FMR LLC in group FMR LLC More: the full row for FMR LLC 5,179,262 $96.9M <0.01% new 13F-HR Timeline Group SR One Capital Management, LP More: the full row for SR One Capital Management, LP 3,794,883 $71M 6.83% new 13F-HR Timeline TPG GP A, LLC in group TPG GP A, LLC More: the full row for TPG GP A, LLC 3,690,146 $69M 1.38% new 13F-HR Timeline Group LIGHTSPEED MANAGEMENT COMPANY, L.L.C. More: the full row for LIGHTSPEED MANAGEMENT COMPANY, L.L.C. 3,608,443 $67.5M 2.81% new 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 3,001,198 $56.2M 1.06% new 13F-HR Timeline Group Sanofi More: the full row for Sanofi 1,991,918 $37.3M 6.98% new 13F-HR Timeline DEERFIELD MANAGEMENT COMPANY, L.P. in group DEERFIELD MANAGEMENT COMPANY,… More: the full row for DEERFIELD MANAGEMENT COMPANY, L.P. 1,046,139 $19.6M 0.2% new 13F-HR Timeline Group Sands Capital Alternatives, LLC More: the full row for Sands Capital Alternatives, LLC 875,000 $16.4M 2.67% new 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 842,978 $15.8M new Timeline HHLR ADVISORS, LTD. in group HHLR ADVISORS, LTD. More: the full row for HHLR ADVISORS, LTD. 831,656 $15.6M 1.87% new 13F-HR Timeline Group General Catalyst Group Management, LLC More: the full row for General Catalyst Group Management, LLC 810,272 $15.2M 8.04% new 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 766,346 $14.3M 0.7% new 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 725,000 $13.6M 0.02% new 13F-HR Timeline Group Foresite Capital Management V, LLC in group Foresite Capital Management V… More: the full row for Foresite Capital Management V, LLC 713,105 $13.3M 3.68% new 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 575,000 $10.8M 0.98% new 13F-HR Timeline EcoR1 Capital, LLC More: the full row for EcoR1 Capital, LLC 555,555 $10.4M 0.52% new 13F-HR Timeline Logos Global Management LP More: the full row for Logos Global Management LP 521,736 $9.76M 0.42% new 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 492,697 $9.22M 0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 471,987 $8.83M <0.01% new 13F-HR Timeline Catalio Capital Management, LP More: the full row for Catalio Capital Management, LP 457,839 $8.57M 1.61% new 13F-HR Timeline Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 425,000 $7.95M 0.53% new 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 393,862 $7.37M 0.01% new 13F-HR Timeline Group Woodline Partners LP More: the full row for Woodline Partners LP 345,746 $6.47M 0.02% new 13F-HR Timeline FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 275,022 $5.15M <0.01% new 13F-HR Timeline Group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 275,000 $5.15M 0.39% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 240,679 $4.5M <0.01% new 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 222,450 $4.16M <0.01% new 13F-HR Timeline Group Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 200,000 $3.74M 0.08% new 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 189,488 $3.55M <0.01% new 13F-HR Timeline Group Cormorant Asset Management, LP More: the full row for Cormorant Asset Management, LP 175,000 $3.27M 0.17% new 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 165,000 $3.09M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 156,602 $2.93M <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 132,801 $2.48M <0.01% new 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 101,531 $1.9M <0.01% new 13F-HR Timeline Group Hudson Bay Capital Management LP in group Hudson Bay Capital Management… More: the full row for Hudson Bay Capital Management LP 72,918 $1.36M 0.01% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 68,758 $1.29M <0.01% new 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 64,621 $1.21M <0.01% new 13F-HR Timeline SEVEN GRAND MANAGERS, LLC More: the full row for SEVEN GRAND MANAGERS, LLC 50,000 $936K 0.04% new 13F-HR Timeline Eversept Partners, LP More: the full row for Eversept Partners, LP 49,658 $929K 0.05% new 13F-HR Timeline TUDOR INVESTMENT CORP ET AL More: the full row for TUDOR INVESTMENT CORP ET AL 44,171 $826K <0.01% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 34,588 $647K <0.01% new 13F-HR Timeline Group MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 32,125 $601K <0.01% new 13F-HR Timeline Group TD Asset Management Inc More: the full row for TD Asset Management Inc 29,134 $545K <0.01% new 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 27,787 $525K <0.01% new 13F-HR Timeline Group Ghisallo Capital Management LLC More: the full row for Ghisallo Capital Management LLC 25,000 $468K 0.01% new 13F-HR Timeline Burkehill Global Management, LP More: the full row for Burkehill Global Management, LP 20,000 $374K 0.01% new 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 19,848 $371K <0.01% new 13F-HR Timeline Group XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 16,552 $310K <0.01% new 13F-HR Timeline Group Omega Fund Management, LLC More: the full row for Omega Fund Management, LLC 2,893 $54.1K 0.03% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 2,000 $37.3K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 1,795 $33.6K <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 1,772 $33.2K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 1,459 $27.3K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 511 $9.56K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 193 $3.61K <0.01% new 13F-HR Timeline Group