13F-HR filed by RA CAPITAL MANAGEMENT, L.P.
RA CAPITAL MANAGEMENT, L.P. filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 71 holding rows worth $9,760,868,193.
- Accession
- 0001104659-26-016482
- Filer
- CIK 1346824
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 72 entries on the cover page, a total value of $9,760,868,193 stated on the cover page (in dollars after the unit check, H1), rows summing to $9,760,868,193 with VALUE read as dollars as filed, 13F file number 028-12884. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 10,281,496 | $2,192,426,207 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 3,365,523 | $743,410,375 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 6,666,837 | $713,618,232 | dollars as filed | |
| AVIDITY BIOSCIENCES INC COM | 05370A108 | Stock | 8,641,031 | $623,277,566 | dollars as filed | |
| VAXCYTE INC COM | 92243G108 | Stock | 10,724,599 | $494,832,998 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 9,905,045 | $407,493,551 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV | N62509109 | COMMON STOCK | 9,550,191 | $335,020,700 | dollars as filed | |
| TYRA BIOSCIENCES INC | 90240B106 | COMMON STOCK | 12,198,625 | $320,701,851 | dollars as filed | |
| WAVE LIFE SCIENCES LTD SHS | Y95308105 | Stock | 18,203,009 | $309,451,153 | dollars as filed | |
| MINERALYS THERAPEUTICS INC | 603170101 | COM | 7,323,750 | $265,778,888 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 10,428,437 | $258,781,664 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 6,995,858 | $195,044,521 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,880,057 | $189,114,934 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 1,976,132 | $156,924,642 | dollars as filed | |
| JANUX THERAPEUTICS INC | 47103J105 | COM | 11,189,693 | $154,417,763 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 20,064,545 | $130,620,188 | dollars as filed | |
| TAYSHA GENE THERAPIES INC | 877619106 | COMMON STOCK | 23,555,648 | $129,556,064 | dollars as filed | |
| ARS PHARMACEUTICALS INC | 82835W108 | COM | 10,860,977 | $126,530,382 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 15,827,186 | $123,452,051 | dollars as filed | |
| BICARA THERAPEUTICS INC | 055477103 | COM | 6,955,993 | $117,069,362 | dollars as filed | |
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 373,787 | $110,169,980 | dollars as filed | |
| GH RESEARCH PLC ORDINARY SHARES | G3855L106 | Stock | 7,676,697 | $97,494,052 | dollars as filed | |
| GERON CORP | 374163103 | COM | 63,771,366 | $84,178,203 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 1,267,156 | $82,618,571 | dollars as filed | |
| CLIMB BIO INC | 28658R106 | COMMON STOCK | 11,293,828 | $77,711,233 | dollars as filed | |
| VOR BIOPHARMA INC | 929033207 | COMMON STOCK | 5,404,998 | $70,697,374 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 432,484 | $69,180,141 | dollars as filed | |
| FULCRUM THERAPEUTICS INC | 359616109 | COMMON STOCK | 6,053,960 | $68,470,288 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 4,178,823 | $66,861,168 | dollars as filed | |
| DIANTHUS THERAPEUTICS INC | 252828108 | COM | 1,611,733 | $66,419,517 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 2,600,000 | $65,000,000 | dollars as filed | |
| EVOMMUNE INC | 30054Y107 | COMMON STOCK | 3,458,770 | $59,214,142 | dollars as filed | |
| JADE BIOSCIENCES INC | 008064206 | COM NEW | 3,671,083 | $56,644,811 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 1,621,620 | $53,124,271 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 5,000,000 | $49,650,000 | dollars as filed | |
| LB PHARMACEUTICALS INC | 50180M108 | COMMON STOCK | 2,208,604 | $49,163,525 | dollars as filed | |
| MONOPAR THERAPEUTICS INC | 61023L207 | COMMON STOCK | 667,207 | $43,568,617 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 1,507,844 | $43,516,378 | dollars as filed | |
| 4D MOLECULAR THERAPEUTICS INC COM | 35104E100 | Stock | 5,653,211 | $42,399,083 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 17,119,096 | $42,284,167 | dollars as filed | |
| ARTIVA BIOTHERAPEUTICS INC | 04317A107 | COM | 9,853,302 | $42,270,666 | dollars as filed | |
| GRAIL INC | 384747101 | COM | 428,266 | $36,655,287 | dollars as filed | |
| ASSEMBLY BIOSCIENCES INC | 045396207 | COMMON STOCK | 1,020,410 | $34,704,144 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 5,811,423 | $32,776,426 | dollars as filed | |
| ACUMEN PHARMACEUTICALS INC | 00509G209 | CMN | 14,932,063 | $31,506,653 | dollars as filed | |
| BENITEC BIOPHARMA INC | 08205P209 | COMMON STOCK | 1,850,000 | $24,919,500 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 2,179,711 | $24,914,097 | dollars as filed | |
| REZOLUTE INC | 76200L309 | COMMON STOCK | 9,180,000 | $21,664,800 | dollars as filed | |
| ACRIVON THERAPEUTICS INC | 004890109 | CMN | 8,340,508 | $20,100,624 | dollars as filed | |
| NKARTA INC | 65487U108 | COMMON STOCK | 10,805,129 | $19,989,489 | dollars as filed | |
| OVID THERAPEUTICS INC | 690469101 | COMMON STOCK | 10,714,000 | $17,463,820 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 7,124,116 | $16,741,673 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 4,401,500 | $16,461,610 | dollars as filed | |
| C4 THERAPEUTICS INC | 12529R107 | COM STK | 8,000,000 | $15,280,000 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 335,000 | $14,070,000 | dollars as filed | |
| DESIGN THERAPEUTICS INC | 25056L103 | COM | 1,461,381 | $13,707,754 | dollars as filed | |
| INSPIRE MED SYS INC COM | 457730109 | Stock | 141,964 | $13,093,340 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 662,968 | $12,039,499 | dollars as filed | |
| RANI THERAPEUTICS HLDGS INC | 753018100 | CMN | 8,500,000 | $11,475,000 | dollars as filed | |
| PERCEPTIVE CAPITAL SOLUTIONS | G70077105 | CL A ORD SHS | 750,000 | $9,772,500 | dollars as filed | |
| ADICET BIO INC | 007002207 | COM NEW | 948,249 | $7,984,257 | dollars as filed | |
| NEWAMSTERDAM PHARMA CO NV-27 | N62509117 | WTS | 333,333 | $7,666,659 | dollars as filed | |
| GENEDX HOLDINGS CORP | 81663L200 | COM CL A | 58,044 | $7,549,203 | dollars as filed | |
| WAYSTAR HLDG CORP | 946784105 | COM | 144,400 | $4,729,100 | dollars as filed | |
| WEREWOLF THERAPEUTICS INC | 95075A107 | CMN | 6,681,307 | $4,232,608 | dollars as filed | |
| HINGE HEALTH INC A | 433313103 | COMMON STOCK | 80,113 | $3,721,249 | dollars as filed | |
| PROGYNY INC COM | 74340E103 | Stock | 96,628 | $2,481,407 | dollars as filed | |
| QIAGEN NV | N72482206 | COM SHS | 43,976 | $2,081,683 | dollars as filed | |
| ORTHOPEDIATRICS CORP | 68752L100 | COMMON STOCK | 109,959 | $1,952,872 | dollars as filed | |
| HEALTH CATALYST INC | 42225T107 | COM | 793,749 | $1,897,060 | dollars as filed | |
| PALATIN TECHNOLOGIES INC | 696077601 | COM NEW | 70,000 | $1,076,600 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-016482 | this filing | 2026-02-17 | acceptance time not in the bulk data set |