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Disclosery

TYRA TYRA BIOSCIENCES INC

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COMMON STOCK (common), issuer CIK 1863127

162 managers (170 13F filers) reported a position in TYRA shares at 2026-06-30, 69,345,962 shares in all. 31 filers opened a position and 25 filers sold out during the quarter.

Managers
162
13F filers
170
New
31
Added
73
Reduced
44
Sold out
25
Shares held by filers
69,345,962

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.12,198,625$390M3.39%013F-HRTimelineGroup
FMR LLCin group FMR LLC8,920,513$285M0.01%+1,172,86513F-HRTimelineGroup
Jupiter Topco LLCin group Janus Henderson4,352,448$139M0.06%13F-HRTimelineGroup
Alta Partners Management Company, L.P.3,823,425$122M95.92%013F-HRTimeline
Nextech Invest Ltd.3,553,585$114M5.39%-502,27613F-HRTimeline
TCG Crossover Management, LLC3,248,980$104M2.49%013F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.3,031,972$96.8M<0.01%+814,04313F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/2,782,567$88.9M0.01%+1,796,50613F-HRTimeline
VANGUARD GROUP INCgroup of 6 filers holding2,179,253$69.6M+620,823Timeline
STATE STREET CORPin group STATE STREET CORP2,140,368$68.4M<0.01%+924,29013F-HRTimelineGroup
Commodore Capital LPin group Commodore Capital LP1,875,000$59.9M3.57%-600,00013F-HRTimelineGroup
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …1,828,607$58.4M1.09%-226,38413F-HRTimelineGroup
BVF INC/ILin group BVF INC/IL1,476,196$47.1M1.21%-500,00013F-HRTimelineGroup
5AM Venture Management, LLC1,029,298$32.9M11.42%013F-HRTimeline
DEERFIELD MANAGEMENT COMPANY, L.P.in group DEERFIELD MANAGEMENT COMPANY,…1,017,000$32.5M0.34%+468,00013F-HRTimelineGroup
Hood River Capital Management LLC1,016,775$32.5M0.24%new13F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC970,734$31M<0.01%+312,25213F-HRTimelineGroup
Caligan Partners LP806,986$25.8M1.24%-469,98213F-HRTimeline
Canaan Partners XI LLC750,000$24M18.82%013F-HRTimeline
Siren, L.L.C.in group Siren, L.L.C.725,000$23.2M0.47%new13F-HRTimelineGroup
Sio Capital Management, LLC695,315$22.2M3.81%+89,87613F-HRTimeline
STEMPOINT CAPITAL LP632,754$20.2M3.5%+439,57713F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP583,133$18.6M0.02%+385,38513F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC463,477$14.8M<0.01%-86,85713F-HRTimelineGroup
JENNISON ASSOCIATES LLC450,964$14.4M0.01%-181,46813F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP449,808$14.4M0.01%+348,19013F-HRTimelineGroup
Defilade Capital Management, L.P.376,870$12M1.61%new13F-HRTimeline
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/349,732$11.2M<0.01%+139,81013F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC347,898$11.1M0.05%+329,18313F-HRTimelineGroup
Woodline Partners LP320,040$10.2M0.03%+19,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP310,084$9.9M<0.01%+91,57613F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY300,322$9.59M<0.01%+179,83713F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC278,307$8.89M0.01%+262,91113F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co267,699$8.55M<0.01%+68,58813F-HRTimelineGroup
Qube Research & Technologies Ltd266,934$8.53M0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS240,227$7.67M<0.01%+50,18813F-HRTimelineGroup
ALGERT GLOBAL LLC239,120$7.64M0.09%+51,11013F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP217,078$6.93M<0.01%+125,25213F-HRTimelineGroup
Affinity Asset Advisors, LLC200,012$6.39M0.31%-57,50013F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources192,340$6.14M<0.01%+179,37013F-HRTimelineGroup
HighVista Strategies LLC184,774$5.9M1.35%+53,47013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC180,881$5.78M<0.01%-66,21713F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO178,263$5.74M<0.01%+111,47413F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC177,672$5.67M<0.01%-43,90913F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC173,559$5.54M0.1%-99,71513F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…162,000$5.17M0.01%new13F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC157,000$5.01M0.04%+115,62513F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC152,585$4.87M<0.01%+137,35513F-HRTimeline
UBS Group AGgroup of 2 filers holding147,633$4.72M+78,240Timeline
Ensign Peak Advisors, Inc146,537$4.68M0.01%+72,47313F-HRTimeline
Trexquant Investment LP132,740$4.24M0.03%-14,57713F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …123,420$3.94M<0.01%-5,44013F-HRTimelineGroup
LORD, ABBETT & CO. LLC121,833$3.89M0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp103,720$3.31M<0.01%+31,50713F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…102,703$3.28M<0.01%+32,28113F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC102,000$3.26M0.06%new13F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC89,205$2.85M0.01%-72,99913F-HRTimeline
OPPENHEIMER & CO INCin group OPPENHEIMER ASSET MANAGEMENT …83,783$2.68M0.03%-40913F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd81,320$2.6M0.03%-2,57613F-HRTimelineGroup
Nuveen, LLCin group TIAA78,829$2.52M<0.01%+27,98913F-HRTimelineGroup
Kalehua Capital Management LLC74,465$2.38M1.37%013F-HR/ATimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO66,607$2.13M<0.01%new13F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC63,805$2.04M<0.01%+43,31113F-HRTimelineGroup
CITIGROUP INCin group CITIGROUP INC62,279$1.99M<0.01%+56,28813F-HRTimelineGroup
Fisher Asset Management, LLC60,230$1.92M<0.01%+31,43013F-HRTimeline
ALPS ADVISORS INC60,159$1.92M0.01%+16,30313F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…59,601$1.9M<0.01%-17,56813F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.48,420$1.85M<0.01%+16,43013F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 3 filers holding55,337$1.77M-7,231Timeline
RHUMBLINE ADVISERS52,039$1.66M<0.01%+12,37913F-HRTimeline
TD Asset Management Inc50,000$1.6M<0.01%013F-HRTimeline
Arkadios Wealth Advisors49,336$1.58M0.02%+1,76913F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD46,697$1.49M<0.01%+13,43913F-HRTimeline
Swiss National Bank44,700$1.43M<0.01%+18,30013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …44,327$1.42M<0.01%+4,10313F-HRTimelineGroup
ExodusPoint Capital Management, LP41,026$1.31M0.01%+26,96013F-HRTimeline
Rafferty Asset Management, LLC38,702$1.24M<0.01%+3,84613F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\36,935$1.18M<0.01%+16,44013F-HRTimelineGroup
Verdad Advisers, LP36,003$1.15M1.1%new13F-HRTimeline
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN33,561$1.07M<0.01%+21,88913F-HRTimelineGroup
Sofinnova Investments, Inc.32,267$1.03M0.06%-171,74813F-HRTimeline
Engineers Gate Manager LP31,958$1.02M0.01%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC29,853$954K<0.01%+43013F-HRTimelineGroup
Tidal Investments LLCin group Tidal Investments LLC29,519$943K<0.01%new13F-HRTimelineGroup
Tema ETFs LLC29,519$943K0.03%new13F-HRTimeline
SG Americas Securities, LLC29,444$940K<0.01%+22,22913F-HRTimeline
PDT Partners, LLC25,684$820K0.04%-16,60013F-HRTimeline
Invesco Ltd.in group Invesco Ltd.24,893$795K<0.01%-84,15913F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…24,544$784K<0.01%+23,14213F-HR/ATimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding24,024$768K+6,614Timeline
STRS OHIO22,100$706K<0.01%+4,00013F-HRTimeline
Creative Planningin group Creative Planning21,803$696K<0.01%-2,14513F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…21,723$694K<0.01%+7,73013F-HRTimelineGroup
LMR Partners LLPin group LMR Partners LLP21,151$676K<0.01%new13F-HRTimelineGroup
Auour Investments LLC21,020$671K0.19%013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC20,282$648K<0.01%-18,07613F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC20,275$648K<0.01%-813,12413F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.20,189$645K<0.01%new13F-HRTimelineGroup
Elmind Capital, LP20,000$639K0.16%-330,00013F-HRTimeline
PROFUND ADVISORS LLC19,588$626K0.02%+3,93213F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc18,017$575K<0.01%+8,48013F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC16,920$540K<0.01%-127,98013F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd16,800$537K0.02%new13F-HRTimelineGroup
FOX RUN MANAGEMENT, L.L.C.14,450$462K0.08%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND12,923$413K<0.01%+5,50013F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…12,123$387K0.09%+7413F-HRTimelineGroup
Police & Firemen's Retirement System of…10,850$347K<0.01%+4,41013F-HRTimeline
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,607$339K<0.01%013F-HRTimelineGroup
Cinctive Capital Management LP10,184$325K0.01%-67,83413F-HRTimeline
CAPSTONE INVESTMENT ADVISORS, LLCin group CAPSTONE INVESTMENT ADVISORS,…10,051$321K<0.01%new13F-HRTimelineGroup
China Universal Asset Management Co., L…9,465$302K0.02%-613F-HRTimeline
Jain Global LLC8,605$275K<0.01%new13F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…8,523$272K<0.01%+48513F-HRTimeline
Allianz Asset Management GmbHin group Allianz SE7,000$268K<0.01%013F-HRTimelineGroup
Savant Capital, LLC7,141$251K<0.01%new13F-HRTimeline
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…7,422$237K<0.01%-13,10013F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC7,419$237K<0.01%+1,07413F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…7,213$230K<0.01%new13F-HRTimelineGroup
CANADA PENSION PLAN INVESTMENT BOARD7,200$230K<0.01%-7,10013F-HRTimeline
ProShare Advisors LLC6,765$216K<0.01%+62313F-HRTimeline
KLP KAPITALFORVALTNING AS5,100$163K<0.01%+2,20013F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…3,339$107K<0.01%+1,34813F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,930$93.6K<0.01%-7513F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC2,906$92K<0.01%new13F-HRTimelineGroup
State of Wyoming2,389$76.3K0.01%new13F-HRTimeline
Hilton Head Capital Partners, LLC2,024$64.6K0.03%+1,25213F-HRTimeline
Chung Wu Investment Group, LLC2,000$63.9K0.04%013F-HRTimeline
Caitong International Asset Management …1,918$61.3K0.01%+2713F-HRTimeline
Steward Partners Investment Advisory, L…1,227$39.2K<0.01%-35013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.1,190$38K<0.01%+63913F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.1,131$36.1K<0.01%-6713F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,126$36K<0.01%+1,03813F-HRTimelineGroup
Versant Capital Management, Inc819$26.2K<0.01%013F-HRTimeline
NISA INVESTMENT ADVISORS, LLC771$24.6K<0.01%+68313F-HRTimeline
Pacer Advisors, Inc.646$21K<0.01%new13F-HRTimeline
GAMMA Investing LLC505$16.1K<0.01%-113F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…421$13.4K<0.01%013F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.369$11.8K<0.01%-34513F-HRTimelineGroup
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…208$6.64K<0.01%-1513F-HRTimelineGroup
Larson Financial Group LLC150$4.79K<0.01%-14513F-HRTimeline
True Wealth Design, LLC142$4.54K<0.01%013F-HRTimeline
Sterling Capital Management LLC129$4.12K<0.01%-72913F-HRTimeline
Smartleaf Asset Management LLC127$4.08K<0.01%013F-HRTimeline
Atlantic Union Bankshares Corpin group Atlantic Union Bankshares Corp100$3.19K<0.01%013F-HRTimelineGroup
Allworth Financial LP100$3.19K<0.01%-413F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.98$3.13K<0.01%-813F-HRTimelineGroup
Arax Advisory Partners87$2.78K<0.01%new13F-HRTimeline
Integrated Wealth Concepts LLC61$1.95K<0.01%new13F-HRTimeline
Farther Finance Advisors, LLC60$1.92K<0.01%013F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$1.76K<0.01%-1513F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…44$1.41K<0.01%-8413F-HRTimelineGroup
SIGNATUREFD, LLC43$1.37K<0.01%013F-HRTimeline
Covestor Ltd16$1K<0.01%+1013F-HRTimeline
Clearstead Advisors, LLC29$921<0.01%013F-HRTimeline
Fortitude Family Office, LLC17$543<0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/15$480<0.01%new13F-HRTimelineGroup
Quarry LP12$383<0.01%new13F-HRTimeline
Global Retirement Partners, LLC7$224<0.01%13F-HRTimeline
SBI Securities Co., Ltd.2$64<0.01%-213F-HRTimeline
TFC Financial Management, Inc.1$32<0.01%013F-HRTimeline
Keating Financial Advisory Services, In…1$32<0.01%new13F-HRTimeline
Silver Grove Financial Group, Inc.1$32<0.01%new13F-HRTimeline