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Disclosery

13F-HR filed by Sio Capital Management, LLC

Sio Capital Management, LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 68 holding rows worth $635,740,442.

Accession
0001214659-26-001854
Filer
CIK 1482416
Filed
2026-02-17
Accepted by EDGAR
acceptance time not in the bulk data set
Ingested
Source
SEC quarterly data set

Original filing

13F report for Q4 2025

A holdings report, 68 entries on the cover page, a total value of $635,740,442 stated on the cover page (in dollars after the unit check, H1), rows summing to $635,740,442 with VALUE read as dollars as filed, 13F file number 028-13691. The quarter's positions are built on this report. The resolved quarter.

The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).

Issuer as filedCUSIPClassAmountValueValue read asType
CELCUITY INC15102K100COM477,067$47,582,663dollars as filed
Cigna Corporation125523100COM172,203$47,395,432dollars as filed
SANOFI SA SPONSORED ADR80105N105ADR971,686$47,087,904dollars as filed
MAXIMUS INC577933104COM500,304$43,186,241dollars as filed
ZIMMER BIOMET HOLDINGS INC COM98956P102Stock385,642$34,676,929dollars as filed
RHYTHM PHARMACEUTICALS INC76243J105COM265,700$28,440,528dollars as filedput
KENVUE INC49177J102COM1,465,442$25,278,875dollars as filed
ORGANON & CO COMMON STOCK68622V106Stock3,421,765$24,534,055dollars as filed
ICON PUB LTD CO SHSG4705A100Stock127,202$23,178,748dollars as filed
WAYSTAR HLDG CORP946784105COM613,725$20,099,494dollars as filed
LIVANOVA PLCG5509L101SHS322,382$19,836,164dollars as filed
DIANTHUS THERAPEUTICS INC252828108COM474,503$19,554,269dollars as filed
BIOHAVEN LTDG1110E107COM1,244,764$14,053,386dollars as filed
STRUCTURE THERAPEUTICS INC COMP86366E106EQUITY201,500$14,014,325dollars as filed
BIOMARIN PHARMACEUTICAL INC09061G101COM232,688$13,828,648dollars as filed
TYRA BIOSCIENCES INC90240B106COMMON STOCK526,002$13,828,593dollars as filed
BRIGHTSPRING HEALTH SVCS10950A106COM308,010$11,534,975dollars as filed
CENTENE CORP DEL COM15135B101Stock274,350$11,289,503dollars as filed
CHARLES RIV LABS INTL INC159864107COM54,985$10,968,408dollars as filed
TELEFLEX INCORPORATED879369106COM86,876$10,602,347dollars as filed
ANTERIS TECHNOLOGIES GLOBAL03675P102COMMON STOCK1,874,641$9,354,459dollars as filed
PROTARA THERAPEUTICS INC74365U107COM STK1,715,394$9,143,050dollars as filed
CROSS CTRY HEALTHCARE INC227483104COM1,068,821$8,657,450dollars as filed
HAEMONETICS CORP MASS COM405024100Stock92,631$7,424,375dollars as filed
ANI PHARMACEUTICALS INC00182C103COM87,272$6,889,252dollars as filed
AQUESTIVE THERAPEUTICS INC COM03843E104Stock993,095$6,415,394dollars as filed
BRIGHT MINDS BIOSCIENCES INC10919W405COMMON STOCK81,883$6,390,149dollars as filed
EDGEWISE THERAPEUTICS INC28036F105COM237,481$5,893,091dollars as filed
ABIVAX SA-00370M103SPONSORED ADS43,124$5,815,487dollars as filed
CRINETICS PHARMACEUTICALS INC COM22663K107Stock124,841$5,811,349dollars as filed
RAPPORT THERAPEUTICS INC COM75383L102Stock185,265$5,620,940dollars as filed
CENCORA INC COM03073E105Stock15,900$5,370,225dollars as filed
MCKESSON CORP COM58155Q103Stock6,400$5,249,856dollars as filed
DISC MEDICINE INC COM254604101Stock57,586$4,572,904dollars as filed
PROQR THERAPEUTICS NVN71542109SHS EURO2,164,181$4,371,646dollars as filed
FULCRUM THERAPEUTICS INC359616109COMMON STOCK382,000$4,320,420dollars as filed
SAVARA INC805111101COM613,888$3,701,745dollars as filed
ORUKA THERAPEUTICS INC COM687604108Stock118,126$3,580,399dollars as filed
Ventyx Biosciences Inc92332V107Common Stock387,751$3,501,392dollars as filed
PMV PHARMACEUTICALS INC69353Y103COM2,636,548$3,295,685dollars as filed
SHOULDER INNOVATIONS INC82537J108COMMON STOCK227,971$3,259,985dollars as filed
ALIGOS THERAPEUTICS INC01626L204COM NEW335,937$3,130,933dollars as filed
VIR BIOTECHNOLOGY INC92764N102COM478,343$2,884,408dollars as filed
ALKERMES PLCG01767105SHS95,353$2,667,977dollars as filed
IDEAYA BIOSCIENCES INC COM45166A102Stock75,730$2,617,986dollars as filed
KYMERA THERAPEUTICS INC501575104COM32,235$2,508,205dollars as filed
Elicio Therapeutics Inc Com28657F103LST Equity Option296,900$2,363,324dollars as filedput
OVID THERAPEUTICS INC690469101COMMON STOCK1,427,495$2,326,817dollars as filed
CONTEXT THERAPEUTICS INC21077P108COM1,341,636$1,972,205dollars as filed
HYPERFINE INC44916K106Common Stock2,000,000$1,958,600dollars as filed
OUTLOOK THERAPEUTICS INC69012T305COM1,125,400$1,778,132dollars as filedput
BRIDGEBIO ONCOLOGY THERAPEUT107924102COM NEW130,628$1,635,463dollars as filed
IBIO INC451033708CMN740,000$1,428,200dollars as filed
Xilio Therapeutics Inc.98422T100COM2,134,537$1,366,531dollars as filed
Adagio Med Hldgs Inc Com00534B100Common Stock1,288,461$1,339,999dollars as filed
AVALO THERAPEUTICS INC05338F306COMMON STOCK72,173$1,310,662dollars as filed
NEUROONE MED TECHNOLOGIES CORP COM64130M209Stock1,140,040$864,150dollars as filed
TELA BIO INC872381108COM636,300$750,834dollars as filed
FOGHORN THERAPEUTICS INC344174107COMMON STOCK122,889$663,601dollars as filed
SENSEONICS HOLDINGS INC81727U303COMMON STOCK115,784$639,128dollars as filed
ENANTA PHARMACEUTICALS INC29251M106COM40,000$630,800dollars as filed
TERNS PHARMACEUTICALS INC COM880881107Stock10,100$408,040dollars as filed
MODULAR MED INC60785L207COM NEW785,824$286,119dollars as filed
NYXOAH S AB6S7WD106SHS50,839$233,859dollars as filed
BOUNDLESS BIO INC10170A100COM163,679$196,415dollars as filed
NEXTCURE INC65343E207COM NEW10,940$155,239dollars as filed
Rocket Pharmaceuticals Inc W Exp 09/02/20277313F114Warrant400,000$7,200dollars as filed
Humacyte Inc W Exp 08/27/20244486Q111SPAC Combination49,998$4,875dollars as filed

Amendment chain

FilingRoleFiledAcceptedIngested
13F-HR 0001214659-26-001854this filing2026-02-17acceptance time not in the bulk data set