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Disclosery

EWTX EDGEWISE THERAPEUTICS INC

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COM (common), issuer CIK 1710072

178 managers (180 13F filers) reported a position in EWTX shares at 2025-06-30, 118,737,946 shares in all. 29 filers opened a position and 42 filers sold out during the quarter.

Managers
178
13F filers
180
New
29
Added
88
Reduced
39
Sold out
42
Shares held by filers
118,737,946

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2025

Filers in the available 13F reports with a share position at 2025-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC15,518,492$203M5.12%+496,77113F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.9,902,633$130M2.19%+993,54213F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP7,305,940$95.8M0.93%+1,150,00013F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,781,046$88.9M<0.01%+296,03813F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …6,142,344$80.5M3.44%+1,747,78813F-HRTimelineGroup
JANUS HENDERSON GROUP PLCin group Janus Henderson5,503,349$72.1M0.04%+221,19513F-HRTimelineGroup
NOVO HOLDINGS A/S5,350,000$70.1M4.95%013F-HRTimeline
BRAIDWELL LP5,210,831$68.3M2.34%+2,752,02313F-HRTimeline
VANGUARD GROUP INCin group VANGUARD GROUP INC4,841,500$63.5M<0.01%+547,09613F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,639,949$60.8M2.28%-1,907,37913F-HRTimelineGroup
Cormorant Asset Management, LP4,251,992$55.7M4.15%+150,00013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.3,160,298$41.4M2.14%+1,463,85413F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG2,775,997$36.4M0.8%+1,347,06813F-HRTimelineGroup
Driehaus Capital Management LLC2,101,781$27.6M0.22%+726,03913F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…2,067,320$27.1M0.49%-11,18913F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC1,797,215$23.6M<0.01%+141,55113F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP1,781,501$23.4M<0.01%+63,77713F-HRTimelineGroup
MPM BIOIMPACT LLC1,720,741$22.6M3.91%+615,29713F-HRTimeline
First Light Asset Management, LLC1,714,019$22.5M2.91%-138,27113F-HRTimeline
Artisan Partners Limited Partnership1,379,068$18.1M0.03%+461,84613F-HRTimeline
Woodline Partners LP1,096,863$14.4M0.08%+5413F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP1,048,936$13.8M<0.01%+381,43713F-HRTimelineGroup
New Leaf Venture Partners, L.L.C.1,030,161$13.5M25.51%013F-HRTimeline
Integral Health Asset Management, LLC1,000,000$13.1M1.22%+325,00013F-HRTimeline
Polar Capital Holdings Plcin group Polar Capital Holdings Plc975,000$12.8M0.07%+725,00013F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC921,965$12.1M0.01%+306,84713F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC783,166$10.3M0.01%+3,40013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY727,714$9.54M<0.01%+318,71713F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC724,899$9.5M0.01%+650,59213F-HRTimelineGroup
Sofinnova Investments, Inc.716,873$9.4M0.64%+374,65513F-HRTimeline
Parkman Healthcare Partners LLC647,331$8.49M0.98%+221,92413F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC631,743$8.28M<0.01%+265,09913F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP602,898$7.9M<0.01%-3,79413F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.595,432$7.81M0.01%+454,88413F-HRTimelineGroup
Foresite Capital Management VI LLCin group Foresite Capital Management V…585,000$7.67M4.31%013F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co579,104$7.59M<0.01%+57,84313F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC568,310$7.45M0.13%013F-HRTimeline
Sio Capital Management, LLC539,730$7.08M2.84%new13F-HRTimeline
Qube Research & Technologies Ltd499,917$6.55M0.01%+102,34413F-HRTimeline
Opaleye Management Inc.490,000$6.42M1.3%+95,00013F-HR/ATimeline
FMR LLCin group FMR LLC470,717$6.17M<0.01%+284,69413F-HRTimelineGroup
Aberdeen Group plcin group Aberdeen Group plc443,319$5.81M0.01%+130,29413F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC442,837$5.81M<0.01%new13F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC431,300$5.65M0.29%+131,30013F-HRTimelineGroup
Granahan Investment Management, LLC405,478$5.32M0.22%+187,81113F-HRTimeline
Eversept Partners, LP392,739$5.15M0.52%new13F-HRTimeline
UBS Group AGgroup of 2 filers holding362,588$4.75M-154,165Timeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC325,249$4.26M<0.01%+227,97113F-HRTimelineGroup
Nuveen, LLCin group TIAA317,173$4.16M<0.01%+114,59313F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.316,500$4.15M0.01%+316,42013F-HRTimelineGroup
VOLORIDGE INVESTMENT MANAGEMENT, LLC284,551$3.73M0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC281,250$3.69M<0.01%+172,68813F-HR/ATimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/254,429$3.34M<0.01%-440,99713F-HRTimelineGroup
Kynam Capital Management, LP253,979$3.33M0.36%new13F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC252,524$3.31M0.08%+27,82413F-HRTimeline
DAFNA Capital Management LLC238,140$3.12M0.86%+55,00013F-HRTimeline
Candriam S.C.A.223,990$2.94M0.02%-1,80613F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp212,858$2.79M<0.01%+2,12313F-HRTimelineGroup
Schonfeld Strategic Advisors LLC167,340$2.19M0.02%-111,63313F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC165,535$2.17M<0.01%+63,35413F-HR/ATimelineGroup
SCHRODER INVESTMENT MANAGEMENT GROUP151,062$1.98M<0.01%+71,91113F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\147,525$1.93M<0.01%-228,53513F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …132,178$1.73M<0.01%+42,75313F-HRTimelineGroup
Exome Asset Management LLC124,470$1.63M1.35%+53,03213F-HR/ATimeline
Jump Financial, LLCin group Jump Financial, LLC121,705$1.6M0.02%new13F-HR/ATimelineGroup
DekaBank Deutsche Girozentrale80,000$1.56M<0.01%013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…115,270$1.51M<0.01%-61,39613F-HRTimelineGroup
Campbell & CO Investment Adviser LLC114,181$1.5M0.09%new13F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…112,570$1.48M<0.01%-73313F-HRTimelineGroup
RHUMBLINE ADVISERS112,483$1.47M<0.01%+3,64613F-HRTimeline
Quantum Private Wealth, LLC100,774$1.32M0.43%+10,05013F-HRTimeline
Moody Aldrich Partners LLC99,848$1.31M0.25%-82,24713F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND93,808$1.23M<0.01%+22,35813F-HR/ATimeline
Swiss National Bank90,000$1.18M<0.01%+7,40013F-HRTimeline
Walleye Capital LLCgroup of 2 filers holding86,882$1.14M+69,248Timeline
TWINBEECH CAPITAL LP78,280$1.03M0.02%-22,54613F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO77,616$1.02M<0.01%-13,75213F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.77,260$1.01M<0.01%013F-HRTimeline
Soleus Capital Management, L.P.76,493$1M0.07%+4,19313F-HRTimeline
HighVista Strategies LLC69,723$914K0.34%-21,48413F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd60,739$796K0.03%new13F-HRTimelineGroup
ALPS ADVISORS INCin group ALPS ADVISORS INC56,798$745K<0.01%-11,17713F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.56,158$736K<0.01%+8,02813F-HRTimelineGroup
OCONNOR, A Distinct Business Unit of UB…55,292$725K0.02%+15,27813F-HRTimelineThe filing omitted confidential holdings, a later amendment may add them.
STATE OF WISCONSIN INVESTMENT BOARD54,019$708K<0.01%-17,11313F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc52,307$686K<0.01%+1,95913F-HRTimelineGroup
HighMark Wealth Management LLC52,065$683K0.33%+51,90013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/50,682$665K<0.01%-244,19913F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC50,185$658K<0.01%+35,42713F-HRTimelineGroup
NORGES BANK47,755$626K<0.01%013F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources45,806$601K<0.01%-48113F-HRTimelineGroup
ExodusPoint Capital Management, LP45,255$593K0.01%new13F-HRTimeline
Verition Fund Management LLC44,069$578K<0.01%+9,35013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC44,065$578K0.01%-2,14313F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding44,040$577K-2,904Timeline
MetLife Investment Management, LLCin group MetLife Investment Management…43,883$575K<0.01%013F-HRTimelineGroup
SEI INVESTMENTS COin group SEI INVESTMENTS CO43,638$572K<0.01%+67613F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL41,663$546K<0.01%-5,14113F-HRTimeline
Quantbot Technologies LP41,463$544K0.01%new13F-HRTimeline
Graham Capital Management, L.P.40,364$529K0.02%+23,31713F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC40,000$524K0.09%+20,00013F-HRTimelineGroup
PRELUDE CAPITAL MANAGEMENT, LLC38,809$509K0.05%-11,18613F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN38,384$503K<0.01%+3,22613F-HRTimelineGroup
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …38,328$502K<0.01%-18,66013F-HRTimelineGroup
Skandinaviska Enskilda Banken AB (publ)37,591$493K<0.01%013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…36,878$483K<0.01%+85013F-HRTimeline
Engineers Gate Manager LP34,909$458K0.01%-1,44913F-HRTimeline
ALGERT GLOBAL LLC34,723$455K0.01%new13F-HR/ATimeline
Handelsbanken Fonder AB28,700$376K<0.01%+6,90013F-HRTimeline
GSA CAPITAL PARTNERS LLP27,276$358K0.03%new13F-HRTimeline
Aquatic Capital Management LLC27,042$355K0.01%new13F-HRTimeline
Numerai GP LLC22,353$293K0.04%new13F-HRTimeline
AlphaQuest LLC21,390$280K0.03%+12,03213F-HRTimeline
SummitTX Capital, L.P.21,380$280K0.01%+11,71613F-HRTimeline
China Universal Asset Management Co., L…21,120$277K0.03%+2,12713F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC19,913$261K<0.01%-260,82213F-HRTimelineGroup
ProShare Advisors LLC18,888$248K<0.01%-1,31513F-HRTimeline
Police & Firemen's Retirement System of…17,356$228K<0.01%+1,90313F-HRTimeline
Creative Planningin group Creative Planning16,910$222K<0.01%+3,83713F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…16,870$221K<0.01%013F-HRTimeline
PROFUND ADVISORS LLC15,085$198K0.01%-60213F-HRTimeline
ARIZONA STATE RETIREMENT SYSTEM13,745$180K<0.01%+1,54413F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…13,561$178K<0.01%new13F-HRTimelineGroup
Nebula Research & Development LLC13,219$173K0.01%new13F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS12,646$166K<0.01%+1,22513F-HRTimeline
Glenmede Investment Management, LP12,542$164K<0.01%13F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC10,712$142K<0.01%+83813F-HRTimelineGroup
KLP KAPITALFORVALTNING AS10,600$139K<0.01%+3,80013F-HRTimeline
SFMG, LLC10,000$131K0.01%013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…9,148$120K<0.01%+1,18813F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS8,193$107K<0.01%+2,68913F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA7,694$100K<0.01%+1,96513F-HR/ATimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…7,594$99.6K<0.01%013F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…7,073$92.7K<0.01%013F-HRTimeline
STRS OHIO6,100$80K<0.01%+2,30013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…6,098$79.9K0.03%+26913F-HRTimelineGroup
SIMPLEX TRADING, LLC4,183$54K<0.01%new13F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD3,400$44.6K<0.01%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT ASSOCIATION…2,849$37K<0.01%013F-HRTimeline
AMALGAMATED BANK2,521$33K<0.01%013F-HRTimeline
GF FUND MANAGEMENT CO. LTD.2,424$31.8K<0.01%013F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\2,009$26.3K<0.01%-1,20413F-HRTimelineGroup
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC1,558$20.4K<0.01%new13F-HRTimelineGroup
Winthrop Capital Management, LLC1,377$18K<0.01%new13F-HRTimeline
Brooklyn Investment Group1,314$17.2K<0.01%new13F-HR/ATimeline
GAMMA Investing LLC1,166$15.3K<0.01%-24113F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,118$14.7K<0.01%+99713F-HR/ATimelineGroup
NISA INVESTMENT ADVISORS, LLC944$12.4K<0.01%-11213F-HRTimeline
CROWLEY WEALTH MANAGEMENT, INC.560$7.34K0.01%013F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …454$6K<0.01%new13F-HRTimelineGroup
Daiwa Securities Group Inc.in group Daiwa Securities Group Inc.344$5K<0.01%013F-HRTimelineGroup
Farther Finance Advisors, LLC374$4.9K<0.01%+36613F-HRTimeline
SIGNATUREFD, LLC363$4.76K<0.01%-12913F-HRTimeline
Quarry LP311$4.08K<0.01%-88913F-HRTimeline
IFP Advisors, Inc0$3.68K<0.01%013F-HRTimelineAmount filed as zero, left out of ratios.
MassMutual Private Wealth & Trust, FSB233$3.06K<0.01%-12313F-HRTimeline
SBI Securities Co., Ltd.207$2.71K<0.01%-3613F-HRTimeline
Sterling Capital Management LLC171$2.24K<0.01%+9613F-HR/ATimeline
ROTHSCHILD INVESTMENT LLC160$2.1K<0.01%+4013F-HRTimeline
Fortitude Family Office, LLC160$2.1K<0.01%013F-HRTimeline
BESSEMER GROUP INCin group BESSEMER GROUP INC185$2K<0.01%new13F-HRTimelineGroup
BFSG, LLC100$1.31K<0.01%013F-HRTimeline
Parallel Advisors, LLC95$1.25K<0.01%-3813F-HRTimeline
Versant Capital Management, Inc95$1.25K<0.01%+5513F-HRTimeline
CWM, LLCin group CWM, LLC109$1K<0.01%+4813F-HRTimelineGroup
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…61$800<0.01%new13F-HRTimelineGroup
Riggs Asset Managment Co. Inc.49$643<0.01%new13F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…49$642<0.01%new13F-HRTimelineGroup
Arax Advisory Partners48$630<0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/40$524<0.01%new13F-HR/ATimelineGroup
COMERICA BANK35$470<0.01%-8613F-HRTimeline
Parkside Financial Bank & Trust35$459<0.01%-513F-HRTimeline
PRINCIPAL SECURITIES, INC.in group PRINCIPAL FINANCIAL GROUP INC27$354<0.01%013F-HRTimelineGroup
Smartleaf Asset Management LLC26$342<0.01%+513F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…24$315<0.01%+513F-HRTimelineGroup
AMERICAN NATIONAL BANK & TRUST2$26<0.01%new13F-HRTimeline
Covestor Ltd8$00%+313F-HRTimelineValue filed as zero, left out of ratios.
CONCOURSE FINANCIAL GROUP SECURITIES, I…0$0013F-HRTimelineValue filed as zero, left out of ratios. Amount filed as zero, left out of ratios.