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Disclosery

ORACLE INVESTMENT MANAGEMENT INC

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13F filer, CIK 1012622, GREENWICH, CT

ORACLE INVESTMENT MANAGEMENT INC reported $167,936,629 across 22 holdings for the quarter ended 2025-12-31, in a 13F-HR filed 2026-02-18. Its ten largest share positions make up 98.01% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001012622-26-000001

Period
2025-12-31
Reported value
$168M
Holdings
22
Top 10 weight
98.01%
New
8
Sold out
6

Largest buys vs the previous quarter

SecurityShares changeApprox. value
ARDXadded+368,798$2.15M
TSHAnew+265,000$1.46M
EWTXnew+38,343$951K
DAWNnew+100,000$932K
PSNLadded+109,908$875K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
PLTRexited-29,500-$5.38M
CNCexited-110,300-$3.94M
TDOCreduced-351,078-$2.46M
NVAXexited-243,000-$2.11M
KOIDexited-22,400-$719K

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q4 2025

Share positions as resolved from 13F-HR 0001012622-26-000001, largest first. % of portfolio is the value over $152,604,688, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
WGSGENEDX HOLDINGS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 1,126,607 shares; 2024Q2: 1,105,768 shares; 2024Q3: 1,045,768 shares; 2024Q4: 1,023,468 shares; 2025Q1: 969,954 shares; 2025Q2: 922,454 shares; 2025Q3: 889,954 shares; 2025Q4: 884,654 shares 884,654$115M75.4%-5,300Timeline
ARDXARDELYX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 2,039,700 shares; 2024Q2: 1,488,131 shares; 2024Q3: 1,369,200 shares; 2024Q4: 2,089,431 shares; 2025Q1: 2,404,438 shares; 2025Q2: 1,430,728 shares; 2025Q3: 1,503,826 shares; 2025Q4: 1,872,624 shares 1,872,624$10.9M7.15%+368,798Timeline
BHVNBIOHAVEN LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 804,850 shares; 2024Q2: 700,450 shares; 2024Q3: 705,250 shares; 2024Q4: 851,770 shares; 2025Q1: 665,945 shares; 2025Q2: 673,166 shares; 2025Q3: 739,986 shares; 2025Q4: 772,181 shares 772,181$8.72M5.71%+32,195Timeline
QDELQUIDELORTHO CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 157,201 shares; 2024Q2: 118,291 shares; 2024Q3: 118,291 shares; 2024Q4: 118,291 shares; 2025Q1: 118,291 shares; 2025Q2: 118,291 shares; 2025Q3: 118,291 shares; 2025Q4: 118,291 shares 118,291$3.38M2.21%0Timeline
FORAFORIAN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 1,355,807 shares; 2024Q2: 1,356,107 shares; 2024Q3: 1,356,107 shares; 2024Q4: 1,366,107 shares; 2025Q1: 1,366,107 shares; 2025Q2: 1,366,107 shares; 2025Q3: 1,366,107 shares; 2025Q4: 1,366,107 shares 1,366,107$2.9M1.9%0Timeline
PSNLPERSONALIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 229,435 shares; 2025Q4: 339,343 shares 339,343$2.7M1.77%+109,908Timeline
TDOCTELADOC HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 565,900 shares; 2025Q2: 381,000 shares; 2025Q3: 705,416 shares; 2025Q4: 354,338 shares 354,338$2.48M1.63%-351,078Timeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 265,000 shares 265,000$1.46M0.96%newTimeline
CAVACAVA GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 17,600 shares; 2024Q2: 18,600 shares; 2024Q3: 18,600 shares; 2024Q4: 18,600 shares; 2025Q1: 18,600 shares; 2025Q2: 18,600 shares; 2025Q3: 17,100 shares; 2025Q4: 17,100 shares 17,100$1M0.66%0Timeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 38,343 shares 38,343$951K0.62%newTimeline
DAWNDAY ONE BIOPHARMACEUTICALS IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 100,000 shares 100,000$932K0.61%newTimeline
ARKGARK ETF TRQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 19,500 shares 19,500$565K0.37%newTimeline
SGMOSANGAMO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,004,724 shares; 2025Q4: 1,035,742 shares 1,035,742$435K0.29%+31,018Timeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: 2,412 shares; 2024Q2: 2,412 shares; 2024Q3: 2,412 shares; 2024Q4: 2,412 shares; 2025Q1: 2,412 shares; 2025Q2: 2,412 shares; 2025Q3: 2,412 shares; 2025Q4: 2,412 shares 2,412$424K0.28%0Timeline
TEMTEMPUS AI INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 6,507 shares 6,507$384K0.25%newTimeline
TSLATESLA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 500 shares; 2025Q4: 500 shares 500$225K0.15%0Timeline
HTZHERTZ GLOBAL HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q1: not reported; 2024Q2: not reported; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 15,000 shares 15,000$77.1K0.05%newTimeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
TELADOC HEALTH INCTELADOC HEALTH INC OPTIONcall650,000$4.55M+179,500
NOVAVAX INCNOVAVAX INC NOTE 5.000%12/1call600,000$4.03Mnew
ARDELYX INCARDELYX INC COMcall600,000$3.5M-32,800
BIOHAVEN LTDBIOHAVEN LTD COMcall232,900$2.63M-42,100
PFIZER INCPFIZER INC CALLcall25,000$622Knew

Sold out in Q4 2025

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
NOVAVAX INCNOVAVAX INC635,000$5.51Mcall
PLTRPALANTIR TECHNOLOGIES INC29,500$5.38Mshares
CNCCENTENE CORP DEL110,300$3.94Mshares
NVAXNOVAVAX INC243,000$2.11Mshares
KOIDKRANESHARES TRUST22,400$719Kshares
BDSXBIODESIX INC15,000$113Kshares

How Q4 2025 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001012622-26-000001 base2026-02-18acceptance time not in the bulk data set

Filings

Every filing of this filer: 13F reports and notices, the 13D and 13G it filed or is a reporting person of, and Forms 3, 4 and 5 it reported as an owner.

FilingSubjectFiledAcceptedIngested
13F-HR 0001012622-26-000001 Quarter ended 2025-12-312026-02-18acceptance time not in the bulk data set
13F-HR 0001012622-25-000003 Quarter ended 2025-09-302025-11-19acceptance time not in the bulk data set
13F-HR 0001085146-25-005305 Quarter ended 2025-06-302025-08-15acceptance time not in the bulk data set
13F-HR 0001085146-25-003330 Quarter ended 2025-03-312025-05-15acceptance time not in the bulk data set
13F-HR 0001085146-25-001704 Quarter ended 2024-12-312025-02-14acceptance time not in the bulk data set
13F-HR 0001085146-24-005974 Quarter ended 2024-09-302024-11-14acceptance time not in the bulk data set
13F-HR 0001085146-24-004012 Quarter ended 2024-06-302024-08-14acceptance time not in the bulk data set
13F-HR 0001085146-24-002646 Quarter ended 2024-03-312024-05-15acceptance time not in the bulk data set
13F-HR 0001085146-24-001504 Quarter ended 2023-12-312024-02-14acceptance time not in the bulk data set
13F-HR 0001085146-23-004496 Quarter ended 2023-09-302023-11-14acceptance time not in the bulk data set
13F-HR 0001085146-23-003446 Quarter ended 2023-06-302023-08-14acceptance time not in the bulk data set
13F-HR 0001085146-23-002441 Quarter ended 2023-03-312023-05-15acceptance time not in the bulk data set
13F-HR 0001085146-23-001340 Quarter ended 2022-12-312023-02-14acceptance time not in the bulk data set
13F-HR 0001085146-22-004130 Quarter ended 2022-09-302022-11-14acceptance time not in the bulk data set
13F-HR 0001085146-22-003129 Quarter ended 2022-06-302022-08-15acceptance time not in the bulk data set
13F-HR 0001085146-22-002187 Quarter ended 2022-03-312022-05-16acceptance time not in the bulk data set
13F-HR 0001085146-22-001109 Quarter ended 2021-12-312022-02-14acceptance time not in the bulk data set
13F-HR 0001085146-21-003363 Quarter ended 2021-09-302021-11-15acceptance time not in the bulk data set
13F-HR 0001085146-21-002585 Quarter ended 2021-06-302021-08-16acceptance time not in the bulk data set
13F-HR 0001085146-21-001783 Quarter ended 2021-03-312021-05-17acceptance time not in the bulk data set
13F-HR 0001085146-21-000976 Quarter ended 2020-12-312021-02-16acceptance time not in the bulk data set
13F-HR 0001085146-20-003059 Quarter ended 2020-09-302020-11-16acceptance time not in the bulk data set
13F-HR 0001085146-20-002321 Quarter ended 2020-06-302020-08-14acceptance time not in the bulk data set
13F-HR 0001085146-20-001615 Quarter ended 2020-03-312020-05-15acceptance time not in the bulk data set
13F-HR 0001085146-20-000893 Quarter ended 2019-12-312020-02-14acceptance time not in the bulk data set
13F-HR 0001085146-19-003019 Quarter ended 2019-09-302019-11-14acceptance time not in the bulk data set
13F-HR 0001085146-19-002336 Quarter ended 2019-06-302019-08-14acceptance time not in the bulk data set
13F-HR 0001085146-19-001658 Quarter ended 2019-03-312019-05-15acceptance time not in the bulk data set
13F-HR 0001085146-19-000938 Quarter ended 2018-12-312019-02-14acceptance time not in the bulk data set
13F-HR 0001085146-18-002764 Quarter ended 2018-09-302018-11-14acceptance time not in the bulk data set
13F-HR 0001085146-18-002087 Quarter ended 2018-06-302018-08-14acceptance time not in the bulk data set
13F-HR 0001085146-18-001524 Quarter ended 2018-03-312018-05-15acceptance time not in the bulk data set
13F-HR 0001085146-18-000880 Quarter ended 2017-12-312018-02-14acceptance time not in the bulk data set
13F-HR 0001085146-17-002460 Quarter ended 2017-09-302017-11-14acceptance time not in the bulk data set
13F-HR 0001085146-17-001898 Quarter ended 2017-06-302017-08-14acceptance time not in the bulk data set
13F-HR 0001085146-17-001291 Quarter ended 2017-03-312017-05-15acceptance time not in the bulk data set
13F-HR 0001085146-17-000784 Quarter ended 2016-12-312017-02-14acceptance time not in the bulk data set
13F-HR 0001085146-16-004853 Quarter ended 2016-09-302016-11-14acceptance time not in the bulk data set
13F-HR/A 0001085146-16-004350 Quarter ended 2016-03-312016-08-15acceptance time not in the bulk data set
13F-HR 0001085146-16-004351 Quarter ended 2016-06-302016-08-15acceptance time not in the bulk data set
13F-HR 0001085146-16-003860 Quarter ended 2016-03-312016-05-16acceptance time not in the bulk data set
13F-HR 0001085146-16-002847 Quarter ended 2015-12-312016-02-09acceptance time not in the bulk data set
13F-HR 0001085146-15-002436 Quarter ended 2015-09-302015-11-16acceptance time not in the bulk data set
13F-HR/A 0001085146-15-002438 Quarter ended 2015-09-302015-11-16acceptance time not in the bulk data set
13F-HR 0001085146-15-001834 Quarter ended 2015-06-302015-08-14acceptance time not in the bulk data set
13F-HR 0001085146-15-001317 Quarter ended 2015-03-312015-05-15acceptance time not in the bulk data set
13F-HR 0001085146-15-000735 Quarter ended 2014-12-312015-02-17acceptance time not in the bulk data set
13F-HR 0001085146-14-002341 Quarter ended 2014-09-302014-11-14acceptance time not in the bulk data set
13F-HR 0001085146-14-001776 Quarter ended 2014-06-302014-08-14acceptance time not in the bulk data set
13F-HR 0001085146-14-001204 Quarter ended 2014-03-312014-05-15acceptance time not in the bulk data set
13F-HR 0001085146-14-000709 Quarter ended 2013-12-312014-02-14acceptance time not in the bulk data set
13F-HR 0001085146-13-002004 Quarter ended 2013-09-302013-11-14acceptance time not in the bulk data set
13F-HR 0001085146-13-001517 Quarter ended 2013-06-302013-08-14acceptance time not in the bulk data set