13F-HR filed by RTW INVESTMENTS, LP
RTW INVESTMENTS, LP filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 91 holding rows worth $9,983,316,876.
- Accession
- 0001493215-26-000060
- Filer
- CIK 1493215
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 91 entries on the cover page, a total value of $9,983,316,876 stated on the cover page (in dollars after the unit check, H1), rows summing to $9,983,316,876 with VALUE read as dollars as filed, 13F file number 028-16670. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 1,993,687 | $1,161,003,688 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 4,842,879 | $842,854,661 | dollars as filed | |
| PTC THERAPEUTICS INC | 69366J200 | COM | 7,746,415 | $588,417,683 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 673,497 | $566,377,302 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 5,059,053 | $441,857,689 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 1,500,000 | $343,635,000 | dollars as filed | |
| RADNET INC | 750491102 | COM | 3,938,500 | $281,011,975 | dollars as filed | |
| TARSUS PHARMACEUTICALS INC | 87650L103 | COMMON STOCK | 3,335,320 | $273,096,002 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 7,592,241 | $269,676,400 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 866,499 | $269,403,204 | dollars as filed | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 1,181,990 | $209,732,306 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 2,712,097 | $204,709,082 | dollars as filed | |
| APELLIS PHARMACEUTICALS INC | 03753U106 | COM | 7,666,764 | $192,589,112 | dollars as filed | |
| ACADIA PHARMACEUTICALS INC | 004225108 | COM | 7,144,524 | $190,830,236 | dollars as filed | |
| ESTABLISHMENT LABS HOLDINGS | G31249108 | COMMON STOCK | 2,588,831 | $188,674,003 | dollars as filed | |
| STOKE THERAPEUTICS INC | 86150R107 | COM | 5,546,856 | $176,057,209 | dollars as filed | |
| REPLIGEN CORP COM | 759916109 | Stock | 1,064,000 | $174,347,040 | dollars as filed | |
| CYTOKINETICS INC | 23282W605 | COM NEW | 2,721,158 | $172,902,379 | dollars as filed | |
| IMMUNOCORE HLDGS PLC ADS | 45258D105 | ADR | 4,869,798 | $169,030,689 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 888,001 | $162,184,503 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 1,481,033 | $151,272,711 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 1,062,072 | $150,633,672 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 4,171,996 | $136,674,589 | dollars as filed | |
| ZAI LAB LTD ADR | 98887Q104 | ADR | 6,959,032 | $122,757,324 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 11,433,354 | $120,050,217 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 715,332 | $114,424,507 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 4,543,895 | $106,418,021 | dollars as filed | |
| XENCOR INC | 98401F105 | COMMON STOCK | 6,777,461 | $103,762,928 | dollars as filed | |
| INSULET CORP COM | 45784P101 | Stock | 324,600 | $92,264,304 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 16,398,297 | $90,190,634 | dollars as filed | |
| MASIMO CORP COM | 574795100 | Stock | 683,294 | $88,869,218 | dollars as filed | |
| UNIQURE NV | N90064101 | SHS | 3,711,462 | $88,815,286 | dollars as filed | |
| Stryker Corporation | 863667101 | COM | 245,000 | $86,110,150 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 2,012,127 | $83,543,513 | dollars as filed | |
| CASTLE BIOSCIENCES INC | 14843C105 | COMMON STOCK | 2,115,237 | $82,282,719 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 3,177,850 | $80,780,947 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 2,500,000 | $76,175,000 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 5,933,815 | $75,359,451 | dollars as filed | |
| REPLIMUNE GROUP INC | 76029N106 | COMMON STOCK | 7,140,352 | $69,404,221 | dollars as filed | |
| ULTRAGENYX PHARMACEUTICAL IN | 90400D108 | COM | 3,000,139 | $69,003,197 | dollars as filed | |
| CRINETICS PHARMACEUTICALS INC COM | 22663K107 | Stock | 1,351,326 | $62,904,225 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 2,058,148 | $62,382,466 | dollars as filed | |
| ROCKET PHARMACEUTICALS INC | 77313F106 | COM | 17,687,772 | $62,084,080 | dollars as filed | |
| COMPASS PATHWAYS PLC | 20451W101 | SPONSORED ADS | 8,757,390 | $60,425,991 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 101,228 | $57,331,490 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 1,637,165 | $55,450,779 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 550,160 | $54,872,958 | dollars as filed | |
| VERASTEM INC | 92337C203 | COMMON STOCK | 6,576,306 | $50,769,082 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 1,672,356 | $46,792,521 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 1,790,837 | $44,788,833 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 1,487,933 | $41,602,607 | dollars as filed | |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 6,250,000 | $40,375,000 | dollars as filed | |
| ARROWHEAD PHARMACEUTICALS IN | 04280A100 | COM | 584,716 | $38,819,295 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 5,952,380 | $35,892,851 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 8,306,063 | $34,470,161 | dollars as filed | |
| NEUROGENE INC | 64135M105 | COMMON STOCK | 1,362,456 | $28,066,594 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 1,350,000 | $22,950,000 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 1,449,273 | $22,362,282 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 1,283,671 | $21,976,448 | dollars as filed | |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 240,000 | $18,674,400 | dollars as filed | |
| FULGENT GENETICS INC | 359664109 | COM | 705,027 | $18,521,059 | dollars as filed | |
| CULLINAN THERAPEUTICS INC | 230031106 | COM | 1,705,960 | $17,656,686 | dollars as filed | |
| HINGE HEALTH INC A | 433313103 | COMMON STOCK | 353,500 | $16,420,075 | dollars as filed | |
| BEAM THERAPEUTICS INC | 07373V105 | COM | 570,394 | $15,811,322 | dollars as filed | |
| HEARTFLOW INC | 42238D107 | COM | 495,000 | $14,429,250 | dollars as filed | |
| COMPASS THERAPEUTICS INC | 20454B104 | COM | 2,500,000 | $13,425,000 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 1,491,228 | $13,212,280 | dollars as filed | |
| LUMEXA IMAGING HOLDINGS INC | 550249106 | COMMON STOCK | 650,000 | $12,025,000 | dollars as filed | |
| LARIMAR THERAPEUTICS INC | 517125100 | COM | 3,125,000 | $11,906,250 | dollars as filed | |
| TEMPUS AI INC CL A | 88023B103 | Stock | 200,000 | $11,810,000 | dollars as filed | |
| KALARIS THERAPEUTICS INC | 482929106 | COM | 1,300,000 | $10,972,000 | dollars as filed | |
| IQVIA HLDGS INC COM | 46266C105 | Stock | 46,000 | $10,368,860 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 742,500 | $9,674,775 | dollars as filed | |
| ATAIBECKLEY INC | N0731H103 | Equity | 2,000,000 | $8,180,000 | dollars as filed | |
| ALLURION TECHNOLOGIES INC COMMON STOCK | 02008G201 | Stock | 5,891,430 | $7,246,459 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 250,000 | $7,215,000 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 100,000 | $6,955,000 | dollars as filed | |
| INVENTIVA SA | 46124U107 | ADS | 1,298,701 | $6,038,960 | dollars as filed | |
| Milestone Pharmaceuticals Inc | 59935V107 | COM | 2,506,102 | $5,062,326 | dollars as filed | |
| EXAGEN INC | 30068X103 | COM | 790,462 | $4,806,009 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 378,346 | $4,612,038 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 372,856 | $4,422,072 | dollars as filed | |
| MIND MEDICINE MINDMED INC | 60255C885 | COM NEW | 300,000 | $4,017,000 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 475,737 | $3,568,028 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 447,607 | $3,446,574 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 200,000 | $3,156,000 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 70,000 | $2,940,000 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 30,000 | $2,382,300 | dollars as filed | |
| IMAGENEBIO INC | 45175G207 | CMN | 334,445 | $2,307,671 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 146,651 | $545,542 | dollars as filed | |
| Rocket Pharmaceuticals Inc W Exp 09/02/202 | 77313F114 | Warrant | 350,000 | $8,505 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001493215-26-000060 | this filing | 2026-02-17 | acceptance time not in the bulk data set |