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Disclosery

EWTX EDGEWISE THERAPEUTICS INC

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COM (common), issuer CIK 1710072

197 managers (199 13F filers) reported a position in EWTX shares at 2025-12-31, 121,825,111 shares in all. 38 filers opened a position and 20 filers sold out during the quarter.

Managers
197
13F filers
199
New
38
Added
69
Reduced
54
Sold out
20
Shares held by filers
121,825,111

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q4 2025

Filers in the available 13F reports with a share position at 2025-12-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC15,518,492$385M7.88%013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.10,428,437$259M2.65%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,630,576$165M<0.01%+279,08913F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP6,575,940$163M0.96%-730,00013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …6,541,210$162M4.35%+371,07913F-HRTimelineGroup
NOVO HOLDINGS A/S5,350,000$133M10.31%013F-HRTimeline
BRAIDWELL LP5,210,831$129M4.14%013F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC4,871,624$121M<0.01%+67,68313F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson4,566,850$113M0.05%-412,48113F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.4,529,990$112M3.35%+632,89113F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,457,974$111M2.03%+662,08013F-HRTimelineGroup
Driehaus Capital Management LLC4,191,193$104M0.71%+1,962,90813F-HRTimeline
Cormorant Asset Management, LP3,285,000$81.5M4.62%-725,00013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY2,910,881$72.2M<0.01%+2,041,20313F-HR/ATimelineGroup
UBS Group AGgroup of 2 filers holding2,215,136$55M+1,961,896Timeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,746,222$43.3M<0.01%+28,58113F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,717,343$42.6M<0.01%+17,43413F-HRTimelineGroup
MPM BIOIMPACT LLC1,655,256$41.1M4.7%-65,48513F-HRTimeline
First Light Asset Management, LLC1,573,701$39.1M2.99%+158,70713F-HRTimeline
Bellevue Group AGin group Bellevue Group AG1,528,518$37.9M0.72%-1,247,47913F-HRTimelineGroup
Integral Health Asset Management, LLC1,500,000$37.2M1.89%013F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,474,797$36.6M<0.01%+1,153,66513F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,213,657$30.1M0.01%+30,52113F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC1,186,467$29.4M0.01%+90,99413F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.1,036,170$25.7M0.01%+958,91013F-HRTimeline
Soleus Capital Management, L.P.910,000$22.6M0.96%new13F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc821,940$20.4M0.03%+202,06213F-HRTimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…765,694$19M0.24%013F-HRTimelineGroup
NORGES BANK751,355$18.6M<0.01%new13F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC746,562$18.5M0.01%+247,91613F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC718,372$17.8M<0.01%+190,54513F-HR/ATimelineGroup
Artisan Partners Limited Partnership704,077$17.5M0.03%-14,09813F-HRTimeline
FMR LLCin group FMR LLC692,955$17.2M<0.01%+439,63013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP681,921$16.9M0.02%new13F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…640,400$15.9M0.03%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co611,384$15.2M<0.01%+13,78113F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC568,310$14.1M0.22%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP559,649$13.9M<0.01%-28,23313F-HRTimelineGroup
Candriam S.C.A.501,214$12.4M0.06%+280,05513F-HR/ATimeline
Opaleye Management Inc.500,000$12.4M1.64%013F-HR/ATimeline
Sofinnova Investments, Inc.437,819$10.9M0.47%-82,42113F-HRTimeline
Parkman Healthcare Partners LLC427,690$10.6M1.01%-122,48313F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.394,695$9.79M0.01%-282,86613F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC372,738$9.25M<0.01%+138,08813F-HRTimelineGroup
STEMPOINT CAPITAL LP360,876$8.96M1.54%new13F-HRTimeline
Squadron Capital Management LLC350,000$8.69M3.88%13F-HRTimeline
Eversept Partners, LP337,340$8.37M0.47%-164,89413F-HRTimeline
Qube Research & Technologies Ltd296,208$7.35M0.01%-259,50513F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …271,385$6.73M0.01%+138,88213F-HRTimelineGroup
KENNEDY CAPITAL MANAGEMENT LLC241,509$5.99M0.13%-9,11313F-HRTimeline
Sio Capital Management, LLC237,481$5.89M0.98%-69,70013F-HRTimeline
Granahan Investment Management, LLC232,295$5.76M0.25%-107,32213F-HRTimeline
Woodline Partners LP224,192$5.56M0.02%+213F-HRTimeline
CITIGROUP INCin group CITIGROUP INC223,294$5.54M<0.01%-315,15913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\214,769$5.33M<0.01%+59,87313F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC202,297$5.02M<0.01%new13F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp198,614$4.93M<0.01%-5,62813F-HRTimelineGroup
Ally Bridge Group (NY) LLC195,000$4.84M7.68%new13F-HRTimeline
HighVista Strategies LLC171,137$4.25M1.09%-36,96413F-HRTimeline
Nuveen, LLCin group TIAA169,466$4.21M<0.01%-3,24113F-HRTimelineGroup
DAFNA Capital Management LLC159,736$3.96M0.92%-54,00013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management151,905$3.77M0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO146,038$3.62M<0.01%+77,31813F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP145,286$3.57M<0.01%-5,77613F-HRTimeline
KVP Capital Advisors, LP133,000$3.3M3.41%13F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC127,136$3.15M<0.01%-92,51013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC126,436$3.14M<0.01%-598,98913F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC123,097$3.05M<0.01%+100,78013F-HRTimelineGroup
Jain Global LLC113,856$2.83M0.03%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…111,387$2.76M<0.01%-3,14413F-HRTimelineGroup
Quantum Private Wealth, LLC106,024$2.63M0.77%+15013F-HRTimeline
Swiss National Bank103,900$2.58M<0.01%+2,00013F-HRTimeline
Exome Asset Management LLC100,046$2.48M1.23%-73,39313F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC90,999$2.26M0.17%+50,99913F-HR/ATimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND88,937$2.21M<0.01%+5,50013F-HRTimeline
SG Americas Securities, LLC88,723$2.2M<0.01%+78,84213F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC86,929$2.16M0.01%+35,81713F-HRTimelineGroup
RHUMBLINE ADVISERS85,075$2.11M<0.01%-19,75413F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.82,096$2.04M<0.01%+22,84013F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC79,915$1.98M0.02%-91013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN75,442$1.87M<0.01%+33,24613F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.75,438$1.87M<0.01%+9,38213F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…70,196$1.74M<0.01%+24,56113F-HRTimelineGroup
DekaBank Deutsche Girozentrale80,000$1.56M<0.01%013F-HRTimeline
Schonfeld Strategic Advisors LLC59,326$1.47M0.01%+7,33713F-HRTimeline
Ishara Investments LP58,000$1.44M1.68%13F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/57,315$1.42M<0.01%+5,92913F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd55,620$1.38M0.04%new13F-HRTimelineGroup
HighMark Wealth Management LLC53,179$1.32M0.54%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc52,747$1.31M<0.01%-3,19413F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP50,848$1.26M<0.01%+24,58213F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…50,392$1.25M<0.01%-40113F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources43,145$1.07M<0.01%-5,07513F-HRTimelineGroup
Moody Aldrich Partners LLC43,134$1.07M0.2%-39,80713F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…42,052$1.04M0.15%new13F-HRTimelineGroup
PRELUDE CAPITAL MANAGEMENT, LLC41,584$1.03M0.08%-7,62113F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD39,997$993K<0.01%+3,37813F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC39,648$984K<0.01%+27,23113F-HRTimelineGroup
Knights of Columbus Asset Advisors LLC38,676$960K0.05%new13F-HRTimeline
ORACLE INVESTMENT MANAGEMENT INC38,343$951K0.62%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…38,291$950K<0.01%-5,59213F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …36,759$912K<0.01%+1,22113F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding36,514$906K+1,091Timeline
Verition Fund Management LLC33,591$834K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO31,250$775K<0.01%-7,84513F-HRTimelineGroup
Handelsbanken Fonder AB31,100$772K<0.01%-7,30013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC30,389$754K0.01%+1,21013F-HRTimeline
DIADEMA PARTNERS LP30,000$744K0.44%new13F-HRTimeline
Elmind Capital, LP30,000$744K0.22%13F-HRTimeline
OPTIMIZE FINANCIAL INC.27,679$687K0.35%+39613F-HRTimeline
Creative Planningin group Creative Planning24,468$607K<0.01%+6,43213F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC21,609$536K<0.01%+8,23013F-HRTimelineGroup
Persistent Asset Partners Ltd21,204$526K0.25%new13F-HRTimeline
LMR Partners LLPin group LMR Partners LLP20,000$496K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…18,865$468K<0.01%013F-HRTimeline
Y-Intercept (Hong Kong) Ltd18,672$463K0.01%-38,62813F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…17,978$446K<0.01%new13F-HRTimelineGroup
China Universal Asset Management Co., L…17,251$428K0.03%-1,21513F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS17,061$423K<0.01%+2,76413F-HRTimelineGroup
ProShare Advisors LLC16,976$421K<0.01%+1,68513F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…16,870$419K<0.01%013F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM14,937$371K<0.01%-61213F-HRTimeline
AlphaCentric Advisors LLC14,703$365K0.36%13F-HRTimeline
WINTON GROUP Ltdin group WINTON GROUP Ltd14,184$352K0.01%new13F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP14,085$350K0.03%-99,15813F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC13,746$341K<0.01%new13F-HRTimelineGroup
Centiva Capital, LP12,500$310K0.02%new13F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.12,360$307K0.05%-8,11113F-HRTimeline
PROFUND ADVISORS LLC11,825$293K0.01%+1613F-HRTimeline
Odyssean, LLC11,753$292K0.21%13F-HRTimeline
KLP KAPITALFORVALTNING AS11,300$280K<0.01%+70013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…11,265$280K<0.01%+4,40213F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…11,263$279K0.08%+3,88313F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC10,571$262K<0.01%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA10,168$253K<0.01%-5,52713F-HRTimelineGroup
VARCOV Co.10,034$249K0.1%13F-HRTimeline
NOMURA HOLDINGS INCin group NOMURA ASSET MANAGEMENT CO LTD10,000$248K<0.01%new13F-HRTimelineGroup
SFMG, LLC10,000$248K0.02%013F-HRTimeline
Rafferty Asset Management, LLC9,849$244K<0.01%new13F-HRTimeline
Connecticut Capital Management Group, L…9,839$244K0.23%13F-HRTimeline
Graham Capital Management, L.P.9,468$235K0.01%-9,32113F-HRTimeline
Lion Point Capital, LP9,100$226K1.17%new13F-HRTimeline
SIMPLEX TRADING, LLC9,069$225K0.01%+1,47913F-HRTimeline
AlphaQuest LLC7,143$177K0.01%-7,13113F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…6,494$161K<0.01%-69613F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC8,177$153K<0.01%new13F-HRTimeline
Quarry LP5,800$144K0.02%new13F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,638$140K<0.01%013F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD3,900$96.8K<0.01%-60013F-HRTimeline
Cygnus Capital Advisors, LLC3,427$85K0.06%13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,849$71K<0.01%013F-HRTimeline
Steward Partners Investment Advisory, L…2,854$70.8K<0.01%+55013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC2,350$58K<0.01%013F-HRTimelineGroup
AMALGAMATED BANK2,120$53K<0.01%-40113F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,079$51.6K<0.01%-18713F-HRTimeline
Seven Fleet Capital Management LP2,000$49.6K0.03%13F-HR/ATimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC1,731$42K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,613$40K<0.01%-2613F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\1,564$38.8K<0.01%-72813F-HRTimelineGroup
Winthrop Capital Management, LLC1,377$34K0.01%013F-HRTimeline
GAMMA Investing LLC1,354$33.6K<0.01%+19613F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,162$28.8K<0.01%+28813F-HRTimeline
Quantbot Technologies LP774$19.2K<0.01%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …728$18K<0.01%+20713F-HRTimelineGroup
Caitong International Asset Management …710$17.6K<0.01%new13F-HR/ATimeline
Farther Finance Advisors, LLC659$16.4K<0.01%+10113F-HRTimeline
Parallel Advisors, LLC626$15.5K<0.01%+53113F-HRTimeline
NORTHWESTERN MUTUAL WEALTH MANAGEMENT COin group NORTHWESTERN MUTUAL INVESTMEN…489$12.1K<0.01%new13F-HR/ATimelineGroup
Sterling Capital Management LLC448$11.1K<0.01%+28513F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.408$10.1K<0.01%-3913F-HRTimelineGroup
SIGNATUREFD, LLC363$9.01K<0.01%013F-HRTimeline
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.344$9K<0.01%013F-HRTimelineGroup
MassMutual Private Wealth & Trust, FSB294$7.3K<0.01%-5013F-HRTimeline
CWM, LLCin group CWM, LLC279$7K<0.01%+14713F-HRTimelineGroup
Larson Financial Group LLC225$5.58K<0.01%+9013F-HRTimeline
EASTERN BANK223$5.53K<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.207$5.14K<0.01%013F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…182$4.52K<0.01%new13F-HR/ATimelineGroup
Smartleaf Asset Management LLC173$4.25K<0.01%+14613F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.161$4K<0.01%-30713F-HRTimelineGroup
Fortitude Family Office, LLC160$3.97K<0.01%013F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…156$3.87K<0.01%+1413F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd152$3.77K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC135$3.35K<0.01%013F-HRTimeline
BFSG, LLC100$2.48K<0.01%013F-HRTimeline
Versant Capital Management, Inc95$2.36K<0.01%013F-HRTimeline
Arax Advisory Partners87$2.16K<0.01%-1913F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…75$1.86K<0.01%+813F-HRTimelineGroup
Allworth Financial LP56$1.39K<0.01%+2313F-HRTimeline
COMERICA BANK35$890<0.01%013F-HRTimeline
Parkside Financial Bank & Trust35$869<0.01%013F-HRTimeline
Bare Financial Services, Inc18$447<0.01%new13F-HRTimeline
SageView Advisory Group, LLC11$273<0.01%new13F-HRTimeline
CIBC Private Wealth Group LLCin group CIBC Bancorp USA Inc.4$99<0.01%new13F-HRTimelineGroup
IFP Advisors, Inc4$99<0.01%013F-HRTimeline
Essential Partners LLC3$74<0.01%new13F-HRTimeline
Covestor Ltd8$00%013F-HRTimelineValue filed as zero, left out of ratios.