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ORBIMED ADVISORS LLC

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13F filer, CIK 1055951, New York, NY

ORBIMED ADVISORS LLC reported $5,396,779,685 across 129 holdings for the quarter ended 2026-06-30, in a 13F-HR filed 2026-08-14. Its ten largest share positions make up 43.03% of the portfolio.

Filed (acceptance time not in the bulk data set), ingested 13F-HR 0001172661-26-003740

Period
2026-06-30
Reported value
$5.4B
Holdings
129
Top 10 weight
43.03%
New
42
Sold out
26

Part of the filer group ORBIMED ADVISORS LLC

How groups are built

Stakes and trades reported after 2026-06-30

13D, 13G and Form 4 filings by this filer's group, dated after the 13F period, on securities the quarter does not hold as shares.

  • ADARX PHARMACEUTICALS INC: 13D 14,913,764 shares, 14% of the class, 13D filed 2026-10-02, 0000947871-26-000917
    Accepted , ingested
  • ELECTRA THERAPEUTICS INC: 13D 6,885,170 shares, 11% of the class, 13D filed 2026-09-25, 0000947871-26-000898
    Accepted , ingested

Largest buys vs the previous quarter

SecurityShares changeApprox. value
UNHnew+161,100$67M
ASNDnew+244,456$65.2M
HUMnew+164,100$65.2M
ODTXnew+3,001,198$56.2M
ARQTnew+2,042,000$53.5M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Largest sells vs the previous quarter

SecurityShares changeApprox. value
ELVNreduced-1,182,906-$60M
PFEexited-1,946,500-$54.7M
IRONreduced-710,015-$51.9M
DHRexited-265,800-$50.4M
SIONreduced-974,825-$42.9M

Ranked by the share change valued at this quarter's implied price (value over shares in the 13F). A position sold out is valued at the previous quarter's price, its last report.

Holdings, Q2 2026

Share positions as resolved from 13F-HR 0001172661-26-003740, largest first. % of portfolio is the value over $5,279,399,985, the sum of the share positions whose value is usable for ratios (method).

SecurityHistorySharesValue% of portfolioChangeLatest eventTimeline
EWTXEDGEWISE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 15,021,721 shares; 2024Q4: 15,021,721 shares; 2025Q1: 15,021,721 shares; 2025Q2: 15,518,492 shares; 2025Q3: 15,518,492 shares; 2025Q4: 15,518,492 shares; 2026Q1: 15,518,492 shares; 2026Q2: 15,518,492 shares 15,518,492$631M11.94%0Timeline
ELVNENLIVEN THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 7,959,538 shares; 2024Q4: 7,959,538 shares; 2025Q1: 7,959,538 shares; 2025Q2: 7,959,538 shares; 2025Q3: 7,959,538 shares; 2025Q4: 7,959,538 shares; 2026Q1: 7,959,538 shares; 2026Q2: 6,776,632 shares 6,776,632$344M6.51%-1,182,906Timeline
LLYELI LILLY & COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 337,600 shares; 2024Q4: 337,600 shares; 2025Q1: 337,600 shares; 2025Q2: 337,600 shares; 2025Q3: 301,200 shares; 2025Q4: 301,200 shares; 2026Q1: 236,800 shares; 2026Q2: 257,900 shares 257,900$309M5.86%+21,100Timeline
MBXMBX BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 3,812,215 shares; 2024Q4: 3,812,215 shares; 2025Q1: 4,002,887 shares; 2025Q2: 4,002,887 shares; 2025Q3: 4,002,887 shares; 2025Q4: 3,935,203 shares; 2026Q1: 3,637,887 shares; 2026Q2: 3,428,736 shares 3,428,736$189M3.58%-209,151Timeline
SVASINOVAC BIOTECH LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 2,718,735 shares; 2024Q4: 2,718,735 shares; 2025Q1: 2,718,735 shares; 2025Q2: 2,718,735 shares; 2025Q3: 2,718,735 shares; 2025Q4: 2,718,735 shares; 2026Q1: 2,718,735 shares; 2026Q2: 2,718,735 shares 2,718,735$184M3.49%0Timeline
AZNASTRAZENECA PLCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 670,200 shares; 2026Q2: 915,700 shares 915,700$171M3.24%+245,500Timeline
GPCRSTRUCTURE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 383,705 shares; 2024Q4: 652,028 shares; 2025Q1: 652,028 shares; 2025Q2: 1,199,300 shares; 2025Q3: 1,139,300 shares; 2025Q4: 1,161,803 shares; 2026Q1: 1,475,403 shares; 2026Q2: 2,209,400 shares 2,209,400$119M2.25%+733,997Timeline
SIONSIONNA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 3,704,959 shares; 2025Q2: 3,704,959 shares; 2025Q3: 3,704,959 shares; 2025Q4: 3,561,655 shares; 2026Q1: 3,530,702 shares; 2026Q2: 2,555,877 shares 2,555,877$112M2.13%-974,825Timeline
CRVSCORVUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 6,943,654 shares; 2024Q4: 6,943,654 shares; 2025Q1: 6,943,654 shares; 2025Q2: 7,165,006 shares; 2025Q3: 7,165,006 shares; 2025Q4: 7,165,006 shares; 2026Q1: 7,165,006 shares; 2026Q2: 7,165,006 shares 7,165,006$107M2.03%0Timeline
AVBPARRIVENT BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 3,027,328 shares; 2024Q4: 3,027,328 shares; 2025Q1: 3,027,328 shares; 2025Q2: 3,027,328 shares; 2025Q3: 3,027,328 shares; 2025Q4: 3,027,328 shares; 2026Q1: 3,027,328 shares; 2026Q2: 3,027,328 shares 3,027,328$105M1.99%02026-10-06, 13D/A: 2,875,962 shares, 5.8% of the class, 13D/A filed 2026-10-08 Timeline
GHGUARDANT HEALTH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 435,200 shares; 2026Q2: 583,700 shares 583,700$87.6M1.66%+148,500Timeline
ARGXARGENX SEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 204,500 shares; 2024Q4: 189,700 shares; 2025Q1: 206,700 shares; 2025Q2: 208,000 shares; 2025Q3: 172,300 shares; 2025Q4: 146,000 shares; 2026Q1: 136,900 shares; 2026Q2: 92,880 shares 92,880$86.2M1.63%-44,020Timeline
MRKMERCK & CO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,316,000 shares; 2024Q4: 829,900 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 663,400 shares; 2026Q2: 663,400 shares 663,400$85.2M1.61%0Timeline
QUREUNIQURE NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 458,500 shares; 2025Q4: 737,400 shares; 2026Q1: 2,136,149 shares; 2026Q2: 1,807,486 shares 1,807,486$83.3M1.58%-328,663Timeline
PRAXPRAXIS PRECISION MEDICINES IQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 94,500 shares; 2026Q1: 172,500 shares; 2026Q2: 230,100 shares 230,100$77M1.46%+57,600Timeline
EWEDWARDS LIFESCIENCES CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: 1,145,302 shares; 2025Q1: 1,532,000 shares; 2025Q2: 1,708,000 shares; 2025Q3: 1,684,000 shares; 2025Q4: 1,842,900 shares; 2026Q1: 1,230,600 shares; 2026Q2: 834,900 shares 834,900$75.5M1.43%-395,700Timeline
PRLDPRELUDE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 10,909,256 shares; 2024Q4: 10,909,256 shares; 2025Q1: 10,909,256 shares; 2025Q2: 10,909,256 shares; 2025Q3: 10,909,256 shares; 2025Q4: 10,909,256 shares; 2026Q1: 10,909,256 shares; 2026Q2: 13,724,571 shares 13,724,571$73.2M1.39%+2,815,315Timeline
ABVXABIVAX SAQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 380,000 shares; 2025Q4: 367,900 shares; 2026Q1: 465,700 shares; 2026Q2: 546,522 shares 546,522$72.8M1.38%+80,822Timeline
DYNDYNE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 708,400 shares; 2024Q4: 1,227,080 shares; 2025Q1: 1,014,611 shares; 2025Q2: 1,031,400 shares; 2025Q3: 2,314,184 shares; 2025Q4: 2,202,184 shares; 2026Q1: 2,917,884 shares; 2026Q2: 3,235,684 shares 3,235,684$71.9M1.36%+317,800Timeline
NTRANATERA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 687,500 shares; 2024Q4: 413,000 shares; 2025Q1: 547,000 shares; 2025Q2: 593,434 shares; 2025Q3: 429,300 shares; 2025Q4: 365,800 shares; 2026Q1: 262,000 shares; 2026Q2: 262,000 shares 262,000$71.1M1.35%0Timeline
CGONCG ONCOLOGY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 691,114 shares; 2024Q4: 1,431,114 shares; 2025Q1: 2,471,994 shares; 2025Q2: 1,877,850 shares; 2025Q3: 1,726,850 shares; 2025Q4: 1,516,550 shares; 2026Q1: 948,267 shares; 2026Q2: 972,800 shares 972,800$69.1M1.31%+24,533Timeline
UNHUNITEDHEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 179,000 shares; 2024Q4: 130,900 shares; 2025Q1: 201,200 shares; 2025Q2: 336,300 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 161,100 shares 161,100$67M1.27%newTimeline
SPRYARS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 8,288,510 shares; 2024Q4: 8,288,510 shares; 2025Q1: 8,288,510 shares; 2025Q2: 8,288,510 shares; 2025Q3: 8,288,510 shares; 2025Q4: 8,288,510 shares; 2026Q1: 8,288,510 shares; 2026Q2: 8,288,510 shares 8,288,510$66.4M1.26%0Timeline
ASNDASCENDIS PHARMA A/SQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 244,456 shares 244,456$65.2M1.24%newTimeline
HUMHUMANA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 164,100 shares 164,100$65.2M1.23%newTimeline
COGTCOGENT BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 371,000 shares; 2026Q1: 322,100 shares; 2026Q2: 1,681,300 shares 1,681,300$65.1M1.23%+1,359,200Timeline
BSXBOSTON SCIENTIFIC CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 3,273,000 shares; 2024Q4: 3,160,300 shares; 2025Q1: 2,813,200 shares; 2025Q2: 2,813,200 shares; 2025Q3: 2,429,300 shares; 2025Q4: 2,419,300 shares; 2026Q1: 2,382,100 shares; 2026Q2: 1,483,200 shares 1,483,200$63.3M1.2%-898,900Timeline
ISRGINTUITIVE SURGICAL INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 433,800 shares; 2024Q4: 401,700 shares; 2025Q1: 291,000 shares; 2025Q2: 291,000 shares; 2025Q3: 287,200 shares; 2025Q4: 263,400 shares; 2026Q1: 208,700 shares; 2026Q2: 157,900 shares 157,900$62.8M1.19%-50,800Timeline
MLYSMINERALYS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 2,002,939 shares; 2024Q4: 1,611,637 shares; 2025Q1: not reported; 2025Q2: 760,351 shares; 2025Q3: 1,469,494 shares; 2025Q4: 980,400 shares; 2026Q1: 2,052,900 shares; 2026Q2: 2,110,300 shares 2,110,300$56.9M1.08%+57,400Timeline
ODTXODYSSEY THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 3,001,198 shares 3,001,198$56.2M1.06%newTimeline
XENEXENON PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 911,420 shares; 2024Q4: 947,877 shares; 2025Q1: 947,877 shares; 2025Q2: 947,877 shares; 2025Q3: 419,600 shares; 2025Q4: 447,200 shares; 2026Q1: 1,059,971 shares; 2026Q2: 892,471 shares 892,471$53.9M1.02%-167,500Timeline
ARQTARCUTIS BIOTHERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 2,042,000 shares 2,042,000$53.5M1.01%newTimeline
BMYBRISTOL-MYERS SQUIBB COQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 775,000 shares; 2026Q1: 925,000 shares; 2026Q2: 925,000 shares 925,000$53.3M1.01%0Timeline
QTTBQ32 BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 2,252,987 shares; 2024Q4: 2,252,987 shares; 2025Q1: 2,252,987 shares; 2025Q2: 2,252,987 shares; 2025Q3: 2,252,987 shares; 2025Q4: 2,252,987 shares; 2026Q1: 2,252,987 shares; 2026Q2: 4,127,987 shares 4,127,987$52.6M1%+1,875,000Timeline
SYKSTRYKER CORPORATIONQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 344,400 shares; 2024Q4: 344,400 shares; 2025Q1: 359,200 shares; 2025Q2: 359,200 shares; 2025Q3: 359,200 shares; 2025Q4: 325,000 shares; 2026Q1: 182,500 shares; 2026Q2: 159,100 shares 159,100$50.1M0.95%-23,400Timeline
CAICARIS LIFE SCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 3,034,858 shares; 2025Q3: 3,034,858 shares; 2025Q4: 3,116,011 shares; 2026Q1: 2,806,811 shares; 2026Q2: 2,806,811 shares 2,806,811$50M0.95%0Timeline
TMOTHERMO FISHER SCIENTIFIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 84,400 shares; 2024Q4: 84,400 shares; 2025Q1: 129,000 shares; 2025Q2: 46,500 shares; 2025Q3: 46,500 shares; 2025Q4: 46,500 shares; 2026Q1: 46,500 shares; 2026Q2: 90,700 shares 90,700$45.5M0.86%+44,200Timeline
PVLAPALVELLA THERAPEUTICS INC NEQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 134,600 shares; 2026Q2: 292,360 shares 292,360$44.7M0.85%+157,760Timeline
ELVELEVANCE HEALTH INC FORMERLYQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 106,200 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 99,100 shares; 2026Q1: 114,700 shares; 2026Q2: 114,700 shares 114,700$44.4M0.84%0Timeline
STTKSHATTUCK LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 6,306,127 shares; 2025Q4: 6,306,127 shares; 2026Q1: 6,306,127 shares; 2026Q2: 6,306,127 shares 6,306,127$43.8M0.83%0Timeline
UPBUPSTREAM BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: 5,693,589 shares; 2025Q1: 5,693,589 shares; 2025Q2: 5,693,589 shares; 2025Q3: 5,693,589 shares; 2025Q4: 5,693,589 shares; 2026Q1: 5,693,589 shares; 2026Q2: 5,693,589 shares 5,693,589$39.4M0.75%0Timeline
CRNXCRINETICS PHARMACEUTICALS INQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,050,055 shares; 2024Q4: 999,000 shares; 2025Q1: 999,000 shares; 2025Q2: 1,149,000 shares; 2025Q3: 1,099,000 shares; 2025Q4: 999,000 shares; 2026Q1: 999,000 shares; 2026Q2: 999,000 shares 999,000$37.4M0.71%0Timeline
RYTMRHYTHM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 435,900 shares; 2024Q4: 400,000 shares; 2025Q1: 380,000 shares; 2025Q2: 248,512 shares; 2025Q3: 215,152 shares; 2025Q4: 239,800 shares; 2026Q1: 314,100 shares; 2026Q2: 322,900 shares 322,900$35.9M0.68%+8,800Timeline
SNDXSYNDAX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,925,300 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 962,300 shares; 2026Q2: 1,542,000 shares 1,542,000$33.7M0.64%+579,700Timeline
FBRXFORTE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: 600,000 shares; 2025Q1: 593,088 shares; 2025Q2: 1,196,955 shares; 2025Q3: 1,196,955 shares; 2025Q4: 1,196,955 shares; 2026Q1: 1,196,955 shares; 2026Q2: 1,577,705 shares 1,577,705$33.5M0.64%+380,750Timeline
CMPXCOMPASS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 22,362,850 shares; 2024Q4: 22,362,850 shares; 2025Q1: 22,362,850 shares; 2025Q2: 15,219,994 shares; 2025Q3: 15,219,994 shares; 2025Q4: 15,219,994 shares; 2026Q1: 15,219,994 shares; 2026Q2: 15,219,994 shares 15,219,994$33.3M0.63%0Timeline
NKTRNEKTAR THERAPEUTICSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 275,000 shares; 2026Q2: 465,346 shares 465,346$32.5M0.62%+190,346Timeline
KRYSKRYSTAL BIOTECH INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 23,500 shares; 2024Q4: 23,500 shares; 2025Q1: 23,500 shares; 2025Q2: 9,200 shares; 2025Q3: 102,745 shares; 2025Q4: 119,800 shares; 2026Q1: 69,100 shares; 2026Q2: 83,200 shares 83,200$30.9M0.59%+14,100Timeline
00Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 12,048,773 shares; 2024Q4: 12,048,773 shares; 2025Q1: 12,048,773 shares; 2025Q2: 12,048,773 shares; 2025Q3: 6,210,899 shares; 2025Q4: 6,210,899 shares; 2026Q1: 6,210,899 shares; 2026Q2: 5,680,186 shares 5,680,186$30.3M0.57%-530,713
AXSMAXSOME THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 386,700 shares; 2025Q2: 427,900 shares; 2025Q3: 531,800 shares; 2025Q4: 253,121 shares; 2026Q1: 213,921 shares; 2026Q2: 117,578 shares 117,578$28.8M0.55%-96,343Timeline
KNSAKINIKSA PHARMACEUTICALS INTLQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 187,199 shares; 2026Q1: 180,599 shares; 2026Q2: 420,600 shares 420,600$26.9M0.51%+240,001Timeline
TRVITREVI THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 1,120,000 shares; 2025Q2: 3,308,400 shares; 2025Q3: 3,308,400 shares; 2025Q4: 3,190,700 shares; 2026Q1: 2,454,400 shares; 2026Q2: 1,430,293 shares 1,430,293$26.7M0.51%-1,024,107Timeline
IRONDISC MEDICINE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,785,571 shares; 2024Q4: 1,785,571 shares; 2025Q1: 1,415,020 shares; 2025Q2: 1,415,020 shares; 2025Q3: 1,415,020 shares; 2025Q4: 1,067,550 shares; 2026Q1: 1,067,550 shares; 2026Q2: 357,535 shares 357,535$26.2M0.5%-710,015Timeline
WSTWEST PHARMACEUTICAL SVSC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 70,600 shares 70,600$25.3M0.48%newTimeline
RLMDRELMADA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,610,600 shares; 2026Q1: 4,715,864 shares; 2026Q2: 3,631,195 shares 3,631,195$25.1M0.48%-1,084,669Timeline
URGNUROGEN PHARMA LTDQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 478,400 shares; 2025Q3: 689,000 shares; 2025Q4: 875,487 shares; 2026Q1: 875,487 shares; 2026Q2: 676,187 shares 676,187$24.9M0.47%-199,300Timeline
STROSUTRO BIOPHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 801,144 shares; 2026Q2: 743,944 shares 743,944$24.7M0.47%-57,200Timeline
SVRASAVARA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 635,000 shares; 2026Q2: 3,959,900 shares 3,959,900$24.4M0.46%+3,324,900Timeline
NPCENEUROPACE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 3,406,335 shares; 2024Q4: 3,406,335 shares; 2025Q1: 3,406,335 shares; 2025Q2: 2,614,184 shares; 2025Q3: 2,614,184 shares; 2025Q4: 2,406,335 shares; 2026Q1: 2,096,527 shares; 2026Q2: 1,505,125 shares 1,505,125$23.9M0.45%-591,402Timeline
AURAAURA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 3,333,333 shares 3,333,333$23.7M0.45%newTimeline
ORICORIC PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 700,000 shares; 2025Q2: 899,281 shares; 2025Q3: 3,641,756 shares; 2025Q4: 3,641,756 shares; 2026Q1: 2,693,929 shares; 2026Q2: 2,015,000 shares 2,015,000$21.8M0.41%-678,929Timeline
HELPCYBIN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 3,840,500 shares; 2026Q1: 3,832,843 shares; 2026Q2: 3,271,400 shares 3,271,400$21.6M0.41%-561,443Timeline
BCRXBIOCRYST PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 901,500 shares; 2025Q4: 1,741,800 shares; 2026Q1: 1,425,200 shares; 2026Q2: 1,852,000 shares 1,852,000$18.5M0.35%+426,800Timeline
BIOABIOAGE LABS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,423,470 shares; 2024Q4: 921,959 shares; 2025Q1: 921,959 shares; 2025Q2: 921,959 shares; 2025Q3: 790,901 shares; 2025Q4: 790,901 shares; 2026Q1: 711,811 shares; 2026Q2: 752,153 shares 752,153$18.4M0.35%+40,342Timeline
LXEOLEXEO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 2,125,000 shares; 2026Q1: 3,602,450 shares; 2026Q2: 3,947,850 shares 3,947,850$18.4M0.35%+345,400Timeline
WHWKWHITEHAWK THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 4,166,000 shares; 2025Q2: 4,166,000 shares; 2025Q3: 4,166,000 shares; 2025Q4: 4,166,000 shares; 2026Q1: 4,166,000 shares; 2026Q2: 3,934,296 shares 3,934,296$18M0.34%-231,704Timeline
DFTXDEFINIUM THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 804,000 shares; 2026Q2: 365,400 shares 365,400$17.2M0.33%-438,600Timeline
SYRESPYRE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 186,145 shares 186,145$16.5M0.31%newTimeline
CRBPCORBUS PHARMACEUTICALS HLDGSQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 912,552 shares; 2024Q4: 1,172,287 shares; 2025Q1: 1,172,287 shares; 2025Q2: 1,172,287 shares; 2025Q3: 1,172,287 shares; 2025Q4: 1,597,287 shares; 2026Q1: 1,737,287 shares; 2026Q2: 1,737,287 shares 1,737,287$16.3M0.31%0Timeline
VERAVERA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 675,872 shares; 2024Q4: 742,572 shares; 2025Q1: 481,065 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 353,500 shares; 2026Q1: 369,596 shares; 2026Q2: 369,596 shares 369,596$15.9M0.3%0Timeline
ALMSALUMIS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: 1,926,423 shares; 2025Q3: 1,926,423 shares; 2025Q4: 1,102,730 shares; 2026Q1: 548,163 shares; 2026Q2: 548,163 shares 548,163$15.4M0.29%0Timeline
EYPTEYEPOINT INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 1,796,000 shares; 2025Q4: 2,468,314 shares; 2026Q1: 1,069,147 shares; 2026Q2: 1,069,147 shares 1,069,147$15.3M0.29%0Timeline
WATWATERS CORPQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 40,300 shares 40,300$15.1M0.29%newTimeline
MNPRMONOPAR THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 157,423 shares 157,423$14.6M0.28%newTimeline
TVTXTRAVERE THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 253,000 shares 253,000$14.4M0.27%newTimeline
TSHATAYSHA GENE THERAPIES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 2,000,000 shares 2,000,000$13.6M0.26%newTimeline
BIIBBIOGEN INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 813,000 shares; 2024Q4: 509,100 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 61,600 shares; 2026Q2: 61,600 shares 61,600$13.3M0.25%0Timeline
RVMDREVOLUTION MEDICINES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 25,900 shares; 2026Q1: 52,000 shares; 2026Q2: 70,500 shares 70,500$13.2M0.25%+18,500Timeline
DNTHDIANTHUS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 115,000 shares 115,000$11.2M0.21%newTimeline
SPRBSPRUCE BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 200,000 shares 200,000$10.8M0.2%newTimeline
LFSTLIFESTANCE HEALTH GROUP INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 500,000 shares; 2026Q2: 947,400 shares 947,400$10.1M0.19%+447,400Timeline
ERASERASCA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 495,900 shares 495,900$9.08M0.17%newTimeline
TARAPROTARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 2,220,000 shares 2,220,000$8.48M0.16%newTimeline
KROSKEROS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,018,734 shares; 2024Q4: 1,018,734 shares; 2025Q1: 1,018,734 shares; 2025Q2: 1,018,734 shares; 2025Q3: 1,018,734 shares; 2025Q4: 804,212 shares; 2026Q1: 759,155 shares; 2026Q2: 759,155 shares 759,155$8.12M0.15%0Timeline
JANXJANUX THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,258,566 shares; 2024Q4: 758,566 shares; 2025Q1: 758,566 shares; 2025Q2: 1,210,300 shares; 2025Q3: 1,766,100 shares; 2025Q4: 1,954,426 shares; 2026Q1: 983,600 shares; 2026Q2: 524,700 shares 524,700$8.06M0.15%-458,900Timeline
TECXTECTONIC THERAPEUTIC INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 574,600 shares; 2026Q1: 226,600 shares; 2026Q2: 226,600 shares 226,600$7.79M0.15%0Timeline
ACETADICET BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,027,944 shares; 2026Q1: 1,027,944 shares; 2026Q2: 844,787 shares 844,787$7.3M0.14%-183,157Timeline
PHVSPHARVARIS N VQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 205,400 shares; 2026Q1: 205,400 shares; 2026Q2: 205,400 shares 205,400$7.1M0.13%0Timeline
ANROALTO NEUROSCIENCE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: 250,000 shares; 2025Q1: 250,000 shares; 2025Q2: 250,000 shares; 2025Q3: 250,000 shares; 2025Q4: 125,000 shares; 2026Q1: 167,500 shares; 2026Q2: 257,852 shares 257,852$6.8M0.13%+90,352Timeline
ZNTLZENTALIS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 1,390,576 shares 1,390,576$6.74M0.13%newTimeline
DRUGBRIGHT MINDS BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 40,000 shares; 2026Q2: 93,000 shares 93,000$6.53M0.12%+53,000Timeline
ALXOALX ONCOLOGY HLDGS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 2,866,256 shares; 2026Q2: 2,866,256 shares 2,866,256$5.93M0.11%0Timeline
XLOXILIO THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 592,300 shares 592,300$5.67M0.11%newTimeline
BCAXBICARA THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 271,910 shares; 2024Q4: 298,301 shares; 2025Q1: 298,301 shares; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 209,100 shares; 2026Q1: 667,300 shares; 2026Q2: 191,100 shares 191,100$5.67M0.11%-476,200Timeline
IMAIMAGENEBIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: 378,556 shares; 2025Q4: 378,556 shares; 2026Q1: 378,556 shares; 2026Q2: 909,269 shares 909,269$5.36M0.1%+530,713Timeline
PTGXPROTAGONIST THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 21,700 shares; 2026Q1: 42,100 shares; 2026Q2: 42,100 shares 42,100$5.16M0.1%0Timeline
ALNYALNYLAM PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 250,300 shares; 2024Q4: 415,600 shares; 2025Q1: 346,100 shares; 2025Q2: 341,900 shares; 2025Q3: 301,600 shares; 2025Q4: 288,800 shares; 2026Q1: 119,000 shares; 2026Q2: 17,000 shares 17,000$5.12M0.1%-102,000Timeline
PALIPALISADE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 1,871,420 shares; 2026Q1: 2,333,000 shares; 2026Q2: 2,333,000 shares 2,333,000$4.88M0.09%0Timeline
ATAIATAIBECKLEY INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 347,000 shares; 2026Q2: 797,500 shares 797,500$4.2M0.08%+450,500Timeline
PTCTPTC THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 23,200 shares; 2026Q1: 49,100 shares; 2026Q2: 49,100 shares 49,100$4.01M0.08%0Timeline
AORTARTIVION INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: 151,000 shares; 2026Q2: 175,000 shares 175,000$3.93M0.07%+24,000Timeline
NMRANEUMORA THERAPEUTICS INC.Quarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 1,500,000 shares; 2024Q4: 804,996 shares; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 2,139,882 shares 2,139,882$3.64M0.07%newTimeline
ACADACADIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 764,600 shares; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 137,000 shares 137,000$3.47M0.07%newTimeline
AMLXAMYLYX PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: 348,000 shares; 2025Q1: 348,000 shares; 2025Q2: 313,200 shares; 2025Q3: 750,600 shares; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 183,400 shares 183,400$3.29M0.06%newTimeline
TYRATYRA BIOSCIENCES INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 768,638 shares; 2024Q4: 1,470,086 shares; 2025Q1: 1,752,831 shares; 2025Q2: 804,603 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 102,000 shares 102,000$3.26M0.06%newTimeline
RAPPRAPPORT THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 76,616 shares 76,616$3.19M0.06%newTimeline
AGMBAGOMAB THERAPEUTICS NVQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 192,740 shares 192,740$2.5M0.05%newTimeline
TARSTARSUS PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: 653,743 shares; 2025Q2: 197,900 shares; 2025Q3: 197,900 shares; 2025Q4: 154,400 shares; 2026Q1: not reported; 2026Q2: 35,581 shares 35,581$2.24M0.04%newTimeline
ACRSACLARIS THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 421,500 shares 421,500$2.23M0.04%newTimeline
CYTKCYTOKINETICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 766,906 shares; 2024Q4: 1,584,005 shares; 2025Q1: 1,509,205 shares; 2025Q2: 1,077,000 shares; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 25,800 shares 25,800$2.2M0.04%newTimeline
NSPRINSPIREMD INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 2,133,405 shares; 2024Q4: 2,133,405 shares; 2025Q1: 2,133,405 shares; 2025Q2: 2,133,405 shares; 2025Q3: 2,133,405 shares; 2025Q4: 3,133,405 shares; 2026Q1: 3,133,405 shares; 2026Q2: 3,133,405 shares 3,133,405$2.19M0.04%0Timeline
OCULOCULAR THERAPEUTIX INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: 157,300 shares; 2026Q1: not reported; 2026Q2: 220,000 shares 220,000$2.16M0.04%newTimeline
EVMNEVOMMUNE INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 161,000 shares 161,000$2.14M0.04%newTimeline
BLTEBELITE BIO INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 13,300 shares 13,300$2.05M0.04%newTimeline
OVIDOVID THERAPEUTICS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 747,000 shares 747,000$2.01M0.04%newTimeline
EPRXEUPRAXIA PHARMACEUTICALS INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: not reported; 2024Q4: not reported; 2025Q1: not reported; 2025Q2: not reported; 2025Q3: not reported; 2025Q4: not reported; 2026Q1: not reported; 2026Q2: 269,000 shares 269,000$1.78M0.03%newTimeline
TRAWTRAWS PHARMA INCQuarterly shares; oldest to newest; scale is this security's eight-quarter maximum; 2024Q3: 605,531 shares; 2024Q4: 605,531 shares; 2025Q1: 605,531 shares; 2025Q2: 605,531 shares; 2025Q3: 605,531 shares; 2025Q4: 605,531 shares; 2026Q1: 605,531 shares; 2026Q2: 1,203,260 shares 1,203,260$1.01M0.02%+597,729Timeline

Options

Puts and calls, as filed. The amount and value describe the underlying shares, not the option premium, so they stay out of % of portfolio (H5).

SecurityTypeAmountValueChange
XBISPDR SERIES TRUST S&P BIOTECHput300,000$47.5Mnew
ABVXABIVAX SA SPONSORED ADScall200,000$26.7Mnew
PTGXPROTAGONIST THERAPEUTICS INC COMcall150,000$18.4Mnew
RVMDREVOLUTION MEDICINES INC Stockcall50,000$9.36Mnew
PVLAPALVELLA THERAPEUTICS INC NE COMMON STOCKcall40,000$6.11M-10,000
UNHUNITEDHEALTH GROUP INC COMcall10,000$4.16Mnew
ELVELEVANCE HEALTH INC FORMERLY COMcall10,000$3.87Mnew
SLSSELLAS LIFE SCIENCES GROUP I COM NEWput92,500$1.37Mnew

Principal amounts

Notes and convertibles filed as a face amount (PRN). A face amount is never added to a share count (H6).

SecurityTypeAmountValueChange
TRAVERE THERAPEUTICS INCTRAVERE THERAPEUTICS INC NOTE 0.500% 5/1principal5,000,000$5.89Mnew
REVOLUTION MEDICINES INCREVOLUTION MEDICINES INC NOTE 0.500% 5/0principal3,500,000$4.38Mnew
COGENT BIOSCIENCES INCCOGENT BIOSCIENCES INC NOTE 1.625%11/1principal1,000,000$1.23M0
VIRIDIAN THERAPEUTICS INCVIRIDIAN THERAPEUTICS INC NOTE 1.750% 5/1principal1,000,000$1.07Mnew

Sold out in Q2 2026

Positions in the previous quarter's report that this quarter's report no longer lists.

SecurityShares beforeValue beforeType
MDXHMDXHEALTH SA124,306,000$286Mcall
RCELAVITA MEDICAL INC40,966,100$154Mcall
MYGNMYRIAD GENETICS INC125,000,000$123Mprincipal
PFEPFIZER INC1,946,500$54.7Mshares
DHRDANAHER CORP DEL265,800$50.4Mshares
ASNDASCENDIS PHARMA A/S181,977$41.6Mshares
RCELAVITA MEDICAL INC40,500,000$40.5Mprincipal
ESPRESPERION THERAPEUTICS INC NE10,570,300$29Mshares
BTSGBRIGHTSPRING HEALTH SVCS INC497,800$21.2Mshares
AMGNAMGEN INC39,900$14Mshares
ALHCALIGNMENT HEALTHCARE INC791,000$13.9Mshares
REGNREGENERON PHARMACEUTICALS14,700$11.4Mshares
CARLCARLSMED INC1,252,600$11.3Mshares
QGENQIAGEN NV250,000$10Mcall
GILDGILEAD SCIENCES INC59,600$8.31Mshares
HRTXHERON THERAPEUTICS INC9,816,940$7.85Mshares
AVTXAVALO THERAPEUTICS INC475,165$7.09Mshares
CMPSCOMPASS PATHWAYS PLC1,150,646$6.36Mshares
ADCTADC THERAPEUTICS SA1,318,026$4.94Mshares
CGEMCULLINAN THERAPEUTICS INC243,006$3.45Mshares
SLNOSOLENO THERAPEUTICS INC100,000$3.35Mcall
JBIOJADE BIOSCIENCES INC185,011$2.6Mshares
CCCCC4 THERAPEUTICS INC856,353$2.25Mshares
RCELAVITA MEDICAL INC544,895$2.02Mshares
KALVKALVISTA PHARMACEUTICALS INC94,400$1.9Mshares
VTGNVISTAGEN THERAPEUTICS INC3,060,000$1.75Mshares

How Q2 2026 was built

Available 13F filings of this filer for the quarter and their roles: the base report is the latest original or restatement, NEW HOLDINGS amendments filed after it are added (method).

FilingRoleAmendmentFiledAcceptedIngested
13F-HR 0001172661-26-003740 base2026-08-14acceptance time not in the bulk data set