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Disclosery

EWTX EDGEWISE THERAPEUTICS INC

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COM (common), issuer CIK 1710072

171 managers (173 13F filers) reported a position in EWTX shares at 2025-09-30, 111,964,044 shares in all. 17 filers opened a position and 23 filers sold out during the quarter.

Managers
171
13F filers
173
New
17
Added
59
Reduced
62
Sold out
23
Shares held by filers
111,964,044

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q3 2025

Filers in the available 13F reports with a share position at 2025-09-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC15,518,492$252M6.04%013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.10,428,437$169M2.08%+525,80413F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP7,305,940$119M0.86%013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,351,487$103M<0.01%-429,55913F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …6,170,131$100M2.96%+27,78713F-HRTimelineGroup
NOVO HOLDINGS A/S5,350,000$86.8M5.59%013F-HRTimeline
BRAIDWELL LP5,210,831$84.5M2.51%013F-HRTimeline
JANUS HENDERSON GROUP PLCin group Janus Henderson4,979,331$80.8M0.04%-524,01813F-HRTimelineGroup
VANGUARD GROUP INCin group VANGUARD GROUP INC4,803,941$77.9M<0.01%-37,55913F-HRTimelineGroup
Cormorant Asset Management, LP4,010,000$65M4.49%-241,99213F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.3,897,099$63.2M2.47%+736,80113F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC3,795,894$61.6M1.78%-844,05513F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG2,775,997$45M0.94%013F-HRTimelineGroup
Driehaus Capital Management LLC2,228,285$36.1M0.26%+126,50413F-HRTimeline
MPM BIOIMPACT LLC1,720,741$27.9M4.57%013F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,717,641$27.9M<0.01%-79,57413F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,699,909$27.6M<0.01%-81,59213F-HRTimelineGroup
Integral Health Asset Management, LLC1,500,000$24.3M1.77%+500,00013F-HRTimeline
First Light Asset Management, LLC1,414,994$23M2.16%-299,02513F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,183,136$19.2M<0.01%+134,20013F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC1,095,473$17.8M0.01%+312,30713F-HRTimelineGroup
New Leaf Venture Partners, L.L.C.1,030,161$16.7M38.82%013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY869,678$14.1M<0.01%+141,96413F-HR/ATimelineGroup
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…765,694$12.4M0.19%-1,301,62613F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC725,425$11.8M0.01%-196,54013F-HRTimelineGroup
Artisan Partners Limited Partnership718,175$11.6M0.02%-660,89313F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.677,561$11M0.01%+82,12913F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc619,878$10.1M0.02%+176,55913F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co597,603$9.69M<0.01%+18,49913F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP587,882$9.54M<0.01%-15,01613F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC568,310$9.22M0.15%013F-HRTimeline
Qube Research & Technologies Ltd555,713$9.01M0.01%+55,79613F-HRTimeline
Parkman Healthcare Partners LLC550,173$8.92M0.98%-97,15813F-HRTimeline
CITIGROUP INCin group CITIGROUP INC538,453$8.73M0.01%-186,44613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC527,827$8.56M<0.01%-103,91613F-HRTimelineGroup
Sofinnova Investments, Inc.520,240$8.44M0.52%-196,63313F-HRTimeline
Eversept Partners, LP502,234$8.15M0.62%+109,49513F-HRTimeline
Opaleye Management Inc.500,000$8.11M1.15%+10,00013F-HRTimeline
VICTORY CAPITAL MANAGEMENT INC498,646$8.09M<0.01%+55,80913F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC431,300$7M0.27%013F-HRTimelineGroup
Granahan Investment Management, LLC339,617$5.51M0.23%-65,86113F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/321,132$5.21M<0.01%+66,70313F-HR/ATimelineGroup
Sio Capital Management, LLC307,181$4.98M1.26%-232,54913F-HRTimeline
Kynam Capital Management, LP253,979$4.12M0.31%013F-HRTimeline
FMR LLCin group FMR LLC253,325$4.11M<0.01%-217,39213F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding253,240$4.11M-109,348Timeline
KENNEDY CAPITAL MANAGEMENT LLC250,622$4.07M0.09%-1,90213F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC234,650$3.81M<0.01%-46,60013F-HR/ATimelineGroup
Woodline Partners LP224,190$3.64M0.02%-872,67313F-HRTimeline
Candriam S.C.A.221,159$3.59M0.02%-2,83113F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC219,646$3.56M<0.01%+54,11113F-HRTimelineGroup
DAFNA Capital Management LLC213,736$3.47M0.86%-24,40413F-HRTimeline
HighVista Strategies LLC208,101$3.38M0.83%+138,37813F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp204,242$3.31M<0.01%-8,61613F-HRTimelineGroup
Exome Asset Management LLC173,439$2.81M1.86%+48,96913F-HRTimeline
Nuveen, LLCin group TIAA172,707$2.8M<0.01%-144,46613F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\154,896$2.51M<0.01%+7,37113F-HRTimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP151,062$2.38M<0.01%013F-HRTimeline
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …132,503$2.15M<0.01%+32513F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…114,531$1.86M<0.01%+1,96113F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP113,243$1.84M0.15%+85,96713F-HRTimeline
Quantum Private Wealth, LLC105,874$1.72M0.5%+5,10013F-HRTimeline
RHUMBLINE ADVISERS104,829$1.7M<0.01%-7,65413F-HRTimeline
Swiss National Bank101,900$1.65M<0.01%+11,90013F-HRTimeline
DekaBank Deutsche Girozentrale80,000$1.55M<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND83,437$1.35M<0.01%-10,37113F-HRTimeline
Moody Aldrich Partners LLC82,941$1.35M0.26%-16,90713F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC80,825$1.31M0.02%-40,88013F-HR/ATimelineGroup
ALLIANCEBERNSTEIN L.P.77,260$1.25M<0.01%013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC75,276$1.22M<0.01%new13F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC69,998$1.14M<0.01%+19,81313F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO68,720$1.11M<0.01%-8,89613F-HR/ATimelineGroup
Invesco Ltd.in group Invesco Ltd.66,056$1.07M<0.01%+9,89813F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.59,256$961K<0.01%-257,24413F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd57,300$929K0.02%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc55,941$907K<0.01%+3,63413F-HRTimelineGroup
HighMark Wealth Management LLC53,179$863K0.38%+1,11413F-HRTimeline
HRT FINANCIAL LP52,203$846K<0.01%new13F-HRTimeline
Schonfeld Strategic Advisors LLC51,989$843K0.01%-115,35113F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/51,386$834K<0.01%+70413F-HRTimeline
ALPS ADVISORS INCin group ALPS ADVISORS INC51,112$829K<0.01%-5,68613F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…50,793$824K<0.01%+13,91513F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC49,205$798K0.06%+10,39613F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources48,220$782K<0.01%+2,41413F-HRTimelineGroup
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…45,635$740K<0.01%-69,63513F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…43,883$712K<0.01%013F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN42,196$684K<0.01%+3,81213F-HRTimelineGroup
ALGERT GLOBAL LLC40,963$664K0.01%+6,24013F-HR/ATimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC40,000$649K0.06%013F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO39,095$634K<0.01%-4,54313F-HRTimelineGroup
Handelsbanken Fonder AB38,400$623K<0.01%+9,70013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD36,619$594K<0.01%-17,40013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …35,538$576K<0.01%-2,79013F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding35,423$575K-8,617Timeline
INTECH INVESTMENT MANAGEMENT LLC29,179$473K<0.01%-14,88613F-HRTimeline
OPTIMIZE FINANCIAL INC.27,283$443K0.23%new13F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP26,266$426K<0.01%new13F-HRTimelineGroup
Trexquant Investment LP22,625$367K<0.01%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC22,317$362K<0.01%-302,93213F-HRTimelineGroup
SummitTX Capital, L.P.20,782$337K0.01%-59813F-HRTimeline
FOX RUN MANAGEMENT, L.L.C.20,471$332K0.05%new13F-HRTimeline
Police & Firemen's Retirement System of…18,865$306K<0.01%+1,50913F-HRTimeline
Graham Capital Management, L.P.18,789$305K0.01%-21,57513F-HRTimeline
China Universal Asset Management Co., L…18,466$300K0.02%-2,65413F-HRTimeline
Creative Planningin group Creative Planning18,036$293K<0.01%+1,12613F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…16,870$274K<0.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA15,695$254K<0.01%+8,00113F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM15,549$252K<0.01%+1,80413F-HRTimeline
ProShare Advisors LLC15,291$248K<0.01%-3,59713F-HRTimeline
ExodusPoint Capital Management, LP14,672$238K<0.01%-30,58313F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS14,297$232K<0.01%+6,10413F-HRTimelineGroup
AlphaQuest LLC14,274$232K0.02%-7,11613F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC13,379$217K<0.01%+11,82113F-HRTimelineGroup
TEACHER RETIREMENT SYSTEM OF TEXAS12,815$208K<0.01%+16913F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC12,417$201K<0.01%-7,49613F-HRTimelineGroup
PROFUND ADVISORS LLC11,809$192K0.01%-3,27613F-HRTimeline
Campbell & CO Investment Adviser LLC11,140$181K0.01%-103,04113F-HRTimeline
Glenmede Investment Management, LP11,137$181K<0.01%-1,40513F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC10,837$176K<0.01%new13F-HRTimelineGroup
KLP KAPITALFORVALTNING AS10,600$172K<0.01%013F-HRTimeline
SFMG, LLC10,000$162K0.01%013F-HRTimeline
SG Americas Securities, LLC9,881$160K<0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC7,590$123K<0.01%+3,40713F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…7,380$120K0.03%+1,28213F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…7,190$117K<0.01%+7,16613F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…6,863$111K<0.01%-21013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…5,638$91.4K<0.01%-1,95613F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD4,500$73K<0.01%+1,10013F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,849$46K<0.01%013F-HRTimeline
AMALGAMATED BANK2,521$41K<0.01%013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC2,350$38K<0.01%+2,16513F-HRTimelineGroup
Steward Partners Investment Advisory, L…2,304$37.4K<0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\2,292$37.2K<0.01%+28313F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.2,266$36.8K<0.01%-15813F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…1,639$26.6K<0.01%-7,50913F-HRTimelineGroup
Winthrop Capital Management, LLC1,377$22K0.01%013F-HRTimeline
GAMMA Investing LLC1,158$18.8K<0.01%-813F-HRTimeline
NISA INVESTMENT ADVISORS, LLC874$14.2K<0.01%-7013F-HRTimeline
KAYNE ANDERSON RUDNICK INVESTMENT MANAG…622$10.1K<0.01%new13F-HRTimeline
CROWLEY WEALTH MANAGEMENT, INC.560$9.08K0.01%013F-HRTimeline
Farther Finance Advisors, LLC558$9.05K<0.01%+18413F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …521$8K<0.01%+6713F-HRTimelineGroup
Optiver Holding B.V.in group Optiver Holding B.V.468$7.59K<0.01%new13F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.447$7.21K<0.01%-67113F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.344$6K<0.01%013F-HRTimelineGroup
SIGNATUREFD, LLC363$5.89K<0.01%013F-HRTimeline
MassMutual Private Wealth & Trust, FSB344$5.58K<0.01%+11113F-HRTimeline
SBI Securities Co., Ltd.207$3.36K<0.01%013F-HRTimeline
Sterling Capital Management LLC163$2.64K<0.01%-813F-HRTimeline
Fortitude Family Office, LLC160$2.6K<0.01%013F-HRTimeline
Advisory Services Network, LLC151$2.46K<0.01%new13F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…142$2.3K<0.01%+8113F-HRTimelineGroup
ROTHSCHILD INVESTMENT LLC135$2.19K<0.01%-2513F-HRTimeline
Larson Financial Group LLC135$2.19K<0.01%new13F-HRTimeline
CWM, LLCin group CWM, LLC132$2K<0.01%+2313F-HRTimelineGroup
Arax Advisory Partners106$1.72K<0.01%+5813F-HRTimeline
BFSG, LLC100$1.62K<0.01%013F-HRTimeline
Parallel Advisors, LLC95$1.54K<0.01%013F-HRTimeline
Versant Capital Management, Inc95$1.54K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…67$1.09K<0.01%+1813F-HRTimelineGroup
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/40$649<0.01%013F-HRTimelineGroup
COMERICA BANK35$581<0.01%013F-HRTimeline
Parkside Financial Bank & Trust35$569<0.01%013F-HRTimeline
Allworth Financial LP33$536<0.01%new13F-HRTimeline
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC27$438<0.01%013F-HRTimelineGroup
Smartleaf Asset Management LLC27$425<0.01%+113F-HRTimeline
MONTAG A & ASSOCIATES INC16$260<0.01%new13F-HRTimeline
Clearstead Advisors, LLC4$65<0.01%new13F-HRTimeline
IFP Advisors, Inc4$65<0.01%+413F-HR/ATimeline
AMERICAN NATIONAL BANK & TRUST2$32<0.01%013F-HRTimeline
Covestor Ltd8$00%013F-HRTimelineValue filed as zero, left out of ratios.