Beutel, Goodman & Co Ltd. More: the full row for Beutel, Goodman & Co Ltd. 3,627,864 $23.8M 0.18% -38,601 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 1,650,000 $10.9M 0.53% +60,995 13F-HR Timeline Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 1,350,015 $8.92M 0.02% +15 13F-HR Timeline Group Vivo Capital, LLC More: the full row for Vivo Capital, LLC 1,350,000 $8.92M 0.81% 0 13F-HR Timeline SCOTIA CAPITAL INC. More: the full row for SCOTIA CAPITAL INC. 1,343,726 $8.78M 0.03% +1,548 13F-HR Timeline PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 1,210,661 $8M 0.69% +669,790 13F-HR Timeline GREAT POINT PARTNERS LLC More: the full row for GREAT POINT PARTNERS LLC 1,200,000 $7.93M 1.87% 0 13F-HR Timeline Jupiter Topco LLC in group Janus Henderson More: the full row for Jupiter Topco LLC 1,046,000 $6.85M <0.01% 13F-HR Timeline Group Rubric Capital Management LP More: the full row for Rubric Capital Management LP 867,424 $5.73M 0.05% +176,254 13F-HR Timeline Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 809,741 $5.35M 0.88% -405,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 746,864 $4.94M 0.02% +306,313 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 730,284 $4.83M 0.01% -237,291 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 711,024 $4.7M <0.01% +61,950 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 611,400 $4.04M 0.27% -88,600 13F-HR Timeline Group Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 610,785 $4.04M 0.67% +177,270 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 519,211 $3.43M <0.01% -243,424 13F-HR Timeline Group CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 502,011 $3.32M <0.01% +271,835 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 441,586 $2.92M <0.01% new 13F-HR Timeline Group Alyeska Investment Group, L.P. in group Alyeska Investment Group, L.P. More: the full row for Alyeska Investment Group, L.P. 375,000 $2.48M 0.01% 0 13F-HR Timeline Group PICTON MAHONEY ASSET MANAGEMENT More: the full row for PICTON MAHONEY ASSET MANAGEMENT 360,878 $2.39M 0.02% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 352,000 $2.33M 1.43% 0 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 329,053 $2.16M <0.01% +293,843 13F-HR Timeline Group Aisling Capital Management LP More: the full row for Aisling Capital Management LP 325,000 $2.15M 0.46% 0 13F-HR Timeline SummitTX Capital, L.P. More: the full row for SummitTX Capital, L.P. 318,784 $2.11M 0.06% -9,213 13F-HR Timeline ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 311,435 $2.06M <0.01% +50,059 13F-HR Timeline Group DV EQUITIES, LLC More: the full row for DV EQUITIES, LLC 276,000 $1.82M 0.26% 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 269,000 $1.78M 0.03% new 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 264,721 $1.75M <0.01% -3,500 13F-HR Timeline Group Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 252,175 $1.67M 2.15% -408,200 13F-HR Timeline CIBC WORLD MARKET INC. More: the full row for CIBC WORLD MARKET INC. 234,673 $1.54M <0.01% +83,723 13F-HR Timeline DAFNA Capital Management LLC More: the full row for DAFNA Capital Management LLC 225,600 $1.49M 0.28% new 13F-HR Timeline TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 221,084 $1.46M <0.01% +210,284 13F-HR Timeline Group BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 212,653 $1.41M 0.03% -111,190 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 158,133 $1.05M <0.01% 0 13F-HR Timeline Group Delaney Capital Management Ltd. More: the full row for Delaney Capital Management Ltd. 117,200 $768K 0.12% -2,200 13F-HR Timeline TD Waterhouse Canada Inc. More: the full row for TD Waterhouse Canada Inc. 79,607 $535K <0.01% -2,118 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 70,265 $464K 0.01% new 13F-HR Timeline Group INGALLS & SNYDER LLC More: the full row for INGALLS & SNYDER LLC 68,450 $452K 0.01% -7,200 13F-HR Timeline Annis Gardner Whiting Capital Advisors,… More: the full row for Annis Gardner Whiting Capital Advisors, LLC 60,000 $397K 0.06% new 13F-HR Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 58,058 $384K <0.01% +4,978 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 53,503 $354K <0.01% +2,943 13F-HR Timeline Group 1832 Asset Management L.P. More: the full row for 1832 Asset Management L.P. 50,432 $333K <0.01% -9,568 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 46,145 $305K <0.01% +39,716 13F-HR Timeline Group Stonepine Capital Management, LLC More: the full row for Stonepine Capital Management, LLC 43,491 $287K 0.22% new 13F-HR/A Timeline BANK OF MONTREAL /CAN/ in group BANK OF MONTREAL /CAN/ More: the full row for BANK OF MONTREAL /CAN/ 38,457 $252K <0.01% +207 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 36,211 $239K <0.01% +10,598 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 34,767 $230K <0.01% new 13F-HR Timeline Group Qube Research & Technologies Ltd More: the full row for Qube Research & Technologies Ltd 34,237 $226K <0.01% new 13F-HR Timeline TORONTO DOMINION BANK in group TORONTO DOMINION BANK More: the full row for TORONTO DOMINION BANK 30,920 $203K <0.01% -1,978 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 21,150 $140K 0.02% +5,390 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 19,800 $131K <0.01% new 13F-HR Timeline Group NATIXIS in group Natixis Investment Managers More: the full row for NATIXIS 17,644 $115K <0.01% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 14,186 $93.5K <0.01% +13,613 13F-HR Timeline Group China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,500 $82.6K <0.01% +2,500 13F-HR Timeline TCI Wealth Advisors, Inc. More: the full row for TCI Wealth Advisors, Inc. 11,000 $72.7K <0.01% 0 13F-HR Timeline Aptus Capital Advisors, LLC More: the full row for Aptus Capital Advisors, LLC 10,500 $69.4K <0.01% 0 13F-HR Timeline GUARDIAN WEALTH ADVISORS, LLC / NC More: the full row for GUARDIAN WEALTH ADVISORS, LLC / NC 10,500 $69.4K <0.01% 0 13F-HR Timeline Shay Capital LLC More: the full row for Shay Capital LLC 10,000 $66.1K 0.01% new 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 10,000 $66.1K 0.01% new 13F-HR/A Timeline Group Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 9,875 $65.3K <0.01% -2,125 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 9,091 $59.4K <0.01% 0 13F-HR Timeline Northwest & Ethical Investments L.P. More: the full row for Northwest & Ethical Investments L.P. 6,237 $41K <0.01% new 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 6,088 $40.2K <0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 3,791 $25.1K 0.01% -34,135 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 2,200 $14.5K <0.01% -6,620 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 52 $344 <0.01% +51 13F-HR Timeline Quarry LP More: the full row for Quarry LP 49 $324 <0.01% new 13F-HR Timeline NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 8 $36 <0.01% -351 13F-HR Timeline Group