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Disclosery

GPCR STRUCTURE THERAPEUTICS INC

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EQUITY (ADR), issuer CIK 1888886

153 managers (156 13F filers) reported a position in GPCR shares at 2025-09-30, 56,638,865 shares in all. 22 filers opened a position and 37 filers sold out during the quarter.

Managers
153
13F filers
156
New
22
Added
58
Reduced
48
Sold out
37
Shares held by filers
56,638,865

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…5,689,187$159M0.03%-1,186,58213F-HRTimelineGroup
FMR LLCin group FMR LLC5,250,368$147M0.01%+335,40313F-HRTimelineGroup
Avoro Capital Advisors LLC5,155,555$144M1.87%new13F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson4,448,826$125M0.06%-124,18013F-HRTimelineGroup
Deep Track Capital, LP4,215,811$118M3.29%-918,10613F-HRTimeline
BVF INC/ILin group BVF INC/IL3,203,917$89.7M3.64%+1,432,50013F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP1,556,109$43.6M0.31%-952,65813F-HRTimelineGroup
Casdin Capital, LLC1,555,000$43.5M3.63%+330,00013F-HRTimeline
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,517,418$42.5M0.52%013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC1,274,551$35.7M0.03%+54,49613F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC1,224,144$34.3M0.01%-364,05413F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC1,139,300$31.9M0.77%-60,00013F-HRTimelineGroup
TCG Crossover Management, LLC1,063,000$29.8M1.46%013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.1,026,811$28.8M1.12%new13F-HRTimelineGroup
Rock Springs Capital Management LP951,154$26.6M1.56%-184,72513F-HRTimeline
Driehaus Capital Management LLC873,504$24.5M0.18%+200,71213F-HRTimeline
Logos Global Management LP850,000$23.8M2.35%013F-HRTimeline
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC787,484$22M0.01%-65,71813F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources745,734$20.9M0.01%+3,95113F-HRTimelineGroup
Pacific Heights Asset Management LLC700,000$19.6M0.87%+240,00013F-HRTimeline
Catalio Capital Management, LP651,810$18.3M3.37%-18,76513F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc586,869$16.4M0.03%+185,24513F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY577,741$16.2M<0.01%-339,60513F-HR/ATimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC504,396$14.1M<0.01%+284,22213F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC486,786$13.6M0.01%-4,40713F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management461,553$12.9M0.03%new13F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC443,800$12.4M0.01%-884,67913F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.443,737$12.4M<0.01%+19,18913F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPgroup of 2 filers holding432,210$12.1M+396,110Timeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.407,700$11.4M0.02%+77,70013F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…373,407$10.5M0.16%013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …372,869$10.4M0.31%new13F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding369,167$10.3M+113,688Timeline
Nantahala Capital Management, LLCin group Nantahala Capital Management,…368,553$10.3M0.64%+200,00013F-HRTimelineGroup
ArrowMark Colorado Holdings LLC323,166$9.05M0.17%+24,22913F-HRTimeline
Bellevue Group AGin group Bellevue Group AG315,857$8.84M0.18%-32,67013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/289,393$8.1M<0.01%-63,47513F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.263,938$7.39M<0.01%+20,60413F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.244,848$6.86M0.02%new13F-HRTimelineGroup
READYSTATE ASSET MANAGEMENT LP237,188$6.64M0.32%+58,57613F-HRTimeline
HighVista Strategies LLC236,236$6.61M1.62%+149,61513F-HRTimeline
SECTORAL ASSET MANAGEMENT INC221,872$6.21M3.83%+170,50313F-HRTimeline
UBS Group AGgroup of 2 filers holding208,092$5.83M+50,941Timeline
Monashee Investment Management LLC200,000$5.6M2.79%-230,00013F-HRTimeline
Pier Capital, LLC197,509$5.53M0.86%-96913F-HRTimeline
First Light Asset Management, LLC197,350$5.53M0.52%+75,12413F-HRTimeline
Rhenman & Partners Asset Management AB180,100$5.04M0.56%+45,00013F-HRTimeline
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.173,931$4.87M1.16%+78,00013F-HRTimelineGroup
Jefferies Financial Group Inc.in group Jefferies Financial Group Inc.170,345$4.77M0.04%new13F-HRTimelineGroup
Handelsbanken Fonder AB168,000$4.7M0.01%-212,00013F-HRTimeline
Eversept Partners, LP166,391$4.66M0.36%+67,05313F-HRTimeline
HSG Holding Ltdin group HSG Holding Ltd266,062$4.61M0.24%013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Ikarian Capital, LLCin group Ikarian Capital, LLC163,237$4.57M0.92%-19,84813F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC153,900$4.31M0.01%+42,00013F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/144,000$4.03M<0.01%+143,80013F-HRTimelineGroup
STEMPOINT CAPITAL LP129,335$3.62M0.73%new13F-HRTimeline
PLATINUM INVESTMENT MANAGEMENT LTD122,758$3.44M0.22%+47,85813F-HRTimeline
Point72 Europe (London) LLP116,697$3.27M0.18%013F-HRTimeline
PFM Health Sciences, LP115,073$3.22M0.27%+58,47913F-HRTimeline
Octagon Capital Advisors LP115,000$3.22M0.5%new13F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC106,400$2.98M0.04%+43,16613F-HR/ATimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS90,431$2.53M<0.01%+24,59513F-HRTimelineGroup
Birchview Capital, LP78,000$2.18M1.65%+42,00013F-HRTimeline
Woodline Partners LP65,440$1.83M0.01%-111,01313F-HRTimeline
BANQUE PICTET & CIE SA64,185$1.8M0.02%-6,21613F-HRTimeline
BANK OF MONTREAL /CAN/in group BANK OF MONTREAL /CAN/60,722$1.7M<0.01%+2,64913F-HRTimelineGroup
DAFNA Capital Management LLC59,000$1.65M0.41%013F-HRTimeline
EXCHANGE TRADED CONCEPTS, LLC58,222$1.63M0.02%-3,51013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO58,148$1.63M<0.01%+15,70613F-HR/ATimelineGroup
MACQUARIE GROUP LTDin group MACQUARIE GROUP LTD58,000$1.62M<0.01%013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC57,958$1.62M<0.01%+3,77713F-HRTimelineGroup
Caption Management, LLC56,682$1.59M0.09%+28,50813F-HRTimeline
Private Capital Advisors, Inc.55,185$1.55M0.17%new13F-HRTimeline
STATE STREET CORPin group STATE STREET CORP46,017$1.29M<0.01%+12,55813F-HRTimelineGroup
Mariner, LLCin group Mariner, LLC44,136$1.24M<0.01%+4,63513F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.62,839$1.23M<0.01%-52313F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC43,674$1.22M0.03%-13,94813F-HRTimeline
Quinn Opportunity Partners LLC42,000$1.18M0.09%013F-HRTimeline
SG Americas Securities, LLC39,700$1.11M<0.01%+20,46113F-HRTimeline
Verition Fund Management LLC39,349$1.1M0.01%-33,63513F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.36,346$1.02M<0.01%+24,18113F-HRTimelineGroup
TD Asset Management Inc36,086$1.01M<0.01%-7,60013F-HRTimeline
TrueMark Investments, LLCin group TrueMark Investments, LLC34,861$976K0.17%-2,90413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.29,559$828K<0.01%+7,06013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …28,532$799K<0.01%-12,25713F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC27,958$783K<0.01%-3,11513F-HRTimelineGroup
Headlands Technologies LLC26,814$751K0.06%+4,47613F-HRTimeline
NOMURA ASSET MANAGEMENT CO LTDin group NOMURA ASSET MANAGEMENT CO LTD25,856$724K<0.01%+98213F-HRTimelineGroup
SIMPLEX TRADING, LLC25,161$704K0.02%+2,06713F-HRTimeline
LPL Financial LLC23,003$644K<0.01%+11,40413F-HRTimeline
Trexquant Investment LP20,192$565K0.01%-61,39613F-HRTimeline
Bleichroeder LP20,000$560K0.11%+10,00013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC16,425$460K<0.01%-14,23013F-HRTimelineGroup
Cubist Systematic Strategies, LLC16,312$457K0.01%-55,37813F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …15,714$440K<0.01%+3,80013F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC15,200$426K0.04%+20013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/13,779$386K<0.01%-12913F-HR/ATimelineGroup
Janney Capital Management LLC13,718$384K0.02%new13F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS12,888$361K<0.01%+2,25313F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC12,220$342K<0.01%+1,54413F-HRTimelineGroup
BRANDYWINE MANAGERS, LLCin group BRANDYWINE MANAGERS, LLC11,057$310K0.3%013F-HRTimelineGroup
PEAK6 LLCin group PEAK6 LLC11,000$308K0.01%+1,55513F-HR/ATimelineGroup
TEACHERS RETIREMENT SYSTEM OF THE STATE…10,751$301K<0.01%-6,90013F-HRTimeline
China Universal Asset Management Co., L…10,444$292K0.02%-1,52313F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA10,293$288K<0.01%+2,71113F-HRTimelineGroup
CCG WEALTH MANAGEMENT, LLC10,000$280K0.13%-140,00013F-HRTimeline
GSA CAPITAL PARTNERS LLP9,886$277K0.02%new13F-HRTimeline
Engineers Gate Manager LP9,593$269K<0.01%-6,26913F-HRTimeline
MISSION WEALTH MANAGEMENT, LP9,583$268K0.01%new13F-HRTimeline
HighTower Advisors, LLC9,000$252K<0.01%new13F-HRTimeline
Parallel Advisors, LLC8,264$231K<0.01%013F-HRTimeline
SIGNATUREFD, LLC6,650$186K<0.01%013F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN6,058$170K<0.01%-1,16513F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…5,121$143K0.04%+88913F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…4,828$135K<0.01%+41313F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.4,500$126K<0.01%-463,80013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC4,490$126K<0.01%-34,18313F-HRTimelineGroup
ANTIPODES PARTNERS Ltd4,078$114K<0.01%+1,14613F-HRTimeline
Mirae Asset Global Investments Co., Ltd.in group Mirae Asset Global Investment…4,056$114K<0.01%-6413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC3,773$106K<0.01%-2,55513F-HR/ATimelineGroup
Steward Partners Investment Advisory, L…2,640$73.9K<0.01%013F-HRTimeline
ASSETMARK, INCin group ASSETMARK, INC2,384$66.8K<0.01%-49313F-HRTimelineGroup
FNY Investment Advisers, LLC1,700$47K0.02%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC1,456$40.8K<0.01%-14413F-HRTimelineGroup
State of Wyoming1,358$38K<0.01%+2813F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,278$35.8K<0.01%-24713F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…1,071$30K<0.01%+90113F-HRTimelineGroup
GROUP ONE TRADING LLC986$27.6K<0.01%-7,07913F-HRTimeline
GAMMA Investing LLC818$22.9K<0.01%+33713F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…742$20.8K<0.01%new13F-HRTimelineGroup
Farther Finance Advisors, LLC670$18.8K<0.01%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc612$17.1K<0.01%new13F-HRTimelineGroup
Dynamic Wealth Strategies, LLC550$15.4K0.01%013F-HRTimeline
HARBOUR INVESTMENTS, INC.500$14K<0.01%new13F-HRTimeline
COUNTRY TRUST BANK500$14K<0.01%013F-HRTimeline
HighMark Wealth Management LLC418$11.7K0.01%new13F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…394$11K<0.01%-50413F-HRTimelineGroup
CWM, LLCin group CWM, LLC355$10K<0.01%013F-HRTimelineGroup
North Star Investment Management Corp.330$9.24K<0.01%013F-HRTimeline
WOLFF WIESE MAGANA LLC286$8.01K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.226$6K<0.01%013F-HRTimelineGroup
Private Wealth Management Group, LLC196$5.49K<0.01%013F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP187$4.67K<0.01%-58013F-HRTimelineGroup
Advisory Services Network, LLC110$3.08K<0.01%new13F-HRTimeline
Ameritas Advisory Services, LLCin group Ameritas Investment Partners,…100$2.8K<0.01%013F-HRTimelineGroup
Washington Trust Advisors, Inc.41$1.15K<0.01%013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC29$1K<0.01%new13F-HRTimelineGroup
Capital Analysts, LLCin group Capital Analysts, LLC18$1K<0.01%new13F-HRTimelineGroup
Global Retirement Partners, LLC10$280<0.01%013F-HRTimeline
Cullen/Frost Bankers, Inc.in group Cullen/Frost Bankers, Inc.8$224<0.01%013F-HRTimelineGroup
Larson Financial Group LLC3$84<0.01%new13F-HRTimeline
HUNTINGTON NATIONAL BANKin group HUNTINGTON NATIONAL BANK2$56<0.01%013F-HRTimelineGroup
Point72 Asia (Singapore) Pte. Ltd.1$28<0.01%013F-HRTimeline