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Disclosery

DFTX DEFINIUM THERAPEUTICS INC

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COM SHS (common), issuer CIK 1813814

348 managers (360 13F filers) reported a position in DFTX shares at 2026-06-30, 114,806,415 shares in all. 142 filers opened a position and 29 filers sold out during the quarter.

Managers
348
13F filers
360
New
142
Added
116
Reduced
64
Sold out
29
Shares held by filers
114,806,415

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
BlackRock, Inc.in group BlackRock, Inc.11,232,834$528M0.01%+2,752,60413F-HRTimelineGroup
Avoro Capital Advisors LLC7,188,888$338M3.04%+2,188,88813F-HRTimeline
Driehaus Capital Management LLC6,845,276$322M1.87%+933,38713F-HRTimeline
Jupiter Topco LLCin group Janus Henderson5,615,645$264M0.11%13F-HRTimelineGroup
Capital World Investors5,367,723$252M0.03%new13F-HRTimeline
FMR LLCin group FMR LLC4,752,921$224M0.01%+2,943,31113F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/4,652,032$219M0.02%+4,582,03113F-HRTimeline
VANGUARD GROUP INCgroup of 8 filers holding4,132,060$194M+1,463,924Timeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC3,644,813$171M0.01%+1,149,41413F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP3,065,390$144M<0.01%+593,51713F-HRTimelineGroup
Capital International Investorsin group Capital International Investo…2,963,410$139M0.03%new13F-HRTimelineGroup
Octagon Capital Advisors LP2,950,000$139M12.74%+510,00013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…2,949,734$139M0.02%+1,644,98513F-HRTimelineGroup
Deep Track Capital, LP2,750,000$129M1.91%-250,00013F-HRTimeline
Commodore Capital LPin group Commodore Capital LP2,000,000$94.1M5.6%013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,800,852$84.7M0.01%+125,44113F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC1,688,587$79.4M0.05%+355,14513F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.1,500,000$70.6M0.61%new13F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,419,493$66.8M1.36%+500,00013F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP1,298,946$61.1M0.05%+98,12113F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP1,169,238$55M0.01%+370,25113F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC1,148,363$54M0.01%+181,75513F-HRTimelineGroup
Nuveen, LLCin group TIAA1,105,314$52M0.01%+407,18413F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co1,083,576$51M0.01%+274,86113F-HRTimelineGroup
Woodline Partners LP1,003,641$47.2M0.15%+250,84913F-HRTimeline
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,000,000$47M0.07%-150,00013F-HRTimelineGroup
Boxer Capital Management, LLC998,500$47M3.54%+400,00013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP921,818$43.4M0.03%-279,79213F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management897,658$42.2M0.08%-376,56313F-HRTimelineGroup
Holocene Advisors, LP796,574$37.5M0.09%-295,39313F-HRTimeline
AWM Investment Company, Inc.784,800$36.9M3.2%-292,09313F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp777,271$36.6M0.01%+24,34913F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc777,253$36.6M0.1%new13F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.1,803,287$34.1M0.01%+1,711,58413F-HRTimeline
UBS Group AGgroup of 2 filers holding710,650$33.4M+214,260Timeline
EVENTIDE ASSET MANAGEMENT, LLC710,000$33.4M0.45%+23,83813F-HRTimeline
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC687,539$32.3M0.02%+554,17013F-HRTimelineGroup
Qube Research & Technologies Ltd682,901$32.1M0.04%+256,84613F-HRTimeline
Candriam S.C.A.614,425$28.9M0.13%-679,20413F-HRTimeline
ArrowMark Colorado Holdings LLC564,069$26.5M1.1%-1,030,64813F-HRTimeline
Catalio Capital Management, LP562,672$26.5M4.97%-475,31213F-HRTimeline
Blackstone Inc.in group Blackstone Inc.561,612$26.4M0.09%+52,94413F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Integral Health Asset Management, LLC550,000$25.9M1.06%+150,00013F-HRTimeline
BAMCO INC /NY/in group Baron Capital520,108$24.5M0.04%new13F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources486,219$22.9M<0.01%new13F-HRTimelineGroup
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.483,980$22.8M0.03%+308,49013F-HRTimelineGroup
Ensign Peak Advisors, Inc466,106$21.9M0.04%-80,67713F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY454,912$21.4M<0.01%+16,33913F-HRTimelineGroup
GREAT POINT PARTNERS LLC425,000$20M4.71%new13F-HRTimeline
RTW INVESTMENTS, LP400,000$18.8M0.16%+100,00013F-HRTimeline
Cormorant Asset Management, LP400,000$18.8M0.96%new13F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…400,000$18.8M2.09%new13F-HRTimelineGroup
ASSETMARK, INCin group ASSETMARK, INC396,542$18.7M0.03%new13F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC365,400$17.2M0.33%-438,60013F-HRTimelineGroup
Duquesne Family Office LLC356,600$16.8M0.39%new13F-HRTimeline
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.315,410$14.8M0.01%+43,69313F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding300,000$14.1MnewTimeline
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd286,990$13.5M2.2%+86,99613F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC266,076$12.5M0.01%-580,82013F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO265,955$12.4M<0.01%+1,41013F-HRTimelineGroup
Sofinnova Investments, Inc.255,903$12M0.64%-88,26313F-HRTimeline
PFM Health Sciences, LP249,020$11.7M1.02%+43,70313F-HRTimeline
HighVista Strategies LLC242,884$11.4M2.6%+57,02813F-HRTimeline
Trexquant Investment LP233,199$11M0.07%new13F-HRTimeline
SEVEN GRAND MANAGERS, LLC225,000$10.6M0.43%013F-HRTimeline
Swiss National Bank221,200$10.4M0.01%+62,80013F-HRTimeline
Eversept Partners, LP217,185$10.2M0.56%+56,46213F-HRTimeline
TD Asset Management Inc209,460$9.85M0.01%new13F-HRTimeline
ROYCE & ASSOCIATES LP208,551$9.81M0.08%-25,50013F-HRTimeline
SEB Asset Management AB208,254$9.8M0.04%new13F-HRTimeline
SUPERSTRING CAPITAL MANAGEMENT LP188,282$8.86M5.59%-163,17913F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc175,000$8.23M0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/164,575$7.74M<0.01%+6,23013F-HRTimelineGroup
Tri Locum Partners LP162,996$7.67M0.94%-206,59213F-HRTimeline
RHUMBLINE ADVISERS158,096$7.44M0.01%+38,12413F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…156,812$7.38M0.1%-54,67613F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…153,477$7.22M0.01%+34,01313F-HRTimelineGroup
LMR Partners LLPin group LMR Partners LLP150,200$7.07M0.05%new13F-HRTimelineGroup
Seven Fleet Capital Management LP148,647$6.99M1.15%+48,76013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …146,368$6.89M0.01%+119,96413F-HRTimelineGroup
Rock Springs Capital Management LP143,187$6.74M0.33%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\142,947$6.72M<0.01%-268,88713F-HRTimelineGroup
SummitTX Capital, L.P.142,489$6.7M0.18%new13F-HRTimeline
STEMPOINT CAPITAL LP137,124$6.45M1.12%-188,35913F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC134,152$6.31M<0.01%+77,05813F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…128,346$6.04M0.01%new13F-HR/ATimeline
BIT Capital GmbH128,131$6.03M0.21%-149,38013F-HRTimeline
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC125,256$5.89M0.02%+33,09113F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN122,033$5.74M<0.01%+82,06013F-HRTimelineGroup
Atika Capital Management LLCin group Atika Capital Management LLC122,000$5.74M0.57%new13F-HRTimelineGroup
AdvisorShares Investments LLC121,381$5.71M0.69%+30,08013F-HRTimeline
Informed Momentum Co LLC120,928$5.69M0.51%new13F-HRTimeline
Schonfeld Strategic Advisors LLC119,610$5.63M0.03%+109,19813F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC117,482$5.53M<0.01%new13F-HRTimelineGroup
ALPS ADVISORS INC110,388$5.19M0.02%new13F-HRTimeline
Data Collective IV GP, LLC100,350$4.72M6.01%013F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA100,063$4.71M<0.01%+2,87113F-HRTimelineGroup
Burkehill Global Management, LP100,000$4.7M0.17%013F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS96,510$4.54M<0.01%+73,15413F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC95,166$4.48M<0.01%+78,78213F-HRTimelineGroup
KEYSTONE INVESTORS PTE LTD95,100$4.47M0.24%13F-HRTimeline
Invesco Ltd.in group Invesco Ltd.91,338$4.3M<0.01%+3,21713F-HRTimelineGroup
Pier Capital, LLC88,598$4.17M0.55%new13F-HRTimeline
LPL Financial LLC86,136$4.05M<0.01%+7,86513F-HRTimeline
Squadron Capital Management LLC85,000$4M1.37%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd84,393$3.97M0.05%new13F-HRTimelineGroup
Shay Capital LLC80,000$3.76M0.42%new13F-HRTimeline
Logos Global Management LP80,000$3.76M0.16%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC79,547$3.74M<0.01%+53,06113F-HRTimelineGroup
SECTORAL ASSET MANAGEMENT INC78,310$3.68M2.57%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…75,859$3.57M0.02%+21,59813F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc74,004$3.48M<0.01%+14,20513F-HRTimelineGroup
Quantinno Capital Management LP70,682$3.32M<0.01%+30,72413F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…70,111$3.3M0.01%+14,90513F-HRTimelineGroup
PLATINUM INVESTMENT MANAGEMENT LTD70,000$3.29M0.81%013F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding64,814$3.05M+13,421Timeline
GROUP ONE TRADING LLC63,943$3.01M0.09%-23,88913F-HRTimeline
ALGERT GLOBAL LLC63,700$3M0.04%new13F-HRTimeline
PEAK FINANCIAL ADVISORS LLC56,915$2.68M1.11%new13F-HRTimeline
Y-Intercept (Hong Kong) Ltd54,466$2.56M0.05%new13F-HRTimeline
Cerity Partners LLCin group Cerity Partners LLC53,883$2.53M<0.01%new13F-HRTimelineGroup
BLAIR WILLIAM & CO/IL53,588$2.52M0.01%-10713F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD52,549$2.47M<0.01%+2,12913F-HRTimeline
Moody Aldrich Partners LLC51,025$2.4M0.43%new13F-HRTimeline
KESTRA PRIVATE WEALTH SERVICES, LLCin group Kestra Advisory Services, LLC50,588$2.38M0.03%013F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC50,296$2.37M<0.01%+10,61313F-HRTimelineGroup
Atom Investors LP49,436$2.33M0.21%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC48,369$2.28M0.01%-53413F-HRTimeline
SIMPLEX TRADING, LLC47,651$2.24M0.06%+6,49513F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND45,800$2.15M<0.01%+16,20013F-HRTimeline
ALLSTATE CORPin group ALLSTATE CORP45,639$2.15M0.02%+27313F-HRTimelineGroup
JENNISON ASSOCIATES LLC45,375$2.13M<0.01%+5,41813F-HRTimeline
Caption Management, LLC45,000$2.12M0.07%+11,24213F-HRTimeline
Polymer Capital Management (HK) LTD44,100$2.07M0.21%new13F-HRTimeline
Aquatic Capital Management LLC43,124$2.03M0.07%new13F-HRTimeline
Ghisallo Capital Management LLC41,500$1.95M0.04%new13F-HRTimeline
CenterBook Partners LP41,255$1.94M0.1%-1,57413F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…40,954$1.93M<0.01%-40,50213F-HRTimelineGroup
Walleye Capital LLCgroup of 2 filers holding39,093$1.84M-1,806Timeline
Police & Firemen's Retirement System of…38,386$1.81M0.01%+11,02513F-HRTimeline
SCOTIA CAPITAL INC.34,722$1.64M0.01%-5,82613F-HRTimeline
TD Waterhouse Canada Inc.36,694$1.59M<0.01%+34,89213F-HRTimeline
STRS OHIO33,500$1.58M0.01%+14,20013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…32,394$1.52M<0.01%+11,52613F-HRTimeline
KINGSWOOD WEALTH ADVISORS, LLC31,444$1.48M0.06%+4,85313F-HRTimeline
Bay Rivers Group31,208$1.47M0.5%+4,86213F-HRTimeline
Vestmark Advisory Solutions, Inc.30,729$1.45M0.01%new13F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…30,625$1.44M<0.01%+3,18413F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM30,411$1.43M0.01%+8,35713F-HRTimeline
Palumbo Wealth Management LLC29,287$1.38M0.29%-8,67913F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO28,582$1.34M<0.01%+46513F-HRTimelineGroup
Cinctive Capital Management LP28,550$1.34M0.05%+15,99913F-HRTimeline
SG Americas Securities, LLC28,262$1.33M<0.01%+17,76913F-HRTimeline
Mariner, LLCin group Mariner, LLC27,207$1.28M<0.01%-7,64413F-HRTimelineGroup
STABLEFORD CAPITAL II LLC27,141$1.28M0.44%new13F-HRTimeline
Janney Montgomery Scott LLC26,664$1.25M<0.01%new13F-HRTimeline
ACT CAPITAL MANAGEMENT, LLC25,000$1.18M0.77%new13F-HRTimeline
KLP KAPITALFORVALTNING AS25,000$1.18M<0.01%new13F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…24,500$1.15M0.01%new13F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP24,391$1.15M<0.01%new13F-HR/ATimelineGroup
Rathbones Group PLC22,800$1.07M<0.01%-7,40013F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC22,401$1.05M<0.01%-1,31213F-HRTimelineGroup
HighTower Advisors, LLC22,313$1.05M<0.01%+3,75413F-HRTimeline
IFG Advisory, LLC22,043$1.04M0.04%new13F-HRTimeline
TFB Advisors LLC21,523$1.01M0.45%new13F-HRTimeline
China Universal Asset Management Co., L…21,358$1M0.06%+1,16613F-HRTimeline
ProShare Advisors LLC20,615$970K<0.01%+1,88413F-HRTimeline
Concurrent Investment Advisors, LLCin group Concurrent Investment Advisor…20,044$943K0.01%-1,24113F-HRTimelineGroup
Birchview Capital, LP20,000$941K0.44%new13F-HRTimeline
Fore Capital, LLC20,000$941K1.25%new13F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC19,969$939K0.01%-5,02113F-HRTimeline
Diversify Advisory Services, LLCgroup of 2 filers holding20,050$855K+9,050Timeline
Sequoia Financial Advisors, LLC17,258$812K<0.01%+1313F-HRTimeline
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC16,626$782K<0.01%new13F-HRTimelineGroup
CARY STREET PARTNERS FINANCIAL LLCin group CARY STREET PARTNERS ASSET MA…15,582$733K0.02%new13F-HRTimelineGroup
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC15,500$729K<0.01%new13F-HRTimelineGroup
DIADEMA PARTNERS LP15,451$727K0.26%new13F-HRTimeline
Twelve Points Wealth Management LLC14,245$670K0.13%+2,00013F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…14,077$662K<0.01%+78213F-HRTimelineGroup
Amundiin group Amundi14,068$662K<0.01%-6813F-HRTimelineGroup
Cetera Investment Advisers14,029$660K<0.01%-17,79513F-HRTimeline
Persistent Asset Partners Ltd13,778$648K0.2%-2,08313F-HRTimeline
PROFUND ADVISORS LLC13,571$638K0.02%-62513F-HRTimeline
FORA Capital, LLC13,378$629K0.04%new13F-HRTimeline
Private Advisor Group, LLC13,336$627K<0.01%new13F-HRTimeline
DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD.in group DYMON ASIA CAPITAL (SINGAPORE…13,289$625K0.1%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…13,220$622K0.14%-8,50713F-HRTimelineGroup
MONEY CONCEPTS CAPITAL CORP13,000$612K0.03%013F-HRTimeline
XPONANCE LLC12,716$598K<0.01%new13F-HRTimeline
State of Wyoming12,448$586K0.06%new13F-HRTimeline
AXQ CAPITAL, LP12,444$585K0.06%new13F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP12,225$575K<0.01%-40113F-HRTimelineGroup
CAPTRUST FINANCIAL ADVISORS12,148$571K<0.01%new13F-HRTimeline
Heritage Wealth Management, Inc. /CA/12,000$564K0.28%-2,37513F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.11,952$562K<0.01%+1,39313F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…11,736$552K0.01%+4,09513F-HRTimelineGroup
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA11,548$543K<0.01%new13F-HRTimelineGroup
Steward Partners Investment Advisory, L…11,540$543K<0.01%-1,70013F-HRTimeline
Sanctuary Advisors, LLC11,502$541K<0.01%+3613F-HRTimeline
ELEVATION POINT WEALTH PARTNERS, LLC11,382$535K0.01%new13F-HRTimeline