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Disclosery

AMLX AMYLYX PHARMACEUTICALS INC

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COM (common), issuer CIK 1658551

199 managers (207 13F filers) reported a position in AMLX shares at 2026-06-30, 114,986,927 shares in all. 48 filers opened a position and 13 filers sold out during the quarter.

Managers
199
13F filers
207
New
48
Added
71
Reduced
60
Sold out
13
Shares held by filers
114,986,927

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC16,727,909$300M0.01%+97,36813F-HRTimelineGroup
BlackRock, Inc.in group BlackRock, Inc.8,827,085$159M<0.01%-1,75113F-HRTimelineGroup
PERCEPTIVE ADVISORS LLCin group PERCEPTIVE ADVISORS LLC8,334,882$150M2.32%+50,00013F-HRTimelineGroup
TCG Crossover Management, LLC6,243,812$112M2.7%013F-HRTimeline
VANGUARD GROUP INCgroup of 7 filers holding6,051,228$109M+245,801Timeline
Commodore Capital LPin group Commodore Capital LP5,650,000$101M6.04%013F-HRTimelineGroup
Jupiter Topco LLCin group Janus Henderson5,236,102$94M0.04%13F-HRTimelineGroup
Saturn V Capital Management LP4,624,101$83M11.91%+274,21613F-HRTimeline
MORGAN STANLEYin group MORGAN STANLEY3,130,808$56.2M<0.01%+955,26113F-HRTimelineGroup
Driehaus Capital Management LLC3,036,970$54.5M0.32%+49,82313F-HRTimeline
First Light Asset Management, LLC3,023,256$54.3M3.3%-167,38913F-HRTimeline
FRANKLIN RESOURCES INCin group Franklin Resources2,950,225$53M0.01%+688,65613F-HRTimelineGroup
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC2,858,239$51.3M0.01%+232,24813F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP2,603,337$46.8M<0.01%+240,17613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC2,335,315$41.9M<0.01%+124,38313F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,863,650$34.9M<0.01%+1,703,98713F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…1,900,000$34.1M0.05%-1,660,76413F-HRTimelineGroup
Siren, L.L.C.in group Siren, L.L.C.1,480,586$26.6M0.54%+250,58613F-HRTimelineGroup
EVENTIDE ASSET MANAGEMENT, LLC1,327,536$23.8M0.32%-186,42213F-HRTimeline
683 Capital Management, LLCin group 683 Capital Management, LLC1,279,512$23M2.11%-250,48813F-HRTimelineGroup
Alyeska Investment Group, L.P.in group Alyeska Investment Group, L.P.1,053,015$18.9M0.05%new13F-HRTimelineGroup
Almitas Capital LLC974,881$17.5M4.2%-1,147,71613F-HRTimeline
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP902,463$16.2M<0.01%-72913F-HRTimelineGroup
Jones Hill Capital LP894,058$16.1M3.41%-704,73613F-HRTimeline
Woodline Partners LP846,387$15.2M0.05%+58713F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP831,740$14.9M<0.01%+51,83213F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/821,841$14.8M<0.01%-508,84813F-HRTimelineGroup
Boxer Capital Management, LLC800,000$14.4M1.08%013F-HRTimeline
Aberdeen Group plcin group Aberdeen Group plc737,670$13.2M0.02%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co725,030$13M<0.01%+8,80513F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…721,002$12.9M0.02%-147,32313F-HRTimeline
GREAT POINT PARTNERS LLC700,000$12.6M2.96%-1,050,00013F-HRTimeline
Balyasny Asset Management L.P.in group Balyasny Asset Management684,974$12.3M0.02%-422,29713F-HRTimelineGroup
Qube Research & Technologies Ltd681,389$12.2M0.01%-20,84713F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP593,435$10.7M0.01%+431,49013F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\557,937$10M<0.01%-709,84813F-HRTimelineGroup
Rock Springs Capital Management LP499,764$8.98M0.44%013F-HRTimeline
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC494,378$8.88M0.42%-506,22613F-HRTimelineGroup
Nantahala Capital Management, LLC486,684$8.74M0.53%-49,00013F-HR/ATimeline
FEDERATED HERMES, INC.in group FEDERATED HERMES, INC.462,205$8.3M0.01%+98,65913F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding445,288$8M-36,120Timeline
Nearwater Capital Markets, Ltd425,000$7.63M0.13%new13F-HRTimeline
Parkman Healthcare Partners LLC398,782$7.16M0.74%-222,67613F-HRTimeline
HighVista Strategies LLC386,080$6.93M1.58%+33,99513F-HRTimeline
STEMPOINT CAPITAL LP384,304$6.9M1.19%-285,38113F-HRTimeline
Logos Global Management LP350,000$6.29M0.27%-350,00013F-HRTimeline
Trexquant Investment LP349,439$6.28M0.04%new13F-HRTimeline
Nuveen, LLCin group TIAA330,521$5.94M<0.01%+65,62413F-HRTimelineGroup
Ensign Peak Advisors, Inc305,441$5.49M0.01%new13F-HRTimeline
iA Global Asset Management Inc.303,786$5.46M0.06%-1,00013F-HRTimeline
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC299,565$5.38M<0.01%new13F-HRTimelineGroup
Tetragon Partners GP Ltdin group Tetragon Partners GP Ltd297,926$5.35M0.87%-19,95113F-HRTimelineGroup
JUPITER ASSET MANAGEMENT LTDin group JUPITER ASSET MANAGEMENT LTD274,944$4.94M0.02%-317,71013F-HRTimelineGroup
Bank of New York Mellon Corpin group Bank of New York Mellon Corp274,435$4.93M<0.01%+23,33113F-HRTimelineGroup
FIRST TRUST ADVISORS LPin group FIRST TRUST ADVISORS LP254,587$4.57M<0.01%new13F-HRTimelineGroup
SummitTX Capital, L.P.227,690$4.09M0.11%+68013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…212,842$3.82M<0.01%-28,71013F-HRTimelineGroup
Cormorant Asset Management, LP200,000$3.59M0.18%-150,00013F-HRTimeline
Aldebaran Capital, LLC195,892$3.52M2.64%-2,00013F-HRTimeline
Walleye Capital LLCin group Walleye Capital LLC186,588$3.35M0.02%+124,87713F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC183,400$3.29M0.06%new13F-HRTimelineGroup
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC178,686$3.21M<0.01%-232,84613F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.174,285$3.13M<0.01%+100,05513F-HRTimelineGroup
ACUTA CAPITAL PARTNERS, LLC168,115$3.02M2.1%+17,04813F-HRTimeline
NORGES BANK159,900$2.87M<0.01%new13F-HRTimeline
Alpha Wave Global, LP155,422$2.79M0.04%+13,08613F-HRTimeline
PRICE T ROWE ASSOCIATES INC /MD/145,133$2.61M<0.01%+23,69413F-HRTimeline
Swiss National Bank144,200$2.59M<0.01%+13,90013F-HRTimeline
PFM Health Sciences, LP143,700$2.58M0.22%-1,57513F-HRTimeline
Invesco Ltd.in group Invesco Ltd.139,942$2.51M<0.01%-31,67813F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN128,164$2.3M<0.01%+53,08113F-HRTimelineGroup
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC125,484$2.25M<0.01%new13F-HRTimelineGroup
Lighthouse Investment Partners, LLCin group Lighthouse Investment Partner…122,909$2.21M0.07%new13F-HRTimelineGroup
Ikarian Capital, LLC117,500$2.11M0.35%new13F-HRTimeline
RHUMBLINE ADVISERS112,920$2.03M<0.01%+4,45313F-HRTimeline
ALPS ADVISORS INC112,447$2.02M0.01%+22,46413F-HRTimeline
Elmind Capital, LP112,000$2.01M0.51%013F-HRTimeline
Campbell & CO Investment Adviser LLC100,963$1.81M0.1%+46,54113F-HRTimeline
Affinity Asset Advisors, LLC98,999$1.78M0.09%new13F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…87,574$1.57M<0.01%+28,22813F-HRTimelineGroup
Quantinno Capital Management LP80,850$1.45M<0.01%new13F-HRTimeline
ALLIANCEBERNSTEIN L.P.104,400$1.45M<0.01%+23,60013F-HRTimeline
CALIFORNIA STATE TEACHERS RETIREMENT SY…79,872$1.43M<0.01%+14,87013F-HR/ATimeline
1492 Capital Management LLC79,751$1.43M0.42%new13F-HRTimeline
CITIGROUP INCin group CITIGROUP INC68,684$1.23M<0.01%+36,90213F-HRTimelineGroup
Schonfeld Strategic Advisors LLC66,804$1.2M0.01%-10,99013F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD61,278$1.1M<0.01%-10,78313F-HRTimeline
Corient Private Wealth LPin group Corient Private Wealth LP59,322$1.07M<0.01%new13F-HR/ATimelineGroup
Moody Aldrich Partners LLC57,802$1.04M0.19%new13F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc56,477$1.01M<0.01%+70413F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC56,258$1.01M<0.01%-915,59613F-HRTimelineGroup
MetLife Investment Management, LLCin group MetLife Investment Management…55,700$1M<0.01%+4,11313F-HRTimelineGroup
SG Americas Securities, LLC55,321$994K<0.01%new13F-HRTimeline
Hudson Bay Capital Management LPin group Hudson Bay Capital Management…50,000$898K<0.01%new13F-HRTimelineGroup
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding47,324$850K-957Timeline
FOX RUN MANAGEMENT, L.L.C.44,817$805K0.13%new13F-HRTimeline
Aquatic Capital Management LLC39,425$708K0.02%new13F-HRTimeline
GSA CAPITAL PARTNERS LLP39,241$705K0.04%new13F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …37,828$679K<0.01%-95313F-HRTimelineGroup
BOOTHBAY FUND MANAGEMENT, LLC36,060$648K0.01%new13F-HRTimeline
JENNISON ASSOCIATES LLC35,841$644K<0.01%new13F-HRTimeline
TUDOR INVESTMENT CORP ET AL35,410$636K<0.01%+4,07613F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND34,300$616K<0.01%+12,40013F-HRTimeline
OPTIMIZE FINANCIAL INC.31,890$573K0.21%-11113F-HRTimeline
Sound Capital Solutions LLC31,890$573K0.13%13F-HRTimeline
Jain Global LLC28,770$517K0.01%new13F-HRTimeline
Numerai GP LLC28,665$515K0.04%-19,88813F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD27,600$496K<0.01%new13F-HRTimeline
Police & Firemen's Retirement System of…27,123$487K<0.01%+3,37113F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC26,891$483K<0.01%new13F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd25,864$465K0.01%new13F-HRTimelineGroup
GUGGENHEIM CAPITAL LLCin group GUGGENHEIM CAPITAL LLC25,387$456K<0.01%-12613F-HRTimelineGroup
Maven Securities LTDin group Maven Securities LTD25,000$449K0.03%-25,00013F-HRTimelineGroup
HRT FINANCIAL LP23,870$428K<0.01%new13F-HRTimeline
State of New Jersey Common Pension Fund…in group State of New Jersey Common Pe…23,232$417K<0.01%+71313F-HRTimelineGroup
MARTINGALE ASSET MANAGEMENT L P22,573$405K0.01%new13F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…22,426$403K0.09%+1,61113F-HRTimelineGroup
PARSONS CAPITAL MANAGEMENT INC/RI21,645$389K0.02%013F-HRTimeline
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC20,819$374K<0.01%-8,27013F-HRTimelineGroup
PROFUND ADVISORS LLC20,710$372K0.01%+3,55813F-HRTimeline
BROWN ADVISORY INCin group BROWN ADVISORY INC19,930$358K<0.01%013F-HRTimelineGroup
ARIZONA STATE RETIREMENT SYSTEM19,825$356K<0.01%+1,72613F-HRTimeline
INTECH INVESTMENT MANAGEMENT LLC19,775$355K<0.01%-5,14613F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO19,750$355K<0.01%-65,52913F-HRTimelineGroup
Premier Path Wealth Partners, LLC18,265$328K0.04%-2,00013F-HRTimeline
VOYA INVESTMENT MANAGEMENT LLCin group VOYA INVESTMENT MANAGEMENT LLC17,847$321K<0.01%+2,62013F-HRTimelineGroup
China Universal Asset Management Co., L…17,695$318K0.02%-1,79313F-HRTimeline
KLP KAPITALFORVALTNING AS17,400$313K<0.01%013F-HRTimeline
Zurcher Kantonalbank (Zurich Cantonalba…16,956$305K<0.01%-23,83413F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS16,577$298K<0.01%-4,56313F-HRTimelineGroup
Creative Planningin group Creative Planning15,881$285K<0.01%-2,00213F-HRTimelineGroup
ProShare Advisors LLC15,685$282K<0.01%-2,46913F-HRTimeline
PRUDENTIAL FINANCIAL INCin group PRUDENTIAL FINANCIAL INC15,110$271K<0.01%+99013F-HRTimelineGroup
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC14,554$269K<0.01%+3,14013F-HRTimelineGroup
Rafferty Asset Management, LLC14,758$265K<0.01%new13F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA14,649$263K<0.01%+2,26613F-HRTimelineGroup
Seven Fleet Capital Management LP14,540$261K0.04%-2,13113F-HRTimeline
STRS OHIO14,000$251K<0.01%+10,60013F-HRTimeline
GLENMEDE TRUST CO NAin group GLENMEDE TRUST CO NA13,685$246K<0.01%new13F-HRTimelineGroup
Amundiin group Amundi12,895$232K<0.01%013F-HRTimelineGroup
GREAT LAKES ADVISORS, LLC12,807$230K<0.01%+2,42713F-HRTimeline
Graham Capital Management, L.P.12,364$222K0.01%new13F-HRTimeline
Magnetar Financial LLCin group Magnetar Financial LLC11,722$211K<0.01%new13F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…11,611$209K<0.01%new13F-HRTimelineGroup
PSP Research LLC10,838$195K0.1%013F-HRTimeline
Pictet Asset Management Holding SAin group Pictet Asset Management Holdi…10,768$193K<0.01%013F-HRTimelineGroup
VICTORY CAPITAL MANAGEMENT INC10,707$192K<0.01%+6313F-HRTimeline
SUSQUEHANNA INTERNATIONAL GROUP, LLPin group SUSQUEHANNA INTERNATIONAL GRO…10,339$186K<0.01%-29,46313F-HRTimelineGroup
Harvest Investment Services, LLC10,214$183K0.03%new13F-HRTimeline
Valeo Financial Advisors, LLC10,045$180K<0.01%+4513F-HRTimeline
Integrated Wealth Concepts LLC8,722$157K<0.01%new13F-HRTimeline
Ameritas Investment Partners, Inc.group of 2 filers holding8,346$150K+1,140Timeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…7,934$142K<0.01%+2113F-HRTimelineGroup
Fulcrum Asset Management LLP4,400$82.3K0.01%new13F-HRTimeline
US BANCORP \DE\in group US BANCORP \DE\3,639$65.4K<0.01%+1,57613F-HRTimelineGroup
GF FUND MANAGEMENT CO. LTD.2,326$41.8K<0.01%-12913F-HRTimeline
Arax Advisory Partners2,235$40.1K<0.01%+74113F-HRTimeline
State of Wyoming2,223$39.9K<0.01%+34013F-HRTimeline
KBC Group NVin group KBC Group NV1,863$33K<0.01%013F-HRTimelineGroup
LORING WOLCOTT & COOLIDGE FIDUCIARY ADV…1,803$32.4K<0.01%013F-HRTimeline
GROUP ONE TRADING LLC1,624$29.2K<0.01%new13F-HRTimeline
BNP PARIBAS ASSET MANAGEMENT Holding S.…in group BNP PARIBAS ASSET MANAGEMENT …1,351$24.3K<0.01%-6713F-HRTimelineGroup
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…1,274$22.9K<0.01%013F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC1,163$20.9K<0.01%+24113F-HRTimeline
Steward Partners Investment Advisory, L…1,000$18K<0.01%013F-HRTimeline
FIFTH THIRD BANCORPin group FIFTH THIRD BANK, NATIONAL AS…972$17.5K<0.01%+21713F-HRTimelineGroup
Kemnay Advisory Services Inc.928$16.7K<0.01%new13F-HRTimeline
Westfuller Advisors, LLC819$14.7K0.01%013F-HRTimeline
EASTERN BANK721$12.9K<0.01%+52113F-HRTimeline
Strive Financial Group ,LLC650$11.7K0.01%new13F-HR/ATimeline
JONES FINANCIAL COMPANIES LLLPin group JONES FINANCIAL COMPANIES LLLP597$10.6K<0.01%+32713F-HRTimelineGroup
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.483$8.67K<0.01%-4513F-HRTimelineGroup
GAMMA Investing LLC433$7.78K<0.01%+1613F-HRTimeline
Silver Grove Financial Group, Inc.424$7.62K<0.01%new13F-HRTimeline
MassMutual Private Wealth & Trust, FSB420$7.54K<0.01%+13813F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…406$7.29K<0.01%+12313F-HRTimelineGroup
Aster Capital Management (DIFC) Ltd393$7.06K<0.01%new13F-HR/ATimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…350$6.29K<0.01%+32413F-HRTimelineGroup
LOS ANGELES CAPITAL MANAGEMENT LLC325$5.84K<0.01%013F-HRTimeline
Sterling Capital Management LLC323$5.8K<0.01%-81413F-HRTimeline
J.Safra Asset Management Corp315$5.66K<0.01%-6213F-HRTimeline
Physician Wealth Advisors, Inc.274$4.92K<0.01%013F-HRTimeline
Farther Finance Advisors, LLC259$4.65K<0.01%+23713F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.220$3.95K<0.01%new13F-HRTimelineGroup
PICTON MAHONEY ASSET MANAGEMENT189$3.39K<0.01%new13F-HRTimeline
Caption Management, LLC174$3.12K<0.01%new13F-HRTimeline
Larson Financial Group LLC142$2.55K<0.01%-5913F-HRTimeline
Quarry LP139$2.5K<0.01%new13F-HRTimeline
SIGNATUREFD, LLC93$1.67K<0.01%-16113F-HRTimeline
HARBOUR INVESTMENTS, INC.90$1.62K<0.01%013F-HRTimeline
Catherine Avery Investment Management L…87$1.56K<0.01%new13F-HRTimeline
Covestor Ltd33$1K<0.01%+2413F-HRTimeline
ROTHSCHILD INVESTMENT LLC55$988<0.01%013F-HRTimeline
SALEM INVESTMENT COUNSELORS INC55$988<0.01%013F-HRTimeline
Caitong International Asset Management …28$503<0.01%-813F-HRTimeline
Allworth Financial LP26$467<0.01%-1413F-HRTimeline
Essential Partners LLC15$269<0.01%013F-HRTimeline
Global Retirement Partners, LLC14$251<0.01%13F-HRTimeline
SBI Securities Co., Ltd.1$18<0.01%013F-HRTimeline