FMR LLC in group FMR LLC More: the full row for FMR LLC 2,830,378 $97.3M <0.01% +13,884 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 1,204,891 $41.4M 1% 0 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 1,141,824 $39.3M 0.06% 0 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 862,592 $29.7M <0.01% +2,240 13F-HR Timeline Group First Light Asset Management, LLC More: the full row for First Light Asset Management, LLC 800,726 $27.5M 1.67% +152,983 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 660,378 $22.7M +51,380 Timeline BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 607,788 $20.9M 0.1% 0 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 606,660 $20.9M 7.24% 0 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 596,900 $20.5M 0.76% -250,251 13F-HR Timeline Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 425,000 $14.6M 0.34% +97,000 13F-HR Timeline Bollard Group LLC More: the full row for Bollard Group LLC 302,953 $10.4M 0.32% 0 13F-HR Timeline KENNEDY CAPITAL MANAGEMENT LLC More: the full row for KENNEDY CAPITAL MANAGEMENT LLC 282,202 $9.7M 0.17% -4,480 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 270,461 $9.3M <0.01% +2,188 13F-HR Timeline Group ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 226,600 $7.79M 0.15% 0 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 219,908 $7.56M <0.01% +6,403 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 205,837 $7.08M 1.16% +48,300 13F-HR Timeline D. E. Shaw & Co., Inc. in group D. E. Shaw & Co., Inc. More: the full row for D. E. Shaw & Co., Inc. 186,550 $6.41M <0.01% +70,430 13F-HR Timeline Group MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 172,101 $5.92M <0.01% -57,494 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 165,525 $5.69M <0.01% +107,177 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 145,028 $4.99M 0.01% -19,391 13F-HR Timeline Group AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 142,448 $4.9M <0.01% -984 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 117,428 $4.04M <0.01% +4,764 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 113,904 $3.92M <0.01% +35,551 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 101,684 $3.5M 0.12% -20,000 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 100,000 $3.44M 0.01% 0 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 90,393 $3.11M <0.01% new 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 73,924 $2.54M <0.01% +11,498 13F-HR Timeline Group RAYMOND JAMES FINANCIAL INC in group RAYMOND JAMES FINANCIAL INC More: the full row for RAYMOND JAMES FINANCIAL INC 72,674 $2.5M <0.01% +8,478 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 71,009 $2.44M 1.7% +51,950 13F-HR Timeline JANE STREET GROUP, LLC in group JANE STREET GROUP, LLC More: the full row for JANE STREET GROUP, LLC 65,821 $2.26M <0.01% new 13F-HR Timeline Group MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 65,373 $2.25M <0.01% +525 13F-HR Timeline Group Connor, Clark & Lunn Investment Managem… More: the full row for Connor, Clark & Lunn Investment Management Ltd. 64,940 $2.23M <0.01% -2,054 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 60,771 $2.09M 0.04% +14,634 13F-HR Timeline JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 55,364 $1.83M <0.01% -3,506 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 48,001 $1.65M <0.01% -116,054 13F-HR Timeline Tetragon Partners GP Ltd in group Tetragon Partners GP Ltd More: the full row for Tetragon Partners GP Ltd 46,516 $1.6M 0.26% +8,928 13F-HR Timeline Group PFM Health Sciences, LP More: the full row for PFM Health Sciences, LP 45,631 $1.57M 0.14% -498 13F-HR Timeline HRT FINANCIAL LP More: the full row for HRT FINANCIAL LP 44,540 $1.53M <0.01% new 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 43,400 $1.49M 0.01% +302 13F-HR Timeline Group Prosight Management, LP More: the full row for Prosight Management, LP 39,731 $1.37M 0.24% -40,141 13F-HR Timeline Trexquant Investment LP More: the full row for Trexquant Investment LP 36,991 $1.27M 0.01% new 13F-HR Timeline Aldebaran Capital, LLC More: the full row for Aldebaran Capital, LLC 36,797 $1.26M 0.95% -387 13F-HR Timeline ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 35,239 $1.21M 0.01% -48,440 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 31,432 $1.08M <0.01% +2,192 13F-HR Timeline Group CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 30,438 $1.05M <0.01% +1,328 13F-HR Timeline Group MONIMUS CAPITAL MANAGEMENT, LP More: the full row for MONIMUS CAPITAL MANAGEMENT, LP 28,143 $967K 0.25% +1,390 13F-HR Timeline Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 25,247 $868K <0.01% +487 13F-HR Timeline Group ALPS ADVISORS INC More: the full row for ALPS ADVISORS INC 19,147 $658K <0.01% +3,861 13F-HR Timeline Fisher Asset Management, LLC More: the full row for Fisher Asset Management, LLC 19,122 $657K <0.01% new 13F-HR Timeline AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 19,001 $653K <0.01% +6,467 13F-HR Timeline Group Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 18,067 $621K 0.01% new 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 17,029 $585K <0.01% -19,841 13F-HR Timeline Group Clearstead Advisors, LLC More: the full row for Clearstead Advisors, LLC 16,630 $572K 0.01% -10,130 13F-HR Timeline UBS Group AG group of 2 filers holding More: the full row for UBS Group AG 15,437 $531K -14,932 Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 14,501 $498K 0.02% +1,500 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 13,773 $473K <0.01% -254 13F-HR Timeline Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 13,514 $465K <0.01% +1,481 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 11,043 $380K <0.01% -423 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 10,806 $371K 0.09% -2,993 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 10,443 $359K <0.01% +366 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 10,039 $345K <0.01% +694 13F-HR Timeline Group Brevan Howard Capital Management LP in group Brevan Howard Capital Managem… More: the full row for Brevan Howard Capital Management LP 9,573 $329K <0.01% new 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 9,128 $314K <0.01% +2,422 13F-HR Timeline Group Creative Planning in group Creative Planning More: the full row for Creative Planning 8,961 $308K <0.01% -3,485 13F-HR Timeline Group FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 8,865 $305K 0.05% new 13F-HR Timeline GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 8,275 $284K 0.02% -10,598 13F-HR Timeline AlphaCentric Advisors LLC More: the full row for AlphaCentric Advisors LLC 6,948 $239K 0.2% +99 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 6,724 $231K <0.01% 0 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 7,460 $231K <0.01% new 13F-HR Timeline AQR CAPITAL MANAGEMENT LLC in group AQR CAPITAL MANAGEMENT LLC More: the full row for AQR CAPITAL MANAGEMENT LLC 6,617 $227K <0.01% -10,317 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 6,388 $220K <0.01% -1,287 13F-HR Timeline Group STATE BOARD OF ADMINISTRATION OF FLORID… More: the full row for STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM 6,060 $208K <0.01% new 13F-HR Timeline Rangeley Capital, LLC More: the full row for Rangeley Capital, LLC 6,000 $206K 0.19% new 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 6,000 $206K 0.13% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 5,996 $206K <0.01% -7,933 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 5,567 $191K <0.01% +4,716 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 5,548 $191K <0.01% +4,401 13F-HR Timeline Group Mirae Asset Global Investments Co., Ltd. group of 2 filers holding More: the full row for Mirae Asset Global Investments Co., Ltd. 5,538 $190K -656 Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 5,503 $189K 0.01% -829 13F-HR Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 5,400 $186K <0.01% +400 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 5,146 $177K <0.01% +2,330 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 4,600 $158K <0.01% 0 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 2,638 $90.7K <0.01% 0 13F-HR Timeline Quantbot Technologies LP More: the full row for Quantbot Technologies LP 1,819 $62.5K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 1,122 $38.6K <0.01% 0 13F-HR Timeline Group US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 1,080 $37.1K <0.01% -56 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 1,000 $34.4K <0.01% 0 13F-HR Timeline Group Chung Wu Investment Group, LLC More: the full row for Chung Wu Investment Group, LLC 800 $27.5K 0.02% new 13F-HR Timeline Arax Advisory Partners More: the full row for Arax Advisory Partners 725 $24.9K <0.01% new 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 661 $22.7K <0.01% -253 13F-HR Timeline Group State of Wyoming More: the full row for State of Wyoming 601 $20.7K <0.01% new 13F-HR Timeline HighMark Wealth Management LLC More: the full row for HighMark Wealth Management LLC 587 $20.2K 0.01% 0 13F-HR Timeline SIMPLEX TRADING, LLC More: the full row for SIMPLEX TRADING, LLC 439 $15.1K <0.01% -912 13F-HR Timeline GF FUND MANAGEMENT CO. LTD. More: the full row for GF FUND MANAGEMENT CO. LTD. 400 $13.8K <0.01% -15 13F-HR Timeline Rockefeller Capital Management L.P. in group Rockefeller Capital Managemen… More: the full row for Rockefeller Capital Management L.P. 370 $12.7K <0.01% 0 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 311 $11K <0.01% new 13F-HR Timeline Group GAMMA Investing LLC More: the full row for GAMMA Investing LLC 290 $9.97K <0.01% -40 13F-HR Timeline Federation des caisses Desjardins du Qu… More: the full row for Federation des caisses Desjardins du Quebec 250 $8.59K <0.01% -250 13F-HR Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 176 $6.05K <0.01% -137 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 141 $4.85K <0.01% -454 13F-HR/A Timeline Axiom Investment Management LLC More: the full row for Axiom Investment Management LLC 125 $4.3K <0.01% new 13F-HR Timeline Farther Finance Advisors, LLC More: the full row for Farther Finance Advisors, LLC 76 $2.61K <0.01% -26 13F-HR Timeline Allworth Financial LP More: the full row for Allworth Financial LP 52 $1.79K <0.01% -13 13F-HR Timeline Marshall & Sterling Wealth Advisors Inc. More: the full row for Marshall & Sterling Wealth Advisors Inc. 50 $1.72K <0.01% 0 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 40 $1.38K <0.01% +14 13F-HR Timeline Group Caldwell Trust Co More: the full row for Caldwell Trust Co 20 $688 <0.01% 0 13F-HR Timeline HUNTINGTON NATIONAL BANK in group HUNTINGTON NATIONAL BANK More: the full row for HUNTINGTON NATIONAL BANK 13 $447 <0.01% 0 13F-HR Timeline Group EASTERN BANK More: the full row for EASTERN BANK 13 $447 <0.01% new 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 11 $378 <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 10 $341 <0.01% new 13F-HR Timeline First Bancorp, Inc /ME/ More: the full row for First Bancorp, Inc /ME/ 8 $275 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 7 $240 <0.01% -12 13F-HR Timeline Group NATIONAL BANK OF CANADA /FI/ in group NATIONAL BANK OF CANADA /FI/ More: the full row for NATIONAL BANK OF CANADA /FI/ 6 $205 <0.01% new 13F-HR Timeline Group Essential Partners LLC More: the full row for Essential Partners LLC 5 $172 <0.01% -32 13F-HR Timeline Zurcher Kantonalbank (Zurich Cantonalba… More: the full row for Zurcher Kantonalbank (Zurich Cantonalbank) 3 $103 <0.01% 0 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 2 $69 <0.01% -9 13F-HR Timeline IFP Advisors, Inc More: the full row for IFP Advisors, Inc 2 $69 <0.01% new 13F-HR Timeline OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 2 $69 <0.01% new 13F-HR Timeline Group