RA CAPITAL MANAGEMENT, L.P. in group RA CAPITAL MANAGEMENT, L.P. More: the full row for RA CAPITAL MANAGEMENT, L.P. 13,011,849 $26.9M 0.23% 0 13F-HR Timeline Group venBio Partners LLC More: the full row for venBio Partners LLC 12,884,638 $26.7M 5.14% 0 13F-HR Timeline BlackRock, Inc. in group BlackRock, Inc. More: the full row for BlackRock, Inc. 7,399,530 $15.3M <0.01% +6,951,731 13F-HR Timeline Group Redmile Group, LLC in group Redmile Group, LLC More: the full row for Redmile Group, LLC 7,392,504 $15.3M 1.03% -571,684 13F-HR Timeline Group Blackstone Inc. in group Blackstone Inc. More: the full row for Blackstone Inc. 6,593,543 $13.6M 0.04% +766,999 13F-HR Timeline Group The filing omitted confidential holdings, a later amendment may add them. VANGUARD GROUP INC group of 4 filers holding More: the full row for VANGUARD GROUP INC 6,509,194 $13.5M +1,927,131 Timeline Driehaus Capital Management LLC More: the full row for Driehaus Capital Management LLC 6,025,240 $12.5M 0.07% +290,620 13F-HR Timeline SILVERARC CAPITAL MANAGEMENT, LLC in group SILVERARC CAPITAL MANAGEMENT,… More: the full row for SILVERARC CAPITAL MANAGEMENT, LLC 5,744,757 $11.9M 1.32% new 13F-HR Timeline Group TCG Crossover Management, LLC More: the full row for TCG Crossover Management, LLC 5,655,487 $11.7M 0.28% -7,356,362 13F-HR Timeline Vivo Capital, LLC More: the full row for Vivo Capital, LLC 3,184,713 $6.59M 0.6% 0 13F-HR Timeline MARSHALL WACE, LLP in group MARSHALL WACE, LLP More: the full row for MARSHALL WACE, LLP 3,071,496 $6.36M 0.01% -685,720 13F-HR Timeline Group 5AM Venture Management, LLC More: the full row for 5AM Venture Management, LLC 3,057,325 $6.33M 2.2% 0 13F-HR Timeline Almitas Capital LLC More: the full row for Almitas Capital LLC 2,938,431 $6.08M 1.46% -235,403 13F-HR Timeline ORBIMED ADVISORS LLC in group ORBIMED ADVISORS LLC More: the full row for ORBIMED ADVISORS LLC 2,866,256 $5.93M 0.11% 0 13F-HR Timeline Group GEODE CAPITAL MANAGEMENT, LLC in group GEODE CAPITAL MANAGEMENT, LLC More: the full row for GEODE CAPITAL MANAGEMENT, LLC 2,787,809 $5.77M <0.01% +2,294,372 13F-HR Timeline Group TWO SIGMA INVESTMENTS, LP in group TWO SIGMA INVESTMENTS, LP More: the full row for TWO SIGMA INVESTMENTS, LP 2,178,176 $4.51M <0.01% +590,343 13F-HR Timeline Group MILLENNIUM MANAGEMENT LLC in group MILLENNIUM MANAGEMENT LLC More: the full row for MILLENNIUM MANAGEMENT LLC 1,543,594 $3.2M <0.01% -444,965 13F-HR Timeline Group STATE STREET CORP in group STATE STREET CORP More: the full row for STATE STREET CORP 1,498,905 $3.1M <0.01% +1,323,077 13F-HR Timeline Group ACADIAN ASSET MANAGEMENT LLC in group ACADIAN ASSET MANAGEMENT LLC More: the full row for ACADIAN ASSET MANAGEMENT LLC 1,313,490 $2.71M <0.01% +212,465 13F-HR Timeline Group JPMORGAN CHASE & CO in group JPMORGAN CHASE & CO More: the full row for JPMORGAN CHASE & CO 1,044,728 $2.3M <0.01% +1,044,629 13F-HR Timeline Group NORTHERN TRUST CORP in group NORTHERN TRUST CORP More: the full row for NORTHERN TRUST CORP 935,669 $1.94M <0.01% +798,705 13F-HR Timeline Group Ensign Peak Advisors, Inc More: the full row for Ensign Peak Advisors, Inc 810,297 $1.68M <0.01% -140,253 13F-HR Timeline Nantahala Capital Management, LLC More: the full row for Nantahala Capital Management, LLC 750,000 $1.55M 0.09% new 13F-HR/A Timeline GOLDMAN SACHS GROUP INC in group GOLDMAN SACHS GROUP INC More: the full row for GOLDMAN SACHS GROUP INC 742,331 $1.54M <0.01% +603,738 13F-HR Timeline Group RENAISSANCE TECHNOLOGIES LLC More: the full row for RENAISSANCE TECHNOLOGIES LLC 603,797 $1.25M <0.01% -128,802 13F-HR Timeline ADAR1 Capital Management, LLC in group ADAR1 Capital Management, LLC More: the full row for ADAR1 Capital Management, LLC 533,660 $1.1M 0.05% new 13F-HR Timeline Group UBS Group AG in group UBS Group AG More: the full row for UBS Group AG 462,943 $958K <0.01% -451,811 13F-HR Timeline Group GSA CAPITAL PARTNERS LLP More: the full row for GSA CAPITAL PARTNERS LLP 413,545 $856K 0.05% +344,558 13F-HR Timeline CHARLES SCHWAB INVESTMENT MANAGEMENT INC in group Charles Schwab Trust Co More: the full row for CHARLES SCHWAB INVESTMENT MANAGEMENT INC 241,113 $499K <0.01% new 13F-HR Timeline Group Bank of New York Mellon Corp in group Bank of New York Mellon Corp More: the full row for Bank of New York Mellon Corp 238,447 $494K <0.01% new 13F-HR Timeline Group BRIDGEWAY CAPITAL MANAGEMENT, LLC More: the full row for BRIDGEWAY CAPITAL MANAGEMENT, LLC 226,072 $468K 0.01% +150,000 13F-HR Timeline Atom Investors LP More: the full row for Atom Investors LP 219,382 $454K 0.04% new 13F-HR Timeline IEQ CAPITAL, LLC More: the full row for IEQ CAPITAL, LLC 175,382 $363K <0.01% +83,149 13F-HR Timeline MORGAN STANLEY in group MORGAN STANLEY More: the full row for MORGAN STANLEY 157,873 $327K <0.01% +59,038 13F-HR Timeline Group Invesco Ltd. in group Invesco Ltd. More: the full row for Invesco Ltd. 149,923 $310K <0.01% +138,943 13F-HR Timeline Group Nuveen, LLC in group TIAA More: the full row for Nuveen, LLC 143,645 $297K <0.01% new 13F-HR Timeline Group SUSQUEHANNA INTERNATIONAL GROUP, LLP in group SUSQUEHANNA INTERNATIONAL GRO… More: the full row for SUSQUEHANNA INTERNATIONAL GROUP, LLP 123,157 $255K <0.01% -1,205,750 13F-HR Timeline Group RHUMBLINE ADVISERS More: the full row for RHUMBLINE ADVISERS 107,902 $223K <0.01% new 13F-HR Timeline DEUTSCHE BANK AG\ in group DEUTSCHE BANK AG\ More: the full row for DEUTSCHE BANK AG\ 107,428 $222K <0.01% new 13F-HR Timeline Group WELLS FARGO & COMPANY/MN in group WELLS FARGO & COMPANY/MN More: the full row for WELLS FARGO & COMPANY/MN 99,926 $207K <0.01% new 13F-HR Timeline Group PRICE T ROWE ASSOCIATES INC /MD/ More: the full row for PRICE T ROWE ASSOCIATES INC /MD/ 89,779 $186K <0.01% new 13F-HR Timeline Verdad Advisers, LP More: the full row for Verdad Advisers, LP 82,200 $170K 0.16% new 13F-HR Timeline BANK OF AMERICA CORP /DE/ in group BANK OF AMERICA CORP /DE/ More: the full row for BANK OF AMERICA CORP /DE/ 76,032 $157K <0.01% -501,751 13F-HR Timeline Group Graham Capital Management, L.P. More: the full row for Graham Capital Management, L.P. 74,821 $155K <0.01% +37,082 13F-HR Timeline XTX Topco Ltd in group XTX Topco Ltd More: the full row for XTX Topco Ltd 69,657 $144K <0.01% +25,516 13F-HR Timeline Group MetLife Investment Management, LLC in group MetLife Investment Management… More: the full row for MetLife Investment Management, LLC 64,959 $134K <0.01% new 13F-HR Timeline Group CITIGROUP INC in group CITIGROUP INC More: the full row for CITIGROUP INC 50,635 $105K <0.01% +50,618 13F-HR Timeline Group MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. in group Mirae Asset Global Investment… More: the full row for MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. 49,682 $103K <0.01% new 13F-HR Timeline Group Squarepoint Ops LLC in group Squarepoint Ops LLC More: the full row for Squarepoint Ops LLC 46,869 $97K <0.01% new 13F-HR Timeline Group AXQ CAPITAL, LP More: the full row for AXQ CAPITAL, LP 40,553 $83.9K 0.01% new 13F-HR Timeline WEALTH ENHANCEMENT ADVISORY SERVICES, L… More: the full row for WEALTH ENHANCEMENT ADVISORY SERVICES, LLC 38,011 $80.8K <0.01% +14 13F-HR Timeline NEW YORK STATE COMMON RETIREMENT FUND More: the full row for NEW YORK STATE COMMON RETIREMENT FUND 33,100 $68.5K <0.01% new 13F-HR Timeline BARCLAYS PLC in group BARCLAYS PLC More: the full row for BARCLAYS PLC 32,884 $68.1K <0.01% +22,369 13F-HR Timeline Group Police & Firemen's Retirement System of… More: the full row for Police & Firemen's Retirement System of New Jersey 31,822 $65.9K <0.01% new 13F-HR Timeline MANUFACTURERS LIFE INSURANCE COMPANY, T… in group MANUFACTURERS LIFE INSURANCE … More: the full row for MANUFACTURERS LIFE INSURANCE COMPANY, THE 30,997 $64.2K <0.01% new 13F-HR Timeline Group ALLIANCEBERNSTEIN L.P. More: the full row for ALLIANCEBERNSTEIN L.P. 26,340 $52.8K <0.01% new 13F-HR Timeline JACOBS LEVY EQUITY MANAGEMENT, INC More: the full row for JACOBS LEVY EQUITY MANAGEMENT, INC 25,507 $52.8K <0.01% new 13F-HR Timeline HC Advisors, LLC More: the full row for HC Advisors, LLC 22,900 $47.4K 0.03% 0 13F-HR Timeline Callan Family Office, LLC in group Callan Family Office, LLC More: the full row for Callan Family Office, LLC 22,419 $46.4K <0.01% 0 13F-HR Timeline Group VOYA INVESTMENT MANAGEMENT LLC in group VOYA INVESTMENT MANAGEMENT LLC More: the full row for VOYA INVESTMENT MANAGEMENT LLC 21,461 $44.4K <0.01% new 13F-HR Timeline Group AMERICAN CENTURY COMPANIES INC in group AMERICAN CENTURY COMPANIES INC More: the full row for AMERICAN CENTURY COMPANIES INC 21,434 $44.4K <0.01% new 13F-HR Timeline Group CAXTON CORP More: the full row for CAXTON CORP 20,946 $43.4K 2.34% 0 13F-HR Timeline The filing omitted confidential holdings, a later amendment may add them. INTECH INVESTMENT MANAGEMENT LLC More: the full row for INTECH INVESTMENT MANAGEMENT LLC 19,424 $40.2K <0.01% new 13F-HR Timeline COMMONWEALTH EQUITY SERVICES, LLC More: the full row for COMMONWEALTH EQUITY SERVICES, LLC 18,451 $38.2K <0.01% new 13F-HR Timeline Bronte Capital Management Pty Ltd. More: the full row for Bronte Capital Management Pty Ltd. 18,095 $37.5K <0.01% new 13F-HR Timeline JSF Financial, LLC More: the full row for JSF Financial, LLC 17,500 $36.2K 0.01% 0 13F-HR Timeline BNP PARIBAS FINANCIAL MARKETS in group BNP PARIBAS FINANCIAL MARKETS More: the full row for BNP PARIBAS FINANCIAL MARKETS 16,616 $34.4K <0.01% +16,150 13F-HR Timeline Group PRUDENTIAL FINANCIAL INC in group PRUDENTIAL FINANCIAL INC More: the full row for PRUDENTIAL FINANCIAL INC 16,385 $33.9K <0.01% new 13F-HR Timeline Group MONETA GROUP INVESTMENT ADVISORS LLC More: the full row for MONETA GROUP INVESTMENT ADVISORS LLC 15,196 $31.5K <0.01% 0 13F-HR Timeline ProShare Advisors LLC More: the full row for ProShare Advisors LLC 14,125 $29.2K <0.01% new 13F-HR Timeline FMR LLC in group FMR LLC More: the full row for FMR LLC 13,242 $27.4K <0.01% +256 13F-HR Timeline Group Lido Advisors, LLC in group Lido Advisors, LLC More: the full row for Lido Advisors, LLC 13,220 $27.4K <0.01% 0 13F-HR Timeline Group Abel Hall, LLC More: the full row for Abel Hall, LLC 12,731 $26.4K <0.01% +133 13F-HR Timeline Beacon Pointe Advisors, LLC More: the full row for Beacon Pointe Advisors, LLC 12,500 $25.9K <0.01% 0 13F-HR Timeline China Universal Asset Management Co., L… More: the full row for China Universal Asset Management Co., Ltd. 12,500 $25.9K <0.01% new 13F-HR Timeline Legal & General Group Plc in group Legal & General Group Plc More: the full row for Legal & General Group Plc 10,483 $21.7K <0.01% new 13F-HR Timeline Group HSBC HOLDINGS PLC in group HSBC HOLDINGS PLC More: the full row for HSBC HOLDINGS PLC 10,105 $21.6K <0.01% 0 13F-HR Timeline Group Tower Research Capital LLC (TRC) in group Tower Research Capital LLC (T… More: the full row for Tower Research Capital LLC (TRC) 10,397 $21.5K <0.01% new 13F-HR Timeline Group XPONANCE LLC More: the full row for XPONANCE LLC 10,179 $21.1K <0.01% new 13F-HR Timeline Ameritas Investment Partners, Inc. in group Ameritas Investment Partners,… More: the full row for Ameritas Investment Partners, Inc. 9,792 $20.3K <0.01% new 13F-HR Timeline Group Russell Investments Group, Ltd. in group Russell Investments Group, Lt… More: the full row for Russell Investments Group, Ltd. 8,628 $17.9K <0.01% new 13F-HR Timeline Group ROYAL BANK OF CANADA in group ROYAL BANK OF CANADA More: the full row for ROYAL BANK OF CANADA 6,156 $13K <0.01% +4,277 13F-HR Timeline Group CALIFORNIA STATE TEACHERS RETIREMENT SY… More: the full row for CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM 1,486 $3.08K <0.01% new 13F-HR/A Timeline NISA INVESTMENT ADVISORS, LLC More: the full row for NISA INVESTMENT ADVISORS, LLC 1,106 $2.29K <0.01% 0 13F-HR Timeline Bradley & Co. Private Wealth Management… More: the full row for Bradley & Co. Private Wealth Management, LLC 1,000 $2.07K <0.01% 0 13F-HR Timeline EverSource Wealth Advisors, LLC in group EverSource Wealth Advisors, L… More: the full row for EverSource Wealth Advisors, LLC 905 $1.87K <0.01% 0 13F-HR Timeline Group Sterling Capital Management LLC More: the full row for Sterling Capital Management LLC 379 $785 <0.01% new 13F-HR Timeline Integrated Wealth Concepts LLC More: the full row for Integrated Wealth Concepts LLC 130 $270 <0.01% new 13F-HR Timeline PNC Financial Services Group, Inc. in group PNC Financial Services Group,… More: the full row for PNC Financial Services Group, Inc. 100 $207 <0.01% 0 13F-HR Timeline Group Caitong International Asset Management … More: the full row for Caitong International Asset Management Co., Ltd 36 $75 <0.01% +30 13F-HR Timeline SBI Securities Co., Ltd. More: the full row for SBI Securities Co., Ltd. 14 $29 <0.01% 0 13F-HR Timeline