Sofinnova Investments, Inc.
Follow13F filer, CIK 1631134, Menlo Park, CA
Sofinnova Investments, Inc. reported $1,934,262,135 across 57 holdings for the quarter ended 2026-06-30, in a 13F-HR filed 2026-08-14. Its ten largest share positions make up 59.81% of the portfolio.
Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001104659-26-096982
- Period
- 2026-06-30
- Reported value
- $1.93B
- Holdings
- 57
- Top 10 weight
- 59.81%
- New
- 13
- Sold out
- 30
Largest buys vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| GMABadded | +3,292,954 | $90.5M |
| SPTXnew | +3,564,871 | $77.4M |
| GILDnew | +343,100 | $43.3M |
| ANABadded | +245,283 | $16.6M |
| NRIXnew | +524,098 | $12.7M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Largest sells vs the previous quarter
| Security | Shares change | Approx. value |
|---|---|---|
| AZNexited | -456,031 | -$89.9M |
| BMYreduced | -1,111,751 | -$64.1M |
| JAZZreduced | -232,986 | -$56.1M |
| RAREreduced | -1,428,383 | -$47.7M |
| UTHRreduced | -83,581 | -$45.3M |
Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.
Holdings, Q2 2026
Share positions as resolved from 13F-HR 0001104659-26-096982, largest first. % of portfolio is the value over $1,872,026,913, the sum of the share positions whose value is usable for ratios (method).
| Security | History | Shares | Value | % of portfolio | Change | Latest event | Timeline |
|---|---|---|---|---|---|---|---|
| NTRANATERA INC | 1,550,280 | $421M | 22.48% | 0 | Timeline | ||
| VERAVERA THERAPEUTICS INC | 2,793,987 | $120M | 6.4% | 0 | Timeline | ||
| GMABGENMAB A/S | 4,045,215 | $111M | 5.94% | +3,292,954 | Timeline | ||
| JAZZJAZZ PHARMACEUTICALS PLC | 365,341 | $88M | 4.7% | -232,986 | Timeline | ||
| RAPPRAPPORT THERAPEUTICS INC | 1,904,408 | $79.4M | 4.24% | 0 | Timeline | ||
| SPTXSEAPORT THERAPEUTICS INC | 3,564,871 | $77.4M | 4.14% | new | Timeline | ||
| AVBPARRIVENT BIOPHARMA INC | 1,696,752 | $58.9M | 3.15% | 0 | Timeline | ||
| RAREULTRAGENYX PHARMACEUTICAL IN | 1,717,505 | $57.3M | 3.06% | -1,428,383 | Timeline | ||
| BIOABIOAGE LABS INC | 2,293,788 | $56.2M | 3% | 0 | Timeline | ||
| BMYBRISTOL-MYERS SQUIBB CO | 876,970 | $50.5M | 2.7% | -1,111,751 | Timeline | ||
| SUPNSUPERNUS PHARMACEUTICALS | 1,036,328 | $48.2M | 2.57% | +82,019 | Timeline | ||
| RYTMRHYTHM PHARMACEUTICALS INC | 408,027 | $45.3M | 2.42% | -42,069 | Timeline | ||
| GILDGILEAD SCIENCES INC | 343,100 | $43.3M | 2.32% | new | Timeline | ||
| UTHRUNITED THERAPEUTICS CORP DEL | 76,489 | $41.4M | 2.21% | -83,581 | Timeline | ||
| COGTCOGENT BIOSCIENCES INC | 1,035,148 | $40.1M | 2.14% | -1,078,403 | Timeline | ||
| AXSMAXSOME THERAPEUTICS INC. | 160,429 | $39.3M | 2.1% | -52,318 | Timeline | ||
| IMTXIMMATICS N.V | 3,669,346 | $37.2M | 1.99% | +38,892 | Timeline | ||
| DYNDYNE THERAPEUTICS INC | 1,658,384 | $36.8M | 1.97% | +24,487 | Timeline | ||
| IMNMIMMUNOME INC | 1,720,316 | $36.5M | 1.95% | +18,412 | Timeline | ||
| IDYAIDEAYA BIOSCIENCES INC | 925,119 | $34.5M | 1.84% | -206,667 | Timeline | ||
| ANABANAPTYSBIO INC | 493,536 | $33.3M | 1.78% | +245,283 | Timeline | ||
| NKTRNEKTAR THERAPEUTICS | 471,763 | $32.9M | 1.76% | -37,783 | Timeline | ||
| PHVSPHARVARIS N V | 881,299 | $30.5M | 1.63% | +62,971 | Timeline | ||
| RCUSARCUS BIOSCIENCES INC | 945,690 | $29.2M | 1.56% | +22,604 | Timeline | ||
| INBXINHIBRX BIOSCIENCES INC | 303,103 | $28.7M | 1.53% | -102,926 | Timeline | ||
| BMRNBIOMARIN PHARMACEUTICAL INC | 358,568 | $20.5M | 1.1% | -423,414 | Timeline | ||
| MANEVERADERMICS INC | 148,993 | $18.3M | 0.98% | +75,678 | Timeline | ||
| ALCALCON AG | 255,824 | $17.2M | 0.92% | -474,148 | Timeline | ||
| INSMINSMED INC | 158,398 | $16.9M | 0.9% | -187,677 | Timeline | ||
| EWTXEDGEWISE THERAPEUTICS INC | 380,923 | $15.5M | 0.83% | -5,575 | Timeline | ||
| NRIXNURIX THERAPEUTICS INC | 524,098 | $12.7M | 0.68% | new | Timeline | ||
| DSGNDESIGN THERAPEUTICS INC | 865,135 | $12.5M | 0.67% | new | Timeline | ||
| DFTXDEFINIUM THERAPEUTICS INC | 255,903 | $12M | 0.64% | -88,263 | Timeline | ||
| TRAXFIRST TRACKS BIOTHERAPEUTICS | 565,199 | $11.4M | 0.61% | new | Timeline | ||
| ABTABBOTT LABORATORIES | 122,998 | $11.2M | 0.6% | new | Timeline | ||
| IRONDISC MEDICINE INC | 146,239 | $10.7M | 0.57% | +67,919 | Timeline | ||
| TENXTENAX THERAPEUTICS INC | 500,039 | $7.28M | 0.39% | +395,639 | Timeline | ||
| SIONSIONNA THERAPEUTICS INC | 144,432 | $6.35M | 0.34% | new | Timeline | ||
| ABSIABSCI CORPORATION | 337,400 | $3.91M | 0.21% | new | Timeline | ||
| MIRMMIRUM PHARMACEUTICALS INC | 27,591 | $3.23M | 0.17% | 0 | Timeline | ||
| JBIOJADE BIOSCIENCES INC | 107,391 | $2.39M | 0.13% | 0 | Timeline | ||
| SVRASAVARA INC | 364,763 | $2.25M | 0.12% | 0 | Timeline | ||
| PRAXPRAXIS PRECISION MEDICINES I | 6,440 | $2.16M | 0.12% | -57,240 | Timeline | ||
| SEPNSEPTERNA INC | 47,506 | $1.59M | 0.08% | 0 | Timeline | ||
| OKURONKURE THERAPEUTICS INC | 321,692 | $1.47M | 0.08% | +179,992 | Timeline | ||
| SGMTSAGIMET BIOSCIENCES INC | 166,667 | $1.29M | 0.07% | new | Timeline | ||
| WVEWAVE LIFE SCIENCES LTD | 189,253 | $1.1M | 0.06% | 0 | Timeline | ||
| AKTSAKTIS ONCOLOGY INC | 32,436 | $1.05M | 0.06% | new | Timeline | ||
| TYRATYRA BIOSCIENCES INC | 32,267 | $1.03M | 0.06% | -171,748 | Timeline | ||
| BOLTBOLT BIOTHERAPEUTICS INC | 137,721 | $530K | 0.03% | 0 | Timeline | ||
| NXTCNEXTCURE INC | 222,654 | $356K | 0.02% | 0 | Timeline | ||
| IMAIMAGENEBIO INC | 31,884 | $188K | 0.01% | 0 | Timeline | ||
| HTFLHEARTFLOW INC | 5,079 | $149K | 0.01% | new | Timeline |
Options
Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).
Sold out in Q2 2026
Positions in the previous quarter's report that this quarter's report no longer lists.
| Security | Shares before | Value before | Type |
|---|---|---|---|
| IWMISHARES TR | 600,000 | $149M | put |
| XBISPDR SERIES TRUST | 1,050,000 | $134M | put |
| AZNASTRAZENECA PLC | 456,031 | $89.9M | shares |
| QQQINVESCO QQQ TR | 150,000 | $86.6M | put |
| IBBISHARES TR | 475,000 | $80.2M | put |
| UTHRUNITED THERAPEUTICS CORP DEL | 80,300 | $47.6M | put |
| BIIBBIOGEN INC | 229,521 | $42.1M | shares |
| CELCCELCUITY INC | 366,175 | $41.8M | shares |
| CELCCELCUITY INC | 300,000 | $34.2M | put |
| AXSMAXSOME THERAPEUTICS INC. | 200,000 | $33.8M | put |
| BBIOBRIDGEBIO PHARMA INC | 409,183 | $30.4M | shares |
| DXCMDEXCOM INC | 393,576 | $24.7M | shares |
| PFEPFIZER INC | 800,000 | $22.5M | call |
| LQDALIQUIDIA CORPORATION | 500,000 | $18.9M | put |
| XENEXENON PHARMACEUTICALS INC | 305,216 | $17.7M | shares |
| SYKSTRYKER CORPORATION | 44,480 | $14.6M | shares |
| ROIVROIVANT SCIENCES LTD | 477,995 | $13.2M | shares |
| CMPXCOMPASS THERAPEUTICS INC | 2,056,161 | $10.9M | shares |
| ORICORIC PHARMACEUTICALS INC | 679,578 | $8.61M | shares |
| TNGXTANGO THERAPEUTICS INC | 395,081 | $8.27M | shares |
| REPLREPLIMUNE GROUP INC | 1,015,400 | $7.77M | call |
| AXGNAXOGEN INC | 210,665 | $6.98M | shares |
| CYTKCYTOKINETICS INC | 91,791 | $6.05M | shares |
| HRMYHARMONY BIOSCIENCES HLDGS IN | 152,695 | $4.28M | shares |
| PCVXVAXCYTE INC | 50,600 | $2.94M | shares |
| CMPXCOMPASS THERAPEUTICS INC | 500,000 | $2.65M | call |
| ESTAESTABLISHMENT LABS HLDGS INC | 33,930 | $1.93M | shares |
| ACADACADIA PHARMACEUTICALS INC | 78,551 | $1.75M | shares |
| SLNOSOLENO THERAPEUTICS INC | 14,689 | $492K | shares |
| ZYMEZYMEWORKS INC | 1,610 | $40.3K | shares |
How Q2 2026 was built
Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).
| Filing | Role | Amendment | Filed | Accepted | Ingested |
|---|---|---|---|---|---|
| 13F-HR 0001104659-26-096982 | base | 2026-08-14 | acceptance time not in the bulk data set |
Filings
Every filing of this filer: 13F reports and notices, the 13D and 13G it filed or is a reporting person of, and Forms 3, 4 and 5 it reported as an owner.
| Filing | Subject | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001104659-26-096982 | Quarter ended 2026-06-30 | 2026-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-26-062256 | Quarter ended 2026-03-31 | 2026-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-26-015127 | Quarter ended 2025-12-31 | 2026-02-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-25-111551 | Quarter ended 2025-09-30 | 2025-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-25-078481 | Quarter ended 2025-06-30 | 2025-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-25-049266 | Quarter ended 2025-03-31 | 2025-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-25-013863 | Quarter ended 2024-12-31 | 2025-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-24-117589 | Quarter ended 2024-09-30 | 2024-11-13 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001104659-24-090054 | Quarter ended 2023-12-31 | 2024-08-15 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001104659-24-089526 | Quarter ended 2024-03-31 | 2024-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-24-087771 | Quarter ended 2024-06-30 | 2024-08-09 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-24-061728 | Quarter ended 2024-03-31 | 2024-05-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-24-015432 | Quarter ended 2023-12-31 | 2024-02-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-23-118095 | Quarter ended 2023-09-30 | 2023-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-23-091230 | Quarter ended 2023-06-30 | 2023-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-23-058987 | Quarter ended 2023-03-31 | 2023-05-11 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-23-020042 | Quarter ended 2022-12-31 | 2023-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-22-115835 | Quarter ended 2022-09-30 | 2022-11-08 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-22-091098 | Quarter ended 2022-06-30 | 2022-08-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-22-060547 | Quarter ended 2022-03-31 | 2022-05-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-22-022072 | Quarter ended 2021-12-31 | 2022-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-21-138952 | Quarter ended 2021-09-30 | 2021-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-21-106048 | Quarter ended 2021-06-30 | 2021-08-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-21-066745 | Quarter ended 2021-03-31 | 2021-05-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-21-023887 | Quarter ended 2020-12-31 | 2021-02-16 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-20-124556 | Quarter ended 2020-09-30 | 2020-11-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-20-094764 | Quarter ended 2020-06-30 | 2020-08-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-20-060328 | Quarter ended 2020-03-31 | 2020-05-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-20-020437 | Quarter ended 2019-12-31 | 2020-02-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001104659-19-064122 | Quarter ended 2019-09-30 | 2019-11-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-19-039265 | Quarter ended 2019-06-30 | 2019-08-13 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-19-026474 | Quarter ended 2019-03-31 | 2019-05-15 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001144204-19-009466 | Quarter ended 2018-12-31 | 2019-02-22 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-19-007829 | Quarter ended 2018-12-31 | 2019-02-14 | acceptance time not in the bulk data set | |
| 13F-HR/A 0001144204-18-060047 | Quarter ended 2018-06-30 | 2018-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-18-060046 | Quarter ended 2018-09-30 | 2018-11-15 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-18-044317 | Quarter ended 2018-06-30 | 2018-08-14 | acceptance time not in the bulk data set | |
| 13F-HR 0001144204-18-028628 | Quarter ended 2018-03-31 | 2018-05-15 | acceptance time not in the bulk data set |