbutus Biopharma Corp | 03879J100 | Common Shares, without par value | 521,900 | $2,510,339 | dollars as filed | call |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 486,684 | $2,428,553 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 572,804 | $2,377,137 | dollars as filed | |
| EUPRAXIA PHARMACEUTICALS INC | 29842P105 | COM 298736 AL 3 EURONET WORLDWIDE INC NOTE 0.750% 3/1 | 300,000 | $2,265,000 | dollars as filed | |
| GERON CORP | 374163103 | COM | 1,500,000 | $1,980,000 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 75,000 | $1,725,000 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 100,000 | $1,600,000 | dollars as filed | put |
| KEZAR LIFE SCIENCES INC | 49372L209 | COM NEW | 229,076 | $1,440,888 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 200,000 | $1,380,000 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 50,000 | $1,196,500 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240QAA0 | NOTE 1.625%11/1 | 1,000,000 | $1,175,800 | dollars as filed | principal |
| PERSPECTIVE THERAPEUTICS INC | 46489V302 | COMMON STOCK | 300,000 | $825,000 | dollars as filed | |
| MACROGENICS INC | 556099109 | COM | 484,308 | $779,736 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 50,000 | $651,500 | dollars as filed | |
| FORTE BIOSCIENCES INC | 34962G208 | COMMON STOCK | 22,400 | $610,848 | dollars as filed | call |
| X4 PHARMACEUTICALS INC | 98420X202 | COMMON STOCK | 145,000 | $580,000 | dollars as filed | |
| Q32 BIO INC | 746964105 | Common Stock | 27,777 | $92,220 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 80,000 | $83,200 | dollars as filed | |
| Rocket Pharmaceuticals Inc W Exp 09/02/202 | 77313F114 | Warrant | 75,000 | $1,823 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001315863-26-000153 | this filing | 2026-02-13 | acceptance time not in the bulk data set |