FMR LLC in group FMR LLC More: the full row for FMR LLC 5,100,216 $94.3M <0.01% +2,220,735 13F-HR Timeline Group BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 4,365,553 $80.7M <0.01% +4,038,471 13F-HR Timeline Group Deep Track Capital, LP More: the full row for Deep Track Capital, LP 3,610,000 $66.7M 0.98% new 13F-HR Timeline Caligan Partners LP More: the full row for Caligan Partners LP 3,163,866 $58.5M 2.82% +1,528,843 13F-HR Timeline TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 3,017,120 $55.8M 1.34% +2,278,737 13F-HR Timeline Affinity Asset Advisors, LLC More: the full row for Affinity Asset Advisors, LLC 2,900,000 $53.6M 2.62% +1,559,160 13F-HR Timeline VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 2,893,766 $53.5M +2,082,033 Timeline STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 2,889,287 $53.4M <0.01% +2,817,633 13F-HR Timeline Group FARALLON CAPITAL MANAGEMENT, L.L.C. More: the full row for FARALLON CAPITAL MANAGEMENT, L.L.C. 2,498,000 $46.2M 0.27% +1,582,000 13F-HR Timeline Point72 Asset Management, L.P. in group Point72 Asset Management, L.P. More: the full row for Point72 Asset Management, L.P. 2,387,026 $44.1M 0.07% +1,470,884 13F-HR Timeline Group Avoro Capital Advisors LLC More: the full row for Avoro Capital Advisors LLC 2,333,333 $43.1M 0.39% +923,333 13F-HR Timeline BVF INC/IL in group BVF INC/IL More: the full row for BVF INC/IL 2,075,545 $38.4M 0.98% +442,700 13F-HR Timeline Group BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 1,913,829 $35.4M <0.01% +1,270,829 13F-HR Timeline Group Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 1,862,250 $34.4M 2.08% +627,250 13F-HR/A Timeline ADAGE CAPITAL PARTNERS GP, L.L.C. in group ADAGE CAPITAL PARTNERS GP, L.… More: the full row for ADAGE CAPITAL PARTNERS GP, L.L.C. 1,729,000 $32M 0.04% +875,000 13F-HR Timeline Group Soleus Capital Management, L.P. More: the full row for Soleus Capital Management, L.P. 1,654,978 $30.6M 1.05% +1,213,000 13F-HR Timeline BRAIDWELL LP More: the full row for BRAIDWELL LP 1,629,182 $30.1M 1.11% new 13F-HR Timeline PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 1,311,715 $24.2M <0.01% new 13F-HR Timeline ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 1,260,689 $23.3M 0.01% new 13F-HR Timeline UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 1,209,059 $22.3M <0.01% +67,079 13F-HR Timeline Group Logos Global Management LP More: the full row for Logos Global Management LP 1,150,000 $21.3M 0.91% +850,000 13F-HR Timeline GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 1,105,118 $20.4M <0.01% +935,229 13F-HR Timeline Group Commodore Capital LP in group Commodore Capital LP More: the full row for Commodore Capital LP 1,018,319 $18.8M 1.12% +535,319 13F-HR Timeline Group RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 1,000,000 $18.5M 0.16% +337,032 13F-HR Timeline Group GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 946,320 $17.5M <0.01% +886,214 13F-HR Timeline Group Trails Edge Capital Partners, LP More: the full row for Trails Edge Capital Partners, LP 891,881 $16.5M 2.62% new 13F-HR Timeline AMERIPRISE FINANCIAL INC in group AMERIPRISE FINANCIAL INC More: the full row for AMERIPRISE FINANCIAL INC 891,405 $16.5M <0.01% +719,256 13F-HR Timeline Group Balyasny Asset Management L.P. in group Balyasny Asset Management More: the full row for Balyasny Asset Management L.P. 861,711 $15.9M 0.03% +130,125 13F-HR Timeline Group Vestal Point Capital, LP More: the full row for Vestal Point Capital, LP 775,000 $14.3M 0.33% new 13F-HR Timeline Seven Fleet Capital Management LP More: the full row for Seven Fleet Capital Management LP 770,765 $14.2M 2.35% +556,946 13F-HR Timeline Parkman Healthcare Partners LLC More: the full row for Parkman Healthcare Partners LLC 766,290 $14.2M 1.45% new 13F-HR Timeline BOOTHBAY FUND MANAGEMENT, LLC More: the full row for BOOTHBAY FUND MANAGEMENT, LLC 702,051 $13M 0.24% +377,793 13F-HR Timeline Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 589,245 $10.9M 0.02% +507,960 13F-HR Timeline Group BAKER BROS. ADVISORS LP in group BAKER BROS. ADVISORS LP More: the full row for BAKER BROS. ADVISORS LP 550,000 $10.2M 0.05% new 13F-HR Timeline Group SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 500,402 $9.25M 1.03% new 13F-HR Timeline Group Davern Capital Partners, LP More: the full row for Davern Capital Partners, LP 468,666 $8.66M 1.48% new 13F-HR Timeline Pivotal bioVenture Partners Investment … in group Pivotal bioVenture Partners I… More: the full row for Pivotal bioVenture Partners Investment Advisor LLC 434,033 $8.02M 2.61% +138,100 13F-HR Timeline Group FRANKLIN RESOURCES INC in group Franklin Resources More: the full row for FRANKLIN RESOURCES INC 404,191 $7.47M <0.01% new 13F-HR Timeline Group Boxer Capital Management, LLC More: the full row for Boxer Capital Management, LLC 375,000 $6.93M 0.52% +75,000 13F-HR Timeline RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 357,200 $6.6M 0.01% +237,086 13F-HR Timeline NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 344,521 $6.37M <0.01% +313,965 13F-HR Timeline Group DV EQUITIES, LLC More: the full row for DV EQUITIES, LLC 332,213 $6.14M 0.89% 13F-HR Timeline Velan Capital Investment Management LP More: the full row for Velan Capital Investment Management LP 324,452 $6M 3.67% +139,330 13F-HR Timeline CITADEL ADVISORS LLC in group CITADEL ADVISORS LLC More: the full row for CITADEL ADVISORS LLC 323,833 $5.98M <0.01% +130,098 13F-HR Timeline Group Schonfeld Strategic Advisors LLC More: the full row for Schonfeld Strategic Advisors LLC 310,008 $5.73M 0.03% new 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 275,000 $5.08M 0.46% new 13F-HR Timeline Eagle Health Investments LP More: the full row for Eagle Health Investments LP 235,093 $4.34M 0.72% new 13F-HR Timeline SPHERA FUNDS MANAGEMENT LTD. in group SPHERA FUNDS MANAGEMENT LTD. More: the full row for SPHERA FUNDS MANAGEMENT LTD. 232,294 $4.29M 0.61% new 13F-HR Timeline Group PERCEPTIVE ADVISORS LLC in group PERCEPTIVE ADVISORS LLC More: the full row for PERCEPTIVE ADVISORS LLC 219,813 $4.06M 0.06% +80,146 13F-HR Timeline Group Caption Management, LLC More: the full row for Caption Management, LLC 210,000 $3.88M 0.14% -245,000 13F-HR Timeline Jump Financial, LLC in group Jump Financial, LLC More: the full row for Jump Financial, LLC 201,902 $3.73M 0.03% +189,092 13F-HR Timeline Group NAN FUNG TRINITY (HK) LTD More: the full row for NAN FUNG TRINITY (HK) LTD 189,000 $3.49M 0.34% 0 13F-HR Timeline ACUTA CAPITAL PARTNERS, LLC More: the full row for ACUTA CAPITAL PARTNERS, LLC 186,308 $3.44M 2.4% +125,500 13F-HR Timeline Walleye Capital LLC in group Walleye Capital LLC More: the full row for Walleye Capital LLC 185,613 $3.43M 0.02% new 13F-HR Timeline Group RTW INVESTMENTS, LP More: the full row for RTW INVESTMENTS, LP 175,000 $3.23M 0.03% -681,962 13F-HR Timeline Ally Bridge Group (NY) LLC More: the full row for Ally Bridge Group (NY) LLC 150,000 $2.77M 3.57% new 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 137,475 $2.54M <0.01% +127,475 13F-HR Timeline Group BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 134,087 $2.48M <0.01% -288,694 13F-HR Timeline Group CenterBook Partners LP More: the full row for CenterBook Partners LP 132,869 $2.46M 0.12% new 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 128,075 $2.37M <0.01% -33,317 13F-HR Timeline Group Moody Aldrich Partners LLC More: the full row for Moody Aldrich Partners LLC 125,582 $2.32M 0.42% -33,742 13F-HR Timeline HighVista Strategies LLC More: the full row for HighVista Strategies LLC 122,610 $2.27M 0.52% +63,988 13F-HR Timeline Aberdeen Group plc in group Aberdeen Group plc More: the full row for Aberdeen Group plc 122,169 $2.26M <0.01% -49,510 13F-HR Timeline Group SECTORAL ASSET MANAGEMENT INC More: the full row for SECTORAL ASSET MANAGEMENT INC 119,923 $2.22M 1.55% new 13F-HR Timeline WELLINGTON MANAGEMENT GROUP LLP in group WELLINGTON MANAGEMENT GROUP L… More: the full row for WELLINGTON MANAGEMENT GROUP LLP 105,261 $1.95M <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 102,653 $1.9M <0.01% new 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 100,633 $1.86M <0.01% new 13F-HR Timeline Group Ikarian Capital, LLC More: the full row for Ikarian Capital, LLC 90,183 $1.67M 0.27% new 13F-HR Timeline TD Asset Management Inc More: the full row for TD Asset Management Inc 77,474 $1.43M <0.01% +26,066 13F-HR Timeline CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 69,014 $1.28M <0.01% new 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 67,094 $1.24M <0.01% +2,669 13F-HR Timeline Group Rafferty Asset Management, LLC More: the full row for Rafferty Asset Management, LLC 56,411 $1.04M <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 53,799 $994K <0.01% new 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 53,290 $985K <0.01% new 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 52,583 $972K 0.01% -74,149 13F-HR Timeline Group DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 41,166 $761K <0.01% -108,834 13F-HR Timeline Group DIMENSIONAL FUND ADVISORS LP in group DIMENSIONAL FUND ADVISORS LP More: the full row for DIMENSIONAL FUND ADVISORS LP 38,158 $707K <0.01% -2,663 13F-HR Timeline Group Verition Fund Management LLC More: the full row for Verition Fund Management LLC 38,240 $707K <0.01% new 13F-HR/A Timeline Man Group plc in group Man Group plc More: the full row for Man Group plc 36,876 $681K <0.01% -9,677 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 36,576 $676K <0.01% new 13F-HR Timeline Group Verdad Advisers, LP More: the full row for Verdad Advisers, LP 32,827 $607K 0.58% new 13F-HR Timeline PROFUND ADVISORS LLC More: the full row for PROFUND ADVISORS LLC 28,309 $523K 0.01% new 13F-HR Timeline GLENMEDE TRUST CO NA in group GLENMEDE TRUST CO NA More: the full row for GLENMEDE TRUST CO NA 28,280 $523K <0.01% +2,550 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP group of 2 filers holding More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 27,227 $503K +10,000 Timeline MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 25,712 $480K <0.01% new 13F-HR Timeline Group Persistent Asset Partners Ltd More: the full row for Persistent Asset Partners Ltd 24,544 $454K 0.14% +16,626 13F-HR Timeline MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 24,499 $453K <0.01% new 13F-HR Timeline Group ENVESTNET ASSET MANAGEMENT INC in group ENVESTNET ASSET MANAGEMENT INC More: the full row for ENVESTNET ASSET MANAGEMENT INC 22,539 $417K <0.01% +2,543 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 22,226 $411K <0.01% new 13F-HR Timeline Group Virtus Investment Advisers, LLC in group Virtus Investment Advisers, L… More: the full row for Virtus Investment Advisers, LLC 22,168 $410K 0.1% new 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 18,145 $350K <0.01% -176,246 13F-HR Timeline Group SEI INVESTMENTS CO in group SEI INVESTMENTS CO More: the full row for SEI INVESTMENTS CO 17,931 $331K <0.01% -38,923 13F-HR Timeline Group BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 17,811 $329K <0.01% +3,169 13F-HR Timeline Group ExodusPoint Capital Management, LP More: the full row for ExodusPoint Capital Management, LP 16,495 $305K <0.01% -1,256 13F-HR Timeline Quadrature Capital Ltd in group Quadrature Capital Ltd More: the full row for Quadrature Capital Ltd 15,405 $285K <0.01% -109,790 13F-HR Timeline Group NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 14,700 $272K <0.01% new 13F-HR Timeline Jain Global LLC More: the full row for Jain Global LLC 12,686 $234K <0.01% new 13F-HR Timeline Woodline Partners LP More: the full row for Woodline Partners LP 12,544 $232K <0.01% new 13F-HR Timeline Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 12,324 $228K <0.01% new 13F-HR Timeline FOX RUN MANAGEMENT, L.L.C. More: the full row for FOX RUN MANAGEMENT, L.L.C. 10,639 $197K 0.03% new 13F-HR Timeline Lynx1 Capital Management LP in group Lynx1 Capital Management LP More: the full row for Lynx1 Capital Management LP 10,100 $187K 0.02% new 13F-HR/A Timeline Group Eversept Partners, LP More: the full row for Eversept Partners, LP 10,000 $185K 0.01% new 13F-HR Timeline US BANCORP \DE\ in group US BANCORP \DE\ More: the full row for US BANCORP \DE\ 5,684 $105K <0.01% +2,297 13F-HR Timeline Group Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 4,055 $74.9K <0.01% new 13F-HR Timeline Group Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 3,792 $70.1K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 3,341 $61.7K <0.01% new 13F-HR Timeline Group PFS Partners, LLC More: the full row for PFS Partners, LLC 2,000 $37K 0.01% 0 13F-HR Timeline Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 1,542 $28.5K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 1,365 $26K <0.01% +1,149 13F-HR Timeline Group Pacer Advisors, Inc. More: the full row for Pacer Advisors, Inc. 942 $17K <0.01% new 13F-HR Timeline CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 575 $10.6K <0.01% new 13F-HR/A Timeline Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 490 $9.05K <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 54 $999 <0.01% new 13F-HR Timeline ROTHSCHILD INVESTMENT LLC More: the full row for ROTHSCHILD INVESTMENT LLC 35 $647 <0.01% new 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 35 $647 <0.01% 0 13F-HR Timeline Group Fortitude Family Office, LLC More: the full row for Fortitude Family Office, LLC 30 $554 <0.01% -33 13F-HR Timeline FIFTH THIRD BANCORP in group FIFTH THIRD BANK, NATIONAL AS… More: the full row for FIFTH THIRD BANCORP 29 $536 <0.01% new 13F-HR Timeline Group ASSETMARK, INC in group ASSETMARK, INC More: the full row for ASSETMARK, INC 22 $407 <0.01% new 13F-HR Timeline Group OSAIC HOLDINGS, INC. in group OSAIC HOLDINGS, INC. More: the full row for OSAIC HOLDINGS, INC. 1 $18 <0.01% 0 13F-HR Timeline Group Parallel Advisors, LLC More: the full row for Parallel Advisors, LLC 1 $18 <0.01% 0 13F-HR Timeline Key Financial Inc More: the full row for Key Financial Inc 1 $18 <0.01% 0 13F-HR Timeline Activest Wealth Management More: the full row for Activest Wealth Management 1 $18 <0.01% 0 13F-HR Timeline Silver Grove Financial Group, Inc. More: the full row for Silver Grove Financial Group, Inc. 1 $18 <0.01% 0 13F-HR Timeline