13F-HR filed by PERCEPTIVE ADVISORS LLC
PERCEPTIVE ADVISORS LLC filed this 13F-HR for the quarter ended 2025-12-31, filed 2026-02-17, with 116 holding rows worth $5,610,284,266.
- Accession
- 0001012975-26-000155
- Filer
- CIK 1224962
- Filed
- 2026-02-17
- Accepted by EDGAR
- acceptance time not in the bulk data set
- Ingested
- Source
- SEC quarterly data set
13F report for Q4 2025
A holdings report, 116 entries on the cover page, a total value of $5,610,284,266 stated on the cover page (in dollars after the unit check, H1), rows summing to $5,610,284,266 with VALUE read as dollars as filed, 13F file number 028-10438. The quarter's positions are built on this report. The resolved quarter.
The information table after summing rows of one CUSIP and put or call (H4), with the CUSIP and issuer name as filed. Values in dollars after the unit check (method).
| Issuer as filed | CUSIP | Class | Amount | Value | Value read as | Type |
|---|---|---|---|---|---|---|
| PRAXIS PRECISION MEDICINES I | 74006W207 | COM NEW | 1,995,986 | $588,296,914 | dollars as filed | |
| CELCUITY INC | 15102K100 | COM | 3,160,200 | $315,198,348 | dollars as filed | |
| RHYTHM PHARMACEUTICALS INC | 76243J105 | COM | 2,546,391 | $272,565,693 | dollars as filed | |
| ASCENDIS PHARMA A/S DKK 1.0 AD | 04351P101 | SPONSORED ADR | 1,081,421 | $230,602,214 | dollars as filed | |
| APOGEE THERAPEUTICS INC COM | 03770N101 | Stock | 2,330,651 | $175,917,537 | dollars as filed | |
| ROIVANT SCIENCES LTD | G76279101 | SHS | 7,985,461 | $173,284,504 | dollars as filed | |
| NUVALENT INC COM | 670703107 | Stock | 1,665,105 | $167,492,912 | dollars as filed | |
| TRAVERE THERAPEUTICS INC | 89422G107 | COM | 4,278,180 | $163,469,258 | dollars as filed | |
| SPDR SER TR | 78464A870 | S&P BIOTECH | 1,100,000 | $134,123,000 | dollars as filed | put |
| EXACT SCIENCES CORP COM | 30063P105 | Stock | 1,200,487 | $121,921,460 | dollars as filed | |
| PROTAGONIST THERAPEUTICS | 74366E102 | COM | 1,350,425 | $117,946,120 | dollars as filed | |
| INHIBRX BIOSCIENCES INC | 45720N103 | COM | 1,452,707 | $114,763,853 | dollars as filed | |
| EDGEWISE THERAPEUTICS INC | 28036F105 | COM | 4,457,974 | $110,624,625 | dollars as filed | |
| IMMATICS N.V | N44445109 | SHS | 10,383,456 | $109,026,288 | dollars as filed | |
| SPYRE THERAPEUTICS INC | 00773J202 | COM NEW | 3,069,225 | $100,547,811 | dollars as filed | |
| AMYLYX PHARMACEUTICALS INC | 03237H101 | COM | 8,284,882 | $100,081,375 | dollars as filed | |
| ARCELLX INC COMMON STOCK | 03940C100 | Stock | 1,466,071 | $95,587,829 | dollars as filed | |
| VIRIDIAN THERAPEUTICS INC | 92790C104 | COM | 3,042,703 | $94,688,917 | dollars as filed | |
| Boston Scientific Corporation | 101137107 | COM | 979,000 | $93,347,650 | dollars as filed | |
| AMICUS THERAPEUTICS INC | 03152W109 | COM | 6,370,851 | $90,720,918 | dollars as filed | |
| ZYMEWORKS INC | 98985Y108 | COM | 3,261,850 | $85,884,511 | dollars as filed | |
| ASTRIA THERAPEUTICS INC COM | 04635X102 | Stock | 6,485,420 | $84,894,147 | dollars as filed | |
| MEIRAGTX HOLDINGS PLC | G59665102 | COMMON STOCK | 10,326,103 | $82,092,519 | dollars as filed | |
| ARTIVION INC | 228903100 | COM | 1,722,290 | $78,553,647 | dollars as filed | |
| CENTESSA PHARMACEUTICALS PLC | 152309100 | SPONSORED ADS | 2,917,634 | $72,970,026 | dollars as filed | |
| DYNE THERAPEUTICS INC COM | 26818M108 | Stock | 3,478,944 | $68,048,145 | dollars as filed | |
| NURIX THERAPEUTICS INC | 67080M103 | COMMON STOCK | 3,555,877 | $67,454,987 | dollars as filed | |
| SOLID BIOSCIENCES INC | 83422E204 | COMMON STOCK | 11,833,539 | $66,741,160 | dollars as filed | |
| BELITE BIO INC | 07782B104 | CMN | 414,239 | $66,261,670 | dollars as filed | |
| ABIVAX SA- | 00370M103 | SPONSORED ADS | 458,343 | $61,809,845 | dollars as filed | |
| INVIVYD INC | 00534A102 | COMMON STOCK | 21,785,166 | $53,809,360 | dollars as filed | |
| ENGENE HOLDINGS INC | 29286M105 | COM | 5,869,076 | $52,997,756 | dollars as filed | |
| REPLIGEN CORP COM | 759916109 | Stock | 315,541 | $51,704,548 | dollars as filed | |
| IMMUNOVANT INC | 45258J102 | COM | 1,994,890 | $50,710,104 | dollars as filed | |
| Intuitive Surgical,Inc. | 46120E602 | COM | 87,919 | $49,793,805 | dollars as filed | |
| SIONNA THERAPEUTICS INC | 829401108 | COMMON STOCK | 1,179,098 | $48,508,092 | dollars as filed | |
| NEUROCRINE BIOSCIENCES INC | 64125C109 | COM | 331,050 | $46,952,821 | dollars as filed | |
| Danaher Corporation | 235851102 | COM | 200,000 | $45,784,000 | dollars as filed | |
| ORUKA THERAPEUTICS INC COM | 687604108 | Stock | 1,476,501 | $44,752,745 | dollars as filed | |
| CYTOMX THERAPEUTICS INC | 23284F105 | COMMON STOCK | 9,680,185 | $41,237,588 | dollars as filed | |
| OMADA HEALTH INC | 68170A108 | COM | 2,396,330 | $37,814,087 | dollars as filed | |
| CIDARA THERAPEUTICS INC | 171757206 | COM NEW | 165,131 | $36,475,787 | dollars as filed | |
| DISC MEDICINE INC COM | 254604101 | Stock | 450,743 | $35,793,502 | dollars as filed | |
| BRIGHT MINDS BIOSCIENCES INC | 10919W405 | COMMON STOCK | 449,290 | $35,062,592 | dollars as filed | |
| PENUMBRA INC COM | 70975L107 | Stock | 110,529 | $34,364,571 | dollars as filed | |
| ALTO NEUROSCIENCE INC COM SHS | 02157Q109 | Stock | 1,784,393 | $31,762,195 | dollars as filed | |
| CARIS LIFE SCIENCES INC | 142152107 | COMMON STOCK | 1,136,206 | $30,654,838 | dollars as filed | |
| JAZZ PHARMACEUTICALS PLC SHS USD | G50871105 | Stock | 170,000 | $28,900,000 | dollars as filed | |
| PALISADE BIO INC | 696389402 | COMMON STOCK | 12,050,000 | $28,317,500 | dollars as filed | |
| RAPT THERAPEUTICS INC | 75382E208 | COM NEW | 825,890 | $27,972,894 | dollars as filed | |
| PALVELLA THERAPEUTICS INC | 697947109 | COMMON STOCK | 266,287 | $27,872,260 | dollars as filed | |
| AXSOME THERAPEUTICS INC. COM | 05464T104 | Stock | 148,900 | $27,195,096 | dollars as filed | |
| AXOGEN INC | 05463X106 | COM | 784,140 | $25,664,902 | dollars as filed | |
| X4 PHARMACEUTICALS INC | 98420X202 | COMMON STOCK | 6,314,452 | $25,257,808 | dollars as filed | |
| BIOCRYST PHARMACEUTICALS INC COM | 09058V103 | Stock | 3,162,529 | $24,667,726 | dollars as filed | |
| NAUTILUS BIOTECHNOLOGY INC | 63909J108 | COM | 12,594,211 | $24,558,711 | dollars as filed | |
| KODIAK SCIENCES INC | 50015M109 | COM | 848,900 | $23,735,244 | dollars as filed | |
| BIOGEN INC COM | 09062X103 | Stock | 124,000 | $21,822,760 | dollars as filed | |
| ALDEYRA THERAPEUTICS INC | 01438T106 | COM | 4,185,632 | $21,681,574 | dollars as filed | |
| ORCHESTRA BIOMED HOLDINGS IN | 68572M106 | COMMON STOCK | 5,127,256 | $21,278,112 | dollars as filed | |
| MIRUM PHARMACEUTICALS INC | 604749101 | COM | 259,545 | $20,501,460 | dollars as filed | |
| RAPPORT THERAPEUTICS INC COM | 75383L102 | Stock | 673,923 | $20,446,824 | dollars as filed | |
| GRAIL INC | 384747101 | COM | 237,342 | $20,314,102 | dollars as filed | |
| IRHYTHM HOLDINGS INC COM | 450056106 | Stock | 108,000 | $19,163,520 | dollars as filed | |
| BETA BIONICS INC | 08659B102 | COMMON STOCK | 602,944 | $18,371,704 | dollars as filed | |
| CVS Health Corporation | 126650100 | COM | 220,000 | $17,459,200 | dollars as filed | |
| CONTINEUM THERAPEUTICS INC CL A | 21217B100 | Stock | 1,464,592 | $16,740,287 | dollars as filed | |
| GUARDANT HEALTH INC COM | 40131M109 | Stock | 160,000 | $16,342,400 | dollars as filed | |
| ADMA BIOLOGICS INC | 000899104 | COM | 883,468 | $16,114,456 | dollars as filed | |
| RELAY THERAPEUTICS INC COM | 75943R102 | Stock | 1,903,245 | $16,101,453 | dollars as filed | |
| GLAUKOS CORP COM | 377322102 | Stock | 140,000 | $15,807,400 | dollars as filed | |
| DEXCOM INC COM | 252131107 | Stock | 225,758 | $14,983,558 | dollars as filed | |
| SAVARA INC | 805111101 | COM | 2,400,000 | $14,472,000 | dollars as filed | |
| CELCUITY INC | 15102KAA8 | NOTE 2.750% 8/0 | 6,500,000 | $14,098,435 | dollars as filed | principal |
| LeonaBio Inc | 04746L203 | COM | 1,859,322 | $14,075,067 | dollars as filed | |
| SEPTERNA INC COM | 81734D104 | Stock | 433,160 | $12,076,501 | dollars as filed | |
| INHIBIKASE THERAPEUTICS INC | 45719W205 | COMMON STOCK | 5,421,568 | $11,114,214 | dollars as filed | |
| Adagio Med Hldgs Inc Com | 00534B100 | Common Stock | 9,876,576 | $10,271,639 | dollars as filed | |
| OCULIS HOLDING AG | H5870P102 | CMN | 493,827 | $9,861,725 | dollars as filed | |
| GOSSAMER BIO INC COM | 38341P102 | Stock | 3,139,669 | $9,732,974 | dollars as filed | |
| MAPLIGHT THERAPEUTICS INC | 56565P103 | COMMON STOCK | 550,000 | $9,660,750 | dollars as filed | |
| XENON PHARMACEUTICALS INC COM | 98420N105 | Stock | 200,791 | $8,999,453 | dollars as filed | |
| OPUS GENETICS INC | 67577R102 | COMMON STOCK | 4,325,000 | $8,693,250 | dollars as filed | |
| ANTERIS TECHNOLOGIES GLOBAL | 03675P102 | COMMON STOCK | 1,675,476 | $8,360,625 | dollars as filed | |
| KESTRA MED TECHNOLOGIES LTD | G52441105 | SHS | 285,000 | $7,558,200 | dollars as filed | |
| CAPRICOR THERAPEUTICS INC | 14070B309 | COMMON STOCK | 242,100 | $6,987,006 | dollars as filed | call |
| BILLIONTOONE INC | 090168105 | CL A | 72,812 | $5,958,934 | dollars as filed | |
| BIOHAVEN LTD | G1110E107 | COM | 500,000 | $5,645,000 | dollars as filed | call |
| KYMERA THERAPEUTICS INC | 501575104 | COM | 69,935 | $5,441,642 | dollars as filed | |
| PEPGEN INC COM | 713317105 | Stock | 829,870 | $5,402,454 | dollars as filed | |
| CRESCENT BIOPHARMA INC | G2545C104 | COMMON STOCK | 453,686 | $5,380,716 | dollars as filed | |
| TENAX THERAPEUTICS INC | 88032L605 | COM NEW | 439,142 | $5,353,141 | dollars as filed | |
| CORVUS PHARMACEUTICALS INC | 221015100 | COM | 692,441 | $5,331,796 | dollars as filed | |
| TECTONIC THERAPEUTIC INC | 878972108 | COMMON STOCK | 250,000 | $5,215,000 | dollars as filed | call |
| AQUESTIVE THERAPEUTICS INC COM | 03843E104 | Stock | 747,193 | $4,826,867 | dollars as filed | |
| TANGO THERAPEUTICS INC | 87583X109 | COM | 513,035 | $4,545,490 | dollars as filed | |
| KRYSTAL BIOTECH INC COM | 501147102 | Stock | 17,500 | $4,314,450 | dollars as filed | |
| COGENT BIOSCIENCES INC | 19240Q201 | COM | 121,082 | $4,300,833 | dollars as filed | |
| OLEMA PHARMACEUTICALS INC | 68062P106 | COM | 165,713 | $4,142,825 | dollars as filed | |
| SCHRODINGER INC COM | 80810D103 | Stock | 202,400 | $3,618,912 | dollars as filed | |
| OUTSET MED INC | 690145206 | COM NEW | 833,333 | $3,091,665 | dollars as filed | |
| SAB BIOTHERAPEUTICS INC | 78397T202 | COMMON STOCK | 803,210 | $3,004,005 | dollars as filed | |
| AVALO THERAPEUTICS INC | 05338F306 | COMMON STOCK | 139,667 | $2,536,353 | dollars as filed | |
| CONNECT BIOPHARMA HLDGS LTD | G23549101 | SHS | 792,696 | $2,235,403 | dollars as filed | |
| IMMIX BIOPHARMA INC | 45258H106 | COMMON STOCK | 338,941 | $1,772,661 | dollars as filed | |
| LEXEO THERAPEUTICS INC | 52886X107 | COMMON STOCK | 139,835 | $1,388,562 | dollars as filed | |
| CUMBERLAND PHARMACEUTICALS I | 230770109 | COM | 341,087 | $1,357,526 | dollars as filed | |
| MEDLINE INC COM CL A | 58507V107 | Stock | 28,000 | $1,176,000 | dollars as filed | |
| PALATIN TECHNOLOGIES INC | 696077601 | COM NEW | 70,000 | $1,076,600 | dollars as filed | |
| LENZ THERAPEUTICS INC | 52635N103 | COM | 50,000 | $800,000 | dollars as filed | |
| BIODESIX INC COM | 09075X207 | Stock | 108,694 | $739,119 | dollars as filed | |
| ENVVENO MEDICAL CORPORATION | 29415J106 | COM | 1,759,035 | $564,298 | dollars as filed | |
| IOVANCE BIOTHERAPEUTICS INC | 462260100 | COM | 152,714 | $416,909 | dollars as filed | |
| REVOLUTION MEDICINES INC | 76155X118 | *W EXP 12/17/202 | 250,000 | $234,975 | dollars as filed | |
| ENSYSCE BIOSCIENCES INC | 293602504 | COM NEW | 86,666 | $79,733 | dollars as filed | |
| SURROZEN INC | 86889P117 | *W EXP 08/01/203 | 166,666 | $3,333 | dollars as filed |
Amendment chain
| Filing | Role | Filed | Accepted | Ingested |
|---|---|---|---|---|
| 13F-HR 0001012975-26-000155 | this filing | 2026-02-17 | acceptance time not in the bulk data set |