13F-HR filed by HighVista Strategies LLC
HighVista Strategies LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 145 holding rows worth $388,309,219.
- Accession
- 0001172661-26-000882
- Filer
- CIK 1335325
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 145 entries on the cover page, a total value of $388,309,219 stated on the cover page (in dollars after the unit check, H1), rows summing to $388,309,219 with VALUE read as dollars as filed, 13F file number 028-14212. The quarter's positions are built on this report. The resolved quarter.
Other managers
- included managerHighVista Private Capital Management LLC
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| DB COMMODITY INDEX TRACKING | 46138B103 | ETF | 1,057,238 | $23,639,842 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 193,001 | $13,423,219 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 336,667 | $11,958,412 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 372,472 | $11,591,329 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 72,185 | $9,734,508 | dollars as filed | |
| REVOLUTION MEDICINES INC COM | 76155X100 | Stock | 120,240 | $9,577,116 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 25,841 | $7,616,376 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 73,287 | $7,371,939 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 114,564 | $7,279,396 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 175,462 | $7,088,665 | dollars as filed | |
| MAZE THERAPEUTICS INC COM | 578784100 | Stock | 170,353 | $7,057,724 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 39,400 | $6,857,176 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 89,229 | $6,735,005 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 73,545 | $6,423,420 | dollars as filed | |
| SOLENO THERAPEUTICS INC | 834203309 | COM | 135,069 | $6,253,695 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 188,206 | $6,165,629 | dollars as filed | |
| BRIDGEBIO PHARMA INC | 10806X102 | COM | 80,205 | $6,134,880 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 241,489 | $6,037,225 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 221,883 | $5,640,266 | dollars as filed | |
| LIQUIDIA CORPORATION COM NEW | 53635D202 | Stock | 156,003 | $5,380,543 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 114,049 | $5,262,221 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 22,928 | $5,064,566 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 75,002 | $4,890,130 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 545,079 | $4,611,368 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 42,867 | $4,588,483 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 124,544 | $4,519,702 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 162,370 | $4,505,768 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 53,564 | $4,385,821 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 171,137 | $4,246,765 | dollars as filed | |
| OCULAR THERAPEUTIX INC | 67576A100 | COM | 344,067 | $4,176,974 | dollars as filed | |
| AGIOS PHARMACEUTICALS INC | 00847X104 | COM | 147,662 | $4,019,360 | dollars as filed | |
| Amazon.com, Inc | 023135106 | COM | 17,397 | $4,015,575 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 150,776 | $3,787,493 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 36,758 | $3,754,462 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 115,539 | $3,667,208 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 498,933 | $3,442,637 | dollars as filed | |
| Microsoft Corp | 594918104 | COM | 6,537 | $3,161,424 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 140,107 | $3,118,782 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 1,300,031 | $3,055,073 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 240,524 | $3,054,655 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 3,588 | $3,017,329 | dollars as filed | |
| XOMA ROYALTY CORPORATION | 98419J206 | COMMON STOCK | 112,917 | $3,002,463 | dollars as filed | |
| TRANSDIGM GROUP INC COM | 893641100 | Stock | 2,175 | $2,892,424 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 40,020 | $2,886,643 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 238,812 | $2,884,849 | dollars as filed | |
| BRIDGEBIO ONCOLOGY THERAPEUT | 107924102 | COM NEW | 229,263 | $2,870,372 | dollars as filed | |
| NVIDIA Corp | 67066G104 | COM | 14,220 | $2,652,030 | dollars as filed | |
| Salesforce.com, Inc | 79466L302 | COM | 8,613 | $2,281,670 | dollars as filed | |
| Visa Inc | 92826C839 | COM | 6,291 | $2,206,316 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 78,682 | $2,193,654 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 11,131 | $2,032,965 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 48,484 | $1,998,026 | dollars as filed | |
| Alphabet Inc. Reg. Shares C | 02079K107 | COM | 6,277 | $1,969,723 | dollars as filed | |
| Broadcom Inc. | 11135F101 | COM | 5,639 | $1,951,658 | dollars as filed | |
| ROCKET COS INC | 77311W101 | COM CL A | 97,430 | $1,886,245 | dollars as filed | |
| Union Pacific Corporation | 907818108 | COM | 8,058 | $1,863,977 | dollars as filed | |
| HEWLETT PACKARD ENTERPRISE CO COM | 42824C109 | Stock | 76,181 | $1,829,867 | dollars as filed | |
| AMRIZE LTD SHS | H2927K103 | Stock | 33,468 | $1,809,949 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 95,631 | $1,736,659 | dollars as filed | |
| FLOWSERVE CORP | 34354P105 | COM | 24,958 | $1,731,586 | dollars as filed | |
| XPO INC COM | 983793100 | Stock | 12,723 | $1,729,183 | dollars as filed | |
| CONSTELLATION ENERGY CORP COM | 21037T109 | Stock | 4,812 | $1,699,935 | dollars as filed | |
| META PLATFORMS INC CL A | 30303M102 | COM | 2,562 | $1,691,151 | dollars as filed | |
| APPLOVIN CORP COM CL A | 03831W108 | Stock | 2,482 | $1,672,422 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 2,839 | $1,653,263 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 16,543 | $1,649,999 | dollars as filed | |
| LUMENTUM HLDGS INC COM | 55024U109 | Stock | 4,317 | $1,591,203 | dollars as filed | |
| MasterCard, Inc | 57636Q104 | COM | 2,784 | $1,589,330 | dollars as filed | |
| CLEVELAND-CLIFFS INC NEW COM | 185899101 | Stock | 118,574 | $1,574,663 | dollars as filed | |
| FERGUSON ENTERPRISES INC COMMON STOCK NEW | 31488V107 | Stock | 6,973 | $1,552,399 | dollars as filed | |
| NextEra Energy,Inc. | 65339F101 | COM | 19,285 | $1,548,200 | dollars as filed | |
| UNIFIRST CORP MASS | 904708104 | COM | 7,727 | $1,490,538 | dollars as filed | |
| CLEAN HARBORS INC COM | 184496107 | Stock | 6,243 | $1,463,859 | dollars as filed | |
| EQT CORP COM | 26884L109 | Stock | 27,090 | $1,452,024 | dollars as filed | |
| CELLDEX THERAPEUTICS INC NEW | 15117B202 | COM NEW | 51,805 | $1,407,024 | dollars as filed | |
| WORKDAY INC CL A | 98138H101 | Stock | 6,486 | $1,393,063 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 106,159 | $1,329,110 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 245,532 | $1,318,507 | dollars as filed | |
| Thermo Fisher Scientific Inc. | 883556102 | COM | 2,269 | $1,314,772 | dollars as filed | |
| TALEN ENERGY CORP COM | 87422Q109 | Stock | 3,488 | $1,307,442 | dollars as filed | |
| Booking Holdings Inc. | 09857L108 | COM | 243 | $1,301,346 | dollars as filed | |
| ORTHOFIX MED INC | 68752M108 | COM | 85,049 | $1,289,343 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 82,536 | $1,271,055 | dollars as filed | |
| UNITY SOFTWARE INC COM | 91332U101 | Stock | 28,663 | $1,266,045 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 35,586 | $1,248,357 | dollars as filed | |
| REDDIT INC CL A | 75734B100 | Stock | 5,300 | $1,218,311 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 29,325 | $1,217,574 | dollars as filed | |
| CIENA CORP COM NEW | 171779309 | Stock | 5,185 | $1,212,616 | dollars as filed | |
| RBC BEARINGS INC COM | 75524B104 | Stock | 2,703 | $1,212,106 | dollars as filed | |
| KBR INC COM | 48242W106 | Stock | 30,006 | $1,206,241 | dollars as filed | |
| Intuit Inc. | 461202103 | COM | 1,813 | $1,200,968 | dollars as filed | |
| API GROUP CORP COM STK | 00187Y100 | Stock | 30,958 | $1,184,453 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 59,643 | $1,166,617 | dollars as filed | |
| EVERPURE INC CL A | 74624M102 | Stock | 17,409 | $1,166,577 | dollars as filed | |
| ACADIA HEALTHCARE COMPANY INC COM | 00404A109 | Stock | 81,630 | $1,158,329 | dollars as filed | |
| GE Vernova Inc. | 36828A101 | COM | 1,768 | $1,155,512 | dollars as filed | |
| RXO, Inc. | 74982T103 | Common Stock, $0.01 par value | 90,938 | $1,149,456 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 32,998 | $1,145,361 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 2,330 | $1,135,293 | dollars as filed | |
| QXO INC COM NEW | 82846H405 | Stock | 58,720 | $1,132,709 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 44,490 | $1,112,695 | dollars as filed | |
| PTC INC COM | 69370C100 | Stock | 6,374 | $1,110,415 | dollars as filed | |
| MASTEC INC COM | 576323109 | Stock | 5,027 | $1,092,719 | dollars as filed | |
| Charles Schwab Corp | 808513105 | COM | 10,601 | $1,059,146 | dollars as filed | |
| NU HLDGS LTD | G6683N103 | ORD SHS CL A | 62,570 | $1,047,422 | dollars as filed | |
| SanDisk Corporation | 80004C200 | COM | 4,378 | $1,039,250 | dollars as filed | |
| PENNYMAC FINL SVCS INC NEW | 70932M107 | COM | 7,806 | $1,029,143 | dollars as filed | |
| AFFIRM HLDGS INC COM CL A | 00827B106 | Stock | 13,086 | $973,991 | dollars as filed | |
| CORPORACION AMER ARPTS S A | L1995B107 | COM | 37,145 | $965,770 | dollars as filed | |
| AMPHENOL CORP NEW | 032095101 | COM | 7,081 | $956,926 | dollars as filed | |
| ENTERGY CORP NEW COM | 29364G103 | Stock | 10,328 | $954,617 | dollars as filed | |
| SEA LTD | 81141R100 | SPONSORD ADS | 7,450 | $950,396 | dollars as filed | |
| FULL TRUCK ALLIANCE CO LTD SPONSORED ADS | 35969L108 | ADR | 87,591 | $939,851 | dollars as filed | |
| MERCADOLIBREINC | 58733R102 | STOK | 465 | $936,631 | dollars as filed | |
| CORE SCIENTIFIC INC NEW | 21874A106 | COM | 63,512 | $924,735 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 35,086 | $922,411 | dollars as filed | |
| VISTRA CORP COM | 92840M102 | Stock | 5,673 | $915,225 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 193,941 | $826,189 | dollars as filed | |
| COMPANIA DE MINAS BUENAVENTU | 204448104 | SPONSORED ADR | 29,649 | $825,132 | dollars as filed | |
| SHIFT4 PMTS INC CL A | 82452J109 | Stock | 12,982 | $817,477 | dollars as filed | |
| HDFC BANK LTD SPONSORED ADS | 40415F101 | ADR | 22,127 | $808,521 | dollars as filed | |
| ICICI BANK LIMITED ADR | 45104G104 | ADR | 26,284 | $783,263 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 3,660 | $780,458 | dollars as filed | |
| TRIP COM GROUP LTD ADS | 89677Q107 | ADR | 10,646 | $765,554 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 26,401 | $738,700 | dollars as filed | |
| GITLAB INC CLASS A COM | 37637K108 | Stock | 19,305 | $724,517 | dollars as filed | |
| NEW ORIENTAL ED & TECHNOLOGY SPON ADR | 647581206 | ADR | 12,817 | $705,320 | dollars as filed | |
| ROBLOX CORP CL A | 771049103 | Stock | 8,431 | $683,164 | dollars as filed | |
| ALCON AG ORD SHS | H01301128 | Stock | 10,440 | $660,643 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 28,005 | $655,877 | dollars as filed | |
| CNX RES CORP COM | 12653C108 | Stock | 17,624 | $648,034 | dollars as filed | |
| BANCO BRADESCO S A | 059460303 | SP ADR PFD NEW | 190,264 | $633,579 | dollars as filed | |
| 3M CO COM | 88579Y101 | Stock | 3,950 | $632,395 | dollars as filed | |
| AUTOLIV INC | 052800109 | COM | 5,243 | $622,344 | dollars as filed | |
| PETROLEO BRASILEIRO S A | 71654V101 | SP ADR NON VTG | 55,200 | $622,104 | dollars as filed | |
| XCELENERGY INC | 98389B100 | COM | 8,058 | $595,164 | dollars as filed | |
| ARGAN INC | 04010E109 | COM | 1,896 | $594,055 | dollars as filed | |
| COUPANG INC | 22266T109 | CL A | 24,792 | $584,843 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 41,443 | $571,913 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 6,835 | $531,831 | dollars as filed | |
| JD.COM INC SPON ADS CL A | 47215P106 | ADR | 17,463 | $501,189 | dollars as filed | |
| NEKTAR THERAPEUTICS | 640268306 | COMMON STOCK | 11,749 | $496,748 | dollars as filed | |
| KANZHUN LIMITED | 48553T106 | SPONSORED ADS | 20,598 | $419,787 | dollars as filed | |
| NOKIA CORP | 654902204 | SPONSORED ADR | 59,524 | $385,120 | dollars as filed | |
| DBV TECHNOLOGIES S A | 23306J309 | SPONSORED ADS | 15,877 | $304,362 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001172661-26-000882 | this filing | 2026-02-17 | acceptance time not in the bulk data set |