Sio Capital Management, LLC
Follow13F filer, CIK 1482416, NEW YORK, NY
Sio Capital Management, LLC reported $604,294,540 across 59 holdings for the quarter ended 2026-06-30, in a 13F-HR filed 2026-08-14. Its ten largest share positions make up 50.15% of the portfolio.
Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001214659-26-010311
- Period
- 2026-06-30
- Reported value
- $604M
- Holdings
- 59
- Top 10 weight
- 50.15%
- New
- 17
- Sold out
- 34
Largest buys vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| ALLOnew | +13,323,431 | $27.7M |
| GMEDnew | +301,816 | $23.8M |
| CORadded | +72,694 | $20.6M |
| IDYAnew | +480,383 | $17.9M |
| CInew | +57,750 | $15.9M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Largest sells vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| ICLRreduced | -218,172 | -$37.9M |
| DNTHreduced | -310,791 | -$30.3M |
| CORTexited | -674,759 | -$27.2M |
| LIVNexited | -421,615 | -$26.8M |
| EMBCexited | -1,847,850 | -$16.3M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Holdings, Q2 2026
Share positions as resolved from 13F-HR 0001214659-26-010311, largest first. % of portfolio is the value over $583,529,158, the sum of the share positions whose value is usable for ratios (method).
| Security | History | Shares | Value | % of portfolio | Change | Latest event | Timeline |
|---|---|---|---|---|---|---|---|
| AVRANTERIS TECHNOLOGIES GLOBAL | 5,545,984 | $54.6M | 9.36% | +163,019 | Timeline | ||
| CORCENCORA INC | 173,588 | $49.1M | 8.42% | +72,694 | Timeline | ||
| MMSMAXIMUS INC | 715,267 | $38.5M | 6.59% | -53,558 | Timeline | ||
| ALLOALLOGENE THERAPEUTICS INC | 13,323,431 | $27.7M | 4.75% | new | Timeline | ||
| GMEDGLOBUS MED INC | 301,816 | $23.8M | 4.09% | new | Timeline | ||
| GSKGSK PLC | 436,700 | $22.9M | 3.92% | +50,821 | Timeline | ||
| TYRATYRA BIOSCIENCES INC | 695,315 | $22.2M | 3.81% | +89,876 | Timeline | ||
| WAYWAYSTAR HLDG CORP | 925,834 | $19M | 3.26% | -716,402 | Timeline | ||
| IDYAIDEAYA BIOSCIENCES INC | 480,383 | $17.9M | 3.07% | new | Timeline | ||
| ORKAORUKA THERAPEUTICS INC | 177,118 | $16.9M | 2.89% | +44,622 | Timeline | ||
| CITHE CIGNA GROUP | 57,750 | $15.9M | 2.73% | new | Timeline | ||
| SNYSANOFI SA | 364,200 | $15.5M | 2.66% | +124,529 | Timeline | ||
| ICLRICON PUB LTD CO | 88,186 | $15.3M | 2.63% | -218,172 | Timeline | ||
| VTRSVIATRIS INC | 954,299 | $15.2M | 2.6% | new | Timeline | ||
| CCRNCROSS CTRY HEALTHCARE INC | 1,098,393 | $14.5M | 2.49% | 0 | Timeline | ||
| RAPPRAPPORT THERAPEUTICS INC | 307,657 | $12.8M | 2.2% | -59,152 | Timeline | ||
| ABTABBOTT LABORATORIES | 128,656 | $11.7M | 2% | -57,918 | Timeline | ||
| CELCCELCUITY INC | 110,022 | $11.5M | 1.97% | -83,821 | Timeline | ||
| ZBHZIMMER BIOMET HOLDINGS INC | 131,445 | $11.3M | 1.94% | +68,832 | Timeline | ||
| REGNREGENERON PHARMACEUTICALS | 18,000 | $11.2M | 1.92% | new | Timeline | ||
| BMYBRISTOL-MYERS SQUIBB CO | 193,500 | $11.1M | 1.91% | new | Timeline | ||
| MDTMEDTRONIC PLC | 142,500 | $11.1M | 1.91% | new | Timeline | ||
| VIRVIR BIOTECHNOLOGY INC | 1,075,274 | $11M | 1.88% | -423,346 | Timeline | ||
| SENSSENSEONICS HLDGS INC | 1,592,692 | $9.05M | 1.55% | +1,476,908 | Timeline | ||
| EYPTEYEPOINT INC | 623,130 | $8.91M | 1.53% | -98,655 | Timeline | ||
| HELPCYBIN INC | 1,300,000 | $8.59M | 1.47% | new | Timeline | ||
| ANIPANI PHARMACEUTICALS INC | 97,305 | $8.05M | 1.38% | -168,238 | Timeline | ||
| TARAPROTARA THERAPEUTICS INC | 1,921,872 | $7.34M | 1.26% | -47,967 | Timeline | ||
| RLMDRELMADA THERAPEUTICS INC | 1,003,562 | $6.94M | 1.19% | +38,562 | Timeline | ||
| TNGXTANGO THERAPEUTICS INC | 208,500 | $6.52M | 1.12% | new | Timeline | ||
| AQSTAQUESTIVE THERAPEUTICS INC | 1,486,175 | $6.18M | 1.06% | -436,712 | Timeline | ||
| DNTHDIANTHUS THERAPEUTICS INC | 59,254 | $5.78M | 0.99% | -310,791 | Timeline | ||
| SIONSIONNA THERAPEUTICS INC | 127,808 | $5.62M | 0.96% | -166,532 | Timeline | ||
| OCULOCULAR THERAPEUTIX INC | 539,493 | $5.3M | 0.91% | -429,104 | Timeline | ||
| ZBIOZENAS BIOPHARMA INC | 208,557 | $5.29M | 0.91% | -123,173 | Timeline | ||
| DRUGBRIGHT MINDS BIOSCIENCES INC | 73,952 | $5.19M | 0.89% | -12,131 | Timeline | ||
| OKURONKURE THERAPEUTICS INC | 1,078,965 | $4.92M | 0.84% | 0 | Timeline | ||
| SVRASAVARA INC | 617,675 | $3.8M | 0.65% | +3,787 | Timeline | ||
| PMVPPMV PHARMACEUTICALS INC | 2,634,137 | $3.53M | 0.6% | -442,443 | Timeline | ||
| AVAHAVEANNA HEALTHCARE HLDGS INC | 369,036 | $3.16M | 0.54% | new | Timeline | ||
| OVIDOVID THERAPEUTICS INC | 1,005,334 | $2.7M | 0.46% | -247,047 | Timeline | ||
| IMNMIMMUNOME INC | 124,168 | $2.63M | 0.45% | -40,942 | Timeline | ||
| ANTXAN2 THERAPEUTICS INC | 529,933 | $2.56M | 0.44% | -127,267 | Timeline | ||
| SERSERINA THERAPEUTICS INC | 1,000,000 | $1.94M | 0.33% | 0 | Timeline | ||
| ALGSALIGOS THERAPEUTICS INC | 327,237 | $1.89M | 0.32% | 0 | Timeline | ||
| IBIOIBIO INC | 904,268 | $1.58M | 0.27% | 0 | Timeline | ||
| XLOXILIO THERAPEUTICS INC | 152,464 | $1.46M | 0.25% | 0 | Timeline | ||
| AORTARTIVION INC | 48,481 | $1.09M | 0.19% | new | Timeline | ||
| BBOTBRIDGEBIO ONCOLOGY THERAPEUT | 130,628 | $995K | 0.17% | 0 | Timeline | ||
| TELATELA BIO INC | 636,300 | $477K | 0.08% | 0 | Timeline | ||
| ADGMADAGIO MED HLDGS INC | 698,989 | $455K | 0.08% | -589,472 | Timeline | ||
| NMTCNEUROONE MED TECHNOLOGIES CO | 82,767 | $252K | 0.04% | new | Timeline | ||
| ENVBENVERIC BIOSCIENCES INC | 180,000 | $248K | 0.04% | new | Timeline | ||
| MODDMODULAR MED INC | 26,190 | $118K | 0.02% | 0 | Timeline | ||
| QTIQT IMAGING HLDGS INC | 15,236 | $62K | 0.01% | new | Timeline | ||
| RCKTWROCKET PHARMACEUTICALS INC | 400,000 | $1.48K | <0.01% | 0 | Timeline | ||
| HUMAWHUMACYTE INC | 49,998 | $477 | <0.01% | 0 | Timeline |
Options
Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).
Sold out in Q2 2026
Positions in the previous quarter's report that this quarter's report no longer lists.
| Security | Shares before | Value before | Type |
|---|---|---|---|
| CORTCORCEPT THERAPEUTICS INC | 674,759 | $27.2M | shares |
| LIVNLIVANOVA PLC | 421,615 | $26.8M | shares |
| EMBCEMBECTA CORP | 1,847,850 | $16.3M | shares |
| ABVXABIVAX SA | 135,800 | $15.1M | shares |
| HAEHAEMONETICS CORP MASS | 220,672 | $12.4M | shares |
| TFXTELEFLEX INCORPORATED | 94,800 | $11.3M | shares |
| BMRNBIOMARIN PHARMACEUTICAL INC | 194,226 | $11M | shares |
| GPCRSTRUCTURE THERAPEUTICS INC | 209,093 | $10.1M | shares |
| BHVNBIOHAVEN LTD | 1,163,926 | $9.85M | shares |
| MNPRMONOPAR THERAPEUTICS INC | 173,506 | $9.51M | shares |
| CRNXCRINETICS PHARMACEUTICALS IN | 249,887 | $9.08M | shares |
| EWTXEDGEWISE THERAPEUTICS INC | 268,986 | $8.47M | shares |
| CMPSCOMPASS PATHWAYS PLC | 1,506,525 | $8.33M | shares |
| QDELQUIDELORTHO CORP | 359,011 | $5.9M | shares |
| REPLREPLIMUNE GROUP INC | 720,036 | $5.51M | shares |
| OGNORGANON & CO | 865,908 | $5.19M | shares |
| IRONDISC MEDICINE INC | 65,203 | $4.17M | shares |
| IARTINTEGRA LIFESCIENCES HLDGS C | 383,140 | $3.61M | shares |
| CNCCENTENE CORP DEL | 100,000 | $3.27M | put |
| PRQRPROQR THRAPEUTICS N V | 1,954,715 | $3.17M | shares |
| SISHOULDER INNOVATIONS INC | 210,641 | $3.06M | shares |
| KYMRKYMERA THERAPEUTICS INC | 32,235 | $2.68M | shares |
| CNTXCONTEXT THERAPEUTICS INC | 917,922 | $2.4M | shares |
| HYPRHYPERFINE INC | 1,000,000 | $1.08M | shares |
| FHTXFOGHORN THERAPEUTICS INC | 122,889 | $587K | shares |
| TERNTERNS PHARMACEUTICALS INC | 10,100 | $532K | shares |
| ENTAENANTA PHARMACEUTICALS INC | 40,000 | $505K | shares |
| NMTCNEUROONE MED TECHNOLOGIES CO | 496,614 | $386K | shares |
| BOLDBOUNDLESS BIO INC | 163,679 | $180K | shares |
| NYXHNYXOAH S A | 50,839 | $148K | shares |
| ELTXELICIO THERAPEUTICS INC | 11,700 | $125K | put |
| ERASERASCA INC | 5,000 | $80.9K | shares |
| OSCROSCAR HEALTH INC | 3,000 | $34.4K | put |
| SLPSIMULATIONS PLUS INC | 200 | $2.36K | shares |
How Q2 2026 was built
Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).
| Filing | Role | Amendment | Filed | Accepted | Ingested |
|---|---|---|---|---|---|
| 13F-HR 0001214659-26-010311 | base | 2026-08-14 | acceptance time not in the bulk data set |
Filings
Every filing of this filer: 13F reports and notices, the 13D and 13G it filed or is a reporting person of, and Forms 3, 4 and 5 it reported as an owner.
| Filing | Subject | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001214659-26-010311 | Quarter ended 2026-06-30 | 2026-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-26-006200 | Quarter ended 2026-03-31 | 2026-05-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-26-001854 | Quarter ended 2025-12-31 | 2026-02-17 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-25-016415 | Quarter ended 2025-09-30 | 2025-11-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-25-011950 | Quarter ended 2025-06-30 | 2025-08-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-25-007756 | Quarter ended 2025-03-31 | 2025-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-25-002716 | Quarter ended 2024-12-31 | 2025-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-24-019074 | Quarter ended 2024-09-30 | 2024-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-24-014597 | Quarter ended 2024-06-30 | 2024-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-24-009242 | Quarter ended 2024-03-31 | 2024-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-24-002438 | Quarter ended 2023-12-31 | 2024-02-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-23-014980 | Quarter ended 2023-09-30 | 2023-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-23-011184 | Quarter ended 2023-06-30 | 2023-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-23-006952 | Quarter ended 2023-03-31 | 2023-05-12 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-23-002122 | Quarter ended 2022-12-31 | 2023-02-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-22-013603 | Quarter ended 2022-09-30 | 2022-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-22-010095 | Quarter ended 2022-06-30 | 2022-08-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-22-006910 | Quarter ended 2022-03-31 | 2022-05-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-22-002510 | Quarter ended 2021-12-31 | 2022-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-21-011737 | Quarter ended 2021-09-30 | 2021-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-21-008651 | Quarter ended 2021-06-30 | 2021-08-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-21-005410 | Quarter ended 2021-03-31 | 2021-05-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-21-001839 | Quarter ended 2020-12-31 | 2021-02-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-20-009535 | Quarter ended 2020-09-30 | 2020-11-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-20-007110 | Quarter ended 2020-06-30 | 2020-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-20-004674 | Quarter ended 2020-03-31 | 2020-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-20-001473 | Quarter ended 2019-12-31 | 2020-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-19-007195 | Quarter ended 2019-09-30 | 2019-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-19-005264 | Quarter ended 2019-06-30 | 2019-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-19-003585 | Quarter ended 2019-03-31 | 2019-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-19-001188 | Quarter ended 2018-12-31 | 2019-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-18-007149 | Quarter ended 2018-09-30 | 2018-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-18-005505 | Quarter ended 2018-06-30 | 2018-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-18-003771 | Quarter ended 2018-03-31 | 2018-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-18-001260 | Quarter ended 2017-12-31 | 2018-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-17-006698 | Quarter ended 2017-09-30 | 2017-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-17-005075 | Quarter ended 2017-06-30 | 2017-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-17-003383 | Quarter ended 2017-03-31 | 2017-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-17-001124 | Quarter ended 2016-12-31 | 2017-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-16-014679 | Quarter ended 2016-09-30 | 2016-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-16-013259 | Quarter ended 2016-06-30 | 2016-08-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-16-011622 | Quarter ended 2016-03-31 | 2016-05-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-16-009594 | Quarter ended 2015-12-31 | 2016-02-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-15-007746 | Quarter ended 2015-09-30 | 2015-11-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-15-006081 | Quarter ended 2015-06-30 | 2015-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-15-004036 | Quarter ended 2015-03-31 | 2015-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001214659-15-001432 | Quarter ended 2014-12-31 | 2015-02-17 | acceptance time not in the bulk data set |