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Disclosery

EWTX EDGEWISE THERAPEUTICS INC

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COM (common), issuer CIK 1710072

207 managers (214 13F filers) reported a position in EWTX shares at 2026-03-31, 118,532,624 shares in all. 36 filers opened a position and 25 filers sold out during the quarter.

Managers
207
13F filers
214
New
36
Added
65
Reduced
66
Sold out
25
Shares held by filers
118,532,624

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q1 2026

Filers in the available 13F reports with a share position at 2026-03-31, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC15,518,492$489M10.66%013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.10,428,437$328M3.48%013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …7,365,038$232M4.74%+823,82813F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP6,575,940$207M1.19%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,472,991$204M<0.01%-157,58513F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson5,915,556$186M0.09%+1,348,70613F-HR/ATimelineGroup
NOVO HOLDINGS A/S5,350,000$169M13.65%013F-HRTimeline
VANGUARD GROUP INCgroup of 6 filers holding4,945,903$156MnewTimeline
Driehaus Capital Management LLC4,477,942$141M1.04%+286,74913F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.4,430,263$140M3.87%-99,72713F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,423,974$139M2.75%-34,00013F-HR/ATimelineGroup
Cormorant Asset Management, LP3,260,000$103M5.18%-25,00013F-HRTimeline
BRAIDWELL LP2,347,583$73.9M2.47%-2,863,24813F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY2,246,028$70.7M<0.01%-664,85313F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,789,819$56.4M<0.01%+43,59713F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,716,823$54.1M<0.01%-52013F-HRTimelineGroup
MPM BIOIMPACT LLC1,660,696$52.3M4.04%+5,44013F-HRTimeline
Integral Health Asset Management, LLC1,600,000$50.4M2.67%+100,00013F-HRTimeline
Bellevue Group AGin group Bellevue Group AG1,528,518$48.1M1.15%013F-HRTimelineGroup
Soleus Capital Management, L.P.1,449,915$45.7M1.85%+539,91513F-HRTimeline
UBS Group AGgroup of 2 filers holding1,425,845$44.9M-789,291Timeline
ALLIANCEBERNSTEIN L.P.1,722,169$42.7M0.01%+685,99913F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,327,360$41.8M<0.01%-147,43713F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,219,717$38.4M0.01%+6,06013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC1,147,176$36.1M0.02%-39,29113F-HRTimelineGroup
FMR LLCin group FMR LLC1,017,052$32M<0.01%+324,09713F-HRTimelineGroup
First Light Asset Management, LLC1,001,846$31.6M2.83%-571,85513F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc826,059$26M0.04%+4,11913F-HRTimelineGroup
Qube Research & Technologies Ltd825,910$26M0.04%+529,70213F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC789,043$24.9M0.02%+42,48113F-HRTimeline
Artisan Partners Limited Partnership659,067$20.8M0.03%-45,01013F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP648,393$20.4M0.02%-33,52813F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC629,820$19.8M<0.01%-88,55213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co596,310$18.8M<0.01%-15,07413F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP576,556$18.2M<0.01%+16,90713F-HRTimelineGroup
Opaleye Management Inc.500,000$15.8M2.07%013F-HRTimeline
Candriam S.C.A.447,416$14.1M0.07%-53,79813F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC429,032$13.5M0.01%+305,93513F-HRTimelineGroup
HEALTHCARE OF ONTARIO PENSION PLAN TRUS…404,200$12.7M0.02%-236,20013F-HRTimeline
Sofinnova Investments, Inc.386,498$12.2M0.61%-51,32113F-HRTimeline
Squadron Capital Management LLC350,000$11M4.41%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC342,867$10.8M0.01%+216,43113F-HRTimelineGroup
Nuveen, LLCin group TIAA335,783$10.6M<0.01%+166,31713F-HRTimelineGroup
Parkman Healthcare Partners LLC322,828$10.2M1.05%-104,86213F-HRTimeline
STEMPOINT CAPITAL LP290,864$9.16M1.76%-70,01213F-HR/ATimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …283,312$8.92M0.02%+11,92713F-HRTimelineGroup
Sio Capital Management, LLC268,986$8.47M1.22%+31,50513F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC264,204$8.32M0.18%+22,69513F-HRTimeline
Woodline Partners LP224,290$7.07M0.03%+9813F-HR/ATimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\221,868$6.99M<0.01%+7,09913F-HRTimelineGroup
PEREGRINE CAPITAL MANAGEMENT LLC208,672$6.57M0.24%new13F-HRTimeline
SEB Asset Management AB206,512$6.51M0.03%13F-HRTimeline
Granahan Investment Management, LLC200,843$6.33M0.31%-31,45213F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC200,661$6.32M<0.01%-1,63613F-HR/ATimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp192,434$6.06M<0.01%-6,18013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC177,244$5.58M<0.01%-195,49413F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC168,678$5.31M<0.01%+41,54213F-HRTimelineGroup
Ally Bridge Group (NY) LLC161,000$5.07M5.04%-34,00013F-HRTimeline
EVENTIDE ASSET MANAGEMENT, LLC149,863$4.72M0.08%-418,44713F-HRTimeline
Freestone Grove Partners LP148,426$4.68M0.03%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO147,573$4.47M<0.01%+1,53513F-HR/ATimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP145,286$4.4M<0.01%013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.138,399$4.36M<0.01%+62,96113F-HRTimelineGroup
KVP Capital Advisors, LP133,000$4.19M3.13%013F-HRTimeline
Quantum Private Wealth, LLC116,624$3.67M1.13%+10,60013F-HRTimeline
Moody Aldrich Partners LLC114,141$3.6M0.65%+71,00713F-HRTimeline
DAFNA Capital Management LLC112,236$3.54M0.8%-47,50013F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.104,863$3.3M<0.01%-289,83213F-HRTimelineGroup
Swiss National Bank103,900$3.27M<0.01%013F-HRTimeline
Schonfeld Strategic Advisors LLC99,075$3.12M0.03%+39,74913F-HRTimeline
HighVista Strategies LLC91,931$2.9M0.8%-79,20613F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC90,599$2.85M0.17%-40013F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND88,937$2.8M<0.01%013F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC87,326$2.75M0.01%+39713F-HRTimelineGroup
RHUMBLINE ADVISERS83,540$2.63M<0.01%-1,53513F-HRTimeline
DekaBank Deutsche Girozentrale80,000$2.57M<0.01%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…73,419$2.31M<0.01%+23,02713F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/69,427$2.19M<0.01%+12,11213F-HRTimeline
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding67,408$2.12M+57,408Timeline
Artia Global Partners LP65,500$2.06M0.47%new13F-HRTimeline
J. Goldman & Co LP61,421$1.93M0.09%new13F-HRTimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.56,778$1.79M<0.01%-25,31813F-HRTimelineGroup
HighMark Wealth Management LLC53,179$1.68M0.68%013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP50,848$1.6M<0.01%013F-HRTimelineGroup
Ishara Investments LP49,200$1.55M1.57%-8,80013F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO49,082$1.55M<0.01%+17,83213F-HRTimelineGroup
Jain Global LLC46,401$1.46M0.02%-67,45513F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…42,615$1.34M0.16%+56313F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc42,537$1.34M<0.01%-10,21013F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources41,726$1.31M<0.01%-1,41913F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC39,153$1.23M<0.01%-49513F-HRTimelineGroup
Caption Management, LLC38,675$1.22M0.06%new13F-HRTimeline
Knights of Columbus Asset Advisors LLC38,414$1.21M0.07%-26213F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…38,084$1.2M0.01%-20713F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding37,209$1.17M+695Timeline
Longaeva Partners L.P.36,931$1.16M0.06%new13F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC35,578$1.12M<0.01%new13F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …35,450$1.12M<0.01%-1,30913F-HRTimelineGroup
STATE OF WISCONSIN INVESTMENT BOARD32,896$1.04M<0.01%-7,10113F-HRTimeline
ALGERT GLOBAL LLC32,520$1.02M0.02%new13F-HR/ATimeline
Creative Planningin group Creative Planning31,268$985K<0.01%+6,80013F-HRTimelineGroup
Handelsbanken Fonder AB31,100$980K<0.01%013F-HRTimeline
TUDOR INVESTMENT CORP ET AL29,889$942K0.01%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…27,409$863K<0.01%-83,97813F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…26,674$840K<0.01%-43,52213F-HRTimelineGroup
China Universal Asset Management Co., L…25,436$801K0.06%+8,18513F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN25,244$795K<0.01%-50,19813F-HR/ATimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS23,911$753K<0.01%+6,85013F-HRTimelineGroup
LMR Partners LLPin group LMR Partners LLP20,000$630K0.01%013F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC19,678$620K<0.01%-1,93113F-HRTimelineGroup
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA19,224$606K<0.01%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd19,108$602K0.01%-36,51213F-HRTimelineGroup
Police & Firemen's Retirement System of…18,865$594K0.01%013F-HRTimeline
CITIGROUP INCin group CITIGROUP INC18,517$583K<0.01%-204,77713F-HRTimelineGroup
INTECH INVESTMENT MANAGEMENT LLC18,480$582K0.01%-11,90913F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…18,091$570K<0.01%+11313F-HRTimelineGroup
Odyssean, LLC17,867$563K0.21%+6,11413F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…16,870$531K<0.01%013F-HRTimeline
Brooklyn Investment Group16,221$511K0.02%new13F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC15,730$495K<0.01%new13F-HRTimelineGroup
AlphaCentric Advisors LLC15,615$492K0.49%+91213F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…14,739$464K<0.01%+3,47413F-HRTimeline
ProShare Advisors LLC14,578$459K<0.01%-2,39813F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM14,540$458K<0.01%-39713F-HRTimeline
Headlands Technologies LLC13,767$434K0.05%new13F-HRTimeline
Verdad Advisers, LP13,052$411K0.46%new13F-HRTimeline
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…12,930$407K<0.01%new13F-HRTimelineGroup
Bridgefront Capital, LLC11,809$372K0.09%new13F-HRTimeline
Seven Fleet Capital Management LP11,701$369K0.12%+9,70113F-HR/ATimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…11,544$364K0.1%+28113F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC11,524$363K<0.01%+95313F-HRTimelineGroup
KLP KAPITALFORVALTNING AS11,300$356K<0.01%013F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC10,605$334K<0.01%new13F-HRTimelineGroup
Persistent Asset Partners Ltd10,053$317K0.12%-11,15113F-HRTimeline
SFMG, LLC10,000$315K0.02%013F-HRTimeline
Elmind Capital, LP10,000$315K0.09%-20,00013F-HRTimeline
Atom Investors LP9,941$313K0.02%new13F-HRTimeline
Connecticut Capital Management Group, L…9,839$310K0.29%013F-HRTimeline
AXQ CAPITAL, LP9,513$300K0.04%new13F-HRTimeline
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP9,129$288K<0.01%new13F-HRTimelineGroup
Lion Point Capital, LP9,100$287K1.71%013F-HRTimeline
PROFUND ADVISORS LLC8,683$274K0.01%-3,14213F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC8,539$269K<0.01%-5,20713F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.8,483$267K<0.01%+8,07513F-HRTimelineGroup
FOX RUN MANAGEMENT, L.L.C.7,976$242K0.04%-4,38413F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…7,623$240K<0.01%new13F-HRTimelineGroup
Quantinno Capital Management LP7,454$235K<0.01%new13F-HRTimeline
STRS OHIO6,900$217K<0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS6,719$212K<0.01%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…6,574$207K<0.01%+8013F-HRTimelineGroup
PSP Research LLC6,500$205K0.14%new13F-HRTimeline
Orion Porfolio Solutions, LLC6,449$203K<0.01%new13F-HRTimeline
Quarry LP6,000$189K0.04%+20013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA5,873$185K<0.01%-4,29513F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,638$178K0.01%013F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC5,600$176K<0.01%-2,57713F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…5,473$172K<0.01%+3,86013F-HRTimelineGroup
Caitong International Asset Management …4,278$135K0.02%+3,56813F-HRTimeline
SG Americas Securities, LLC3,804$120K<0.01%-84,91913F-HRTimeline
Cygnus Capital Advisors, LLC3,427$108K0.07%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\2,973$93.7K<0.01%+1,40913F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,849$90K<0.01%013F-HRTimeline
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC2,737$86K<0.01%+1,00613F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.2,378$74.9K<0.01%+29913F-HRTimeline
Steward Partners Investment Advisory, L…2,354$74.2K<0.01%-50013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC2,350$74K<0.01%013F-HRTimelineGroup
GAMMA Investing LLC2,289$72.1K<0.01%+93513F-HRTimeline
SIMPLEX TRADING, LLC1,832$57.7K<0.01%-7,23713F-HRTimeline
Eleva Capital SAS17,460$55K0.02%13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC1,677$52.8K<0.01%+51513F-HRTimeline
KBC Group NVin group KBC Group NV1,560$49K<0.01%new13F-HRTimelineGroup
Winthrop Capital Management, LLC1,377$43K0.01%013F-HRTimeline
Parallel Advisors, LLC1,032$32.5K<0.01%+40613F-HR/ATimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …972$30.6K<0.01%+24413F-HRTimelineGroup
Kemnay Advisory Services Inc.756$23.8K<0.01%new13F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…732$23.1K<0.01%+55013F-HRTimelineGroup
Farther Finance Advisors, LLC645$21.4K<0.01%-1413F-HRTimeline
SUMMIT SECURITIES GROUP LLC678$21.4K0.01%new13F-HRTimeline
Centiva Capital, LP539$17K<0.01%-11,96113F-HRTimeline
Sterling Capital Management LLC438$13.8K<0.01%-1013F-HRTimeline
SIGNATUREFD, LLC363$11.4K<0.01%013F-HRTimeline
CWM, LLCin group CWM, LLC351$11.1K<0.01%+7213F-HRTimelineGroup
MassMutual Private Wealth & Trust, FSB294$9.26K<0.01%013F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.261$8.22K<0.01%+10013F-HR/ATimelineGroup
EASTERN BANK223$7.03K<0.01%013F-HRTimeline
Aster Capital Management (DIFC) Ltd310$6.82K<0.01%+15813F-HRTimeline
SBI Securities Co., Ltd.206$6.49K<0.01%-113F-HRTimeline
Larson Financial Group LLC176$5.54K<0.01%-4913F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…175$5.51K<0.01%+1913F-HR/ATimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…172$5.42K<0.01%+9713F-HRTimelineGroup
Fortitude Family Office, LLC160$5.04K<0.01%013F-HRTimeline
Smartleaf Asset Management LLC162$4.91K<0.01%-1113F-HRTimeline
Advisory Services Network, LLC151$4.77K<0.01%new13F-HRTimeline
ROTHSCHILD INVESTMENT LLC135$4.25K<0.01%013F-HRTimeline
BFSG, LLC100$3.15K<0.01%013F-HRTimeline
Versant Capital Management, Inc95$2.99K<0.01%013F-HRTimeline
Allworth Financial LP84$2.65K<0.01%+2813F-HRTimeline
Parkside Financial Bank & Trust35$1.1K<0.01%013F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…33$1.04K<0.01%new13F-HRTimelineGroup
Bare Financial Services, Inc18$567<0.01%013F-HRTimeline