13F-HR filed by Soleus Capital Management, L.P.
Soleus Capital Management, L.P. filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-12, with 95 holding rows worth $2,710,906,126.
- Accession
- 0001802630-26-000002
- Filer
- CIK 1802630
- Filed
- 2026-02-12
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 95 entries on the cover page, a total value of $2,710,906,126 stated on the cover page (in dollars after the unit check, H1), rows summing to $2,710,906,126 with VALUE read as dollars as filed, 13F file number 028-20043. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| SPDR SER TR | 78464A870 | S&P BIOTECH | 2,900,000 | $353,597,000 | dollars as filed | put |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 941,059 | $232,008,686 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 1,808,258 | $180,355,653 | dollars as filed | |
| NOVOCURE LTD | G6674U108 | ORD SHS | 8,530,665 | $110,301,498 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 362,966 | $106,980,599 | dollars as filed | |
| TG THERAPEUTICS INC COM | 88322Q108 | Stock | 3,139,312 | $93,582,891 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 1,297,094 | $86,088,129 | dollars as filed | |
| BIOMARIN PHARMACEUTICAL INC | 09061G101 | COM | 1,320,000 | $78,447,600 | dollars as filed | |
| GLOBUS MED INC CL A | 379577208 | Stock | 887,000 | $77,443,970 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 2,534,565 | $77,228,196 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 5,207,284 | $74,151,724 | dollars as filed | |
| TWIST BIOSCIENCE CORP | 90184D100 | COM | 1,861,802 | $59,056,359 | dollars as filed | |
| ORGANOGENESIS HOLDINGS INC | 68621F102 | COMMON STOCK | 9,985,951 | $51,727,226 | dollars as filed | |
| SYNDAX PHARMACEUTICALS INC | 87164F105 | COM | 2,247,110 | $47,211,781 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 573,614 | $45,309,770 | dollars as filed | |
| INSULET CORP COM | 45784P101 | Stock | 150,000 | $42,636,000 | dollars as filed | |
| NEUROPACE INC | 641288105 | COMMON STOCK | 2,703,208 | $41,737,532 | dollars as filed | |
| AXOGEN INC | 05463X106 | COM | 1,206,855 | $39,500,364 | dollars as filed | |
| ANI PHARMACEUTICALS INC | 00182C103 | COM | 486,243 | $38,384,022 | dollars as filed | |
| ALKERMES PLC | G01767105 | SHS | 1,322,364 | $36,999,745 | dollars as filed | |
| LIVANOVA PLC | G5509L101 | SHS | 567,500 | $34,918,275 | dollars as filed | |
| GSK PLC SPONSORED ADR | 37733W204 | ADR | 639,000 | $31,336,560 | dollars as filed | |
| GERON CORP | 374163103 | COM | 23,290,000 | $30,742,800 | dollars as filed | |
| UNITED THERAPEUTICS CORP DEL COM | 91307C102 | Stock | 60,000 | $29,235,000 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 1,110,000 | $28,216,200 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 608,958 | $28,097,322 | dollars as filed | |
| ALNYLAM PHARMACEUTICALS INC COM | 02043Q107 | Stock | 70,000 | $27,835,500 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 299,399 | $27,613,570 | dollars as filed | |
| VERICEL CORP | 92346J108 | COM | 764,000 | $27,511,640 | dollars as filed | |
| ARGENX SE SPONSORED ADR | 04016X101 | ADR | 31,726 | $26,679,980 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 764,000 | $25,876,680 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 175,982 | $24,959,527 | dollars as filed | |
| KINIKSA PHARMACEUTICALS INTL P ORD SHS CL A | G52694109 | Stock | 587,000 | $24,213,750 | dollars as filed | |
| EDAP TMS S A | 268311107 | SPONSORED ADR | 7,309,254 | $24,047,446 | dollars as filed | |
| TELEFLEX INCORPORATED | 879369106 | COM | 190,000 | $23,187,600 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 1,219,394 | $23,131,904 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 910,000 | $22,581,650 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 10,875,000 | $22,293,750 | dollars as filed | |
| PHARVARIS NV | N69605108 | COMMON STOCK | 702,052 | $19,481,943 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 7,708,727 | $19,040,556 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 646,390 | $18,654,815 | dollars as filed | |
| TENET HEALTHCARE CORP COM NEW | 88033G407 | Stock | 92,500 | $18,381,600 | dollars as filed | |
| ARCUS BIOSCIENCES INC | 03969F109 | COM | 711,983 | $16,966,555 | dollars as filed | |
| ENLIVEN THERAPEUTICS INC COM | 29337E102 | Stock | 1,025,000 | $15,785,000 | dollars as filed | |
| MBX BIOSCIENCES INC COM | 55287L101 | Stock | 408,900 | $12,896,706 | dollars as filed | |
| RIGEL PHARMACEUTICALS INC | 766559702 | COMMON STOCK | 300,034 | $12,850,456 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 796,744 | $12,293,760 | dollars as filed | |
| TREVI THERAPEUTICS INC COM | 89532M101 | Stock | 900,000 | $11,268,000 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 268,500 | $11,046,090 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 383,368 | $10,688,300 | dollars as filed | |
| ORTHOPEDIATRICS CORP | 68752L100 | COMMON STOCK | 525,447 | $9,331,939 | dollars as filed | |
| TERNS PHARMACEUTICALS INC COM | 880881107 | Stock | 212,710 | $8,593,484 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 38,811 | $8,572,962 | dollars as filed | |
| INSMED INC COM PAR $.01 | 457669307 | Stock | 48,500 | $8,440,940 | dollars as filed | |
| CERUS CORP | 157085101 | COM | 4,000,000 | $8,240,000 | dollars as filed | |
| ERASCA INC COM | 29479A108 | Stock | 2,162,162 | $8,043,243 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 441,978 | $8,026,320 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 3,803,942 | $7,265,529 | dollars as filed | |
| EVOLUS INC | 30052C107 | COM | 1,070,000 | $7,115,500 | dollars as filed | |
| CG ONCOLOGY INC | 156944100 | COMMON STOCK | 170,000 | $7,058,400 | dollars as filed | |
| ANAPTYSBIO INC | 032724106 | COM | 135,000 | $6,544,800 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 40,354 | $6,455,026 | dollars as filed | |
| STRUCTURE THERAPEUTICS INC COMP | 86366E106 | EQUITY | 90,000 | $6,259,500 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 45,000 | $6,068,475 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 190,000 | $5,758,900 | dollars as filed | |
| MOONLAKE IMMUNOTHERAPEUTICS CLASS A ORD | 61559X104 | Stock | 400,000 | $5,272,000 | dollars as filed | |
| NEOGENOMICS INC | 64049M209 | COM NEW | 427,504 | $5,027,447 | dollars as filed | |
| NATERA INC COM | 632307104 | Stock | 20,000 | $4,581,800 | dollars as filed | |
| CALCIMEDICA INC | 38942Q202 | COM NEW | 683,904 | $4,506,927 | dollars as filed | |
| PULMONX CORP | 745848101 | COM | 2,038,323 | $4,504,694 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 120,000 | $4,262,400 | dollars as filed | |
| Indivior PLC | G4766E116 | Common Stock | 100,000 | $3,588,000 | dollars as filed | |
| UROGEN PHARMA LTD | M96088105 | COMMON STOCK | 150,000 | $3,513,000 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 125,000 | $3,286,250 | dollars as filed | |
| KARYOPHARM THERAPEUTICS INC | 48576U205 | COMMON STOCK | 440,000 | $3,238,400 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 100,000 | $2,633,000 | dollars as filed | |
| VIKING THERAPEUTICS INC | 92686J106 | COM | 70,000 | $2,462,600 | dollars as filed | |
| QUIDELORTHO CORP COM | 219798105 | Stock | 75,000 | $2,142,000 | dollars as filed | |
| INSPIREMD INC | 45779A846 | COM | 1,150,000 | $2,047,000 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 25,000 | $1,975,000 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 30,000 | $1,956,000 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 69,874 | $1,746,850 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 100,000 | $1,683,000 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 60,000 | $1,677,600 | dollars as filed | |
| GRAIL INC | 384747101 | COM | 11,000 | $941,490 | dollars as filed | |
| FRACTYL HEALTH INC | 35168W103 | COM | 400,000 | $880,000 | dollars as filed | |
| STAAR SURGICAL CO COM PAR $0.01 | 852312305 | Stock | 25,000 | $577,250 | dollars as filed | |
| VERACYTE INC COM | 92337F107 | Stock | 10,000 | $421,000 | dollars as filed | |
| JASPER THERAPEUTICS INC | 471871202 | COM NEW | 200,000 | $366,000 | dollars as filed | |
| QUOIN PHARMACEUTICALS LTD | 74907L409 | SPONSORED ADS | 25,000 | $360,750 | dollars as filed | |
| MADRIGAL PHARMACEUTICALS INC COM | 558868105 | Stock | 500 | $291,170 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 10,000 | $222,600 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 10,000 | $195,600 | dollars as filed | |
| DELCATH SYSTEMS INC | 24661P807 | COMMON STOCK | 10,000 | $101,000 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 10,000 | $88,600 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001802630-26-000002 | this filing | 2026-02-12 | acceptance time not in the bulk data set |