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Disclosery

UPB UPSTREAM BIO INC

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COMMON STOCK (common), issuer CIK 2022626

142 managers (149 13F filers) reported a position in UPB shares at 2026-06-30, 50,573,705 shares in all. 37 filers opened a position and 29 filers sold out during the quarter.

Managers
142
13F filers
149
New
37
Added
65
Reduced
28
Sold out
29
Shares held by filers
50,573,705

Shares held by filers adds up every 13F filer's report, so a share reported by a parent and by its subsidiary counts twice (H9). Managers counts each filer group once.

13D and 13G filers

No 13D or 13G on this security in the data. Structured 13D/G data starts 2024-12-18.

Insider trades

No Form 4 transaction on this security in the data.

13F holders, Q2 2026

Filers in the available 13F reports with a share position at 2026-06-30, filer groups collapsed to one row (method), largest first. Options and principal amounts are left out. A group row states no % of portfolio, since each member reports its own portfolio: the members' percents are listed under it. A value about 1,000 times or 1/1,000 of the price other filers imply is shown as filed but neither ranks the row nor enters a sum.

HolderSharesValue% of portfolioChangeSource
FMR LLCin group FMR LLC8,162,897$56.5M<0.01%+61,33413F-HRTimelineGroup
ORBIMED ADVISORS LLCin group ORBIMED ADVISORS LLC5,693,589$39.4M0.75%013F-HRTimelineGroup
NORGES BANK3,768,619$26.1M<0.01%new13F-HRTimeline
BlackRock, Inc.in group BlackRock, Inc.3,753,358$26M<0.01%+382,66913F-HRTimelineGroup
VANGUARD GROUP INCgroup of 6 filers holding2,868,896$19.9M+17,049Timeline
Decheng Capital LLC2,724,868$18.9M2.58%013F-HRTimeline
ENAVATE SCIENCES GP, LLC2,459,703$17M4.93%013F-HRTimeline
MILLENNIUM MANAGEMENT LLCin group MILLENNIUM MANAGEMENT LLC1,143,775$7.91M0.01%+206,45213F-HRTimelineGroup
D. E. Shaw & Co., Inc.in group D. E. Shaw & Co., Inc.1,036,044$7.17M<0.01%+215,56413F-HRTimelineGroup
JPMORGAN CHASE & COin group JPMORGAN CHASE & CO1,012,044$7.01M<0.01%+549,04313F-HRTimelineGroup
Qube Research & Technologies Ltd978,500$6.77M0.01%+359,17913F-HRTimeline
Parkman Healthcare Partners LLC935,247$6.47M0.66%+148,46413F-HRTimeline
GEODE CAPITAL MANAGEMENT, LLCin group GEODE CAPITAL MANAGEMENT, LLC931,261$6.45M<0.01%-19,35613F-HRTimelineGroup
SEB Asset Management AB878,473$6.08M0.02%013F-HRTimeline
Woodline Partners LP831,481$5.75M0.02%013F-HRTimeline
STATE STREET CORPin group STATE STREET CORP766,323$5.3M<0.01%+60,97313F-HRTimelineGroup
Y-Intercept (Hong Kong) Ltd693,555$4.8M0.09%-307,07613F-HRTimeline
Bain Capital Life Sciences Investors, L…in group Bain Capital Life Sciences In…600,949$4.16M0.25%-266,26213F-HRTimelineGroup
AQR CAPITAL MANAGEMENT LLCin group AQR CAPITAL MANAGEMENT LLC544,869$3.77M<0.01%+472,69813F-HRTimelineGroup
MORGAN STANLEYin group MORGAN STANLEY524,632$3.63M<0.01%-27,97713F-HRTimelineGroup
BNP PARIBAS FINANCIAL MARKETSin group BNP PARIBAS FINANCIAL MARKETS511,546$3.54M<0.01%+385,54613F-HRTimelineGroup
Walleye Capital LLCin group Walleye Capital LLC498,490$3.45M0.02%new13F-HRTimelineGroup
Trexquant Investment LP466,430$3.23M0.02%+289,77313F-HRTimeline
Point72 Asset Management, L.P.in group Point72 Asset Management, L.P.453,011$3.13M<0.01%+274,84313F-HRTimelineGroup
BANK OF AMERICA CORP /DE/in group BANK OF AMERICA CORP /DE/391,762$2.71M<0.01%+343,30213F-HRTimelineGroup
DIMENSIONAL FUND ADVISORS LPin group DIMENSIONAL FUND ADVISORS LP381,613$2.64M<0.01%+301,61113F-HRTimelineGroup
Altshuler Shaham Ltd380,061$2.63M0.03%013F-HRTimeline
ARROWSTREET CAPITAL, LIMITED PARTNERSHIPin group ARROWSTREET CAPITAL, LIMITED …357,756$2.48M<0.01%+172,66913F-HRTimelineGroup
SAMSARA BIOCAPITAL, LLC353,717$2.45M0.2%-382,33013F-HRTimeline
Propel Bio Management, LLC350,389$2.42M1.27%+8,61013F-HRTimeline
WELLINGTON MANAGEMENT GROUP LLPin group WELLINGTON MANAGEMENT GROUP L…342,353$2.37M<0.01%013F-HRTimelineGroup
NORTHERN TRUST CORPin group NORTHERN TRUST CORP297,346$2.06M<0.01%+36,35413F-HRTimelineGroup
Squarepoint Ops LLCin group Squarepoint Ops LLC290,904$2.01M<0.01%+246,27813F-HRTimelineGroup
Voleon Capital Management LP285,234$1.97M0.04%new13F-HRTimeline
CHARLES SCHWAB INVESTMENT MANAGEMENT INCin group Charles Schwab Trust Co262,456$1.82M<0.01%+4,72713F-HRTimelineGroup
JACOBS LEVY EQUITY MANAGEMENT, INC253,092$1.75M0.01%new13F-HRTimeline
GOLDMAN SACHS GROUP INCin group GOLDMAN SACHS GROUP INC246,917$1.71M<0.01%-69,67013F-HRTimelineGroup
XTX Topco Ltdin group XTX Topco Ltd242,346$1.68M0.02%+33,06913F-HRTimelineGroup
DEUTSCHE BANK AG\in group DEUTSCHE BANK AG\241,447$1.67M<0.01%+60,55813F-HRTimelineGroup
UBS Group AGgroup of 2 filers holding235,302$1.63M+3,460Timeline
Schonfeld Strategic Advisors LLC225,760$1.56M0.01%+64,41113F-HRTimeline
Jump Financial, LLCin group Jump Financial, LLC223,223$1.54M0.01%-96,17713F-HRTimelineGroup
SPHERA FUNDS MANAGEMENT LTD.in group SPHERA FUNDS MANAGEMENT LTD.219,700$1.52M0.22%-138,30013F-HRTimelineGroup
ACADIAN ASSET MANAGEMENT LLCin group ACADIAN ASSET MANAGEMENT LLC175,110$1.21M<0.01%new13F-HRTimelineGroup
HRT FINANCIAL LP170,590$1.18M<0.01%new13F-HRTimeline
Boxer Capital Management, LLC150,000$1.04M0.08%013F-HRTimeline
RENAISSANCE TECHNOLOGIES LLC131,300$909K<0.01%+69,20013F-HRTimeline
EntryPoint Capital, LLC129,446$896K0.22%+55,87813F-HRTimeline
ALGERT GLOBAL LLC118,630$821K0.01%new13F-HRTimeline
Bank of New York Mellon Corpin group Bank of New York Mellon Corp85,747$593K<0.01%+4,36413F-HRTimelineGroup
Nuveen, LLCin group TIAA84,770$587K<0.01%+9,23413F-HRTimelineGroup
AMERICAN CENTURY COMPANIES INCin group AMERICAN CENTURY COMPANIES INC78,194$541K<0.01%-9,43013F-HRTimelineGroup
Man Group plcin group Man Group plc73,823$511K<0.01%+52,66913F-HRTimelineGroup
GSA CAPITAL PARTNERS LLP69,348$480K0.03%+30,11613F-HRTimeline
ALLIANCEBERNSTEIN L.P.51,680$465K<0.01%+20,67013F-HRTimeline
Simplify Asset Management Inc.62,113$430K0.01%-15,68013F-HRTimeline
ALPS ADVISORS INC55,228$382K<0.01%+11,23613F-HRTimeline
Quantinno Capital Management LP54,838$379K<0.01%+5,44913F-HRTimeline
Virtus Investment Advisers, LLCin group Virtus Investment Advisers, L…53,638$371K0.09%+43,59213F-HRTimelineGroup
Invesco Ltd.in group Invesco Ltd.53,397$370K<0.01%+12,88713F-HRTimelineGroup
Brevan Howard Capital Management LPin group Brevan Howard Capital Managem…50,369$349K<0.01%new13F-HRTimelineGroup
Swiss National Bank48,100$333K<0.01%013F-HRTimeline
Russell Investments Group, Ltd.in group Russell Investments Group, Lt…47,543$329K<0.01%+43,89613F-HRTimelineGroup
Allspring Global Investments Holdings, …in group Allspring Global Investments …43,182$299K<0.01%new13F-HRTimelineGroup
RHUMBLINE ADVISERS42,384$293K<0.01%+1,18113F-HRTimeline
TWO SIGMA INVESTMENTS, LPin group TWO SIGMA INVESTMENTS, LP42,325$293K<0.01%new13F-HRTimelineGroup
ExodusPoint Capital Management, LP41,045$284K<0.01%-50,38613F-HRTimeline
CITIGROUP INCin group CITIGROUP INC40,339$279K<0.01%+35,28413F-HRTimelineGroup
CALIFORNIA STATE TEACHERS RETIREMENT SY…38,634$267K<0.01%-1,02713F-HR/ATimeline
Stonepine Capital Management, LLC33,432$231K0.18%-1,56813F-HR/ATimeline
Mariner, LLCin group Mariner, LLC33,141$229K<0.01%+5,82713F-HRTimelineGroup
WELLS FARGO & COMPANY/MNin group WELLS FARGO & COMPANY/MN29,497$204K<0.01%+11,09513F-HRTimelineGroup
BARCLAYS PLCin group BARCLAYS PLC29,208$202K<0.01%+4,48813F-HRTimelineGroup
Creative Planningin group Creative Planning28,483$197K<0.01%+17,63313F-HRTimelineGroup
PRICE T ROWE ASSOCIATES INC /MD/28,058$195K<0.01%+1,62413F-HRTimeline
Quantbot Technologies LP28,178$195K0.01%+27,51513F-HRTimeline
AXQ CAPITAL, LP27,068$187K0.02%-43513F-HRTimeline
nVerses Capital, LLC24,029$166K0.26%new13F-HRTimeline
DNB Asset Management ASin group DNB Asset Management AS23,600$163K<0.01%+8513F-HRTimelineGroup
Graham Capital Management, L.P.22,508$156K<0.01%new13F-HRTimeline
LOS ANGELES CAPITAL MANAGEMENT LLC22,385$155K<0.01%new13F-HRTimeline
Verdad Advisers, LP21,810$151K0.14%new13F-HRTimeline
MetLife Investment Management, LLCin group MetLife Investment Management…20,852$144K<0.01%+1,47213F-HRTimelineGroup
SG Americas Securities, LLC20,338$141K<0.01%new13F-HRTimeline
SEI INVESTMENTS COin group SEI INVESTMENTS CO20,026$139K<0.01%new13F-HRTimelineGroup
WINTON GROUP Ltdin group WINTON GROUP Ltd19,800$137K<0.01%new13F-HRTimelineGroup
IEQ CAPITAL, LLC19,535$135K<0.01%new13F-HRTimeline
DIADEMA PARTNERS LP19,093$132K0.05%-2,51613F-HRTimeline
Mirae Asset Global Investments Co., Ltd.group of 2 filers holding18,651$129K+224Timeline
Shay Capital LLC18,000$125K0.01%+8,00013F-HRTimeline
Quadrature Capital Ltdin group Quadrature Capital Ltd17,988$124K<0.01%new13F-HRTimelineGroup
Entropy Technologies, LP17,542$121K<0.01%-5,79413F-HRTimeline
STATE OF WISCONSIN INVESTMENT BOARD17,065$118K<0.01%-24,60613F-HRTimeline
MANUFACTURERS LIFE INSURANCE COMPANY, T…in group MANUFACTURERS LIFE INSURANCE …15,735$109K<0.01%+39713F-HRTimelineGroup
JANE STREET GROUP, LLCin group JANE STREET GROUP, LLC15,594$108K<0.01%new13F-HRTimelineGroup
MERCER GLOBAL ADVISORS INC /ADV13,352$92.4K<0.01%new13F-HR/ATimeline
Legal & General Group Plcin group Legal & General Group Plc12,561$86.9K<0.01%+2,95213F-HRTimelineGroup
Engineers Gate Manager LP12,491$86.4K<0.01%new13F-HRTimeline
STRS OHIO12,000$83K<0.01%+2,20013F-HRTimeline
CANADA PENSION PLAN INVESTMENT BOARD11,500$79.6K<0.01%new13F-HRTimeline
HSBC HOLDINGS PLCin group HSBC HOLDINGS PLC10,793$77.6K<0.01%-629,53313F-HRTimelineGroup
WEALTH ENHANCEMENT ADVISORY SERVICES, L…10,017$75.4K<0.01%new13F-HRTimeline
PRELUDE CAPITAL MANAGEMENT, LLC10,550$73K0.01%new13F-HRTimeline
AMERIPRISE FINANCIAL INCin group AMERIPRISE FINANCIAL INC10,487$72.6K<0.01%new13F-HRTimelineGroup
Police & Firemen's Retirement System of…9,456$65.4K<0.01%013F-HRTimeline
China Universal Asset Management Co., L…8,661$59.9K<0.01%-92913F-HRTimeline
KLP KAPITALFORVALTNING AS5,900$40.8K<0.01%013F-HRTimeline
NEW YORK STATE COMMON RETIREMENT FUND5,200$36K<0.01%+5,10013F-HRTimeline
Persistent Asset Partners Ltd4,855$33.6K0.01%-64013F-HRTimeline
Tower Research Capital LLC (TRC)in group Tower Research Capital LLC (T…4,788$33.1K<0.01%+3,36313F-HRTimelineGroup
PUBLIC EMPLOYEES RETIREMENT SYSTEM OF O…4,700$32.5K<0.01%new13F-HRTimeline
NISA INVESTMENT ADVISORS, LLC4,278$29.6K<0.01%-15,28013F-HRTimeline
Ameritas Investment Partners, Inc.group of 2 filers holding2,741$19K-31Timeline
Integrated Wealth Concepts LLC2,479$17.2K<0.01%new13F-HRTimeline
Global Retirement Partners, LLC1,870$12.9K<0.01%13F-HRTimeline
Arax Advisory Partners1,771$12.3K<0.01%+1,69413F-HRTimeline
GAMMA Investing LLC1,164$8.05K<0.01%+44913F-HRTimeline
GF FUND MANAGEMENT CO. LTD.1,145$7.92K<0.01%-5813F-HRTimeline
ROYAL BANK OF CANADAin group ROYAL BANK OF CANADA1,091$7K<0.01%new13F-HRTimelineGroup
Zurcher Kantonalbank (Zurich Cantonalba…965$6.68K<0.01%+48813F-HRTimeline
Quarry LP893$6.18K<0.01%new13F-HRTimeline
Allworth Financial LP778$5.38K<0.01%+51513F-HRTimeline
Rockefeller Capital Management L.P.in group Rockefeller Capital Managemen…738$5.11K<0.01%013F-HRTimelineGroup
Sterling Capital Management LLC710$4.91K<0.01%-38413F-HRTimeline
PNC Financial Services Group, Inc.in group PNC Financial Services Group,…387$2.68K<0.01%new13F-HRTimelineGroup
Farther Finance Advisors, LLC353$2.44K<0.01%+27213F-HRTimeline
ROTHSCHILD INVESTMENT LLC287$1.99K<0.01%+22613F-HRTimeline
EverSource Wealth Advisors, LLCin group EverSource Wealth Advisors, L…272$1.88K<0.01%+5013F-HRTimelineGroup
US BANCORP \DE\in group US BANCORP \DE\264$1.83K<0.01%-32613F-HRTimelineGroup
IFP Advisors, Inc242$1.68K<0.01%+24113F-HRTimeline
Physician Wealth Advisors, Inc.160$1.11K<0.01%new13F-HRTimeline
Essential Partners LLC146$1.01K<0.01%-25613F-HRTimeline
N.E.W. Advisory Services LLC120$830<0.01%013F-HRTimeline
SJS Investment Consulting Inc.76$526<0.01%+7413F-HRTimeline
Silver Grove Financial Group, Inc.28$194<0.01%new13F-HRTimeline
SIMPLEX TRADING, LLC20$138<0.01%new13F-HRTimeline
OSAIC HOLDINGS, INC.in group OSAIC HOLDINGS, INC.19$131<0.01%-37013F-HRTimelineGroup
Clearstead Advisors, LLC15$105<0.01%new13F-HRTimeline
JPL Wealth Management, LLC14$97<0.01%new13F-HRTimeline
NATIONAL BANK OF CANADA /FI/in group NATIONAL BANK OF CANADA /FI/1$7<0.01%new13F-HRTimelineGroup
Freestone Grove Partners LP1$7<0.01%013F-HRTimeline
Covestor Ltd39$00%+3513F-HRTimelineValue filed as zero, left out of ratios.