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Disclosery

SPRB SPRUCE BIOSCIENCES INC

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COM NEW (common), issuer CIK 1683553

60 managers (63 13F filers) reported a position in SPRB shares at 2026-06-30, 2,002,949 shares in all. 35 filers opened a position and 4 filers sold out during the quarter.

Managers
60
13F filers
63
New
35
Added
16
Reduced
3
Sold out
4
Shares held by filers
2,002,949

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
AIGH Capital Management LLC250,000$13.5M1.22%new13F-HRTimeline
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC200,000$10.8M0.2%new13F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.187,836$10.1M<0.01%+170,89813F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC160,981$8.69M0.01%+49,09313F-HRTimelineGroup
VANGUARD GROUP INCgroup of 4 filers holding156,640$8.46M+132,337Timeline
Ikarian Capital, LLC121,356$6.55M1.07%013F-HRTimeline
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.81,671$4.41M0.01%+30,00013F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC70,548$3.81M<0.01%+57,65913F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC67,717$3.66M0.17%+9,11713F-HRTimelineGroup
Cable Car Capital, LP60,000$3.24M0.07%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC51,905$2.8M<0.01%-18,09413F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP50,450$2.72M<0.01%+45,05013F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC42,080$2.27M0.04%013F-HRTimeline
STEMPOINT CAPITAL LP41,388$2.23M0.39%+35,02813F-HRTimeline
Eversept Partners, LP40,000$2.16M0.12%new13F-HRTimeline
Carlyle Group Inc.in group Carlyle Group Inc.38,620$2.09M0.02%013F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC32,348$1.75M<0.01%+26,84213F-HRTimelineGroup
Affinity Asset Advisors, LLC30,000$1.62M0.08%new13F-HRTimeline
DIADEMA PARTNERS LP30,000$1.62M0.57%+20,00013F-HRTimeline
Stonepine Capital Management, LLC28,795$1.55M1.18%new13F-HR/ATimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.28,278$1.53M<0.01%new13F-HRTimelineGroup
Quinn Opportunity Partners LLC26,810$1.45M0.07%013F-HRTimeline
UBS Group AGin group UBS Group AG23,381$1.26M<0.01%+19,46213F-HRTimelineGroup
ExodusPoint Capital Management, LP22,000$1.19M0.01%013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP21,083$1.14M<0.01%new13F-HRTimelineGroup
Rosalind Advisors, Inc.20,000$1.08M0.41%new13F-HRTimeline
Knott David M Jr20,000$1.08M0.57%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC18,834$1.02M<0.01%new13F-HRTimelineGroup
Balyasny Asset Management L.P.in group Balyasny Asset Management12,138$655K<0.01%-27,86213F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP8,813$477K<0.01%new13F-HRTimelineGroup
Persistent Asset Partners Ltd7,677$415K0.13%+5,14913F-HRTimeline
STATE BOARD OF ADMINISTRATION OF FLORID…7,182$388K<0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp6,779$366K<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co5,896$318K<0.01%new13F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC4,700$254K<0.01%new13F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY4,411$238K<0.01%+2,99613F-HRTimelineGroup
Pale Fire Capital SEin group Pale Fire Capital3,818$206K0.01%new13F-HRTimelineGroup
RHUMBLINE ADVISERS3,519$190K<0.01%new13F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\2,652$143K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN2,329$126K<0.01%new13F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND1,900$103K<0.01%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC1,265$68.3K<0.01%+32613F-HRTimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…1,252$67.6K<0.01%new13F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,127$63K<0.01%new13F-HRTimelineGroup
Lion Point Capital, LP1,000$54K0.26%013F-HRTimeline
Police & Firemen's Retirement System of…864$46.7K<0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC674$36.4K<0.01%new13F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS453$24.5K<0.01%new13F-HRTimelineGroup
FMR LLCin group FMR LLC343$18.5K<0.01%new13F-HRTimelineGroup
Legal & General Group Plcin group Legal & General Group Plc264$14.2K<0.01%new13F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…247$13.3K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…246$13.3K<0.01%+10613F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…217$11.7K<0.01%new13F-HRTimelineGroup
SBI Securities Co., Ltd.201$10.9K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA166$8K<0.01%new13F-HRTimelineGroup
Sterling Capital Management LLC43$2.32K<0.01%new13F-HRTimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP30$1.65K<0.01%-16313F-HRTimelineGroup
CALDWELL SUTTER CAPITAL, INC.13$702<0.01%013F-HRTimeline
Friedenthal Financial7$378<0.01%new13F-HRTimeline
Cassaday & Co Wealth Management LLC2$108<0.01%013F-HRTimeline