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Disclosery

GPCR STRUCTURE THERAPEUTICS INC

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EQUITY (ADR), issuer CIK 1888886

194 managers (197 13F filers) reported a position in GPCR shares at 2025-12-31, 65,776,487 shares in all. 63 filers opened a position and 27 filers sold out during the quarter.

Managers
194
13F filers
197
New
63
Added
52
Reduced
62
Sold out
27
Shares held by filers
65,776,487

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,712,251$606M0.03%+3,461,88313F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…7,121,984$495M0.09%+1,432,79713F-HRTimelineGroup
Avoro Capital Advisors LLC6,555,555$456M4.48%+1,400,00013F-HR/ATimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson5,090,148$354M0.16%+641,32213F-HRTimelineGroup
Deep Track Capital, LP4,111,782$286M6.52%-104,02913F-HRTimeline
BVF INC/ILin group BVF INC/IL3,479,022$242M8.15%+275,10513F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY2,087,834$145M0.01%+1,510,09313F-HR/ATimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/1,671,138$116M0.01%+1,381,74513F-HRTimeline
Driehaus Capital Management LLC1,642,444$114M0.78%+768,94013F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,432,529$99.6M0.58%-123,58013F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC1,284,210$89.3M0.05%+496,72613F-HRTimelineGroup
Casdin Capital, LLC1,175,000$81.7M5.08%-380,00013F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC1,161,803$80.8M1.65%+22,50313F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,078,698$75M2.24%+51,88713F-HRTimelineGroup
TCG Crossover Management, LLC920,857$64M2.12%-142,14313F-HRTimeline
Capitolis Liquid Global Markets LLCin group CAPITOLIS LIQUID GLOBAL MARKE…878,300$61.1M0.36%new13F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources870,582$60.5M0.01%+124,84813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.848,851$59M0.02%+819,29213F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\841,162$58.5M0.02%new13F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC772,518$53.7M0.04%+328,71813F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…767,993$53.4M0.68%+394,58613F-HRTimelineGroup
Rock Springs Capital Management LP748,236$52M2.67%-202,91813F-HRTimeline
Pacific Heights Asset Management LLC700,000$48.7M1.82%013F-HRTimeline
Logos Global Management LP600,000$41.7M2.78%-250,00013F-HRTimeline
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC506,959$35.3M0.02%+20,17313F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…467,800$32.5M0.06%new13F-HRTimeline
FARALLON CAPITAL MANAGEMENT, L.L.C.454,000$31.6M0.16%new13F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
BlackRock, Inc.in group BlackRock, Inc.430,082$29.9M<0.01%+166,14413F-HRTimelineGroup
HSG Holding Ltdin group HSG Holding Ltd266,062$24.4M1.29%013F-HRTimelineGroup
STEMPOINT CAPITAL LP351,073$24.4M4.19%+221,73813F-HRTimeline
EcoR1 Capital, LLC334,380$23.3M1.06%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC285,518$19.9M<0.01%-938,62613F-HRTimelineGroup
ArrowMark Colorado Holdings LLC271,213$18.9M0.42%-51,95313F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/265,400$18.5M0.02%+121,40013F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc264,869$18.4M0.03%-322,00013F-HRTimelineGroup
Catalio Capital Management, LP252,901$17.6M3.11%-398,90913F-HR/ATimeline
Capricorn Fund Managers Ltd252,600$17.6M4.23%new13F-HRTimeline
VOLORIDGE INVESTMENT MANAGEMENT, LLC250,000$17.4M0.06%new13F-HRTimeline
Monashee Investment Management LLC225,000$15.6M8.82%+25,00013F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC224,332$15.6M<0.01%-280,06413F-HR/ATimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management216,199$15M0.03%-245,35413F-HRTimelineGroup
UBS Group AGin group UBS Group AG202,477$14.1M<0.01%-5,61513F-HRTimelineGroup
Sio Capital Management, LLC201,500$14M2.32%new13F-HRTimeline
HighVista Strategies LLC193,001$13.4M3.46%-43,23513F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding176,705$12.3M-192,462Timeline
TD Asset Management Inc174,674$12.1M0.01%+138,58813F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP168,584$11.7M0.01%new13F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC152,560$10.6M0.01%-1,121,99113F-HRTimelineGroup
Rhenman & Partners Asset Management AB147,600$10.3M0.96%-32,50013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC147,217$10.2M0.01%new13F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG145,167$10.1M0.19%-170,69013F-HRTimelineGroup
Eversept Partners, LP127,561$8.87M0.5%-38,83013F-HRTimeline
Woodline Partners LP123,902$8.62M0.03%+58,46213F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC115,200$8.01M0.01%-38,70013F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.115,000$8M0.02%-129,84813F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding111,797$7.78M+85,941Timeline
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.102,993$7.16M0.06%-67,35213F-HRTimelineGroup
RTW INVESTMENTS, LP100,000$6.96M0.07%new13F-HRTimeline
Jain Global LLC99,996$6.95M0.07%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding95,543$6.65M-336,667Timeline
SummitTX Capital, L.P.94,671$6.58M0.2%new13F-HRTimeline
NEXTBio Capital Management LP94,443$6.57M3.85%13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …96,387$6.53M0.01%+67,85513F-HRTimelineGroup
SIMPLEX TRADING, LLC92,668$6.45M0.18%+67,50713F-HRTimeline
Birchview Capital, LP90,000$6.26M3.66%+12,00013F-HRTimeline
Soleus Capital Management, L.P.90,000$6.26M0.27%new13F-HRTimeline
B Group, Inc.90,000$6.26M4.64%new13F-HRTimeline
Trexquant Investment LP89,945$6.26M0.06%+69,75313F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD87,874$6.11M1.41%-34,88413F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…86,310$5.96M0.11%new13F-HRTimelineGroup
PEREGRINE CAPITAL MANAGEMENT LLC84,324$5.86M0.18%new13F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …83,052$5.78M0.01%+67,33813F-HRTimelineGroup
Verition Fund Management LLC78,149$5.44M0.03%+38,80013F-HRTimeline
Boxer Capital Management, LLCin group Boxer Capital Management, LLC75,000$5.22M1.14%new13F-HRTimelineGroup
PFM Health Sciences, LP68,248$4.75M0.48%-46,82513F-HRTimeline
Burkehill Global Management, LP60,000$4.17M0.27%new13F-HRTimeline
Longaeva Partners L.P.60,000$4.17M0.5%new13F-HRTimeline
BANQUE PICTET & CIE SA59,881$4.16M0.04%-4,30413F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.59,238$4.12M0.01%-3,60113F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC55,300$3.85M<0.01%+38,87513F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC55,148$3.84M<0.01%-2,81013F-HRTimelineGroup
Parkman Healthcare Partners LLC55,000$3.83M0.36%new13F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/54,341$3.68M<0.01%-6,38113F-HRTimelineGroup
Integral Health Asset Management, LLC50,000$3.48M0.18%new13F-HRTimeline
SEVEN GRAND MANAGERS, LLC50,000$3.48M0.26%new13F-HRTimeline
Buckland Partners Management Co LLC50,000$3.48M1.93%13F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC49,726$3.46M0.02%+21,76813F-HRTimelineGroup
Pier Capital, LLC48,757$3.39M0.54%-148,75213F-HRTimeline
FLAX POND CAPITAL, LLC48,721$3.39M2.52%13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP48,224$3.35M<0.01%+2,20713F-HRTimelineGroup
ANTIPODES PARTNERS Ltd46,291$3.25M0.07%+42,21313F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC44,388$3.09M<0.01%new13F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC44,155$3.07M<0.01%+1913F-HRTimelineGroup
Headlands Technologies LLC43,729$3.04M0.25%+16,91513F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.41,000$2.85M0.6%-132,93113F-HRTimelineGroup
ACT CAPITAL MANAGEMENT, LLC38,500$2.68M2.17%13F-HRTimeline
Informed Momentum Co LLC38,054$2.65M0.29%new13F-HRTimeline
DAFNA Capital Management LLC37,000$2.57M0.6%-22,00013F-HRTimeline
TUDOR INVESTMENT CORP ET AL35,053$2.44M0.01%new13F-HRTimeline
Vestal Point Capital, LP35,000$2.43M0.09%new13F-HRTimeline
TrueMark Investments, LLCin group TrueMark Investments, LLC33,893$2.36M0.45%-96813F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/31,678$2.2M<0.01%+17,89913F-HRTimelineGroup
DCF Advisers, LLC30,000$2.09M0.69%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…26,274$1.83M<0.01%new13F-HRTimelineGroup
EXCHANGE TRADED CONCEPTS, LLC25,981$1.81M0.02%-32,24113F-HRTimeline
Quinn Opportunity Partners LLC25,000$1.74M0.08%-17,00013F-HRTimeline
SECTORAL ASSET MANAGEMENT INC23,872$1.66M1.33%-198,00013F-HRTimeline
Maven Securities LTDin group Maven Securities LTD20,000$1.39M0.18%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd19,193$1.33M0.04%new13F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC17,606$1.22M<0.01%new13F-HRTimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…17,297$1.2M0.01%+6,54613F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO14,903$1.04M<0.01%new13F-HRTimelineGroup
WEXFORD CAPITAL LP14,835$1.03M0.27%new13F-HRTimeline
J. Goldman & Co LP13,601$946K0.04%new13F-HRTimeline
BRANDYWINE MANAGERS, LLCin group BRANDYWINE MANAGERS, LLC13,357$929K0.46%+2,30013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO12,956$901K<0.01%-45,19213F-HRTimelineGroup
Quadrature Capital Ltdin group Quadrature Capital Ltd12,761$888K0.01%new13F-HRTimelineGroup
DNB Asset Management ASin group DNB Asset Management AS12,639$879K<0.01%-24913F-HRTimelineGroup
Allianz Asset Management GmbHin group Allianz SE12,000$835K<0.01%new13F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC11,570$805K<0.01%-65013F-HRTimelineGroup
China Universal Asset Management Co., L…10,888$757K0.06%+44413F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA10,200$709K<0.01%-9313F-HRTimelineGroup
SG Americas Securities, LLC10,147$706K<0.01%-29,55313F-HRTimeline
Y-Intercept (Hong Kong) Ltd10,132$705K0.02%new13F-HRTimeline
Bleichroeder LP10,000$696K0.12%-10,00013F-HRTimeline
MISSION WEALTH MANAGEMENT, LP9,583$666K0.01%013F-HRTimeline
HighTower Advisors, LLC9,320$648K<0.01%+32013F-HRTimeline
SmartHarvest Portfolios, LLC9,056$630K0.22%13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS8,746$608K<0.01%-81,68513F-HRTimelineGroup
Schonfeld Strategic Advisors LLC8,727$607K<0.01%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.8,623$600K<0.01%-27,72313F-HRTimelineGroup
Janney Capital Management LLC8,513$592K0.04%-5,20513F-HRTimeline
LPL Financial LLC8,109$564K<0.01%-14,89413F-HRTimeline
PEAK6 LLCin group PEAK6 LLC7,955$553K0.02%-3,04513F-HR/ATimelineGroup
BARCLAYS PLCin group BARCLAYS PLC7,833$545K<0.01%+4,06013F-HRTimelineGroup
MML INVESTORS SERVICES, LLC7,825$544K<0.01%new13F-HRTimeline
Vestmark Advisory Solutions, Inc.7,534$524K0.01%new13F-HRTimeline
Parallel Advisors, LLC7,352$511K0.01%-91213F-HRTimeline
Private Capital Advisors, Inc.7,348$511K0.05%-47,83713F-HRTimeline
CITIGROUP INCin group CITIGROUP INC7,335$510K<0.01%+5,87913F-HRTimelineGroup
PSP Research LLC6,719$467K0.41%13F-HRTimeline
SIGNATUREFD, LLC6,650$463K0.01%013F-HRTimeline
Cetera Investment Advisers6,596$459K<0.01%new13F-HRTimeline
Gilbert & Cook, Inc.5,682$395K0.05%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN5,664$394K<0.01%-39413F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…5,267$366K<0.01%+1,21113F-HRTimelineGroup
Blueshift Asset Management, LLC5,213$363K0.1%new13F-HRTimeline
Quadcap Wealth Management, LLC7,483$355K0.04%new13F-HRTimeline
Concurrent Investment Advisors, LLCin group Concurrent Investment Advisor…5,000$348K<0.01%new13F-HRTimelineGroup
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP4,830$336K<0.01%new13F-HRTimelineGroup
Ikarian Capital, LLCin group Ikarian Capital, LLC4,824$336K0.04%-158,41313F-HRTimelineGroup
Independent Advisor Alliance4,543$316K0.01%new13F-HRTimeline
E. Ohman J:or Asset Management AB4,518$314K0.01%new13F-HRTimeline
GABELLI FUNDS LLCin group GAMCO Investors (Gabelli)4,000$278K<0.01%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…3,967$276K0.07%-1,15413F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…3,926$273K<0.01%-90213F-HRTimelineGroup
Merit Financial Group, LLC3,688$256K<0.01%new13F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP3,645$254K<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp3,604$251K<0.01%new13F-HRTimelineGroup
PROFUND ADVISORS LLC3,507$244K0.01%new13F-HRTimeline
CIBC WORLD MARKET INC.3,248$226K<0.01%new13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.3,200$223K<0.01%-440,53713F-HRTimelineGroup
ProShare Advisors LLC2,957$206K<0.01%new13F-HRTimeline
Banque Cantonale Vaudoisein group Banque Cantonale Vaudoise2,945$205K0.01%new13F-HRTimelineGroup
Steward Partners Investment Advisory, L…2,540$177K<0.01%-10013F-HRTimeline
Persistent Asset Partners Ltd2,436$169K0.08%new13F-HRTimeline
ASSETMARK, INCin group ASSETMARK, INC2,095$146K<0.01%-28913F-HRTimelineGroup
Police & Firemen's Retirement System of…1,829$127K<0.01%new13F-HRTimeline
State of Wyoming1,761$122K0.01%+40313F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,312$91.2K<0.01%+3413F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP1,046$72.7K<0.01%+85913F-HRTimelineGroup
GAMMA Investing LLC930$64.7K<0.01%+11213F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…731$50.8K<0.01%-1113F-HR/ATimelineGroup
Farther Finance Advisors, LLC690$48K<0.01%+2013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…578$40.2K<0.01%-49313F-HRTimelineGroup
COUNTRY TRUST BANK500$34.8K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC480$33K<0.01%+12513F-HRTimelineGroup
WOLFF WIESE MAGANA LLC400$27.8K0.02%+11413F-HRTimeline
SOA Wealth Advisors, LLC.350$24.3K<0.01%new13F-HRTimeline
North Star Investment Management Corp.330$23K<0.01%013F-HRTimeline
Private Wealth Management Group, LLC196$13.6K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.186$13K<0.01%-4013F-HRTimelineGroup
Dynamic Wealth Strategies, LLC150$10.4K0.01%-40013F-HRTimeline
SHP Wealth Management100$6.96K<0.01%13F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…60$4.17K<0.01%new13F-HR/ATimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…41$2.85K<0.01%-35313F-HRTimelineGroup
BESSEMER GROUP INCin group BESSEMER GROUP INC29$2K<0.01%013F-HRTimelineGroup
BELLEVUE ASSET MANAGEMENT, LLC15$1.04K<0.01%new13F-HRTimeline
Capital Analysts, LLCin group Capital Analysts, LLC18$1K<0.01%013F-HR/ATimelineGroup
Ancora Advisors LLCin group Ancora Advisors LLC10$695<0.01%new13F-HRTimelineGroup
Cullen/Frost Bankers, Inc.in group Cullen/Frost Bankers, Inc.8$556<0.01%013F-HRTimelineGroup
Larson Financial Group LLC5$348<0.01%+213F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK2$139<0.01%013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC2$139<0.01%-4,48813F-HRTimelineGroup