Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 13,063,687 $27.3M 0.94% new 13F-HR Timeline B Group, Inc. More: the full row for B Group, Inc. 11,414,285 $23.9M 13.54% 0 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 11,081,434 $23.2M <0.01% -428,886 13F-HR Timeline Group Jupiter Topco LLC in group Janus Henderson More: the full row for Jupiter Topco LLC 10,689,452 $22.4M 0.01% 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 10,436,760 $21.8M <0.01% +8,560,420 13F-HR Timeline Group Octagon Capital Advisors LP More: the full row for Octagon Capital Advisors LP 10,276,317 $21.5M 1.97% 0 13F-HR Timeline PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 8,425,065 $17.6M 0.27% -503,084 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 7,124,116 $14.9M 0.13% 0 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 5,785,189 $12.1M <0.01% 0 13F-HR Timeline Group Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 5,253,403 $11M 0.02% +4,841,631 13F-HR Timeline Group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 4,799,875 $10M 0.76% 0 13F-HR Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 4,500,000 $9.4M 0.01% 0 13F-HR Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 4,182,785 $8.74M 0.48% -804,714 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 3,760,485 $7.86M <0.01% +2,214,245 13F-HR Timeline Group WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 3,703,936 $7.74M <0.01% +799,025 13F-HR Timeline Group VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 3,655,116 $7.64M +1,514,227 Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 3,578,020 $7.48M <0.01% -1,795,931 13F-HR Timeline Group FEDERATED HERMES, INC. in group FEDERATED HERMES, INC. More: the full row for FEDERATED HERMES, INC. 3,136,607 $6.56M 0.01% 0 13F-HR Timeline Group Squadron Capital Management LLC More: the full row for Squadron Capital Management LLC 3,000,000 $6.27M 2.15% 0 13F-HR Timeline Propel Bio Management, LLC More: the full row for Propel Bio Management, LLC 2,582,388 $5.4M 2.82% +1,467,388 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 2,500,000 $5.22M 0.12% 0 13F-HR Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,475,648 $5.17M <0.01% +1,839,451 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,474,069 $5.17M <0.01% -2,077,464 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 2,333,000 $4.88M 0.09% 0 13F-HR Timeline Group GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 2,284,819 $4.78M 1.13% -1,120,938 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 2,257,106 $4.72M 0.68% +523,635 13F-HR Timeline Group HighVista Strategies LLC More: the full row for HighVista Strategies LLC 2,030,927 $4.24M 0.97% +11,601 13F-HR Timeline Siren, L.L.C. in group Siren, L.L.C. More: the full row for Siren, L.L.C. 2,000,000 $4.18M 0.08% new 13F-HR Timeline Group Artia Global Partners LP More: the full row for Artia Global Partners LP 1,992,367 $4.16M 0.79% 0 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 1,910,205 $3.99M 0.01% +1,247,305 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,875,694 $3.92M 0.01% -1,395,151 13F-HR Timeline Group PLATINUM INVESTMENT MANAGEMENT LTD More: the full row for PLATINUM INVESTMENT MANAGEMENT LTD 1,730,866 $3.62M 0.89% +499,452 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 1,726,662 $3.61M 0.17% -538,183 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 1,229,000 $2.57M 3.31% new 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 1,197,620 $2.5M <0.01% +916,970 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 1,124,800 $2.35M <0.01% -329,600 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 1,016,850 $2.13M <0.01% +1,002,578 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 969,457 $2.03M <0.01% new 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 934,155 $1.95M <0.01% -1,169,198 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 750,000 $1.57M 0.26% +475,022 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 737,307 $1.54M <0.01% -429,644 13F-HR Timeline Group BIT Capital GmbH More: the full row for BIT Capital GmbH 574,000 $1.2M 0.04% +419,000 13F-HR Timeline Simplify Asset Management Inc. More: the full row for Simplify Asset Management Inc. 450,543 $942K 0.01% +100,543 13F-HR Timeline Creek Drive Management Group LLC More: the full row for Creek Drive Management Group LLC 440,000 $920K 0.57% -100,000 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 437,137 $914K 0.02% +267,489 13F-HR Timeline LANDSCAPE CAPITAL MANAGEMENT, L.L.C. in group LANDSCAPE CAPITAL MANAGEMENT,… More: the full row for LANDSCAPE CAPITAL MANAGEMENT, L.L.C. 436,726 $913K 0.06% +111,707 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 434,983 $909K <0.01% +358,983 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 398,790 $833K <0.01% -2,355,613 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 348,469 $728K <0.01% +335,557 13F-HR Timeline Group ACT CAPITAL MANAGEMENT, LLC More: the full row for ACT CAPITAL MANAGEMENT, LLC 307,500 $643K 0.42% +50,000 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 272,204 $569K 0.09% +59,104 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 173,861 $363K <0.01% -23,213 13F-HR Timeline Group Virtu Financial LLC in group Virtu Financial LLC More: the full row for Virtu Financial LLC 167,156 $349K 0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 160,773 $336K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 144,000 $301K <0.01% new 13F-HR Timeline Group LPL Financial LLC More: the full row for LPL Financial LLC 142,154 $297K <0.01% +32,000 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 130,263 $272K <0.01% -74,327 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 126,602 $265K <0.01% +98,962 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 125,567 $262K <0.01% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 124,691 $261K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 121,152 $254K <0.01% new 13F-HR Timeline Pale Fire Capital SE in group Pale Fire Capital More: the full row for Pale Fire Capital SE 111,410 $233K 0.02% 0 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 99,660 $208K 0.2% new 13F-HR Timeline SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 88,000 $184K 0.13% 0 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 87,875 $184K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 85,978 $180K <0.01% -110,961 13F-HR Timeline Group EntryPoint Capital, LLC More: the full row for EntryPoint Capital, LLC 78,498 $164K 0.04% -997 13F-HR Timeline Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 77,398 $162K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 64,715 $144K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 68,536 $143K <0.01% -19,168 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 67,890 $142K 0.01% new 13F-HR Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 67,674 $141K <0.01% new 13F-HR Timeline Group LOS ANGELES CAPITAL MANAGEMENT LLC More: the full row for LOS ANGELES CAPITAL MANAGEMENT LLC 58,385 $122K <0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 52,040 $109K <0.01% new 13F-HR Timeline Quinn Opportunity Partners LLC More: the full row for Quinn Opportunity Partners LLC 50,000 $104K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 43,530 $91K <0.01% new 13F-HR Timeline Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 41,464 $86.7K 0.03% -194,884 13F-HR Timeline PCG Wealth Advisors, LLC More: the full row for PCG Wealth Advisors, LLC 41,100 $85.9K 0.02% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 40,132 $83.9K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 36,253 $75.8K <0.01% +34,023 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 33,100 $69.2K <0.01% new 13F-HR Timeline WINTON GROUP Ltd in group WINTON GROUP Ltd More: the full row for WINTON GROUP Ltd 32,227 $67.4K <0.01% +20,727 13F-HR Timeline Group Total Clarity Wealth Management, Inc. More: the full row for Total Clarity Wealth Management, Inc. 31,795 $66.5K 0.01% +4,795 13F-HR Timeline INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 31,153 $65.1K <0.01% new 13F-HR Timeline SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 30,905 $64.6K <0.01% new 13F-HR Timeline Group STRS OHIO More: the full row for STRS OHIO 28,900 $60.4K <0.01% new 13F-HR Timeline VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 28,143 $58.8K <0.01% new 13F-HR Timeline Group TWO SIGMA SECURITIES, LLC More: the full row for TWO SIGMA SECURITIES, LLC 27,450 $57.4K <0.01% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 25,896 $54K <0.01% -17,834 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 24,561 $51.3K <0.01% +11,436 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 22,550 $47.1K <0.01% -166,711 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 22,265 $46.5K <0.01% new 13F-HR Timeline Group NFSG Corp More: the full row for NFSG Corp 20,250 $42.3K 0.01% +3,250 13F-HR Timeline VICTORY CAPITAL MANAGEMENT INC More: the full row for VICTORY CAPITAL MANAGEMENT INC 19,757 $41.3K <0.01% +3,303 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 19,325 $40.4K <0.01% new 13F-HR Timeline Voleon Capital Management LP More: the full row for Voleon Capital Management LP 18,847 $39.4K <0.01% new 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 29,228 $33.2K <0.01% new 13F-HR Timeline CHOREO, LLC More: the full row for CHOREO, LLC 15,743 $32.9K <0.01% 0 13F-HR Timeline Cetera Investment Advisers More: the full row for Cetera Investment Advisers 15,506 $32.4K <0.01% +5,000 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 14,323 $29.9K <0.01% new 13F-HR Timeline Group XPONANCE LLC More: the full row for XPONANCE LLC 14,066 $29.4K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 13,395 $28K <0.01% new 13F-HR Timeline Group Kestra Advisory Services, LLC in group Kestra Advisory Services, LLC More: the full row for Kestra Advisory Services, LLC 12,504 $26.1K <0.01% new 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 12,081 $25.2K <0.01% -41,761 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 11,770 $24.6K <0.01% new 13F-HR Timeline Group NorthCrest Asset Manangement, LLC More: the full row for NorthCrest Asset Manangement, LLC 12,203 $24K <0.01% new 13F-HR Timeline CIBC Bancorp USA Inc. in group CIBC Bancorp USA Inc. More: the full row for CIBC Bancorp USA Inc. 10,148 $21.2K <0.01% new 13F-HR Timeline Group FNY Investment Advisers, LLC More: the full row for FNY Investment Advisers, LLC 8,500 $17K 0.01% -1,451 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 4,568 $10K <0.01% new 13F-HR Timeline Group Quantbot Technologies LP More: the full row for Quantbot Technologies LP 4,741 $9.91K <0.01% +4,360 13F-HR Timeline State of Wyoming More: the full row for State of Wyoming 3,643 $7.61K <0.01% new 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 2,538 $5.3K <0.01% new 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 2,500 $5.22K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 2,033 $4.25K <0.01% new 13F-HR/A Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 551 $1.15K <0.01% new 13F-HR Timeline Group Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 500 $1.04K <0.01% 0 13F-HR Timeline Group Quarry LP More: the full row for Quarry LP 498 $1.04K <0.01% new 13F-HR Timeline Avion Wealth More: the full row for Avion Wealth 500 $1K <0.01% 0 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 66 $137 <0.01% -2,000 13F-HR Timeline Group HARBOUR INVESTMENTS, INC. More: the full row for HARBOUR INVESTMENTS, INC. 16 $33 <0.01% new 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 1 $2 <0.01% new 13F-HR Timeline