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Disclosery

PRLD PRELUDE THERAPEUTICS INC

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CMN (common), issuer CIK 1678660

72 managers (75 13F filers) reported a position in PRLD shares at 2026-06-30, 49,599,407 shares in all. 34 filers opened a position and 13 filers sold out during the quarter.

Managers
72
13F filers
75
New
34
Added
25
Reduced
8
Sold out
13
Shares held by filers
49,599,407

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC13,724,571$73.2M1.39%+2,815,31513F-HRTimelineGroup
BAKER BROS. ADVISORS LPin group BAKER BROS. ADVISORS LP10,123,824$54M0.27%013F-HRTimelineGroup
RA CAPITAL MANAGEMENT, L.P.in group RA CAPITAL MANAGEMENT, L.P.6,475,882$34.5M0.3%new13F-HRTimelineGroup
Soleus Capital Management, L.P.3,378,378$18M0.62%new13F-HRTimeline
VANGUARD GROUP INCgroup of 4 filers holding2,504,461$13.3M+1,112,039Timeline
Kynam Capital Management, LP2,415,087$12.9M0.71%+822,53613F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.1,797,501$9.58M<0.01%+1,475,61513F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.1,019,832$5.44M0.78%+461,49313F-HRTimelineGroup
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP993,369$5.29M<0.01%+69,74313F-HRTimelineGroup
ADAR1 Capital Management, LLCin group ADAR1 Capital Management, LLC900,900$4.8M0.23%+748,07513F-HRTimelineGroup
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC844,993$4.5M<0.01%+462,25613F-HRTimelineGroup
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC841,862$4.49M<0.01%+539,40413F-HRTimelineGroup
ADAGE CAPITAL PARTNERS GP, L.L.C.in group ADAGE CAPITAL PARTNERS GP, L.…766,095$4.08M0.01%new13F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC611,359$3.25M<0.01%+99,84013F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY503,860$2.69M<0.01%+181,69913F-HRTimelineGroup
STATE STREET CORPin group STATE STREET CORP428,787$2.29M<0.01%+290,55613F-HR/ATimelineGroup
UBS Group AGin group UBS Group AG318,797$1.7M<0.01%+254,29213F-HRTimelineGroup
RENAISSANCE TECHNOLOGIES LLC281,200$1.5M<0.01%+6,00013F-HRTimeline
NORTHERN TRUST CORPin group NORTHERN TRUST CORP240,599$1.28M<0.01%+190,47913F-HRTimelineGroup
MARSHALL WACE, LLPin group MARSHALL WACE, LLP190,692$1.02M<0.01%-168,21413F-HRTimelineGroup
Connor, Clark & Lunn Investment Managem…125,606$669K<0.01%+16,52113F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC120,834$644K<0.01%-115,63513F-HRTimelineGroup
Hillsdale Investment Management Inc.81,400$434K0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp68,187$363K<0.01%new13F-HRTimelineGroup
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co67,622$360K<0.01%new13F-HRTimelineGroup
BRIDGEWAY CAPITAL MANAGEMENT, LLC64,500$344K0.01%+11,00013F-HRTimeline
Squarepoint Ops LLCin group Squarepoint Ops LLC59,540$317K<0.01%new13F-HRTimelineGroup
PANAGORA ASSET MANAGEMENT INC47,574$254K<0.01%new13F-HRTimeline
Mariner, LLCin group Mariner, LLC45,261$241K<0.01%new13F-HRTimelineGroup
Nuveen, LLCin group TIAA37,023$197K<0.01%new13F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP35,210$187K<0.01%013F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.34,742$185K<0.01%new13F-HRTimelineGroup
Cerity Partners LLCin group Cerity Partners LLC32,875$175K<0.01%013F-HRTimelineGroup
State of Wyoming32,862$175K0.02%new13F-HRTimeline
Graham Capital Management, L.P.29,770$159K<0.01%+18,42713F-HRTimeline
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\27,824$148K<0.01%new13F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN25,325$135K<0.01%new13F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/23,875$127K<0.01%-32,65013F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/22,758$122K<0.01%new13F-HRTimeline
CITADEL ADVISORS LLCin group CITADEL ADVISORS LLC22,554$120K<0.01%-101,82413F-HR/ATimelineGroup
RHUMBLINE ADVISERS22,074$118K<0.01%new13F-HRTimeline
ExodusPoint Capital Management, LP15,475$82.5K<0.01%new13F-HRTimeline
BARCLAYS PLCin group BARCLAYS PLC14,529$77.4K<0.01%+5,92913F-HRTimelineGroup
NEW YORK STATE COMMON RETIREMENT FUND14,200$75.7K<0.01%new13F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC13,652$74.4K<0.01%013F-HRTimelineGroup
MANGROVE PARTNERS IM, LLC13,352$71.2K<0.01%new13F-HRTimeline
Qube Research & Technologies Ltd13,110$69.9K<0.01%-3,30713F-HRTimeline
CITIGROUP INCin group CITIGROUP INC13,033$69.5K<0.01%+13,02813F-HRTimelineGroup
MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd.in group Mirae Asset Global Investment…12,784$68.1K<0.01%new13F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP12,672$68K<0.01%new13F-HRTimeline
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO13,538$66.7K<0.01%+13,47613F-HRTimelineGroup
Spark Investment Management LLC10,600$56.5K0.11%new13F-HRTimeline
Police & Firemen's Retirement System of…10,492$55.9K<0.01%new13F-HRTimeline
ALLIANCEBERNSTEIN L.P.10,530$36K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC6,430$34.3K<0.01%new13F-HRTimeline
FMR LLCin group FMR LLC5,629$30K<0.01%-38013F-HRTimelineGroup
STRS OHIO5,500$29.3K<0.01%new13F-HRTimeline
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS4,104$21.9K<0.01%+4,00913F-HRTimelineGroup
GROUP ONE TRADING LLC3,907$20.8K<0.01%013F-HRTimeline
Legal & General Group Plcin group Legal & General Group Plc2,699$14.4K<0.01%new13F-HRTimelineGroup
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA2,658$14K<0.01%+32713F-HRTimelineGroup
Ameritas Investment Partners, Inc.in group Ameritas Investment Partners,…2,520$13.4K<0.01%new13F-HRTimelineGroup
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…2,377$12.7K<0.01%new13F-HRTimelineGroup
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…2,220$11.8K<0.01%new13F-HRTimelineGroup
NISA INVESTMENT ADVISORS, LLC1,634$8.71K<0.01%013F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…1,171$6.24K<0.01%013F-HRTimelineGroup
Quarry LP755$4.02K<0.01%new13F-HRTimeline
Fortitude Family Office, LLC230$1.23K<0.01%013F-HRTimeline
Sterling Capital Management LLC97$517<0.01%new13F-HRTimeline
SBI Securities Co., Ltd.22$117<0.01%-2,61913F-HRTimeline
Caitong International Asset Management …18$96<0.01%new13F-HRTimeline
Optiver Holding B.V.in group Optiver Holding B.V.4$21<0.01%-1613F-HRTimelineGroup