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Disclosery

SYRE SPYRE THERAPEUTICS INC

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COM NEW (common), issuer CIK 1636282

256 managers (267 13F filers) reported a position in SYRE shares at 2026-06-30, 95,817,421 shares in all. 88 filers opened a position and 20 filers sold out during the quarter.

Managers
256
13F filers
267
New
88
Added
104
Reduced
57
Sold out
20
Shares held by filers
95,817,421

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

Each filer's latest stake. The shares are the aggregate the reporting persons state, which can include entities that file no 13F.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC13,026,187$1.16B0.05%+1,245,16313F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.6,506,605$578M0.01%+985,38413F-HRTimelineGroup
VANGUARD GROUP INCgroup of 7 filers holding6,423,758$570M+2,234,993Timeline
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC4,319,496$383M5.95%+536,27113F-HRTimelineGroup
RTW INVESTMENTS, LP4,251,996$377M3.22%+80,00013F-HRTimeline
Paradigm Biocapital Advisors LPin group Paradigm Biocapital Advisors …3,840,778$341M6.38%+1,883,51213F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP3,057,416$271M0.01%+450,38513F-HRTimelineGroup
Venrock Adviser, LLC2,985,448$265M8.04%-700,00013F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/2,960,855$263M0.03%+1,362,12513F-HRTimeline
Driehaus Capital Management LLC2,799,166$249M1.44%+8,38113F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,562,265$239M0.01%+841,35313F-HRTimelineGroup
Capital World Investors2,315,553$206M0.02%+1,648,98913F-HRTimeline
Jupiter Topco LLCin group Janus Henderson2,206,936$196M0.08%13F-HRTimelineGroup
TCG Crossover Management, LLC1,900,582$169M4.06%013F-HRTimeline
TANG CAPITAL MANAGEMENT LLCin group TANG CAPITAL MANAGEMENT LLC1,892,200$168M7.63%013F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/1,777,854$158M0.01%+549,76113F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,722,300$153M0.21%new13F-HRTimelineGroup
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…1,581,505$140M0.02%-243,30613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC1,478,059$131M0.01%+1,208,12113F-HRTimelineGroup
FRANKLIN RESOURCES INCin group Franklin Resources1,472,943$131M0.03%+590,11013F-HRTimelineGroup
Remedium Capital Partners, LLC1,464,169$130M28.78%+7,93813F-HRTimeline
UBS Group AGgroup of 2 filers holding1,365,142$121M+486,593Timeline
Affinity Asset Advisors, LLC1,279,134$114M5.55%013F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,093,026$98.9M0.01%+113,72713F-HRTimelineGroup
Holocene Advisors, LP1,015,170$90.1M0.21%new13F-HRTimeline
MARSHALL WACE, LLPin group MARSHALL WACE, LLP991,693$88M0.07%+852,43413F-HRTimelineGroup
Polar Capital Holdings Plcin group Polar Capital Holdings Plc988,009$87.7M0.25%+195,16213F-HRTimelineGroup
EMERALD ADVISERS, LLCgroup of 2 filers holding968,701$86M-52,777Timeline
Siren, L.L.C.in group Siren, L.L.C.968,598$86M1.75%+150,00013F-HRTimelineGroup
Capital International Investorsin group Capital International Investo…955,196$84.8M0.02%-790,93313F-HRTimelineGroup
BRAIDWELL LP879,467$78.1M2.89%-53,35613F-HRTimeline
Commodore Capital LPin group Commodore Capital LP846,786$75.2M4.48%-1,065,59413F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP674,529$59.9M0.01%+95,62213F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co652,958$58M0.01%+90,30513F-HRTimelineGroup
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…628,138$55.8M0.05%+136,48913F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC553,980$49.2M0.03%+261,85413F-HRTimeline
Candriam S.C.A.546,312$48.5M0.22%-63,97013F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY499,963$44.4M<0.01%+253,24413F-HRTimelineGroup
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC431,694$38.3M0.03%+377,72413F-HRTimelineGroup
SAMLYN CAPITAL, LLCin group SAMLYN CAPITAL, LLC400,075$35.5M0.59%+3,41413F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC356,082$31.6M0.01%+196,86513F-HRTimelineGroup
Integral Health Asset Management, LLC325,000$28.9M1.18%new13F-HRTimeline
Woodline Partners LP306,049$27.2M0.08%+40,15713F-HRTimeline
JENNISON ASSOCIATES LLC303,180$26.9M0.02%new13F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC283,982$25.2M1.19%-54,34113F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS259,923$23.1M0.01%+241,29313F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp245,193$21.8M<0.01%+53,79813F-HRTimelineGroup
Bellevue Group AGin group Bellevue Group AG229,931$20.4M0.43%new13F-HRTimelineGroup
Cormorant Asset Management, LP225,000$20M1.02%new13F-HRTimeline
SEVEN GRAND MANAGERS, LLC225,000$20M0.8%+125,00013F-HRTimeline
EVENTIDE ASSET MANAGEMENT, LLC201,616$17.9M0.24%new13F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC196,712$17.5M0.01%+50,07313F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC186,145$16.5M0.31%new13F-HRTimelineGroup
FRONTIER CAPITAL MANAGEMENT CO LLC182,931$16.2M0.15%new13F-HRTimeline
Nuveen, LLCin group TIAA181,105$16.1M<0.01%+27,20613F-HRTimelineGroup
NEUBERGER BERMAN GROUP LLCin group NEUBERGER BERMAN GROUP LLC180,884$16.1M0.01%new13F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\174,459$15.5M<0.01%+45,21713F-HRTimelineGroup
Universal- Beteiligungs- und Serviceges…in group Universal- Beteiligungs- und …172,923$15.4M0.02%+2,54213F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management147,042$13.1M0.02%+91,56513F-HRTimelineGroup
Soleus Capital Management, L.P.147,000$13.1M0.45%new13F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC139,605$12.4M0.02%new13F-HRTimelineGroup
ARMISTICE CAPITAL, LLC137,588$12.2M0.34%+16,65713F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…134,757$12M0.01%+124,82613F-HRTimelineGroup
Ensign Peak Advisors, Inc126,620$11.2M0.02%-21,91713F-HRTimeline
Invesco Ltd.in group Invesco Ltd.120,541$10.7M<0.01%-11,84913F-HRTimelineGroup
Blackstone Inc.in group Blackstone Inc.120,177$10.7M0.03%-172,67013F-HRTimelineGroupThe filing omitted confidential holdings, a later amendment may add them.
Rhenman & Partners Asset Management AB119,300$10.6M1%new13F-HRTimeline
TD Asset Management Inc115,990$10.3M0.01%-21,40013F-HRTimeline
Swiss National Bank112,500$9.99M0.01%+16,00013F-HRTimeline
STEMPOINT CAPITAL LP106,926$9.49M1.64%-60,68013F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …104,516$9.28M0.01%-8,32513F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC103,100$9.15M0.01%-5,03513F-HRTimelineGroup
Boxer Capital Management, LLC100,000$8.88M0.67%new13F-HRTimeline
RHUMBLINE ADVISERS94,763$8.41M0.01%+9,64213F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC94,069$8.35M<0.01%+48,28313F-HRTimelineGroup
F/m Investments LLC92,618$8.22M0.42%-6,84213F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPgroup of 2 filers holding92,412$8.2M+10,349Timeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC87,370$7.76M0.01%+27,81513F-HRTimelineGroup
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.85,950$7.63M0.01%new13F-HRTimelineGroup
Granahan Investment Management, LLC82,991$7.37M0.26%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC82,593$7.33M<0.01%+70,58713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN82,506$7.32M<0.01%+49,29813F-HRTimelineGroup
HighVista Strategies LLC77,807$6.91M1.57%-68,45713F-HRTimeline
MERCER GLOBAL ADVISORS INC /ADV71,145$6.32M0.01%+5413F-HR/ATimeline
B Group, Inc.70,000$6.21M3.53%-30,00013F-HRTimeline
Trexquant Investment LP67,007$5.95M0.04%new13F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…64,687$5.74M0.01%+5,44513F-HR/ATimeline
Informed Momentum Co LLC60,393$5.36M0.48%new13F-HRTimeline
SILVERARC CAPITAL MANAGEMENT, LLCin group SILVERARC CAPITAL MANAGEMENT,…59,959$5.32M0.59%-126,65913F-HRTimelineGroup
PRINCIPAL FINANCIAL GROUP INCin group PRINCIPAL FINANCIAL GROUP INC59,747$5.3M<0.01%+55,44813F-HRTimelineGroup
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…58,387$5.18M0.02%new13F-HRTimelineGroup
Atle Fund Management AB57,030$5.06M1.36%-5,70513F-HRTimeline
RAYMOND JAMES FINANCIAL INCin group RAYMOND JAMES FINANCIAL INC53,627$4.76M<0.01%+33,87213F-HRTimelineGroup
ALLIANCEBERNSTEIN L.P.92,540$4.67M<0.01%+21,64013F-HRTimeline
ROYCE & ASSOCIATES LP51,789$4.6M0.04%new13F-HRTimeline
XTX Topco Ltdin group XTX Topco Ltd50,483$4.48M0.06%+26,04813F-HRTimelineGroup
Monashee Investment Management LLC50,000$4.44M7.45%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc49,141$4.36M<0.01%+4,34913F-HRTimelineGroup
Cinctive Capital Management LP48,978$4.35M0.17%+21,54813F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP47,698$4.23M<0.01%+113F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…47,466$4.21M0.01%-16,53613F-HRTimelineGroup
PFM Health Sciences, LP46,217$4.1M0.36%new13F-HRTimeline
SCHRODER INVESTMENT MANAGEMENT GROUP44,586$4.02M<0.01%-19,09813F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD45,030$4M0.01%+18,50713F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…43,316$3.85M0.02%+4,90913F-HRTimelineGroup
NOMURA ASSET MANAGEMENT CO LTDgroup of 2 filers holding43,071$3.82M+43,071Timeline
Moody Aldrich Partners LLC42,458$3.77M0.68%new13F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding42,323$3.76M+1,903Timeline
Rock Springs Capital Management LP42,254$3.75M0.18%new13F-HRTimeline
Maven Securities LTDin group Maven Securities LTD40,000$3.55M0.24%new13F-HRTimelineGroup
Engineers Gate Manager LP38,474$3.42M0.04%new13F-HRTimeline
Rafferty Asset Management, LLC36,767$3.26M0.01%-20,15313F-HRTimeline
Caption Management, LLC36,000$3.2M0.11%new13F-HRTimeline
Ghisallo Capital Management LLC30,000$2.66M0.05%new13F-HRTimeline
FRED ALGER MANAGEMENT, LLCin group FRED ALGER MANAGEMENT, LLC28,834$2.56M0.01%-30,61913F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.26,452$2.35M<0.01%new13F-HRTimelineGroup
CASTLEARK MANAGEMENT LLC26,420$2.35M0.06%new13F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND26,165$2.32M<0.01%+3,90013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…26,143$2.32M<0.01%+12,18813F-HRTimeline
Handelsbanken Fonder AB26,000$2.31M0.01%new13F-HRTimeline
TEACHERS RETIREMENT SYSTEM OF THE STATE…25,799$2.29M0.02%013F-HRTimeline
Creative Planningin group Creative Planning25,713$2.28M<0.01%+10,22713F-HRTimelineGroup
Waverly Advisors, LLC25,512$2.26M0.01%-45413F-HRTimeline
Aquatic Capital Management LLC25,222$2.24M0.08%new13F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC22,937$2.04M<0.01%+2,06313F-HRTimelineGroup
Freestone Grove Partners LP22,777$2.02M0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…21,968$1.95M0.01%+3,60813F-HRTimeline
PROFUND ADVISORS LLC19,419$1.72M0.05%-6,62413F-HRTimeline
Schonfeld Strategic Advisors LLC19,089$1.69M0.01%new13F-HRTimeline
Ellsworth Advisors, LLC16,553$1.69M0.28%-5,41013F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.18,146$1.61M<0.01%+17,64813F-HRTimelineGroup
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…18,129$1.61M0.01%+1,40913F-HRTimelineGroup
STATE BOARD OF ADMINISTRATION OF FLORID…18,076$1.6M<0.01%+4,17113F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC17,628$1.57M0.01%+1,18513F-HRTimeline
KENNEDY CAPITAL MANAGEMENT LLC17,310$1.54M0.03%+43713F-HRTimeline
ALGERT GLOBAL LLC16,460$1.46M0.02%new13F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…15,638$1.39M<0.01%+15,63313F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM15,471$1.37M0.01%+2,03313F-HRTimeline
DIADEMA PARTNERS LP15,000$1.33M0.47%new13F-HRTimeline
Neo Ivy Capital Management14,551$1.29M0.3%+13,95313F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO13,941$1.24M<0.01%+4,96613F-HRTimelineGroup
China Universal Asset Management Co., L…13,821$1.23M0.07%-11713F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC13,550$1.2M<0.01%+1,15013F-HRTimelineGroup
Seven Fleet Capital Management LP13,300$1.18M0.19%-6,39013F-HRTimeline
KLP KAPITALFORVALTNING AS12,800$1.14M<0.01%+1,90013F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP12,771$1.13M<0.01%new13F-HRTimelineGroup
SG Americas Securities, LLC12,727$1.13M<0.01%-66913F-HRTimeline
ProShare Advisors LLC12,599$1.12M<0.01%-89913F-HRTimeline
Atom Investors LP12,457$1.11M0.1%new13F-HRTimeline
Global Endowment Management, LPin group Global Endowment Management, …12,123$1.08M0.11%-6,06113F-HRTimelineGroup
STRS OHIO11,500$1.02M<0.01%+7,00013F-HRTimeline
Calamos Advisors LLCin group Calamos Advisors LLC11,323$1.01M<0.01%new13F-HRTimelineGroup
VIRGINIA RETIREMENT SYSTEMS ET Al11,250$999K0.01%-16,30013F-HRTimeline
Diametric Capital, LP10,000$888K0.09%new13F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA9,966$885K<0.01%new13F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP9,779$868K<0.01%-168,61013F-HRTimelineGroup
Quantbot Technologies LP8,884$789K0.03%+8,79613F-HRTimeline
Persistent Asset Partners Ltd8,760$778K0.25%+3,95713F-HRTimeline
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…8,288$736K0.01%new13F-HRTimelineGroup
Man Group plcin group Man Group plc7,714$685K<0.01%-1,83213F-HRTimelineGroup
ENVESTNET ASSET MANAGEMENT INCin group ENVESTNET ASSET MANAGEMENT INC7,666$681K<0.01%new13F-HRTimelineGroup
XPONANCE LLC7,291$647K<0.01%+84613F-HRTimeline
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…6,760$600K0.02%+1,16713F-HRTimelineGroup
State of Wyoming6,690$594K0.06%new13F-HRTimeline
AlphaCentric Advisors LLC6,670$592K0.5%+3613F-HRTimeline
TEACHER RETIREMENT SYSTEM OF TEXAS6,554$582K<0.01%+27413F-HRTimeline
BOOTHBAY FUND MANAGEMENT, LLC6,453$573K0.01%-186,57813F-HRTimeline
Harvest Investment Services, LLC6,432$571K0.09%new13F-HRTimeline
Fieldview Capital Management, LLC6,392$567K0.16%new13F-HRTimeline
Allspring Global Investments Holdings, …in group Allspring Global Investments …6,090$541K<0.01%new13F-HRTimelineGroup
Quantinno Capital Management LP6,015$534K<0.01%+1,45413F-HRTimeline
High Net Worth Advisory Group LLC6,000$533K0.11%013F-HRTimeline
OMERS ADMINISTRATION Corp5,200$462K<0.01%new13F-HRTimeline
DARK FOREST CAPITAL MANAGEMENT LP5,192$461K0.03%new13F-HRTimeline
E Fund Management Co., Ltd.5,184$460K0.01%-1,97213F-HRTimeline
CAPTRUST FINANCIAL ADVISORS5,023$446K<0.01%new13F-HRTimeline
Connor, Clark & Lunn Investment Managem…4,801$426K<0.01%new13F-HRTimeline
MARTINGALE ASSET MANAGEMENT L P4,425$393K0.01%-4,65513F-HRTimeline
Virtu Financial LLCin group Virtu Financial LLC4,351$386K0.01%-3,74013F-HRTimelineGroup
CIBC Bancorp USA Inc.in group CIBC Bancorp USA Inc.4,122$366K<0.01%new13F-HRTimelineGroup
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…4,050$360K0.08%-4,06013F-HRTimelineGroup
WEXFORD CAPITAL LP4,000$355K0.05%new13F-HRTimeline
Artia Global Partners LP4,000$355K0.07%new13F-HRTimeline
PSP Research LLC4,000$355K0.19%-1,15913F-HRTimeline
LANDSCAPE CAPITAL MANAGEMENT, L.L.C.in group LANDSCAPE CAPITAL MANAGEMENT,…3,875$344K0.02%-1,32513F-HRTimelineGroup
Jump Financial, LLCin group Jump Financial, LLC3,813$339K<0.01%new13F-HRTimelineGroup
Swiss Life Asset Management Ltdin group Swiss Life Asset Management L…3,601$320K<0.01%new13F-HRTimelineGroup
Bridgefront Capital, LLC3,577$318K0.08%-5,07513F-HRTimeline
STIFEL FINANCIAL CORPin group STIFEL FINANCIAL CORP3,011$267K<0.01%new13F-HRTimelineGroup
TWO SIGMA SECURITIES, LLC3,003$267K0.02%-3,84813F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…3,001$266K0.01%-5,78913F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC2,909$258K<0.01%new13F-HRTimelineGroup
VARCOV Co.2,895$257K0.1%new13F-HRTimeline
Aster Capital Management (DIFC) Ltd2,865$254K0.05%new13F-HR/ATimeline
Amundiin group Amundi2,793$248K<0.01%new13F-HRTimelineGroup
Empowered Funds, LLC2,731$242K<0.01%new13F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS2,661$236K<0.01%new13F-HRTimelineGroup
TUDOR INVESTMENT CORP ET AL2,645$235K<0.01%-5,71913F-HRTimeline
Orion Porfolio Solutions, LLC2,577$229K<0.01%new13F-HRTimeline
CIBC Asset Management Inc2,429$216K<0.01%new13F-HRTimeline

Events

  • Paradigm Biocapital Advisors LP and 3 other reporting persons reported 4,457,450 SYRE shares, 5.1% of the class, as of 2026-09-24, in a 13G filed 2026-10-01. 0001104659-26-112828

    Accepted , ingested